Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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La sostenibilità nel servizio sociale. Il ruolo dei processi di co-creazione
No full textCome costruire servizi di welfare e interventi professionali orientati alla sostenibilità sociale? Quali processi e relazioni ne sostengono l’attuazione?
Il volume affronta questi interrogativi dalla prospettiva del servizio sociale e concentrandosi sui processi di co-creazione, intesi come pratiche partecipative attraverso cui istituzioni, professionisti, cittadini e organizzazioni civiche progettano, gestiscono e valutano insieme servizi e interventi.
A partire da una ricerca qualitativa condotta in tre servizi sociali del Nord Italia, il testo analizza gli effetti riconducibili alla sostenibilità sociale, nonché le condizioni e i processi che li hanno prodotti, e sviluppa una riflessione teorico-interpretativa sul rapporto tra partecipazione, sostenibilità sociale e
servizio sociale. Il libro offre quindi a studenti, professionisti e decisori politici impegnati nell’ambito dei servizi sociali strumenti concettuali e operativi per concepire la sostenibilità sociale come esito non scontato né meramente tecnico dei processi di co-creazione nei servizi di welfare
FlexReg: an R package for fitting a general class of mixture regression models with bounded responses in a Bayesian framework
No full textCivil society organisations and community bonds in post-pandemic small-scale localities: balancing cohesion and fragmentation
Full text linkDevelopment of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy
Full text link: PROTACs (proteolysis-targeting chimeras) enable selective protein degradation through the ubiquitin-proteasome system and offer opportunities to target moonlighting proteins with nonenzymatic functions. We report the design, synthesis, and biological evaluation of NAMPT-directed PROTACs derived from our previously described inhibitor MV78 (7). A modular click chemistry strategy facilitated rapid assembly of a focused library by varying linker architectures and E3 ligase recruiters, with emphasis on the impact of a triazole unit. Structure-activity relationship studies revealed that eliminating the triazole from the linker and introducing an (S)-methyl group on the VHL ligand markedly enhanced degradation. The optimized degrader, U42, exhibited low nanomolar antiproliferative activity, robust intracellular and extracellular NAMPT degradation, excellent metabolic stability, favorable pharmacokinetics, and sustained efficacy in mammosphere models, three-dimensional breast cancer cultures not previously explored with NAMPT degraders. These findings highlight U42 as a lead compound and provide strong rationale for advancing NAMPT-directed PROTACs as a therapeutic strategy in breast cancer
Lope de Vega, entre egolatría autorial y crítica literaria: algunas catas
No full textLa proyección de la imagen autorial lopesca asume diferentes posturas según se trate del ámbito poético o del campo teatral. En el primero el Fénix necesita exhibir sus referentes cultos, tanto españoles como italianos, conforme al precepto de la imitatio propio del estilo áulico; en el segundo afirma su primacía y originalidad, ocultando los verdaderos modelos paradigmáticos. Las guerras literarias en que se vio involucrado, por lo general a pesar suyo, le impiden una honestidad intelectual que sabe mostrar tan solo en el caso de Góngora y, por más señas, post mortem. Por lo demás, las relaciones de amistad personal y sus objetivos autopromocionales obstaculizan la construcción de un canon realmente conforme a sus gustos literarios, con algunas relevantes excepciones. Un rasgo de indudable modernidad estriba en su empeño en mostrarse no solo atento, sino activo promotor o censor del mercado editorial coetáne
Case Report: Intensive multidisciplinary motor-cognitive rehabilitation treatment in Gerstmann–Sträussler–Scheinker syndrome
No full textGerstmann–Sträussler–Scheinker syndrome (GSS) is a genetic, autosomal dominant prion brain disease that causes ataxia and slow cognitive decline. Herein, we describe a 34-year-old woman (S.C.B.) diagnosed with GSS (variant Pro102Leu). In 2018, she presented with gait instability without falls, early fatigue, and dizziness; after 3years, urinary incontinence, initial insomnia and rapid-eye movement sleep behavior disorder, writing difficulties, and occasional dysphagia had appeared. S.C.B. was admitted to the Neurorehabilitation Unit due to the progressive worsening of her balance and walking ability [Timed Up and Go (TUG): not evaluated; Berg Balance Scale (BERG): 5/56]. At admission, neurological, neuropsychological, physiotherapeutic, occupational, and speech assessments were performed. She was completely dependent in basic (ADL) and instrumental activities of daily living (iADL) (ADL: 5/6; iADL: 4/8; Barthel Index: 60); furthermore, moderate cognitive decline and depressive symptoms were observed. After 4weeks of intensive motor-cognitive rehabilitation treatment, an improvement was observed in all the intervention areas, leading to a global gain in autonomy (TUG: 1 min 50 s; BERG: 10/56; Barthel Index: 70). This case report highlights the importance of tailored motor-cognitive rehabilitation and how these interventions can enhance patients’ quality of life and their ability to cope with their symptoms. In conclusion, this case contributes to a broader understanding of treatment options that clinicians can propose to patients
