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Alterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet
No full textBackground and Objectives: In this study, the effects of an eight-week exercise and nutrition program on blood lipids, glucose, insulin, insulin resistance (HOMA-IR), leptin, ghrelin, irisin, malondialdehyde (MDA), and Growth Differentiation Factor 15 (GDF15) in overweight women were investigated. Materials and Methods: A total of 48 women volunteers participated in this study. The participants were randomly divided into four groups: control (C), exercise (E), nutrition (N), exercise + nutrition (E + N). While no intervention was applied to group C, the other groups participated in the predetermined programs for 8 weeks. At the beginning and end of this study, body composition was measured and blood samples were taken. Results: It was determined that the body composition components, lipid profile indicators, insulin, glucose, insulin resistance, leptin, ghrelin, irisin, and MDA parameters examined in this study showed positive changes in the intervention groups. Group E had a greater effect on body muscle percentage, MDA, and irisin levels, while group N had a greater effect on blood lipids and ghrelin levels. Conclusions: As a result, it is thought that lifestyle changes are important to improve cardiovascular health and combat obesity, and that maintaining a healthy diet together with exercise may be more effective
Optimization Of Serotonin Supplemented Sperm Washing Medium
No full textDoktora tezi.Bu tez çalışmasında, tüp bebek ve aşılama tedavi yöntemlerinde in vitro koşullarda kullanılmak üzere sperm hızını arttıran serotonin etken maddeli yeni bir sperm yıkama solüsyonun (medyum) geliştirilmesi hedeflenmiştir. Türkiye ve Dünya'da serotonin etkin maddeli geliştirilen ilk sperm yıkama solüsyonudur. Bu prospektif kohort çalışma, serotonin (5-HT), L-karnitin (L-C) ve Koenzim Q10 (CoQ10) gibi etken maddeler ile zenginleştirilmiş yeni bir sperm yıkama ortamının (SWM) sperm hareketliliğini artırma ve DNA hasarını azaltma potansiyelini araştırmak amacıyla yapılmıştır. Bu etken maddelerin doz belirleme işlemi gerçekleştirildikten sonra oluşturulan 5-HT/L-C/CoQ10 sperm yıkama medyumu çok sık kullanılan iki ticari sperm yıkama medyumu ile (SWM Origio®, Danimarka ve SWM Irvine Scientific®, Santa Ana, CA, ABD) karşılaştırılmıştır. Acıbadem Mehmet Ali Aydınlar Üniversitesi Atakent Hastanesi kliniğine gelen gönüllülerden alınan semen örneği aşağıda belirtilen üç farklı sperm yıkama medyumu ile analiz edilmek üzere üçe bölünmüştür; 1- Origio® SWM; HEPES, sodyum bikarbonat, insan serum albümini (HSA), taurin ve gentamisin sülfat, 2- Irvine Scientific® SWM; HEPES, sodyum bikarbonat ve HSA, 3- 5-HT/L-C/CoQ10 SWM; serotonin, L-C ve CoQ10 ile takviye edilmiş HEPES tamponlu insan tubal sıvısı (HTF). Sperm hareketliliği, apoptoz, reaktif oksijen türleri (ROS) ve DNA fragmantasyon oranları değerlendirilmiştir. Gruplar arasında genel ve progresif sperm hareketliliğinde istatistiksel olarak anlamlı bir fark bulunmamıştır. Ancak, 5-HT/L-C/CoQ10 SWM' deki spermatozoalar daha düşük apoptoz, nekroz ve ROS seviyeleri ve daha yüksek canlılık oranı göstermiştir. Gruplar arasında DNA fragmantasyon indeksinde anlamlı bir fark gözlenmemiştir. 5-HT/L-C/CoQ10 SWM, diğer iki ticari sperm yıkama ortamına göre sperm oksidatif stres ve apoptoz oranını azaltmıştır. Bu tez çalışması kapsamında elde edilen veriler, geliştirdiğimiz medyumun fertilizasyon başarı oranlarını arttırmak üzere bir sonraki denemelere geçebilecek potansiyeli olduğunu göstermiştir
Harmanlanmış Mobil Öğrenmenin EFL Öğrencilerinin Kelime Gelişimi Üzerindeki Etkisi
