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Respuestas cardiocirculatorias, metabólicas y perceptivas en competición de esgrima en silla de ruedas de élite
Full text linkLa esgrima en silla de ruedas es un deporte caracterizado por esfuerzos de carácter intermitente donde el ritmo de las acciones es máximo. Existe carencia bibliográfica sobre la evolución de la fatiga en este deporte, en contraste con la información referente a la modalidad olímpica. El objetivo de este estudio fue calcular los valores cardiocirculatorios, metabólicos y perceptivos en una competición internacional de esgrima en silla de ruedas para aumentar los recursos en la programación específica del entrenamiento en este deporte. Compitieron 16 tiradores de categoría A (7) y categoría B (9), a los que se monitorizó la frecuencia cardiaca, el lactato en sangre y la percepción de esfuerzo en cada fase de la competición. Tanto la frecuencia cardiaca (p = .014) como el lactato en sangre (p = .037) y la percepción de esfuerzo (p = .04) aumentaron más en la fase de eliminación directa que en la poule, y se estabilizó en el tramo final de competición. En conclusión, todos los parámetros analizados tienden a incrementarse tras la fase de poule y llegan a sus valores máximos en las eliminaciones directas. A pesar de que los valores metabólicos superaron levemente el umbral aeróbico, es necesario crear una estrategia de entrenamiento para demorar la fatiga y evitar así errores coordinativos, lo cual es tan importante en esta modalidad paralímpica que necesita alta precisión a velocidad máxima.Este estudio recibió una financiación de 6.500 € del proyecto titulado “Variables Fisiológicas de Esgrima en Silla de Ruedas” (#2023-233-003) de la Universidad Católica de Valencia y se llevó a cabo en la Facultad de Ciencias de la Actividad Física y del Deporte y Fisioterapia de la Universidad Católica de Valencia, EspañaCiencias de la Actividad Física y del Deport
Circulating tumor DNA for predicting recurrence in patients with operable breast cancer: a systematic review and meta-analysis
Full text linkThe incorporation of circulating tumor DNA (ctDNA) into the management of operable breast cancer (BC)
has been hampered by the heterogeneous results from different studies. We aimed to assess the prognostic value of
ctDNA in patients with operable (non metastatic) BC.This work was supported by Lombardy Region Italy [grant
agreement number RR33] as part of the project ‘I controlli
periodici (follow-up) dopo la diagnosi e le terapie in pazienti
liberi da malattia e asintomatici: verso una person-
alizzazione delle strategie di follow-up’.Medicin
Structural attributes and macrofaunal assemblages associated with rose gorgonian gardens (Leptogorgia sp. nov.) in Central Chile: opening the door for conservation actions
Full text linkGorgonians (like corals) are important habitat-
forming organisms that support a diversity of macrofauna.
This study explored structural attributes of gorgonian gardens formed by rose gorgonians (Leptogorgia sp. nov.) and
associated macrofaunal assemblages in Caleta Pichicuy
(Central Chile). Hierarchical sampling was conducted at
20 m depth (maximum colony abundances) in order to assess
spatial variability in abundance and colony attributes at two
spatial scales (among sites and rocky walls). The abundance
and composition of the associated vagile and sessile macro-
fauna were also examined using univariant (Taxa richness and Shannon index (H’e)) and multivariant approaches
and were compared with adjacent bare rocky habitats. Our
results showed a high abundance of gorgonians (ca. 28.9–
36.5 colonies m −2 ) compared to other gorgonian gardens
in the world. For structural attributes, our results showed
smaller colonies with thicker holdfasts in more exposed
sites, suggesting the influence of hydrodynamic forces on the
