RIUCV (Univ. Católica de Valencia)
Not a member yet
4539 research outputs found
Sort by
Prospective Randomized Controlled Clinical Trial of the Long-Term Effects of Omeprazole on Healthy Dogs
Full text linkAuthor Contributions: Conceptualization and methodology, L.G.-V.; statistical analysis design G.M.;
writing—original draft preparation, P.F.N. and L.G.-V.; writing—review and editing, L.G.-V., P.F.N.,
M.R.S. and A.V.; funding acquisition, C.S. All authors have read and agreed to the published version
of the manuscript.The use of omeprazole as a preventive treatment for gastrointestinal ulcers in veterinary
medicine has been questioned during previous years. The aim of the present study is to assess the
long-term effect of omeprazole on cobalamin and serum gastrin levels in healthy dogs. Eighteen
healthy dogs were included: 10 in the control group and 8 in the omeprazole group. Three samples
were collected: before starting the treatment (T0), 30 days after the start of treatment (T1), and at
60 days (T2). The mean cobalamin value (ng/L) in the control group was 481.4 (±293.70) at T0, 481.4
(±170.21) at T1, and 513.2 (±174.50) at T2. In the omeprazole group, the values were 424.62 (±161.57)
at T0, 454.5 (±160.96) at T1, and 414.87 (±127.90) at T2. No statistically significant changes were
detected in cobalamin levels between the three-time period in both study groups. These results agree
with previous findings in felines but contrast with human medicine studies. The median gastrin
values (pg/mL) in the control group were 62.45 [30.17–218.75] at T0, 76.06 [30.67–199.87] at T1, and
63.02 [35.81–176.06] at T2. The median gastrin value in the omeprazole group was 67.59 [55.96–101.60]
at T0, 191.77 [75.31–1901.77] at T1, and 128.16 [43.62–1066.46] at T2. Statistically significant differences
were detected (p = 0.008), indicating an increase in gastrin levels after initiating treatment with
omeprazole. In conclusion, the increased levels of gastrin observed in this population underscore the
importance of conducting a comprehensive clinical assessment to identify potential gastrointestinal
disorders, particularly in consideration of the usage of omeprazole as a preventive treatmentVeterinari
Computational Analysis of Polymeric Biodegradable and Customizable Airway Stent Designs
Full text linkAuthor Contributions: Study design, M.M., C.D.-J., C.S.-M. and J.L.L.-V.; conceptualization, C.D.-J.,
R.F.-P. and M.M.; stent geometries, M.M., C.S.-M. and J.L.L.-V.; numerical model and simulations,
A.A.-A. and M.M.; data curation experimental model, C.D.-J. and A.P.-J.; writing—original draft
preparation, M.M., C.S.-M., R.F.-P., C.D.-J. and J.L.L.-V.; writing—review and editing, M.M., C.S.-M.,
J.L.L.-V., R.F.-P. and C.D.-J.; supervision, M.M., C.D.-J., R.F.-P., C.S.-M. and J.L.L.-V.; funding acquisition, M.M., C.D.-J. and R.F.-P. All authors have read and agreed to the published version of
the manuscript.The placement of endotracheal prostheses is a procedure used to treat tracheal lesions when
no other surgical options are available. Unfortunately, this technique remains controversial. Both
silicon and metallic stents are used with unpredictable success rates, as they have advantages but also
disadvantages. Typical side effects include restenosis due to epithelial hyperplasia, obstruction and
granuloma formation. Repeat interventions are often required. Biodegradable stents are promising in
the field of cardiovascular biomechanics but are not yet approved for use in the respiratory system.
