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Vides en els marges a la València del segle XV
Full text linkAquest article se centra en la descripció de l’altra mirada de la València del segle XV, la de la marginació social, que es podia manifestar pel fet d’exercir diversos oficis considerats com a immorals. En les pàgines següents s’ofereix una descripció de dos col·lectius femenins particularment tractats com a vils i menyspreables: el de les curanderes, fetilleres i bruixes, la força de les quals hom considerava que partia d’un origen demoníac, i el de les prostitutes, dedicades a cobrir un «mal menor» en la societat, però vistes com a indignes per la societat a causa de l’exercici pràctic del seu ofici.This article focuses on the description of the other look of Valencia in the fifteenth century, that of social marginalisation, which could be manifested by the exercise of various immoral offices. The following pages describe two female groups, particularly treated as vile: those of healers, sorcerers, and witches, whose strength was considered to be of demonic origin, and prostitutes, dedicated to covering a «minor evil» in society, but viewed as indignant by society due to the practical exercise of their profession.Humanidade
A Longstanding Duality: Discursive Construction of the EU vs the UK in the British Broadsheets' News Discourse of the Brexit Referendum
Full text linkThe relationship between the United Kingdom and the European Union has always been tumultuous and problematic, and European integration has always been a controversial topic in the UK’s contemporary politics. However, current research on the Brexit referendum's news discourse hardly addresses this topic directly. Therefore, this paper analyses the discursive construction of the UK versus the EU during the campaign coverage of the Brexit referendum in major British broadsheets. To do so, a corpus of four major British broadsheets along ideological lines (left-right) and Brexit stance (Leave-Remain) was analysed by applying a mixed method approach of Corpus Assisted Discourse Studies (Discursive News Values Analysis along with some Corpus Linguistic tools and techniques). The way news values were adopted in the campaign coverage of the British broadsheets shows a certain continuation of historical discourses around the relationship of the entities. The results show that news values during the campaign coverage were adopted by the pro-leave outlets to construct a highly negative and elite-associated image of the EU in contrast to the UK, while the pro-remain broadsheets mostly focused on a limited, practical and economic argument in favour of the EU, maintaining and highlighting the importance of UK independence.Economí
Improving the Accuracy of Metatarsal Osteotomies in Minimally Invasive Foot Surgery Using a Digital Inclinometer: Preliminary Study
Full text linkConceptualization, C.F.-V. and J.F.-T.; data curation, J.F.-T. and C.F.-V.; formal
analysis, E.N.-G. and J.F.-T.; investigation, C.F.-V., E.N.-G., N.F.-E. and J.F.-T.; methodology, J.F.-T.;
supervision, J.F.-T. and N.F.-E.; validation, J.F.-T., E.N.-G. and N.F.-E.; writing—original draft, C.F.-V.;
writing—review and editing, C.F.-V., E.N.-G., N.F.-E. and J.F.-T. All authors have read and agreed to
the published version of the manuscript.Minimally invasive foot surgery (MIS) has become a common procedure to treat various
pathologies, and accuracy in the angle of metatarsal osteotomies is crucial to ensure optimal results.
This randomized controlled trial with 37 patients investigates whether the implementation of a digital
inclinometer can improve the accuracy of osteotomies compared to traditional freehand techniques.