colony morphology. Taxa richness and H’e of vagile fauna
showed threefold and twofold, respectively, higher values
in gorgonian gardens compared to bare walls, but no differences were observed for sessile fauna. In addition, PCoA
and PERMANOVA evidenced a distinctive assemblages’
composition between habitats for both vagile and sessile
fauna. Correlation analyzes and dbRDA showed, however,
little association between structural attributes and associated
faunal assemblages (R2 = 0.06, and ca. 3–9.4% of the total
variation explained, respectively). Our results constitute the
first assessment of structural habitat complexity and accompanying fauna in these gorgonian gardens and establish the
baseline for understanding possible future changes associated to human activities.Open Access funding provided thanks to the CRUE-CSIC
agreement with Springer Nature. JCC received financial support from
Dirección de Posgrado and Programa de Magíster en Ecología Marina,
Universidad Católica de la Santísima Concepción. IAH received finan-
cial support from COPAS COASTAL ANID FB210021.Ciencias del Ma
Early life stages of the invasive Atlantic blue crab Callinectes sapidus in the Western Mediterranean Sea
Full text linkA. Gil-Fern´andez: Writing – review & editing, Writing – original
draft, Visualization, Project administration, Methodology, Investigation,
Formal analysis, Data curation, Conceptualization. M. Rodilla: Writing
– review & editing, Supervision, Resources, Methodology, Conceptual-
ization. P. Prado: Writing – review & editing, Writing – original draft,
Funding acquisition. S. Falco: Writing – review & editing, Supervision,
Resources, Funding acquisition, Conceptualization.The early life cycle of the Atlantic blue crab Callinectes sapidus includes seven zoeal stages that develop in coastal
waters, and a later megalopal stage that colonizes estuaries. Although these stages have been largely studied in
native ecosystems, very little is known about larval patterns in smaller-scale, invaded, estuarine environments
such as those available in the Mediterranean Sea. The general aim of this study is to assess the distribution and
abundance of early life stages of C. sapidus in the communication channels of the Albufera lagoon with the
Mediterranean Sea, and in adjacent coastal waters. Different sampling methods were employed to target each life
stage. (1) For zoeae, planktonic tows were conducted using a 300 μm manta net along 200 m transects parallel to
the coastline at distances of 300, 1000 and 3000 m from the shore. (2) A small and manageable passive collector
model was used to capture megalopae and juveniles in estuarine areas. This system was first tested from 2020 to
2021 in a single channel, with a weekly sampling frequency, and two more channels were added in 2022.
Additionally, intensive daily sampling was conducted in one of the channels from September to November 2022
during the settlement peak. Results showed that zoeae of C. sapidus were more abundant in August 2021, at 1000
m from the coast, and appear to have a disjoint temporal distribution with zoeae of other crab species. Megalopae
and juveniles were more abundant from September to November at all sampling sites and times. In 2022, collectors featured a dominance of megalopae at two of the sites (ca. 73%), while the site with the lowest salinity
showed a dominance of juveniles (84%). For megalopae, comparative results from the intensive and the regular
sampling campaigns showed that time of residence within collectors is just a single day. For juveniles, higher
numbers were detected with increased deployment time, suggesting a need for enhanced habitat complexity.Ciencias del Ma
Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment
Full text linkM.P. designed, acquired, analyzed, and interpreted the data; M.P. and E.O.
