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Selective IgA Deficiency and Blood Component Transfusion: In Search of the Lost Evidence
Get PDFAuthor Contributions: Conceptualization: P.S.; data curation: A.B., A.B.G., P.A.C., M.S., and M.J.M.;
formal analysis: P.S.; drafting and critical revision: J.d.l.R. and I.G.-S. All authors have read and
agreed to the published version of the manuscriptSelective IgA deficiency (IgA-D) has been historically considered a high-risk entity for developing allergic/anaphylactic reactions after blood transfusion (AATRs). However, it has been suggested that the IgA-D-related anaphylactic transfusion reaction is not evidence-based. Methods: We conducted three different approaches to collect evidence about epidemiology, AATRs, and transfusion management of patients with IgA-D at La Fe University Hospital. Firstly, we analysed the prevalence of IgA-D in a population of patients diagnosed with acute leukaemia, The second approach consisted of collecting transfusion data from IgA-D patients. Finally, we reviewed the IgA levels of patients recorded in the hemovigilance system suffering an AATR. Results: IgA-D prevalence was 1 in 334 patients. At least one blood component was transfused to 23 patients diagnosed with IgA-D. Plasma was transfused to eight IgA-D patients, while six patients received red blood cells, platelets, and plasma. No adverse reactions were reported in any patient. AATRs occurred in 325 men and 264 women with a median age of 52 years. Severe reactions occurred in 56 patients (1/14,520 components). Mean IgA levels were 215 mg/dL (4–5570) for mild reactions and 214 mg/dL (14–824) for severe reactions (p = ns). Washed platelets were administered to two patients who developed severe and repeated AATRs. Both had normal IgA levels. Conclusions: Since the AATRs related to IgA-D are extremely low, as reported in current hemovigilance systems, IgA-D should not be considered a high-risk entity to develop AATRs. On the contrary, our findings support standard transfusion management of IgA-D patients.Medicin
Comparative study of positioning and technical-tactical indicators between teams of different performance levels in the Qatar 2022 FIFA World Cup
Get PDFThe aim of the study was to identify the technical-tactical indicators and differentiate collective positioning between the qualified teams and teams non-qualified for the final phase of the FIFA World Cup Qatar 2022, considering effective playing time. The aim was also to understand the interaction of variables that significantly increased the likelihood of being qualified in the analysed championship. We conducted a comparative analysis that covered all matches played (N=64), evaluating 93 technical-tactical indicators, 24 collective positional indicators and six hybrid indicators. The absolute technical-tactical indicators were normalised based on the effective playing time of each team in each match. We used t-tests and binary logistic regression (R2 Nagelkerke = .738 – AUC = .955) to analyse differences and determine their statistical significance (p<.05). Our analysis revealed significant differences in 33 indicators, suggesting that certain technical-tactical aspects played a crucial role in teams’ performance. Furthermore, through multivariate analysis, we were able to identify that offensive efficiency in set pieces, the height of the defensive line during the offensive phase, and the ability to reduce the available playing space for the opposing team during the defensive phase emerged as the main indicators that allowed us to classify the teams’ performance. These findings enable coaches to use the identified key indicators as performance predictors to devise match strategies aimed at enhancing the effectiveness of their teams.Ciencias de la Actividad Física y del Deport
Effect of Bivalves’ Sand Burial Capacity on Predation in the Invasive Blue Crab, Callinectes sapidus
Get PDFAuthor Contributions: Conceptualization, P.P. and S.F.; data curation, P.P.; formal analysis, P.P. and
S.F.; investigation, P.P.; methodology, P.P. and I.G.; study design, P.P. and S.F.; data analysis, P.P.;
resources, P.P. and S.F.; supervision, P.P.; visualization, P.P., I.G. and S.F.; writing—original draft, P.P.;
writing—review and editing, S.F. and I.G. All authors have read and agreed to the published version
of the manuscript.In the Ebro Delta (Catalonia, Spain), the abundance of burrowing bivalves has dramatically
decreased, with the blue crab, Callinectes sapidus, being blamed by shellfish collectors. Trends from
2010 evidence a decrease in the capture of clams (Ruditapes spp.) before 2016 (start of blue crab
fisheries), although a further decline in both clams and cockles (Cerastoderma glaucum) occurred
in 2018. In contrast, captures of razor clams (Ensis siliqua) have increased by 3.6-fold since 2016.