No full text▪️ This study is part of a dissertation titled “The Impact of Blended Mobile Learning on EFL Students’ Vocabulary Development” which was presented as a poster in Isatt2023: Living and Leading in the Next Era: Connecting Teaching, Research, Citizenship and Equity in Italy in July 2023 at a conference, and the abstract was published in the proceeding book.The study's objective is to examine the effects of Blended Mobile Learning (BML) on the vocabulary development of EFL preparatory students and their views of BML. As a mixed method study, it was conducted with 40 preparatory students at a state university in Turkey. While the control group studied vocabulary by reading texts only in the classroom by adhering to the textbook, the experimental group, in addition to the same instruction, was taught vocabulary outside the classroom in a virtual classroom opened through the Google Classroom application. A pre-test and a post-test were administered to the students to determine the impact of BML on their vocabulary development. The results of the tests were analyzed with SPSS program and the vocabulary development of groups was compared via an independent T-test. Additionally, a structured interview was done with the students of the experimental group to determine their views of BML. Students' responses were analyzed using the MAXQDA 2020 program with the method of content analysis. This research has led to the conclusion that BML, as a teaching method, strengthens the vocabulary development of the preparatory students and motivates them to learn vocabulary
"Örgütsel Farklılıklar" Kavramının Görsel Haritalama Tekniği Kullanılarak Bibliyometrik Analizi
No full textIn this study, it is aimed to perform a bibliometric analysis of the research related to the concept of organizational differences and to make inferences about the general structure of the field. In this direction, in the research, 303 scientific publications on "organizational differences" were examined with the bibliometric analysis method using the Web of Science database, and then the obtained data were visualized using the VOSviewer software program. Bibliometric methods such as keyword analysis, citation analysis, co-author analysis, co-citation analysis of authors were used on the identified scientific publications. Using bibliometric methods, a comprehensive view of the dynamics of the field is presented; the development of the literature on the concept of "organizational differences" has been mapped by determining the basic studies, types, years, authors, countries and publication areas. As a result of the study, it was found that the subject of "organizational differences" was not studied sufficiently in the literature; the most publications on a country basis were from America, the most publications on a year basis were published in 2019, and the most commonly cited author was Alstemark B. It is thought that the findings obtained as a result of the analysis will provide resources for future studies on "organizational differences"
A New Azide-Bridged Polymeric Manganese (III) Schiff Base Complex with an Allylamine-Derived Ligand: Structural Characterization and Activity Spectra
No full textThis paper reports the synthesis and structural characterization of a novel azide-bridged polymeric manganese (III) Schiff base complex, using 2-((allylimino)methyl)-6-ethoxyphenol as a ligand. The crystal structure of the synthesized compound, elucidated by single-crystal X-ray diffraction analysis, indicates that it crystallizes in the monoclinic space group P21/c. The complex is found to display an octahedral geometry in which the central manganese Mn(III) coordinates with two bidentate donor Schiff base ligands via oxygen and nitrogen atoms. In addition, the metallic centers are linked together to form a one-dimensional chain bridged by end-to-end azide ligands. To offer a more thorough characterization of the synthesized compound, the study incorporates experimental data from FT-IR, UV-Vis, and cyclic voltammetry, alongside computational results from Hirshfeld surface analysis and DFT calculations conducted for both the ligand and complex. The computational analyses provided valuable insights into the intrachain and interchain interactions within the crystal structure, clarified the conformational characteristics of the isolated ligand molecule, and aided in the interpretation of the experimental IR spectra. Furthermore, an assessment of the compound’s drug-like properties was conducted using activity spectra for substances (PASS) predictions, revealing potential pharmacological activities. © 2024 by the authors.Semnan University, Adam Mickiewicz University.