drafted the manuscript and critically revised the content; M.L. drafted figures and tables. All authors
have read and agreed to the published version of the manuscript.Chronic fatigue syndrome (CFS) is a heterogeneous disorder with a genetically associated
vulnerability of the catecholamine metabolism (e.g., catechol O-methyltransferase polymorphisms),
in which environmental factors have an important impact. Alpha-methyl-p-tyrosine (AMPT; also
referred to as metyrosine) is an approved medication for the treatment of pheochromocytoma. As
a tyrosine hydroxylase inhibitor, AMPT may be a potential candidate for the treatment of diseases
involving catecholamine alterations. However, only small-scale clinical trials have tested AMPT repurposing
in a few other illnesses. The current case report compiles genetic and longitudinal biochemical
data for over a year of follow-up of a male patient sequentially diagnosed with sustained overstress,
neurasthenia, CFS (diagnosed in 2012 as per the Center for Disease Control (CDC/Fukuda)), and
postural orthostatic tachycardia syndrome (POTS) over a 10-year period and reports the patient’s
symptom improvement in response to low–medium doses of AMPT. This case was recognized as a
stress-related CFS case. Data are reported from medical records provided by the patient to allow a
detailed response to treatment targeting the hyperadrenergic state presented by the patient. We highlight
the lack of a positive response to classical approaches to treating CFS, reflecting the limitations of
CFS diagnosis and available treatments to alleviate patients’ symptoms. The current pathomechanism
hypothesis emphasizes monoamine alterations (hyperadrenergic state) in the DA/adrenergic system
and a dysfunctional autonomic nervous system resulting from sympathetic overactivity. The response
of the patient to AMPT treatment highlights the relevance of pacing with regard to stressful situations
and increased activity. Importantly, the results do not indicate causality between AMPT and its action
on the monoamine system, and future studies should evaluate the implications of other targets.This research was funded by several economic organizations. ML was supported by the
UCV predoctoral fellowship (VIDI UCV2023_2026). EO received funding support from UCV2020-270-
001. MP received funding support from the Ministerio de Ciencia e Innovacion (RYC2022-035438-I).Medicin
Enhanced Timeliness and Co-Administration of Meningitis B Vaccination in Children: Impact of Funding in Valencian Community, Spain
Full text linkAuthor Contributions: Conceptualization, J.J. and E.P.-V.; Data Curation, J.J.; Formal Analysis, J.J.,
E.P.-V., P.E.-P., C.B.-C., J.A.L.-R. and A.O.-S.; Methodology, J.J. and E.P.-V.; Resources, J.A.L.-R., E.P.-V.
and A.O.-S.; Software, J.J.; Supervision, E.P.-V. and J.A.L.-R.; Validation, A.O.-S., E.P.-V. and J.A.L.-R.;
Visualization, J.J., C.B.-C. and P.E.-P.; Writing: J.J., C.B.-C. and P.E.-P. All authors have read and agreed
to the published version of the manuscript.Public funding of vaccines may enhance vaccination rates, co-administration, and timeliness. The impacts of including the serogroup B meningococcus vaccine (MenB) into the national immunisation schedule on vaccination rates, co-administration rates, and timeliness were assessed using a population-based pre-funding (2022) and post-funding (2023) study design. MenB vaccination rates improved after funding and were in line with previously funded vaccines. Co-administration rates also increased significantly. Timely administration increased, protecting children at an early age. Public funding has a positive impact on vaccine accessibility and early protection. Consistent population characteristics highlight the role of funding.Medicin
The exemplarity of divine justice in behind in the portuguese version Vision of Tundal
Full text linkNo imaginário da sociedade cristã medieval a justiça terrena não
era concebida como uma ação desvinculada da justiça divina, pois coexistiam
tanto no mundo dos vivos quanto no mundo dos mortos. No entanto, segundo
os discursos clericais, a verdadeira justiça era aquela realizada por Deus no
pós-morte, que determina as sentenças destinadas às almas no Além. Este é
estruturado em espaços associados às condutas morais cristãs: o Inferno, Purgatório e Paraíso. As narrativas visionárias se tornaram um instrumento essencial
na divulgação dessa retórica cristã ao dar uma projeção visual de um Deus juiz
que pune, salva e recompensa os eleitos e os danados, de acordo com os seus
merecimentos, no post-mortem. Neste artigo, analisamos as descrições da justiça divina sobre as almas nos lugares do Além na versão portuguesa da Visão
de Túndalo como elementos de exemplaridade que visam instruir e aconselhar
a sociedade medieval sobre as ações comportamentais deste mundo, levando
ao caminho da salvação ou da danação. Discutimos também um panorama
