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Heavy metal concentrations in sharks, rays and chimaeras from the western Mediterranean Sea
No full textThe potential bioaccumulation of pollutants, such as heavy metals, may pose a threat to the western Mediterranean chondrichthyans and human consumers. Therefore, the first extensive assessment of cadmium (Cd), lead
(Pb), and copper (Cu) concentrations in the muscle tissue of 17 species of sharks, rays, and chimaeras in this
region was conducted via Microwave Assisted Extraction (MAE) and Graphite Furnace Atomic Absorption
Spectrometry (GFAAS). Significant differences between species were observed, particularly related to the rabbit
fish (Chimaera monstrosa) and the velvet belly lantern shark (Etmopterus spinax), which exceeded the European
Union (EU) Commission Regulation 2023/915 threshold of Cd. Overall, heavy metal concentrations correlated
negatively with size and trophic level but positively with depth. Although the consumption of these species may
entail minimal risk to adult humans, caution is advised, especially for children. These findings are important due
to the widespread consumption of chondrichthyans in many western Mediterranean regions.Biodiversity Foundation of the Ministry for the Ecological Transition and Demographic Challenge under the project ECEME (CA_BM_2019)Catalan Institute for Ocean Governance Research (ICATMAR)FPU grant of the Spanish Ministry of Universities (MIU)IMEDMAR-UCVValencian Marine Mammal Stranding Network and the Conselleria de Agricultura, Desarrollo Rural, Emergencia Climática y Transición Ecológica of the Generalitat Valenciana (Spain)OCECOSVAL project (GVA-THINKINAZUL/2021/033) within the ThinkInAzul programmeMCIN with funding from European Union NextGenerationEU (Grant number: PRTR-C17.I1)EDUCV grant for in-training predoctoral research personnel of the Catholic University of Valencia (Grant number: PREE-2019-002)Ciencias del Ma
Potential impact of nirsevimab and bivalent maternal vaccine against RSV bronchiolitis in infants: A population-based modelling study
Get PDFA new monoclonal antibody (nirsevimab; Beyfortus®) and a bivalent prefusion RSV vaccine
(Abrysvo®) for maternal immunization have been approved recently. This is a modelling study to estimate the potential impact of different immunization programs with these products on RSV-bronchiolitis.Funding support from Sanofi and AstraZeneca.Medicin
Reel Versus Twiddler Syndrome in a Patient With a Pacemaker: A Case Report of Iatrogenic Manipulation
Get PDFAuthor Contributions
All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the
work.
Concept and design: Fernando de la Guia-Galipienso, Marisa de la Guia-Fayos, Miguel Angel LopezAranda, Jose Manuel Simon-Machi, Aurelio Quesada-Dorador
Acquisition, analysis, or interpretation of data: Fernando de la Guia-Galipienso, Marisa de la GuiaFayos, Miguel Angel Lopez-Aranda, Jose Manuel Simon-Machi, Aurelio Quesada-Dorador
Drafting of the manuscript: Fernando de la Guia-Galipienso, Marisa de la Guia-Fayos, Miguel Angel
Lopez-Aranda, Jose Manuel Simon-Machi, Aurelio Quesada-Dorador
Critical review of the manuscript for important intellectual content: Fernando de la Guia-Galipienso,
Marisa de la Guia-Fayos, Miguel Angel Lopez-Aranda, Jose Manuel Simon-Machi, Aurelio Quesada-Dorador
Supervision: Fernando de la Guia-Galipienso, Marisa de la Guia-Fayos, Miguel Angel Lopez-Aranda, Jose
Manuel Simon-Machi, Aurelio Quesada-DoradorTwiddler syndrome is a rare entity in which patient manipulation causes lead dislocation with lead
retraction. Reel syndrome, on the other hand, is observed after external manipulation, intentional or
unintentional, in which the leads move along their transverse axis and is considered a variant of Twiddler
syndrome. We present the clinical case of a 91-year-old female who, after pacemaker implantation,
presented with dizziness and chest discomfort following constant manipulation of the pacemaker, resulting
in complete retraction of the lead tip into the pouch, which is unusual in the literature to date.Medicin
Factores personales y psicológicos predictores de los síntomas depresivos en la persona mayor en cinco ciudades de Colombia, 2021
Get PDFLa Política Pública Nacional de Envejecimiento y Vejez 2022-2031 define como persona mayor a los individuos de 60 años y más de edad; dicha política expone que deben optimizarse las oportunidades de bienestar mental, físico y social de las personas mayores mediante la cultura del cuidado, estableciendo entornos, estilos de vida y hábitos saludables que permitan mantener la funcionalidad y capacidad de las personas mayores. En este sentido es necesario pensar el “envejecimiento activo y saludable y de una vejez digna, autónoma e independiente en condiciones de igualdad, equidad y no discriminación”, prestando especial atención al bienestar, calidad de vida, la salud física y la salud mental de la persona mayor. En cuanto a la salud mental, la sintomatología depresiva o la depresión es la afectación mental más frecuente en las personas mayores, su aparición parece relacionarse con reducción de la calidad de vida, aumento de las enfermedades físicas, entre otros factores.
