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[Reseña]. Solanes Corella, A. (2023) ¿Castigar o premiar? Las sanciones positivas. València: Tirant lo Blanch.
No full textLa
obra de Ángeles Solanes Corella, Catedrática
en Filosofía del Derecho de la
Universidad de Valencia, publicada por la
Editorial Tirant lo Blanch en septiembre
de 2023, se inscribe con acierto en las
nuevas tendencias que están emergiendo
en los últimos tiempos, que aspiran
a potenciar la función promocional del
Derecho en detrimento de su faceta protectora-
represiva, más propia del modelo
liberal clásico. “¿Castigar o premiar? Las
sanciones positivas” es el título de la obra
a la que nos referiremos en el presente
texto, la cual está dividida en cuatro capítulos,
precedidos de una introducción,
que nos sitúa, desde el inicio, en la tesitura
de ampliar nuestra mirada hacia fines y
técnicas del ordenamiento distintos a la
mera coacción, permitiéndonos imaginar
nuevos horizontes que permitirán al Derecho
asegurar su eficacia y su función
como ordenador de las conductas.Filosofí
Quella cotale presenza della sua umanità passionata: images and affections in the specchio di croce by Domenico Cavalca
Get PDFRiprendendo la spiritualità monastica medievale, insieme con la tradizione patristica, Domenico Cavalca (anni Ottanta del Duecento-1341), dell’Ordine dei Predicatori di Pisa, si fa catalizzatore in positivo di immagini dal forte impatto visivo e affettivo, promuovendo per un pubblico di laici devoti un graduale percorso di educazione all’affettività. Formatosi particolarmente alla scuola di s. Bernardo di Clairvaux, Cavalca promuove il Cristianesimo non già come una “religione del Libro”, ma come religione della Parola, di un Verbo Incarnato e vivo, unico e personale. Il Deus-homo crucifixus è il Libro scritto nella Parola incarnata, e chiede al meditante di contemplare, come ‘vedere’ e ‘sentire’ insieme, questo passaggio. L’adorazione della croce diviene allora il modello di una meditazione affet-tiva che suscita immagini capaci di trasporre nello spirito come nel corpo la testimonianza di Paolo ai Galati, Christo confixus sum cruci. Sfruttando una chiave psicologica comune ai predicatori (l’uomo composto di cogitatus, affectus e memoria), il Nostro ripropone ciò che era il positivo (o l’impulso) della spiritualità monastica, il ritorno cioè a Dio attraverso l’Uomo del Figlio, e così recuperare quell’immagine impressa nella creatura prima del peccato.Taking up medieval monastic spirituality, together with the patris-tic tradition, Domenico Cavalca (1380s-1341), of the Order of Preachers of Pisa, became a positive catalyst for images with a strong visual and affective impact, promoting for an audience of devout lay people a gradual path of education to affectivity. Trained especially at the school of St. Bernard of Clairvaux, Cavalca promotes Christianity not as a "religion of the Book", but as a religion of the Word, of an Incarnate and living Word, unique and personal. The Deus-homo crucifixus is the Book written in the incarnate Word, and asks the meditator to contemplate, as if to 'see' and 'feel' together, this passage.Adoration of the cross then becomes the model of an affective meditation that gives rise to images capable of transposing Paul's testimony to the Galatians into the spirit as well as into the body, Christo confixus sum cruci. Exploiting a psychological key common to preachers (the man composed of cogitatus, affectus and memory), Ours re-proposes what was the positive (or impulse) of monastic spirituality, that is, the return to God through the Man of the Son, and thus recover that image imprinted on the creature before sinHumanidade
The beautiful fortresses of Monstrelet’s chronicles and their continuation in Georges d’Amboise’s manuscripts (Paris, Bibliothèque Nationale de France, ms. 2678-2679)
Get PDFLes Chroniques de Monstrelet font mention de forteresses de manière
laconique, avec quelques adjectifs peu explicites. Les descriptions sont
rares et lacunaires. Pour Jean Pichore et le Maître de Philippe de Gueldre
chargés d’illustrer ces récits, la difficulté n’est pas mince. Les images qu’ils
donnent de ces lieux fortifiés sont pourtant parmi les plus réussies, quelle que
soit la part des stéréotypes ou des éléments empruntés au réel. L’inventaire de ce
qui définit la beauté de ces forts et de ces citadelles – hautes silhouettes emblématiques,
masses imposantes au décor sobre ou surchargé, intérieurs luxueux -
éclaire l’évolution du goût et des sensibilités des contemporains entre tradition
française et influence italienne. Le cardinal Georges d’Amboise, bibliophile
commanditaire de ces manuscrits et propriétaire de points forts qu’il construit
ou réaménage, retrouvait ainsi, malgré invraisemblances et maladresses, le
discours architectural, les concepts et le lexique de son tempsMonstrelet’s Chronicles laconically mention fortresses, with adjectives
that are not very explicit. The descriptions are few and incomplete.