Payame Noor University.
Fundacao para a Ciencia e a Tecnologia (FCT)
Responsibility of the Sub-Employer, the Principal Employer and the Employer’s Representative for Administrative Fines Resulting from the Failure to Provide Employment and Termination Declarations in Compliance with the Law
No full text5510 sayılı Kanun’da idari para cezasını gerektiren birçok hal düzenlenmiştir. Çalışmamızda, bu idari para cezalarından olan işe giriş ve işten ayrılış bildirgelerinin kanuna uygun verilmemesinden kaynaklanan idari para cezaları özelinde alt işverenin, asıl işverenin ve işveren vekilinin sorumlulukları ele alınmaya çalışılmıştır. Bu yapılırken gerek 506 sayılı Kanun gerekse 5510 sayılı Kanun döneminde öğretide yapılan değerlendirmeler, Yargıtay içtihatları ve SGK tarafından iç işleyişi düzenlemek amacıyla çıkarılan genelgelerden yararlanılmıştır. Çalışmada öncelikle, işverenlerin bu idari para cezalarının muhatabı olmasına dayanak mevzuat hükmüne işaret edilmiş ve ardından tüzel kişi işverenin bu idari para cezalarından sorumlu olabilmesinin hukuki zemini ortaya konulmaya çalışılmıştır. Ardından alt işveren-asıl işveren ilişkisinin varlığı durumunda, bu idari para cezasının muhatabı olup olamayacakları ve tesis edilen idari para cezasının tahsilinden sorumluluk durumları ortaya konulmaya çalışılmıştır. Son olarak da işveren vekilinin bu idari para cezalarından sorumluluğu ele alınmıştır. İşveren vekilinin sorumluluğu ile ilgili inceleme yapılırken 506 sayılı Kanun dönemine ilişkin durum detaylı olarak incelenmiştir. Zira bu husus, 5510 sayılı Kanun döneminde öğretide detaylı olarak incelenmemiş olup aynı zamanda konuya ilişkin yol gösterici nitelikte bulunan Yargıtay Hukuk Genel Kurulu’nun 25.09.1996 tarihli kararı bu Kanun dönemine ilişkindir
Utilizing Metaheuristics to Estimate Wind Energy Integration in Smart Grids With A Comparative Analysis of Ten Distributions
No full textRenewable energy presents the most favorable approach to address the escalating challenge of greenhouse gas emissions while simultaneously guaranteeing the safeguarding of the environment. This article utilizes ten different distributions to approximate the wind energy integration in smart grids. The employed distributions are Rayleigh, Poisson, Weibull, Normal, Gamma, Laplace, LogNormal, Nakagami, Birnbaum Saunders, and Burr. The parameters of each distribution are calculated based on metaheuristic methods such as particle swarm optimization and genetic algorithms. Six error criteria have been employed to evaluate the precision of introduced distributions and metaheuristic methods. The approximation is performed by utilizing the wind data collected over three years hourly in the Marmara region of Turkiye. The empirical findings indicate that Gamma, Burr, and Weibull distributions exhibit more significant superiority than the remaining distributions across all datasets
Adoption of Lean Construction and AI/IoT Technologies in Iran's Public Construction Sector: A Mixed-Methods Approach Using Fuzzy Logic
No full textThe construction sector in Iran faces substantial inefficiencies, including high material wastage, posing environmental and economic risks. This study investigated the adoption of Lean Construction (LC) practices and AI/IoT technologies in Iran's public construction sector using a mixed-methods approach. This research examined the organizational, technical, and infrastructural factors across four key provinces-Tehran, Isfahan, Khorasan Razavi, and Fars-and employed fuzzy logic to address the uncertainties in adoption decisions. Data from 28 key stakeholder interviews were analyzed using Python 3.9, with libraries such as Pandas 1.3.3, NumPy 1.21.2, and skfuzzy 0.4.2 for the statistical analysis and NVivo 12 for the thematic coding. The analysis revealed that organizational readiness and leadership support were the critical drivers of adoption, particularly in Isfahan and Khorasan Razavi, which exhibited the highest adoption