Dentro de los aportes del presente estudio, con su realización se buscó llamar la atención acerca de la importancia de contar con servicios de salud que incluyan la salud mental, dada la transición demográfica y epidemiológica; las orientaciones mundiales sobre el envejecimiento saludable; el proceso de envejecimiento normal del individual y la reciente política nacional promulgada en Colombia en el año 2022. Para esto se planteó el objetivo de determinar los factores personales y psicológicos que predicen los síntomas depresivos en la persona mayor en Medellín, Pereira, Santa Marta, Popayán y Bucaramanga (ciudades de Colombia) en el año 2021, con el fin de aportar evidencia al mejoramiento de su salud y bienestar mental, a través de identificar los factores que más influyen, cuya prevención de manera temprana posibilita plantear estrategias teóricas y prácticas que favorezcan la promoción de la salud mental de la población envejecida, bajo un abordaje multidisciplinario donde conversen la psicología, la gerontología y la epidemiología.
De esta forma se realizó una investigación de enfoque cuantitativo con diseño analítico, en 2506 personas mayores de 60 años residentes en cinco ciudades del país seleccionadas con muestreo estratificado por ciudad, por conglomerados y bietápico. Las variables de interés fueron los síntomas depresivos, según la escala CES-D analizada con medidas bioestadísticas que permitieron dar cumplimiento a los objetivos con análisis univariado (caracterización), bivariado (cálculo de factores asociados con regresión logística) y multivariado (cálculo de factores predictores y correspondencias múltiples). Las pruebas de hipótesis calculadas se acompañaron del valor p y la medida epidemiológica usada fue la razón de prevalencias o razón de proporciones (RP) acompañada del intervalo de confianza del 95%.
De esta forma se encontró que la mitad de las personas mayores encuestadas (49,8%), padecen síntomas depresivos, distribuyédose entre leve (14,8%), moderado (21,4%) y severo (13,6%). Además, se halló que los factores personales y psicológicos influyen significativamente en la aparición de síntomas depresivos y son principalmente los factores psicológicos como el riesgo suicida, la desesperanza y la baja percepción de felicidad los que actúan como predictores de los síntomas depresivos. Así se halló que en el reconocimiento del proceso de envejecimiento que viven actualmente las poblaciones y la evidencia de las afectaciones mentales (principalmente la depresión y sus síntomas de alarma) se ve la necesidad de anticipar acciones preventivas interdiciplinarias e intersectoriales que deben implementarse en la actualidad, con el fin de lograr su reducción o control, como un ejercicio de verlar por la salud mental como un derecho humano universalThe National Public Policy on Aging and Old Age 2022-2031, defines an any person aged 60 years or older. This policy states that the opportunities for mental, physical and social well-being of older people must be optimized through a culture of care, establishing healthy environments, lifestyles and habits that allow the functionality and capacity of older people to be maintained. In this sense, it is necessary to think about "active and healthy aging and a dignified, autonomous and independent old age in conditions of equality, equity and non-discrimination", paying special attention to the well-being, quality of life, physical health and mental health of the older person. Regarding mental health, depression is the most common psychiatric disorder among the elderly; Its presence reduces the quality of life, increases physical illnesses and shortens life.
Within the contributions of this study, its implementation sought to draw attention to the need to have comprehensive mental health services for older people, given the demographic and epidemiological transition; global guidance on healthy aging; the normal aging process of the individual and the recent national policy enacted in Colombia in the year 2022. For this, the objective was set to determine the personal and psychological factors that predict depressive symptoms in the elderly in five cities in Colombia, in the year 2021, in order to provide evidence to improve their health and mental well-being, through identifying the factors that most influence, whose early prevention makes it possible to propose theoretical and practical strategies for the promotion of the mental health of the aging population, under a multidisciplinary approach where psychology, gerontology and epidemiology converse.