L’ineguaglianza economica tra lavoratori autonomi e lavoratori salariati nell’Atene classica
No full textA differenza dell’immagine tradizionale, trasmessa soprattutto da storici e filosofi di V e IV secolo a.C., che vede l’Atene democratica polarizzata tra i ceti possidenti e il popolo, quest’ultimo inteso come un blocco economicamente e socialmente monolitico, l'analisi delle fonti coeve, a partire da alcuni versi del Pluto di Aristofane, rivela la consapevolezza che i lavoratori autonomi avevano circa la propria maggiore sicurezza sociale derivata dall’esercizio di una professione che consentiva loro di mantenere un tenore di vita modesto, ma dignitoso, diversamente dai lavoratori salariati che non possedendo un bagaglio di conoscenze tecniche fondavano il proprio mantenimento su lavori occasionali al servizio di terzi, rimanendo pertanto più esposti al rischio di cadere dalla povertà nella miseria in occasione di congiunture economiche sfavorevoli
Oligarchici e democratici a confronto? Etica, politica e società nei Sicioni di Menandro
No full textUnder pressure: trade competition from low-wage countries and demand for immigrant labor in Italy
Full text linkThis study examines whether trade competition from low-wage countries (LWCs) influences immigration patterns in an advanced economy. We focus on Italy between 2003 and 2013, a period characterized by rising market pressure from China and Eastern Europe. Using census data on sectoral employment, administrative records on immigrants by nationality, and disaggregated bilateral trade data, we investigate whether heightened import competition acted as a pull factor for migrant workers by exploiting the differential exposure of local labor markets. To identify the exogenous component of these trade shocks, we adopt a shift-share instrumental variable strategy, while disaggregating immigrant data by nationality allows us to control in detail for the role of local networks and for bilateral push and pull factors. Our findings indicate that trade competition from LWCs significantly increased local immigrant shares. Exploring potential mechanisms, we find indirect evidence that firms under competitive pressure sought to cut labor costs by relying on a more flexible, lower-paid workforce, primarily composed of foreign workers
Gasotransmitters bridging tumor biology and immunity: from pathophysiological insights to therapeutic potential
Full text linkThe tumor microenvironment (TME) is a highly intricate and dynamic milieu, comprising neoplastic, immune and stromal cells in concert with extracellular matrix components, all engaged in continuous bidirectional crosstalk that critically orchestrates disease progression and therapeutic resistance. Beyond the local context, the TME is deeply shaped also by systemic influences, such as inflammatory mediators, metabolic cues and hematopoietic perturbations, collectively fostering a tumor-permissive macroenvironment. The interplay between local and systemic signals plays a pivotal role in modulating cellular differentiation, immune dynamics and stromal architecture, thereby sustaining malignancy. Among the myriad regulatory modulators involved in this complex network, endogenously produced gasotransmitters, namely carbon monoxide (CO), nitric oxide (NO) and hydrogen sulfide (H2S), have emerged as key modulators of tumor biology. These small, diffusible molecules exert a context-dependent spectrum of both pro-and anti-tumorigenic effects, influenced by their concentration, cellular source and tumor-specific microenvironmental conditions. Through the modulation of redox balance, metabolic signaling and epigenetic regulators, gasotransmitters impact immune cell functions, stromal remodeling and tumor cell behavior, thereby contributing to either immune evasion and therapy resistance or, conversely, to tumor suppression. Despite their growing relevance, the molecular mechanism governing these dualistic roles remain incompletely elucidated. This review provides a comprehensive overview of the current knowledge regarding the roles of CO, NO and H2S in shaping TME. We focus on their influence on immune, stromal and tumor cell differentiation, metabolism and function, and discuss how this understanding could inform novel therapeutic strategies aimed at reprogramming the TME to enhance clinical outcomes in cancer treatment