Patients were randomly allocated to group A (n = 15) receiving inclinometer-assisted surgery or group
B (n = 22) receiving conventional surgery. Osteotomies were performed and outcomes were evaluated
using an inclinometer. The inclinometer group showed a significant decrease in plantar pressure
from 684.1 g/cm2 pretreatment to 449.5 g/cm2 post-treatment (p < 0.001, Cohen’s d = 5.477). The
control group decreased from 584.5 g/cm2 to 521.5 g/cm2 (p = 0.001, Cohen’s d = 0.801). The effect
size between groups was large (Cohen’s d = −2.572, p < 0.001). The findings indicate a significant
improvement in accuracy and reduction in outliers when using an inclinometer, suggesting that this
technology has the potential to improve surgical practice and patient outcomes in minimally invasive
metatarsal osteotomies.Podologí
Role of Exosomal miR-205-5p Cargo in Angiogenesis and Cell Migration
Full text linkExosomes or small extracellular vesicles (sEVs) represent a pivotal component in intercellular communication, carrying a diverse array of biomolecules. Several factors can affect sEVs release dynamics, as occurs in hyperglycemia or inflammation. In fact, sEVs release has been associated with the promotion of physio-pathological processes. Among the sEVs cargo, microRNAs play an essential role in cell-to-cell regulation. More concretely, miR-205-5p is related to angiogenesis and cell proliferation. The aim of this study is to understand the specific role of sEVs containing miR-205-5p under high glucose conditions. ARPE-19 cells were cultured with high glucose (HG) for 5 days. sEVs were isolated and characterized. sEVs from ARPE-19 were used for angiogenesis and cell proliferation. HG increased sEVs release but downregulated miR-205-5p cargo expression compared to the control. sEVs from HG-treated ARPE-19 cells promoted tube formation and migration processes. In contrast, miR-205-5p overexpression (by mimic transfection) decreased angiogenesis and cell migration. Our results demonstrate how ARPE-19 cells respond to HG challenge by increasing sEVs with weak miR-205-5p cargo. The absence of this miRNA in sEVs is enough to promote angiogenesis. In contrast, restoring sEVs-miR-205-5p levels decreased it. These findings open new possibilities in sEVs-based therapies containing miR-205-5p against angiogenesis.This research was funded by the Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación Española, grant number PID2020-117875GB-10; Instituto de Salud Carlos III grant number PI21/00083; and the European Union research fund HORIZON MSCA 2021-DN-01-01_RETORNA 101073316.Medicin
Dopaminergic neuron loss in mice due to increased levels of wild‑type human α‑Synuclein only takes place under conditions of accelerated aging
Full text linkUnderstanding the intricate pathogenic mechanisms behind Parkinson’s disease (PD) and its
multifactorial nature presents a significant challenge in disease modeling. To address this, we explore
genetic models that better capture the disease’s complexity. Given that aging is the primary risk
factor for PD, this study investigates the impact of aging in conjunction with overexpression of
wild‑type human α‑synuclein (α‑Syn) in the dopaminergic system. This is achieved by introducing a
novel transgenic mouse strain overexpressing α‑Syn under the TH‑promoter within the senescence‑
accelerated SAMP8 (P8) genetic background. Behavioral assessments, conducted at both 10
and 16 months of age, unveil motor impairments exclusive to P8 α‑SynTg mice, a phenomenon
conspicuously absent in α‑SynTg mice. These findings suggest a synergistic interplay between
heightened α‑Syn levels and the aging process, resulting in motor deficits. These motor disturbances
correlate with reduced dopamine (DA) levels, increased DA turnover, synaptic terminal loss, and
notably, the depletion of dopaminergic neurons in the substantia nigra and noradrenergic neurons in
the locus coeruleus. Furthermore, P8 α‑SynTg mice exhibit alterations in gut transit time, mirroring
early PD symptoms. In summary, P8 α‑SynTg mice effectively replicate parkinsonian phenotypes by
combining α‑Syn transgene expression with accelerated aging. This model offers valuable insights into
the understanding of PD and serves as a valuable platform for further research.This work was funded by grants from Ministerio de Ciencia e Innovacion (PID2020-117937 GB-I00, RED2018-
102723-T, and CIBERNED CB06/05/0086) and Generalitat Valenciana (PROMETEO/2021/028) to I.F. R.S-C.
was recipient of a predoctoral fellowship of the Ministerio de Educación, Cultura y Deporte (FPU Program).Medicin
After the Franciscan Question? Sources and historiography on Francis of Assisi
Full text linkL’articolo presenta considerazioni sulla questione francescana,
nata col Sabatier, ritenendo che non sia del tutto superata dalla storiografia,
ma che restino alcune questioni francescane. Si parte dalla considerazione che
sono ancora validi due punti metodologici di Sabatier: l’utilizzo degli scritti di
Francesco come pietra di paragone delle fonti biografiche e la considerazione
che tutte le fonti sono di parte e che risultano più pericolose sul piano storico
quelle che nascondono la loro parzialità. Con l’aggiunta di un terzo punto
che deriva dalle scoperte del Sabatier, sviluppate con quella di Delorme della
Legenda antiqua Perusina/Compilatio Assisiensis, che cioè le testimonianze
dei compagni sono fondamentali, anche se le ultime ricerche mostrano che va
attenuata la contrapposizione tra le fonti poiché esse sono intrecciate tra loro.