The aim of the present study is to summarize important information and to evaluate the role of
different geometrical features for the fabrication of a new tracheo-bronchial prosthesis prototype,
which should be biodegradable, adaptable to the patient’s lesion and producible by 3D printing. A
parametric design and subsequent computational analysis using the finite element method is carried
out. Two different stent designs are parameterized and analyzed. The biodegradable material chosen
for simulations is polylactic acid. Experimental tests are conducted for assessing its mechanical
properties. The role of the key design parameters on the radial force of the biodegradable prosthesis
is investigated. The computational results allow us to elucidate the role of the pitch angle, the wire
thickness and the number of cells or units, among other parameters, on the radial force. This work
may be useful for the design of ad hoc airway stents according to the patient and type of lesion.Biotecnologí
Response to: “An egg is not a chicken and an embryo is not a child”
Full text linkLa Revista Fertility and Sterility publica en su número
de mayo de este año el artículo titulado “An egg is not
a chicken and an embryo is not a child” que contiene,
a nuestro juicio, graves errores que merecen una réplica
desde la evidencia científica para que sea conocida por
los especialistas de bioética de habla hispánica...MedicinaInstituto de Ciencias de la Vid
A corpus-assisted approach to discursive news values analysis
Full text linkThe main aim of this paper is the elaboration of an analytical tool for comparative
studies. For this purpose, I used a combination of Discursive News Values Analysis (DNVA) and
Corpus Linguistics (CL) to analyse a corpus of British Broadsheets’ news coverage of the Brexit
campaign. The four major British broadsheets which were analysed were The Guardian, The
Independent, The Times, and The Daily Telegraph. A specific procedure was designed following
previous studies on the topic and considering the challenges and opportunities that such a mixedmethod
approach (DNVA and CL) can face in exploring journalistic discursive practices and
mapping the cultural and ideological discourses around certain topics. Some initial results of the
case study are presented to show how the suggested procedure works in practice. From the present
study’s findings, the procedure seems to work in a reliable manner, although some challenges should
be considered and addressed in future studies.Educació
Behavioural traits related with resilience or vulnerability to the development of cocaine-induced conditioned place preference after exposure of female mice to vicarious social defeat
Full text linkMaria ´Angeles Martínez-Caballero: Formal analysis, Investigation,
Methodology, Visualization, Writing – original draft. Claudia Calpe-
L´opez: Formal analysis, Visualization, Writing – original draft. Maria
Pilar García-Pardo: Formal analysis, Writing – review & editing. Maria
Carmen Arenas: Methodology, Writing – review & editing. Jose Enri-
que de la Rubia Ortí: Formal analysis, Writing – review & editing. Raquel Bayona-Babiloni: Investigation, Visualization. Maria
Asunci´on Aguilar: Conceptualization, Methodology, Writing - Review
& Editing, Supervision, Project administration, Funding acquisition.Exposure to stress induced by intermittent repeated social defeat (IRSD) increases vulnerability to the development of cocaine-induced conditioned place preference (CPP) among male mice; however, some defeated mice
are resilient to these effects of stress. In the present study we evaluated the effects of vicarious IRSD (VIRSD) in
female mice and explored behavioural traits that are potentially predictive of resilience. C57BL/6 female mice (n
= 28) were exposed to VIRSD, which consisted of the animals witnessing a short experience of social defeat by a
male mouse on postnatal day (PND) 47, 50, 53 and 56. The control group (n = 10) was not exposed to stress.
Blood samples were collected on PND 47 and 56 for corticosterone and interleukin-6 determinations. On PND
57–58, female mice performed several behavioural tests (elevated plus maze, hole-board, object recognition,
social interaction, TST and splash tests). Three weeks later, the effects of cocaine (1.5 mg/kg) on the CPP
paradigm were assessed. VIRSD decreased corticosterone levels (on PND 56), increased interleukin-6 levels,
enhanced novelty-seeking, improved recognition memory and induced anxiety- and depression-like symptoms.
Control and VIRSD female mice did not acquire CPP, although some stressed individuals with certain behavioural
traits - including a high novelty-seeking profile or the development of depression-like behaviour in the splash test
shortly after VIRSD - acquired cocaine CPP. Our results confirm that some behavioural traits of female mice are
associated with vulnerability or resilience to the long-term effects of social stress on cocaine reward, as previously observed in males.This work is part of the R+D+i project PID2020-118945RB-I00,
financed by the Spanish Government MCIN/AEI/10.130
39/501100011033 (Maria A´o Aguilar). Maria A Martínez-Caballero is
granted by University of Valencia (“Atracció de talent”).Medicin
Surgical Site Infiltration with Comfort-in Device and Traditional Syringe in Dogs Undergoing Regional Mastectomy: Evaluation of Intra- and Postoperative Pain and Oxidative Stress