Predation risk for these taxa, with contrasting burrowing capacities (1.7 ± 0.3 cm, 0.4 ± 0.2 cm, and
26.3 ± 0.1 cm, respectively), was assessed using predation preference (N = 5 tanks; 5 individuals of
each species) and no-choice experiments (N = 5 tanks; 15 individuals of the same taxa) in the absence
and presence of sand. The results showed that, in the absence of sand, razor clams were fully preyed
upon in 24 h, clams in 96 h, and cockles reached 60% after 144 h. Conversely, when sand was present,
only 4% of razor clams were predated, while clams and cockles reached 60–100% in 120–144 h. The
no-choice results featured similar patterns, depending on substrate availability. Overall, clams and
cockles appear to be greatly vulnerable to blue crab predation, whereas razor clams may escape
thanks to their deeper burrowing capacity.Ciencias del Ma
Evaluación del estrés en conejos silvestres mediante la determinación de la concentración de corticosterona
Get PDFEl conejo europeo (Oryctolagus cuniculus) es una especie clave en los ecosistemas mediterráneos de la Península Ibérica. En España, los principales factores de mortalidad para la especie son las enfermedades, la depredación y la caza. Cuando un animal se encuentra en un estado de estrés, se observan unas respuestas fisiológicas típicas, como la activación del eje hipotálamo-hipófisis-adrenal y del sistema nervioso autónomo, lo que a su vez conduce a la liberación de glucocorticoesteroides y catecolaminas. Para evaluar las respuestas fisiológicas al estrés, se utilizan indicadores invasivos y no invasivos. El objetivo del presente trabajo es determinar la concentración de corticosterona en muestras de suero de conejos europeos. Secundariamente, se ha evaluado cómo influyen los diferentes factores en la concentración de corticosterona. Para el análisis de las muestras, se ha utilizado un Kit ELISA y se han obtenido los resultados mediante un análisis estadístico. El valor medio de corticosterona analizado en las 93 muestras ha sido de 4.1138 ng/ml. Se ha observado una discordancia con los valores de referencia. Los parámetros que influyen en la concentración de corticosterona han sido, las zonas geográficas y el método de captura. Los animales capturados por trampeo tienen concentraciones de corticosterona superiores al método de abatimiento. Los parámetros que no influyen han sido la edad, el sexo, el año, la mixomatosis, la enfermedad vírica hemorrágica y la estación del año. Teniendo en cuenta los resultados obtenidos, sería recomendable utilizar un kit ELISA específico y que el número de muestras obtenidas de cada parámetro fuese homogéneo.The European rabbit (Oryctolagus cuniculus) is a keystone species in the Mediterranean ecosystems of the Iberian Peninsula. In Spain, the main mortality factors for the species are diseases, predation, and hunting. In situations where an animal is stressed, typical physiological responses are observed, such as the activation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, which in turn leads to the release of glucocorticoids and catecholamines. In order to evaluate physiological responses to stress, invasive and non-invasive indicators are used. The aim of the present work is to determine the concentration of corticosterone in serum samples of European rabbits. Secondarily, the influence of different factors on corticosterone concentration has been assessed. Consequently, ELISA kit was used to analyse the samples, whereas the results were evaluated by statistical analysis. The mean value of corticosterone analyzed in the 93 samples was 4.1138 ng/ml. Thus, a discrepancy with the reference values was observed. The parameters influencing corticosterone concentration were the geographical areas and the trapping method. Animals captured by trapping had higher corticosterone concentrations tan those captured by the trapping method. The parameters not influencing this corticosterone concentration were age, sex, year, myxomatosis, viral hemorrhagic disease, and the time of the year. Taking into account the results obtained, it would be advisable to use a specific ELISA kit and a homogeneous number of simples for each parameterVeterinari
Comparative Study of the Expansive Behaviour of Different Internal Bleaching Agents
Get PDFConceptualisation, A.P.-S. (Alba Pallarés-Serrano).; methodology, A.P.-S. (Alba
Pallarés-Serrano) and A.P.-S. (Antonio Pallarés-Sabater); software, A.P.-S. (Antonio Pallarés-Serrano)
and G.M.-M.; validation, A.P.-S. (Antonio Pallarés-Sabater) and A.P.-S. (Antonio Pallarés-Serrano);
formal analysis, S.P.-S.; investigation, A.P.-S. (Alba Pallarés-Serrano); resources, G.M.-M.; data
curation, S.P.-S. and G.M.-M.; writing—original draft preparation, A.P.-S. (Alba Pallarés-Serrano);
writing—review and editing, A.P.-S. (Alba Pallarés-Serrano); visualisation, G.M.-M. and S.P.-S.;
supervision, A.P.-S. (Antonio Pallarés-Sabater); project administration, S.P.-S. and G.M.-M.; funding
acquisition, A.P.-S. (Antonio Pallarés-Sabater) and A.P.-S. (Antonoi Pallarés-Serrano). All authors
have read and agreed to the published version of the manuscript.Internal bleaching is a conservative treatment applied to a darkened endodontically treated