For Jean Pichore and the Master of Philippe de Gueldre, charged with illustrating
these accounts, this was no mean feat. However, the images they give
are among the most successful, whatever the extent of stereotypes or elements
borrowed from reality. An inventory of what define the beauties of these forts
and citadels - tall and emblematic silhouettes, imposing masses with sober or
overloaded decorations, luxurious interiors - sheds light on the evolution of
contemporary tastes and sensibilities between French tradition and Italian influence.
Cardinal Georges d’Amboise, the bibliophile who commissioned these
manuscripts and owned fortifications he built or refurbished, was thus able to
recognize and appreciate the architectural discourse, concepts and lexicon of
his time, despite a few improbabilities and clumsinessHumanidade
Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes
Get PDFZ.A., M.R.H., F.G.-G., and M.J.V. initiated,
designed, and supervised the study; Z.A. and E.M. performed most
experiments; Z.A., E.M., and M.J.V. contributed to experimental work
and data analysis; M.R.H., S.R.-G., P.M.-M., and F.G.-G. contributed
to bioinformatic analysis; Z.A., M.R.H., E.M., J.A.L.-G., F.G.-G., and
M.J.V. prepared the manuscript. All authors discussed the results and
approved the manuscript.Identifying novel breast cancer biomarkers will improve patient stratification, enhance therapeutic outcomes, and help
develop non-invasive diagnostics. We compared the proteomic profiles of whole-cell and exosomal samples of representative breast cancer cell subtypes to evaluate the potential of extracellular vesicles as non-invasive disease biomarkers in
liquid biopsies. Overall, differentially-expressed proteins in whole-cell and exosome samples (which included markers
for invasion, metastasis, angiogenesis, and drug resistance) effectively discriminated subtypes; furthermore, our results
confirmed that the proteomic profile of exosomes reflects breast cancer cell-of-origin, which underscores their potential
as disease biomarkers. Our study will contribute to identifying biomarkers that support breast cancer patient stratification
and developing novel therapeutic strategies. We include an open, interactive web tool to explore the data as a molecular
resource that can explain the role of these protein signatures in breast cancer classification.This study was supported by the European Research Coun-
cil (grant ERC-CoG-2014-648831 “MyNano”) and the H2020
EU-OpenScreen-Drive project (grant agreement No. 823893). Our
screening platform is part of the European Infrastructure, ERIC EU-
OpenScreen, and the Excellence Network, TeNTaCLES (Translational NeTwork for the CLinical application of Extracellular Vesicle-Tenta-
cles-RED2018-102411-T). This research was also supported by the
Spanish Ministry of Science and Innovation (PID2019-108806RB-
I00; PID2020-117211GB-I00; PID2021-124430OA-I00 funded by
MICIU/AEI/https://doi.org/10.13039/501100011033 and by FEDER,
UE; and partially funded by the Institute of Health Carlos III (proj-
ect IMPaCT-Data, IMP/00019), co-funded by ERDF and CIBERONC
(project n. CB22/12/00048). The proteomic analysis was performed
in the proteomics facility of SCSIE University of Valencia, which
belongs to ProteoRed, PRB2-ISCIII, supported by grant PT13/0001.
Agreement 2019 between IVO and the Association “Mou-te per elles.”Medicin
The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen
Get PDFAuthor Contributions: Conceptualization, F.R. and F.R.-R.; software, J.A.P.-R., I.V. and F.R.; writing—
original draft preparation, F.R., F.R.-R. and J.M.H.-A.; writing—review, editing and visualization
J.A.P.-R., J.M.H.-A., F.R.-R., I.V. and F.R.; funding acquisition, J.M.H.-A. and J.A.P.-R. All authors have
read and agreed to the published version of the manuscript.Collagen, a versatile family of proteins with 28 members and 44 genes, is pivotal in
maintaining tissue integrity and function. It plays a crucial role in physiological processes like
wound healing, hemostasis, and pathological conditions such as fibrosis and cancer. Collagen is a
target in these processes. Direct methods for collagen modulation include enzymatic breakdown
and molecular binding approaches. For instance, Clostridium histolyticum collagenase is effective in
treating localized fibrosis. Polypeptides like collagen-binding domains offer promising avenues for
tumor-specific immunotherapy and drug delivery. Indirect targeting of collagen involves regulating
cellular processes essential for its synthesis and maturation, such as translation regulation and
microRNA activity. Enzymes involved in collagen modification, such as prolyl-hydroxylases or
lysyl-oxidases, are also indirect therapeutic targets. From another perspective, collagen is also a
natural source of drugs. Enzymatic degradation of collagen generates bioactive fragments known as
matrikines and matricryptins, which exhibit diverse pharmacological activities. Overall, collagenderived peptides present significant therapeutic potential beyond tissue repair, offering various
strategies for treating fibrosis, cancer, and genetic disorders. Continued research into specific collagen
targeting and the application of collagen and its derivatives may lead to the development of novel
treatments for a range of pathological conditions.Centro de Investigación Translacional San Alberto Magno of the Universidad Católica de Valencia San Vicente MártirMedicin
Functional brain connectivity prior to the COVID-19 outbreak predicts mental health trajectories during two years of pandemic
Get PDFWhile acknowledging the hardships caused by COVID-19, the pandemic
also provided a unique opportunity to study mental well-being and individual vulnerability or resilience. Sociodemographic, psychological factors, and lifestyles, have been identified as predictors of mental health
during COVID-19. Our previous study demonstrated the relevance of the
interplay between psychological measures and brain networks’ functional connectivity (FC). However, important questions remain to be addressed. For
example, can FC—alone or in combination with other measures – predict
longer-term mental health? Additionally, most studies focus on emotional
aspects (psychological distress), although mental health (MH) comprises emotional, psychological (personal growth, [PG]), and social (loneliness) well-
being components, which were differently impacted during the pandemic.