Restano alcuni blocchi problematici, alcune questioni francescane sulle
quali non vi è uniformità fra gli storici. 1. La gerarchia delle fonti. 2. Le letture
riduttive della rilevanza storica di Francesco, sia nel senso che lui non poteva
fuoriuscire dagli schemi del suo tempo, sia nel senso che le sue immagini sono
prodotte dalla cultura e dalle ideologie dei diversi periodi storici. 3. Continuità
o cesura tra Francesco e l’Ordine dei Minori. 4 Rapporto di Francesco
con i movimenti popolari. 5. Suo rapporto col papa e la gerarchia ecclesiastica.
6. Estensione della sua predicazione di pace nella cristianità anche agli
“infedeli”The article presents considerations on the Franciscan question,
born with Sabatier, believing that it is not completely overcome by historiography,
but that some Franciscan questions remain. The author starts from the
consideration that two methodological points of Sabatier are still valid: the
use of the writings of Francis as a touchstone of the biographical sources and
the consideration that all sources are biased and those that hide their bias are
more dangerous on a historical level. With the addition of a third point that
derives from the discoveries of Sabatier, developed with that of Delorme of
the Legenda antiqua Perusina/Compilatio Assisiensis, that is, that the testimonies
of the companions are fundamental, even if the latest research shows
that the contraposition between the sources must be attenuated since they are
intertwined with each other. Some problematic blocks remain some Franciscan
questions on which there is no uniformity among historians. 1. The hierarchy
of sources. 2. The reductive readings of Francis' historical relevance, both in
the sense that he could not escape the mould of his time, and in the sense that
his images are produced by the culture and ideologies of the different historical
periods. 3. Continuity or caesura between Francis and the Order of Minors.
4 Francis' relationship with popular movements. 5. His relationship with the
pope and the ecclesiastical hierarchy. 6. Extension of his preaching of peace
in Christianity also to the "infidels".Humanidade
Regulándonos Juntos: Propuesta de Intervención de Regulación Emocional en Familia
Full text linkLa inteligencia emocional en los padres es crucial para el desarrollo saludable de los niños, ya que les permite comprender y gestionar adecuadamente sus propias emociones, lo que influye en el ambiente emocional del hogar. Cuando los padres carecen de estrategias de regulación emocional, pueden transmitir patrones negativos de comportamiento emocional a sus hijos. Esto podría ocasionar dificultades para los niños al comprender y gestionar sus propias emociones, lo que podría manifestarse en problemas de conducta, baja autoestima o dificultades en las relaciones interpersonales, entre otras. El objetivo del trabajo es diseñar un programa de intervención cuyo objetivo es dotar a los progenitores o familia de recursos con la finalidad de que aprendan a regular emocionalmente a sus hijos/as. El programa está compuesto por nueve sesiones, a través de las cuales, tanto progenitores como menores incorporan conocimientos sobre la regulación emocional con el objetivo de mejorar su compresión sobre las emociones y adquirir estrategias de regulación emocional ante situaciones conflictivas. La realización del programa puede tener un impacto significativo en el bienestar emocional y la cohesión familiar, ofreciendo a las familias las herramientas necesarias para cultivar relaciones saludables y enfrentar los desafíos de la vida con resiliencia y compresión.Emotional intelligence in parents is crucial for the healthy development of children, as it allows them to understand and adequately manage their own emotions, which influences the emotional environment of the home. When parents lack emotional regulation strategies, they can transmit negative patterns of emotional behavior to their children. This can result in difficulties for children to understand and manage their own emotions, which can manifest in behavioral problems, low self-esteem or difficulties in interpersonal relationships, among others. The objective of the