tooth to restore its original colour, either as a single treatment or as a treatment prior to a subsequent
prosthetic phase. The aim of this study was to objectively measure and compare using an experimental
model the expansive capacity of four bleaching groups: carbamide peroxide 37% (CP 37%), hydrogen
peroxide 30% (HP 30%), HP 30% mixed with sodium perborate (SP) and SP mixed with distilled
water. A total of 150 lower incisors (n = 30 in each group) were prepared for the Walking Bleach
technique and a glass tube with oil was introduced into the coronal access cavity to measure the
expansive capacity through oil displacement, due to the reaction that occurs when bleaching agents
interact with dental tissues. The results after 10 days were analysed with the Games–Howell post
hoc test to compare the samples. Significant higher expansion was observed with HP 30% (p < 0.05)
and lower expansion with SP (p < 0.05) compared to the other groups. No significant differences
were observed between CP 37% (p > 0.05) and HP 30% + SP (p > 0.05). This provides significant and
observable information on the behaviour of each bleaching group and its evolution after 10 days.Odontologí
Naturally Colored Ice Creams Enriched with C-Phycocyanin and Spirulina Residual Biomass: Development of a Fermented, Antioxidant, Tasty and Stable Food Product
Get PDFAuthor Contributions: Conceptualization, A.R.C.B.; methodology, M.B., C.F., M.A. and A.R.C.B.;
investigation, A.R.C.B.; data curation, M.B. and C.F.; writing—original draft preparation, M.B., C.F.
and M.A.; writing—review and editing, M.B., C.F., M.A. and A.R.C.B.; visualization, A.R.C.B. All
authors have read and agreed to the published version of the manuscript.Naturally colored fermented foods currently represent the trend toward a global demand for healthier products. This work produced naturally blue and green ice creams using C-phycocyanin (C-PC) and spirulina residual biomass (RB). The ice creams were assessed based on microbiological analysis, color stability over 6 months, antioxidant activity before and after in vitro digestion, and sensory evaluation. Considering the microorganisms that must be analyzed in accordance with Brazilian legislation, no growth was detected during the storage period. L*, a*, and b* were maintained according to the expected colors. The blue color was intoned over the shelf life (SC-PC *b −9.46 to −19.44 and MC-PC *b from −9.87 to −18.04). The antioxidant activity of the fermented ice creams SC-PC and SRB increased from 15.4 to 41.3 and from 15.3 to 38.0 µM TE/g, respectively, after bioaccessibility analysis. The C-PC ice cream’s appearance received the highest rating, with 70.26% of volunteers expressing a strong preference, highlighting its attractiveness. However, there were no significant differences compared to control samples in the global acceptance. The RB ice cream presented lower results for flavor but moderate acceptance. Thus, these fermented ice creams presented color stability over 6 months, and their antioxidant activity increased after in vitro digestion, highlighting their biological potential.Biotecnologí
Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment
Get PDFMultiple Sclerosis (MS) is a neurodegenerative disease characterized by motor and non-
motor symptoms, including emotional distress, anxiety, and depression. These emotional symptoms
currently have a pharmacological treatment with limited effectiveness; therefore, it is necessary to
delve into their relationship with other psychological, functional, or prefrontal alterations. Addition-
ally, exploring non-pharmacological therapeutic alternatives that have shown benefits in addressing
emotional distress in MS patients is essential. The aim is to establish a predictive model for the presence of
anxiety and depression in MS patients, based on variables such as psychological well-being, functional
activity, and prefrontal symptoms. Additionally, this study aimed to propose non-pharmacological
therapeutic alternatives based on this model.This research was funded by the Catholic University Foundation San Vicente Mártir, for
the research project The Impact of Triglycerides on Multiple Sclerosis (Promotion code 2018-203-001).Medicin
Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain
Get PDFA. O.-S. is the guarantor of the paper,
taking responsibility for the integrity of the work as a whole,
from inception to published article. M. L.-L. contributed to
data acquisition, cleaning, analysis, and interpretation; drafting
the article and revising it critically for important intellectual content;
and final approval of the version to be published. M. A. contributed
to data interpretation; drafting the article and revising it critically for
important intellectual content; and final approval of the version to
be published. J. D.-D. contributed to study conception and design;
data acquisition, analysis, and interpretation; drafting the article;
and final approval of the version to be published. H.-D. E., J. N.,
and P. V.-B. contributed to data acquisition, cleaning, analysis,
and interpretation; revising the article critically for important intel-
lectual content; and final approval of the version to be published.