Full text linkAuthor Contributions: Conceptualization, G.L.C. and P.L.; methodology, F.B. and F.L.; validation,
R.F.P.; formal analysis, F.S.; investigation, G.L.C.; data curation, G.B., V.N. and F.B.; writing—original
draft preparation, G.L.C. and P.L.; writing—review and editing, G.L.C. and P.L.; visualization, M.P.;
supervision, F.M., P.L. and G.L.C.; project administration, G.L.C. and F.B.; All authors have read and
agreed to the published version of the manuscript.The surgical site infiltration of a local anesthetic is defined as the direct injection of a
drug. This study aimed to compare the effects of surgical site infiltration with 4 mg kg−1
lidocaine
using a Comfort-in device and traditional syringe on oxidative status and intra- and postoperative
pain in dogs undergoing regional mastectomy. Sixty adult female dogs divided into C (Comfort-in
device), S (traditional syringe), and CTR (control) groups received 2 µg kg−1 dexmedetomidine and
4 mg kg−1
tramadol IM, 5 mg kg−1
tiletamine/zolazepam IV, and isoflurane. The physiological and
anesthesiological parameters were measured. The assessment of intra- and postoperative responses
to the surgical stimulus was performed using a cumulative pain scale (CPS score of 0–4) and the
Colorado Pain Scale (CSU-CAPS score of 0–4). The hematological and biochemical parameters and
inflammatory oxidative status were measured. The CPS scores showed no significant differences
between the C and S groups (p = 0.236), while the comparison between the CTR, C, and S groups,
respectively, showed a significant difference (p < 0.001). The postoperative analgesia scores were
significantly lower in the C group compared to those of the S and CTR groups (p < 0.001). In the C
group, no subject received rescue analgesia during the intra- and postoperative periods. The level of
oxidative inflammatory stress was lower in group C than those in S and CTR groups, and no side
effects were observed in all the groups.Veterinari
Estudio preliminar de la población y dinámica reproductiva de Echinaster sepositus (Spinulosida: Echinasteridae) en Cala del Racó
Full text linkThis study aims to provide new information on the ecology of this species through the temporal
characterization of the population of E. sepositus in Cala del Racó (Alicante, Spain) and the in situ monitoring
of its reproductive cycle.Este estudio pretende aportar nueva información sobre la ecología de esta especie mediante la caracterización temporal de la población de E. sepositus en la Cala del Racó (Alicante, España) y el monitoreo in situ
de su ciclo reproductivo.Ciencias del Ma
Síntesis y caracterización de películas antimicrobianas basadas en hidrogeles de alginato con aplicaciones biomédicas
Full text linkEl alginato es un polímero lineal biocompatible, no tóxico y biodegradable; utilizado ampliamente en aplicaciones biomédicas como apósitos para heridas, liberador de agentes bioactivos, sistemas de inmovilización de células y en medicina regenerativa.
En la presente tesis se han fabricado hidrogeles biocompatibles en forma de película a partir de alginato. Estos materiales se han combinado con diferentes compuestos: zinc, ácido acético, bórax, ácido bórico, cobalto y extracto de arándanos rojos. Gracias a dicha combinación, se han logrado obtener películas que poseen distintas capacidades bioactivas como, por ejemplo, la actividad antibacteriana frente a bacterias multirresistentes a antibióticos. Además de todo eso, poseen capacidad antiviral frente a un virus con envoltura sustituto del síndrome respiratorio severo agudo coronavirus 2 (SARS-CoV-2) y virus sin envoltura. Incluso, en algunos casos, se ha logrado actividad anticancerígena. Todo ello se ha conseguido sin comprometer la biocompatibilidad del material base.
Primero se ha conseguido sintetizar una película de alginato entrecruzada con calcio y con zinc y, demostró, más de un 95% de inactivación frente a virus con y sin envoltura. Además, presentó actividad antibacteriana frente a Staphylococcus epidermidis resistente a meticilina y capacidad anticancerígena frente a melanoma y cáncer de colon. Tras ello, se ha desarrollado una película de alginato entrecruzada con calcio que contiene una dilución del 10% v/v de ácido acético que demostró poseer actividad anticancerígena frente a melanoma y cáncer de colon y actividad antiviral frente a virus con y sin envoltura. Por otro lado, se ha sintetizado una película de alginato entrecruzada con calcio que contiene una dilución del 3% p/v de bórax que presentó actividad antiviral frente a virus con envoltura y capacidad antibacteriana. Por otra parte, se ha desarrollado una película de alginato entrecruzada con calcio y con cobalto que tuvo actividad antiviral frente a virus con envoltura, inactivación antibacteriana frente a Staphylococcus aureus resistente a meticilina (MRSA) y actividad anticancerígena frente a melanoma y cáncer de colon. Finalmente, se sintetizó una película de alginato entrecruzado con calcio y compuesta de materiales naturales y biodegradables, como el extracto de arándanos rojos, que presentó un 90% de inactivación antibacteriana frente a MRSA después de tan solo 30 min de contacto. Además, demostró 100% de inactivación frente a virus con y sin envoltura.