likelihood scores (0.5000). Tehran and Fars showed slightly lower scores due to regulatory barriers and financial limitations. The findings highlight the need for targeted leadership training, regulatory reforms, and infrastructure investments to accelerate the adoption of these technologies. This study aligned with the Sustainable Development Goals (SDG 9: Industry, Innovation, and Infrastructure and SDG 11: Sustainable Cities and Communities) by offering practical recommendations for advancing sustainable practices in Iran's construction sector. The insights provided have broader implications for other developing economies facing similar challenges, contributing to global efforts toward sustainable development
The Role of Artificial Intelligence Technologies on Consumptıon Habits in Social Media Marketing: An Intergenerational Examination
No full textGünümüzde yapay zekâ temelli uygulamaların sosyal medya pazarlamasında hızla önem kazanması, marka ve reklamverenlerin de dikkatini çekmiştir. Bu doğrultuda sosyal medya pazarlaması ve yapay zekâ temelli uygulamalarının, kullanıcıların tüketim motivasyonları üzerinde nasıl bir rol üstlendiği önemli bir araştırma konusu olarak karşımıza çıkmaktadır. Yukarıdaki bilgiler doğrultusunda araştırmanın temel amacı, sosyal medya pazarlamasında kullanılan yapay zekâ teknolojilerinin, Y ve Z kuşağına mensup bireylerin tüketim alışkanlıkları üzerindeki rolünü ortaya çıkarmaktadır. Nitel araştırma yöntemlerinden derinlemesine görüşme yöntemine başvurularak gerçekleştirilen araştırmada, yapay zekâ uygulamaları kuşaklar arasındaki farklılıklar ekseninde irdelenmektedir. Araştırma bulgularına göre her iki kuşağına mensup katılımcıların, yapay zekâ temelli uygulamalarını deneyimleme pratikleri ve takip etme motivasyonlarında etkileşim unsurunun önemine yönelik farklılıkların ortaya çıktığı tespit edilmiştir. Ayrıca kullanıcıların yapay zekâ temelli uygulamalara yönelik deneyimleri Z kuşağı üzerinde tüketim alışkanlıklarını olumlu yönde güdülerken, Y kuşağına mensup kullanıcılar üzerinde daha zayıf bir motivasyon sağladığı görülmektedir. Bu bağlamda Y ve Z kuşağına mensup kullanıcıların sosyal medya pazarlamasının geleceğinde yapay zekâ uygulamalarının daha fazla önem kazanacağına ilişkin ortak bir bakış açısına sahip oldukları öne çıkmaktadır
Reliability and Validity of Attentional Style Questionnaire: Turkish Form
No full textAttention is an important part of cognitive and perceptual processes. Attention includes both external processes related to the environment and internal processes such as heredity. In addition, measuring attention processes, which have two dimensions, top-down and bottom-up, is important in terms of both learning processes and determining some psychopathologies. Based on this, it was aimed to adapt the Attention Style Questionnaire (ASQ) into Turkish in this study. The study group includes of 372 university students. Data collection materials included personal information form, Attention Styles Questionnaire and Control Dimension of Self-regulation Scale. Language validity and criterion-related validity analysis were performed for validity studies. Confirmatory factor analysis and test-retest analysis were utilized for reliability studies. The two-factor structure in the original structure of the scale was confirmed through confirmatory factor analysis results. Furthermore, the ASQ was found to be highly correlated with the Control Dimension of Self-regulation Scale. According to the findings obtained for reliability, Cronbach's alpha coefficients were found as .81 for the cognitive avoidance sub-dimension and .70 for the focusing sub-dimension. Test-retest correlation coefficients were determined as .76 for the cognitive avoidance sub-dimension and .75 for the focusing sub-dimension. Research results indicate that Attention Style Questionnaire is a reliable and valid measurement tool in determining the style of the attention to university students in Türkiye