sobre as aplicações da justiça realizada no plano terreno por meio de ações de
monarcas portugueses da Dinastia de Avis.In the imagination of medieval Christian society, earthly justice was not conceived as an action disconnected from divine justice, they coexisted in both the world of the living and the world of the dead. However, according to clerical discourses, God carried out true justice in the afterlife, which determines the sentences destined for souls in the Beyond structured in spaces associated with Christian moral conduct, Hell, Purgatory and Paradise. Visionary narratives became an essential instrument in the dissemination of this Christian rhetoric by providing a visual projection of a judging God who punishes, saves and rewards the elect and the damned, according to their merits, in the post-mortem. In this article, we analyse the descriptions of divine justice over souls in the places of the Afterlife in the Portuguese version of the Tundal Vision as exemplary elements that aim to instruct and advise medieval society on the behavioural actions of this world that lead to the path of salvation or damnation. An over-view of the applications of justice carried out on earth through the Portuguese king's actions of the Avis dynasty is also mentioned.Humanidade
Comparison of aesthetic treatments for molar-incisor hypomineralisation: Systematic review and meta-analysis
Full text linkThis systematic review and meta-analysis aimed to analyse the effects of treatments on changes in
enamel colour in teeth with MIH lesions and determine whether resin infiltration is the most aesthetic treatment.Odontologí
Sensitivity of marine invertebrates to acidification of seawater by an atmosphere enriched with CO2
Full text linkOcean acidification, a consequence of increasing atmospheric CO2, results from oceans absorbing about one-third of CO2 emissions, leading to a decrease in pH. This phenomenon can cause sublethal or lethal damage to marine organisms some of which are crucial for coastal ecosystems and human economies. Understanding how to reproduce acidified seawater in a laboratory is essential for assessing potential impacts. Our protocol uses a CO2-enriched atmosphere to determine the pH tolerance of Mysidopsis juniae, exposed at pH 6.8 and 7.0, and larvae of Arbacia lixula, exposed at pH 7.2. M. juniae showed lethal responses at pH 6.8 ± 0.3, while A. lixula exhibited delayed larval development as a sublethal reaction at pH 7.2 ± 0.3. However, these pH levels are extreme and cannot be predicted for future oceanic conditions. Other studies have indicated negative sublethal effects on similar organisms at higher pH levels than those observed in this study. Continued experiments are necessary to prepare for and inform about the dangers of ocean acidification, and also to develop other types of studies.La acidificación de los océanos, consecuencia del aumento del CO₂ atmosférico, se debe a que los océanos absorben aproximadamente un tercio de las emisiones de CO₂, lo que provoca una disminución del pH. Este fenómeno puede causar daños subletales o letales a los organismos marinos, algunos de los cuales son cruciales para los ecosistemas costeros y las economías humanas. Saber cómo reproducir agua de mar acidificada en un laboratorio es esencial para evaluar sus posibles efectos. Nuestro protocolo utiliza una atmósfera enriquecida con CO₂ para determinar la tolerancia al pH de Mysidopsis juniae, expuesta a pH 6.8 y 7.0, y de larvas de Arbacia lixula, expuestas a pH 7.2. M. juniae mostró respuestas letales a pH 6.8 ± 0.3, mientras que A. lixula exhibió un retraso en el desarrollo larvario como reacción subletal a pH 7.2 ± 0.3. Aunque estos niveles de pH son extremos y no se prevén para las condiciones futuras del océano. Otros estudios indican impactos subletales negativos en organismos similares a niveles de pH superiores a los experimentados en este artículo. Es necesario continuar los experimentos para prepararse e informar sobre los peligros de la acidificación de los océanos, y también para desarrollar otros tipos de estudios.Ciencias del Ma
Geografía y diáspora de la locura: las instituciones psiquiátricas valencianas durante la Guerra Civil española
Full text linkLa ciudad de Valencia recibió grandes contigentes de población civil y militar evacuada durante la Guerra Civil Española, lo que supuso un notable aumento de la presión sobre su infraestructura asistencial. Este artículo analiza la articulación de la asistencia psiquiátrica en Valencia durante la contienda, en la que tuvo un papel muy destacado la (poco conocida) figura del psiquiatra Fernando Domingo Simó. Entre otras cuestiones, la investigación confirma que las instituciones psiquiátricas valencianas padecieron entonces un aumento significativo de la mortalidad debido al hambre y al hacinamiento de los internos, tal como sucedió en otros asilos españoles durante la guerra.Medicin