This study aims to investigate if there exists specificity between FC measures
and long-term changes across MH components, knowing the links between
brain networks and ‘resilience processes’.Medicin
International consensus statement on the design, delivery and evaluation of sport-based interventions aimed at promoting social, psychological and physical well-being in prison
Get PDFThe aim is to develop an international consensus
statement to advise on designing, delivering and
evaluating sport-based interventions (SBIs) aimed at
promoting social, psychological and physical well-being in
prison.This research was made possible by two support grants from Ulster
University: the University’s Early Career Researcher Impact Fund, and the School
of Applied Social and Policy Sciences’ Impact Fund. Funders had no role in study
design, data collection, data analysis, decision to publish or preparation of the
manuscript for publication.Psicologí
Predictive Factors for Difficulty in Simulation Methodology in Teacher Education
No full textSimulation methodology in teacher education offers a wide range of
practice opportunities in a controlled environment. However, even though not
much has been written about the benefits of simulation in teacher training, even
less has been said about the difficulties perceived by the participants in doing
simulation.Educació
The ‘rich cloths’ of bishop Juan Rodríguez de Fonseca, ten tapestries of the Redemption of man. Visual metaphors in service of power in the late Middle Ages
Get PDFDon Juan Rodríguez de Fonseca, obispo, representante diplomático, político habilidoso y amante de las bellas artes, fue uno de los personajes
más atractivos y singulares de finales del siglo XV y comienzos del XVI. De
elevado gusto y fina sensibilidad hacia los productos artísticos, el prelado
poseyó una de las series de tapices más ambiciosa y reproducida de la época,
la Historia de la Redención del Hombre. La colección, repartida hoy día entre
la Catedral de Palencia, la Catedral de Burgos, y el Metropolitan Museum de
Nueva York, destaca tanto por sus cualidades artísticas como por el contenido retórico de su iconografía, al transmitir, a través de esta historia bíblica,
valores y enseñanzas que contribuyeron a reforzar la memoria simbólica del
poder. Esta serie se convirtió en uno de los conjuntos más habituales en las
colecciones reales y eclesiásticas de las primeras dos décadas del siglo XVI, con múltiples ediciones dispersas por el mundo. Por desgracia, nuestra gran
colección fue vendida en parte, lo que supuso una pérdida irreparable para el
patrimonio artístico español.Don Juan Rodríguez de Fonseca, bishop, diplomatic representative, gifted politician, and lover of the arts was one of the most engaging
and remarkable figures during the late 15th and early 16th centuries. With an
elevated sense and fine sensibility for artistic works, the prelate owned one of
that period’s most ambitious and reproduced series of tapestries, the Story of
the Redemption of Man. The collection, now spread among the Cathedral of
Palencia, the Cathedral of Burgos, and the Metropolitan Museum in New York,
stands out for both its artistic qualities and the rhetorical content of its iconography, transmitting, through this Biblical narrative, values and teachings that
contributed to reinforcing the symbolic memory of power. It became one of the
most frequent series in the royal and ecclesiastical collections in the first two
decades of the 16th century, with numerous reproductions scattered worldwide.
Regrettably, part of our great collection was sold, meaning an irreparable loss
for the Spanish artistic heritage.Humanidade
SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants
Get PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rapidly evolving RNA virus behind the COVID-19 pandemic, has spawned numerous variants since its 2019 emergence. The multifunctional Nonstructural protein 14 (NSP14) enzyme, possessing exonuclease and messenger RNA (mRNA) capping capabilities, serves as a key player. Notably, single and co-occurring mutations within NSP14 significantly influence replication fidelity and drive variant diversification. This study comprehensively examines 120 co-mutations, 68 unique mutations, and 160 conserved residues across NSP14 homologs, shedding light on their implications for phylogenetic patterns, pathogenicity, and residue interactions. Quantitative physicochemical analysis categorizes 3953 NSP14 variants into three clusters, revealing genetic diversity. This research underscoresthe dynamic nature of SARS-CoV-2 evolution, primarily governed by NSP14 mutations. Understanding these genetic dynamics provides valuable insights for therapeutic and vaccine development.Ciencias Experimentale