S.A.D. contributed to study conception and design, and interpreta-
tion; and final approval. All authors have read and approved the
manuscript.Determining pneumococcal pneumonia (PP) burden in the elderly population is challenging due to limited data on invasive PP (IPP) and, in particular, noninvasive PP (NIPP) incidence. Using retrospective cohorts of adults aged ≥50 years in Denmark (2 782 303) and the Valencia region, Spain (2 283 344), we found higher IPP hospitalization rates in Denmark than Valencia (18.3 vs 9/100 000 person-years [PY], respectively). Conversely, NIPP hospitalization rates were higher in Valencia (48.2 vs 7.2/100 000 PY). IPP and NIPP rates increased with age and comorbidities in both regions, with variations by sex and case characteristics (eg, complications, mortality). The burden of PP in adults is substantial, yet its true magnitude remains elusive. Discrepancies in clinical practices impede international comparisons; for instance, Valencia employed a higher frequency of urinary antigen tests compared to Denmark. Additionally, coding practices and prehospital antibiotic utilization may further influence these variations. These findings could guide policymakers and enhance the understanding of international disparities in disease burden assessments.The VITAL project has received funding
from the Innovative Medicines Initiatives 2 Joint Undertaking
(grant agreement number 806776) and the Dutch Ministry of
Health, Welfare and Sport. The Joint Undertaking receives sup-
port from the European Union’s Horizon 2020 research inno-
vation program and EFPIA members.Medicin
Early indicators of childhood apraxia of speech in late talkers: general guidelines to intervention
Get PDFEn este trabajo presentamos la diferente
respuesta a la intervención de dos perfiles de hablante
tardío. Concretamente, se aplicó el programa Target
Word©, del centro Hanen, que conjuga la técnica de la
estimulación focalizada con la orientación a padres sobre estrategias que promueven el desarrollo del lenguaje.In this paper we present the different
response to intervention of two profiles of late talkers. Specifically, the Target Word© program (Hanen
Centre) was implemented, which is addressed to late-talking children and their families. It combines the
technique of focused stimulation with guidance to
parents on strategies that stimulate global language
development.Psicologí
Ausiàs March. Cantos de amor. Versión castellana de Jorge de Montemayor
No full textEl libro que el lector tiene en sus manos es una edición filológica de la versión castellana de los cantos de amor del poeta valenciano Ausiàs March (1400-1459), preparada y publicada (València, 1560) por el escritor portugués Jorge de Montemayor (c. 1520-1561). A esta versión la precedió otra, de Baltasar de Romaní, publicada en València en 1539, que recoge tan solo 46 poemas. La de Montemayor, aunque tampoco llega a ser completa, eleva el corpus traducido en la anterior a 97 composiciones. La traducción del autor portugués supone un digno intento de aclimatación de los viejos poemas de March a los presupuestos estéticos y conceptuales de la poesía renacentista castellana, lo que, sin duda, explica el éxito considerable que alcanzó, del que dan fe las reediciones de que fue objeto en 1562 y 1579. Estas últimas son fruto de unos nuevos contextos específicos de producción, ajenos a la editio princeps, tal como evidencian la incorporación de nuevos paratextos y la supresión de otros del libro publicado en 1560. Por otra parte, la anotación crítica exhaustiva de las variantes de los tres testimonios textuales, permite concluir que el texto más fiable es el de la edición príncipe, que aún pudo revisar Montemayor, mientras que las dos reediciones póstumas que le siguieron, salvo en algunos casos muy contados, empeoran el de la edición originaria.Humanidade