In this way, a quantitative investigation with an analytical design was carried out, which allowed measuring the characteristics that affect the mental health of 2,506 people aged 60 and over residing in five cities of the country: Medellín, Santa Marta, Bucaramanga, Pereira and Popayán, which They were selected through stratified sampling by city, by clusters and two-stage. The variables of interest were depressive symptoms, according to the CES-D scale analyzed with biostatistical measures that allowed the objectives to be met with univariate (characterization), bivariate (calculation of factors associated with logistic regression) and multivariate (calculation of predictive factors) analysis. and multiple correspondences). The calculated hypothesis tests were accompanied by the p value and the epidemiological measure used was the prevalence ratio or proportion ratio (PR) accompanied by the 95% confidence interval.
In the surveyed population, it was found that half of the elderly people surveyed (49.8%) suffer from depressive symptoms, ranging between mild (14.8%), moderate (21.4%) and severe (13.6%). . Furthermore, it was found that personal and psychological factors significantly influence the appearance of depressive symptoms in the elderly and it is mainly psychological factors such as suicide risk, hopelessness and low perception of happiness that act as predictors of depressive symptoms. . Therefore, it is concluded that in recognition of the aging process that populations are currently experiencing and the evidence of mental disorders (mainly depression and its alarm symptoms), there is a need to anticipate interdisciplinary and intersectoral preventive actions that must be implemented. currently, in order to achieve its reduction or control, as an exercise in seeing mental health as a universal human right.PsicologíaCiencias de la Salu
Toxicidad de Zn en Chlamydomonas acidophila (Negoro, 1944) para posible estrategia de biorremediación del Drenaje Ácido de Minas
Get PDFEl Drenaje Ácido de Minas (DAM), caracterizado por tener pH ácidos y una elevada presencia de metales disueltos, es uno de los principales problemas de la industria minera y sus actuales técnicas de remediación presentan limitaciones en términos de eficiencia, costes y complejidad operativa.
El objetivo de este trabajo es evaluar la posible variación de la toxicidad del Zn dependiendo del pH, determinando la EC50 a pH 3,6 y 7, siendo este un estudio preliminar para determinar si el alga extremófila Chlamydomonas acidophila podría representar una opción para la remediación del DAM.
El crecimiento de C. acidophila se estimó a ambos pH mediante el cálculo de la tasa de crecimiento a través de mediciones de densidad óptica, clorofila a in vivo y turbidez. El ensayo de toxicidad se llevó a cabo durante 144 horas tanto a pH 3,6 como a pH 7, exponiendo los organismos a diferentes concentraciones de Zn.
C. acidophila creció a ambos pH, pero el crecimiento fue significativamente mayor (p<0,05) a pH 3,6, siendo la tasa de crecimiento 0,16 a pH 7 y 0,20 a pH 3,6.
Los ensayos de toxicidad indicaron una tendencia general de inhibición del crecimiento a mayor concentración de Zn y a mayor tiempo de exposición. La EC50 media obtenida fue de 1,33 g/L (≈ 4623,36 μM) a pH 3,6 e 0,45 g/L (≈ 1580,53 μM) a pH 7.
Se confirmó tanto la naturaleza acidófila de la cepa estudiada, como una mayor toxicidad del Zn a pH 7.Acid Mine Drainage (DAM), characterized by acidic pH and a high presence of dissolved metals, is one of the main problems of the mining industry and its current remediation techniques present limitations in terms of efficiency, costs and operational complexity.
The aim of this work is to evaluate the possible variation of Zn toxicity depending on pH, determining the EC50 at pH 3,6 and 7, being this a preliminary study to determine if the extremophile alga Chlamydomonas acidophila could represent an option for the remediation of DAM.
Growth of C. acidophila was estimated at both pHs by calculating the growth rate through measurements of optical density, chlorophyll a in vivo and turbidity. The toxicity test was carried out for 144 hours at both pH 3,6 and pH 7, exposing the organisms to different concentrations of Zn.
C. acidophila grew at both pHs, but growth was significantly higher (p < 0,05) at pH 3,6, the growth rate being 0,16 at pH 7 and 0,20 at pH 3,6.
Toxicity tests indicated a general trend of growth inhibition at higher Zn concentration and longer exposure time. The mean EC50 obtained was 1,33 g/L (≈ 4623,36 μM) at pH 3,6 and 0,45 g/L (≈ 1580,53 μM) at pH 7.
