Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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Multivariate portfolio choice via quantiles
No full textWe first show how the quantile approach used for univariate optimal portfolio choice can also be useful when dealing with the multivariate case. Specifically, when a related multivariate risk-sharing problem (in the absence of a financial market) can be solved explicitly, then the multivariate optimal portfolio choice is shown to reduce to a one-dimensional problem that can be dealt with using the quantile approach. We then use this finding to develop an efficient algorithm to determine optimal portfolios. We also develop a numerical approach that makes it possible to obtain approximate solutions for general multivariate portfolio selection problems
Editorial: Tumor-host interactions: metabolic and signaling pathways altered in cancer, immune and stromal cells
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The SIS NET ICU study: characteristics of patients with severe community acquired pneumonia admitted to Italian ICUs—a multicenter prospective observational study
No full textBackground: The SIS-NET ICU study aimed to describe the epidemiology of severe community-acquired pneumonia (CAP) among patients admitted to Italian intensive care units (ICUs). This study also aimed to describe the clinical and microbiological characteristics, outcomes, and treatments received by the included patients. Methods: We conducted a prospective, observational, multicenter study. We included patients consecutively admitted to the ICUs of 13 participating centers during the study period for acute respiratory failure due to CAP. The study period spanned from January to November 2025. The analyses aimed to describe the epidemiological and clinical characteristics, diagnostic pathways, factors associated with ICU mortality, and type of respiratory support during the ICU stay. Results: We included a cohort of 150 patients with a mean age of 63 years and a male predominance (61%). The occurrence rate of CAP in the participating ICUs was 2.5%. Streptococcus pneumoniae, Haemophilus influenzae, Influenza A and Respiratory Syncytial Virus were the predominant isolated microorganisms. The average APACHE II score was 17 (SD 7.9) and the median SOFA score was 7 (SD 3.9). The comorbidity burden was substantial. A high proportion of patients was managed with non-invasive respiratory supports. Rapid microbiological testing methods were early adopted in 63% of patients, with substantial impact on antimicrobial therapy decisions. Each 10-year increase in age was associated with a 54% increase in the odds of death (aOR 1.54, 95% CI 1.06-2.35; p = 0.02) and immunosuppressed status was associated with higher odds of death (aOR 3.13, 95% CI 1.04-9.63; p = 0.04). Polymicrobial infection showed a trend towards higher mortality (aOR 2.47, 95% CI 0.94-6.89; p = 0.06), although this association did not reach conventional statistical significance. Conclusions: Our study demonstrated the predominance of common pathogens as microbiological isolates in patients with severe CAP in Italy. Age, and immunosuppressed status were independently associated with a higher odds of mortality