Esta investigación ha proporcionado películas avanzadas basadas en alginato de calcio que son muy prometedoras para su uso en aplicaciones biomédicasAlginate is a biocompatible, non-toxic and biodegradable linear polymer widely used in biomedical applications such as wound dressings, bioactive agent releaser, cell immobilization systems and in regenerative medicine.
In this thesis, biocompatible hydrogels have been manufactured in film form from alginate. These materials have been combined with different compounds: zinc, acetic acid, borax, boric acid, cobalt and cranberry extract. Thanks to this combination, it has been possible to obtain films that have different bioactive capacities such as, for example, antibacterial activity against multi-resistant bacteria. In addition to all that, they have antiviral capacity against an enveloped virus substitute for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and non-enveloped viruses. In some cases, anticancer activity has even been achieved. All this has been attained without compromising the biocompatibility of the base material.
Thus, it has been possible to synthesize an alginate film cross-linked with calcium and zinc that demonstrated more than 95% inactivation against enveloped and non-enveloped viruses. In addition, it presented antibacterial activity against meticilin resistant Staphylococcus epidermidis and anticancer capacity against melanoma and colon cancer. On the other hand, a calcium cross-linked alginate film containing a 10% v/v dilution of acetic acid has been developed, which was shown to have anticancer activity against melanoma and colon cancer and antiviral activity against enveloped and non-enveloped viruses. Likewise, an alginate film cross-linked with calcium containing a 3% w/v dilution of borax has been synthesized that presented antiviral activity against enveloped viruses and antibacterial capacity. On the other hand, an alginate film cross-linked with calcium and cobalt has been developed that had antiviral activity against enveloped viruses, antibacterial inactivation against meticilin resistant Staphylococcus aureus (MRSA) and anticancer activity against melanoma and colon cancer. Finally, an alginate film cross-linked with calcium and composed of natural and biodegradable materials, such as cranberry extract, was synthesized, which presented 90% antibacterial inactivation against MRSA after only 30 min of contact. In addition, it demonstrated 100% inactivation against enveloped and non-enveloped viruses.
This research has provided advanced calcium alginate-based films that show great promise for use in biomedical applications.MedicinaCiencias de la Vida y del Medio Natura
From socrates and philosophy as an art of living to philosophical practice
Full text linkEste artículo se centra en presentar una nueva forma, aunque paradójicamente antigua, de entender la filosofía. Se trata de la filosofía como arte de vivir, cuyo ejemplo paradigmático lo encontramos en la figura socrática, aquel personaje enigmático del siglo V a. C que impactó a la humanidad no tanto por su obra como por su vida y su forma de filosofar. En este artículo, trataremos de comprender tanto el significado como el valor de su filosofía, partiendo de la revitalización que ha hecho de la misma el historiador Pierre Hadot. Finalmente, veremos cómo la Práctica Filosófica se abre paso en nuestra actualidad con el fin de recuperar este espíritu originario con el que nació la filosofía.This article focuses on presenting a new, though paradoxi-cally old, way of understanding philosophy. This is philosophy as an art of living, the paradigmatic example of which can be found in the Socratic figure, that enigmatic character from the 5th century BC who had an im-pact on humanity not so much for his work than for his life and his way of philosophising. In this article, we will try to understand both the meaning and the value of his philosophy, on the basis of the historian Pierre Hadot's revitalisation of it. Finally, we will see how the contemporary international movement of Philosophical Practice is making space in our times in order to recover this Socratic spirit with which philosophy was bornFilosofí
Seeing horror through the lens of health: embodied suffering, focalization and dissociation in The Babadook
No full textThis essay analyzes the representation of dissociative identity
disorder in Jennifer Kent’s debut feature, The Babadook (2014). Although
the film’s exploration of psychological themes such as maternal ambivalence, grief, and repression have already been widely discussed in the
critical literature, I argue that such readings tend to mitigate the embodied nature of the suffering that Kent’s film depicts. Using Arthur Frank’s
concept of chaos stories as well as Edward Branigan’s work on film narrative, I show how The Babadook provides a valuable, fictional example of
how dissociative identity disorder can be depicted in cinematic language.
Through Kent’s use of internal and external focalization, amongst other
filmic techniques, the film promotes an ethic of witnessing whereby spectators can actively see the disorienting impact the protagonist’s suffering
has on her life. In this way, The Babadook gives health care practitioners
insight into the complexity of her subjectivized illness experience.Humanidade