work is to design an intervention program whose objective is to provide parents or families with resources so that they learn to emotionally regulate their children. The program is made up of nine sessions, through which both parents and children incorporate knowledge about emotional regulation with the aim of improving their understanding of emotions and acquiring emotional regulation strategies in conflictive situations. Completing the program can have a significant impact on emotional well-being and family cohesion, offering families the tools necessary to cultivate healthy relationships and face life's challenges with resilience and understanding.Psicologí
Practical interest and didactic approach as the fundamental principles of the Castigos y dotrinas que un sabio dava a sus hijas. New contributions to the a corpus of castilian texts about the education of women
Full text linkEste artículo aborda el análisis de los Castigos y dotrinas que un
sabio dava a sus hijas, un breve tratado presumiblemente anónimo y fechado
en torno a los últimos años del siglo XV. En cuanto al tema, puede quedar
inserto en el corpus de publicaciones que atienden a la naturaleza femenina y,
en especial, a su formación, dirigida esencialmente a su labor como perfectas
esposas. Los Castigos y dotrinas que un sabio dava a sus hijas trasciende el
debate filógino-misógino en favor de una nueva organización, la didácticodoctrinal,
que experimentará su apogeo en el siglo siguiente con textos tan
insignes como los que legaron Luis Vives, Erasmo de Róterdam o Luis de León.
En este sentido, nuestro artículo abunda en el componente práctico que se deriva
de las enseñanzas ofrecidas a lo largo del texto, así como en las estrategias didácticas que el emisor (un padre) sigue para trasladar la doctrina de manera
eficiente a sus destinatarias (sus hijas).This article proposes the analysis of the Castigos y dotrinas que
un sabio dava a sus hijas, a short treatise presumably anonymous and dated
around the last years of the 15th century. In terms of subject matter, the text
is part of the corpus of publications that examine the nature of women and,
in particular, their instruction, essentially aimed at their role as perfect wives.
The Castigos y dotrinas que un sabio dava a sus hijas transcends the philogino-
misogino debate in favour of a new organisation, the didactic-doctrinal one.
This organisation would experience its apogee in the next century with such
distinguished texts as those legated by Luis Vives, Erasmus of Rotterdam and
Luis de León. In this way, our article emphasises the practical component that
derives from the instructions offered throughout the text, as well as the didactic
strategies that the sender (a father) follows to efficiently convey the doctrine
to his receivers (his daughters).Humanidade
Translating Esther into (judeo-) provençal between spirituality, biblical exegesis and linguistic investigation
Full text linkIl libro di Ester nella tradizione ebraica riveste un ruolo estremamente importante. Esso insegna come, con l’aiuto di Dio, è possibile che
un evento disastroso, come il piano architettato dal perfido ministro Haman
per distruggere il popolo ebraico, si ribalti in un evento gioioso e riservi un
lieto fine. Per questa ragione, nella storia ebraica, troppo spesso segnata da
persecuzioni ed emarginazione, le vicende narrate in questo libro biblico divennero un fondamentale modello di pensiero e comportamento, per dare speranza e conforto al popolo. La memoria di questi eventi si rinnova ogni anno
nella festa di Purim, il cui evento centrale è la lettura della Megillat-Ester (“il Libro di Ester”). Nella Provenza della prima metà del Trecento, il tema di Ester
comincia a ricevere un’attenzione particolare. In quest’epoca e luogo sono
composti testi in ebraico, come trattati esegetici, poesie religiose, parodie, ed
anche parafrasi in giudeo-provenzale del libro biblico. Queste parafrasi, in
versi e in rima, sono rielaborazioni letterarie pensate per essere recitate durante la festa di Purim. In questo contributo, sono analizzate le varie possibili rese
in giudeo-provenzale dei versetti 1-6 del primo capitolo del Libro di Ester.