Both the acidophilic nature of the studied strain and the higher toxicity of Zn at pH 7 were confirmed.Ciencias del Ma
Impact of Minimally Invasive Intra-Capsular Metatarsal Osteotomy on Plantar Pressure Decrease: A Cross-Sectional Study
Get PDFConceptualization, C.F.-V., C.N.-R. and J.F.-T.; Data curation, S.G.-V. and
J.F.-T.; Formal analysis, S.G.-V., C.N.-R., E.N.-G. and J.F.-T.; Investigation, C.F.-V., C.N.-R., E.N.-G.,
N.F.-E. and J.F.-T.; Methodology, J.F.-T.; Supervision, J.F.-T. and N.F.-E.; Validation, S.G.-V., C.F.-V.,
C.N.-R., J.F.-T., E.N.-G. and N.F.-E.; Writing—original draft, C.F.-V. and C.N.-R.; Writing—review and
editing, C.F.-V., C.N.-R., E.N.-G., N.F.-E. and J.F.-T. All authors have read and agreed to the published
version of the manuscript.Metatarsalgia is a common pathology that is initially treated conservatively, but failure to do so requires surgery, such as the minimally invasive distal metatarsal osteotomy (DICMO). In this prospective study of 65 patients with primary metatarsalgia who underwent DICMO, plantar pressures, American Orthopaedic Foot and Ankle Society
MetaTarsoPhalangeal-InterPhalangeal scale (AOFAS-MTP-IP) and Visual Analog Scale (VAS) were
evaluated pre-operatively and post-operatively and there was a subgroup in which an inclinometer
was used to observe the importance of the inclination of the osteotomy.Podologí
Advances in Brain Stimulation, Nanomedicine and the Use of Magnetoelectric Nanoparticles: Dopaminergic Alterations and Their Role in Neurodegeneration and Drug Addiction
Get PDFAuthor Contributions: Conceptualization, M.P.; methodology, S.G., A.M., A.M.-M., N.A., I.G.-J. and
M.P.; resources, S.G., A.M., A.M.-M., N.A., I.G.-J. and M.P.; data curation, M.P.; writing—original
draft preparation, S.G., A.M., A.M.-M., N.A., I.G.-J. and M.P.; writing—review and editing, M.P.;
supervision, M.P.; project administration, M.P.; funding acquisition, M.P. All authors have read and
agreed to the published version of the manuscriptRecent advancements in brain stimulation and nanomedicine have ushered in a new era of
therapeutic interventions for psychiatric and neurodegenerative disorders. This review explores the
cutting-edge innovations in brain stimulation techniques, including their applications in alleviating
symptoms of main neurodegenerative disorders and addiction. Deep Brain Stimulation (DBS)
is an FDA-approved treatment for specific neurodegenerative disorders, including Parkinson’s
Disease (PD), and is currently under evaluation for other conditions, such as Alzheimer’s Disease.
This technique has facilitated significant advancements in understanding brain electrical circuitry
by enabling targeted brain stimulation and providing insights into neural network function and
dysfunction. In reviewing DBS studies, this review places particular emphasis on the underlying
main neurotransmitter modifications and their specific brain area location, particularly focusing on
the dopaminergic system, which plays a critical role in these conditions. Furthermore, this review
delves into the groundbreaking developments in nanomedicine, highlighting how nanotechnology
can be utilized to target aberrant signaling in neurodegenerative diseases, with a specific focus on
the dopaminergic system. The discussion extends to emerging technologies such as magnetoelectric
nanoparticles (MENPs), which represent a novel intersection between nanoformulation and brain
stimulation approaches. These innovative technologies offer promising avenues for enhancing
the precision and effectiveness of treatments by enabling the non-invasive, targeted delivery of
therapeutic agents as well as on-site, on-demand stimulation. By integrating insights from recent
research and technological advances, this review aims to provide a comprehensive understanding
of how brain stimulation and nanomedicine can be synergistically applied to address complex
neuropsychiatric and neurodegenerative disorders, paving the way for future therapeutic strategies.Medicin
“The fury of Mary” in the Milagros de Nuestra Señora
Get PDFSabemos que el castigo, en oposición al premio, es uno de los
polos sobre los que se estructura la narrativa de los Milagros de Nuestra Señora,
de Gonzalo de Berceo, un texto que está en el centro del canon de la literatura
espiritual. El objeto del presente estudio, nunca antes planteado, es analizar
las modalidades del castigo en esta obra, en relación con las ideas de vengan-
za y de justicias divina y humana, y por tanto con la ira divina, la ira regia y
la ley del talión. Para ello me baso en la bibliografía sobre la venganza y el
castigo en otros ámbitos textuales, lo que permite proponer una clasificación
del castigo en seis tipos: profecía de maldición, amenaza, castigo indirecto,
perdón (tras el castigo o la penitencia), incitación al castigo y castigo directo.