Questi primi versetti, che descrivono la città di Susa e i banchetti che il re
approntò nel giardino del suo palazzo, sono stati ampiamente commentati e
diversamente interpretati, per via della loro difficoltà, dovuta alla sinteticità
dell’originale e all’abbondanza di termini rari e oscuri. Attraverso una indagine comparata sulle scelte traduttorie e sulle fonti, risulta chiaro come queste
parafrasi, per quanto create per un intento letterario e performativo, riflettano
al contempo le posizioni degli autori in materia di esegesi del testo biblico.
Infine, è presentata anche la traduzione provenzale “cristiana” di Est. 1:1-6,
conservata nel ms. Paris, BNF, 2426 (XV sec.). La comparazione tra versioni
provenienti da ambienti tanto diversi permette di cogliere come la traduzione
sia un processo condizionato dal contesto del traduttore, dal messaggio che egli
vuole veicolare, dalla tradizione in cui si riconosce. Tuttavia, a ispirare tanti
testi su Ester (cristiani ed ebrei) nella Provenza tra Trecento e Quattrocento,
potrebbe essere stata anche una identificazione tra re Assuero e il suo lussuoso
palazzo nella capitale Susa e la corte pontificia di Avignone.The Book of Esther plays an extremely important role in Jewish
tradition. It teaches how, with God’s help, it is possible that a catastrophic event,
such as the evil plan devised by the minister Haman to destroy the Jewish
people, can turn into a joyful event and reserve a happy ending. For this reason,
in Jewish history, too often marked by persecution and marginalization, the
events narrated in this biblical book became a fundamental model of thought
and behavior, to give hope and comfort to the Jewish people. The memory of
these events is renewed every year during the feast of Purim, whose central
event is the reading of the Megillat-Ester (“the Book of Esther”). In Provence,
in the first half of the fourteenth century, the theme of Esther began to receive
particular attention. In this time and place, texts in Hebrew were composed,
such as exegetical treatises, religious poems, parodies, and even Judeo-
Provençal paraphrases of the biblical book. These paraphrases, in verse and rhyme, are literary elaborations composed to be recited during Purim. This
contribution analyses the various possible renderings in Judeo-Provençal of
Est. 1:1-6. These first versets, which describe the city of Susa and the banquets
that the king prepared in the garden of his palace, have been widely commented on and interpreted differently: in fact, they are particularly difficult, due to
the conciseness of the original and the abundance of rare and unclear terms.
Through a comparative investigation of translation choices and sources, it is
clear how these paraphrases, although created for a literary and performative
intent, at the same time reflect the authors’ positions regarding the exegesis of
the biblical text. Finally, the Provençal “Christian” translation of Est. 1:1-6,
preserved in the ms. Paris, BNF, 2426 (15th century) is also presented. The
comparison between versions coming from such different environments allows
us to understand how translation is a process conditioned by the context of the
translator, the message he wants to convey, and the tradition in which he/she
recognizes himself. However, what inspired many texts (Christians and Jewish) on Esther in Provence between the fourteenth and fifteenth centuries, may
also have been an identification between King Ahasuerus and his luxurious
palace in the capital Susa, and the papal court of Avignon.Humanidade
[Reseña]. Conill Sancho, J. (2021). Nietzsche frente a Habermas. Genealogías de la razón. Madrid: Tecnos
No full textNietzsche frente a Habermas. Genealogías
de la razón es la última obra
publicada por el profesor Jesús Conill,
catedrático emérito de Filosofía Moral
en la Universidad de Valencia. Su
labrado ensayo parece proyectar dos
momentos aparentemente separados: la
genealogía habermasiana y nietzscheana.
Sin embargo, un puente central hilvana
ambos dominios: la relación razón-fe,
desentrañando una religión abierta a la
razón como también iluminaron José Gómez
Caffarena y Manuel Fraijó. Como
destino final, el autor consigue ilustrar
cómo podríamos experimentar nuevas
formas en que la religión se nos acontece
desde la racionalidad moderna. Para
ello, Conill establece una comparativa
entre sus distintas filosofías de la religión
(cristiana).Filosofí