Además, se comprueba que las intervenciones de María modulan los principios
de las justicias divina y humana, sin llegar a invalidarlos. Este estudio pone de
relieve también que la posición de castigo y saña no es en la Virgen la última
ni la definitiva, sino que quienes la han traicionado, si se arrepienten, acaban
beneficiándose de la piedad de María.We know that punishment, as opposed to reward, is one of the poles
on which the narrative of the Milagros de Nuestra Señora, by Gonzalo de Berceo,
is structured, a text that is at the centre of the canon of spiritual literature. The
object of the present study, never before proposed, is to analyze the modalities of punishment in this work, connected to the ideas of revenge and divine and human
justice, and therefore to divine wrath, royal wrath and the Talion law. To do this,
I base myself on the bibliography on revenge and punishment in other textual
areas, which allows me to propose a classification of punishment into six types:
prophecy of a curse, threat, indirect punishment, forgiveness (after punishment
or penance), incitement to punishment and direct punishment. Furthermore, it is
proven that Mary’s interventions modulate the principles of divine and human
justice, without invalidating them. This study also highlights that the Virgin’s
position of punishment and fury is not the last or the definitive one, but that those
who have betrayed her, if they repent, end up benefiting from Mary’s mercy.Humanidade
Ketogenic effect of coconut oil in ALS patients
Get PDFSC-J: Data curation, Formal analysis, Investigation, Methodology,
Writing – review & editing. EO: Data curation, Formal analysis,
Investigation, Methodology, Validation, Writing – review & editing.
RL-B: Data curation, Formal analysis, Investigation, Writing – review
& editing. MO-C: Data curation, Formal analysis, Investigation,
Writing – review & editing. PM-M: Investigation, Methodology,
Validation, Visualization, Writing – review & editing. JE:
Conceptualization, Funding acquisition, Investigation, Supervision,
Validation, Visualization, Writing – original draft, Writing – review &
editing.A recent pilot study in amyotrophic lateral sclerosis (ALS) patients analyzed the
effect of a Mediterranean diet (MeDi) supplemented with nicotinamide riboside
(NR, a NAD+ promoter), pterostilbene (PTER, a natural antioxidant) and/or
coconut oil on anthropometric variables in ALS patients. The results suggested
that the MeDi supplemented with NR, PTER and coconut oil is the nutritional
intervention showing the greatest benefits at anthropometric levels. Over the
last 30 years, glucose intolerance has been reported in ALS patients. Thus,
suggesting that an alternative source of energy may be preferential for motor
neurons to survive. Ketone bodies (KBs), provided through a MeDi with a lower
carbohydrate content but enriched with medium chain triglycerides, could
be a therapeutic alternative to improve the neuromotor alterations associated
with the disease. Nevertheless, the use of a coconut oil-supplemented diet, as
potentially ketogenic, is a matter of controversy. In the present report we show
that a MeDi supplemented with coconut oil increases the levels of circulating
KBs in ALS patients.The author(s) declare that financial support was received for the
research, authorship, and/or publication of this article. This research
study was funded by the Catholic University of Valencia San Vicente
Mártir (grant number 2024-298-003), by the University of Valencia
(grant number OTR2017-18255INVES) and by Scientia BioTech
(Valencia, Spain). NR was provided by Elysium Health. Inc., New
York, USA. PTER was obtained from Laurus Labs, Hyderabad,
Telangana, India; and the coconut oil through https://www.
herbolarionavarro.es, Valencia, Spain.Nutrición humana y dietétic
Analysis of Heart Rate Variability in Individuals Affected by Amyotrophic Lateral Sclerosis
Get PDFConceptualization, R.M.-R. and C.V.-C.; methodology, J.P.; formal analysis,
J.P.; investigation, N.d.B.; resources, J.M.-R.; data curation, J.C.-L.; writing—original draft preparation,
R.M.-R. and D.S.-C.; writing—review and editing, M.B.-N. and J.A.-J.; supervision, J.E.d.l.R.O.; project
administration, J.E.d.l.R.O.; funding acquisition, J.E.d.l.R.O. All authors have read and agreed to the
published version of the manuscript.The goal of this study is to determine HRV using Polar
H7 Bluetooth technology in ALS patients, comparing the obtained measurements with values from
healthy individuals.This study was funded by Catholic University of Valencia San Vicente Mártir, grant number
2017-216-001.Medicin