Archivio istituzionale della ricerca - Università dell'Insubria
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Interaction-induced phases in the half-filled Bernevig-Hughes-Zhang model in one dimension
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In Silico Classification Model to Screen the Potential Thyroid Hormone System-Disrupting Activity of Per- and Polyfluoroalkyl Substances
No full textShared Decision-Making in Solid Organ Transplantation: A Review
Get PDFSolid organ transplantation entails numerous complex medical and ethical decisions. Shared decision-making (SDM) has been advocated as the optimal model for navigating these decisions, providing a collaborative framework that enhances person-centered care. This approach involves patients, caregivers, and healthcare professionals in the decision-making process, ensuring that clinical decisions align with patient preferences, values, and individual circumstances alongside clinical indications. This paper reviews the implementation of SDM throughout the transplantation journey, from diagnosis and transplant referral, pre-transplant assessments, waiting lists, to the organ offer, perioperative period, and long-term follow-up. Barriers to SDM include factors at the patient, provider, and system levels, including inadequate patient–provider communication. Effective SDM requires tailored educational resources, prognostic tools, clinician training, collaborative care models, and supportive policies. Additionally, leveraging technology, such as artificial intelligence and mobile applications, can enhance patient engagement and decision quality.
SDM promotes equity by involving all patients—including those from more vulnerable groups—in meaningful conversations about their treatment options, thereby mitigating disparities in access and outcomes. Future research should focus on the long-term impacts of SDM interventions, the development of comprehensive prognostic tools incorporating patient-reported outcomes, and systemic changes to integrate SDM into clinical practice, aiming to improve patient outcomes and person-centered care
Design and validation of thermal comfort questionnaire using exploratory and confirmatory factor analyses
Get PDFWithin the field of indoor environmental quality, several objective and subjective techniques have been developed to monitor conditions and provide user feedback. One such approach features occupant-centred questionnaires, indicating different aspects of comfort, including thermal, visual, acoustic or related to air quality. This study introduces the development and validation of such a questionnaire to optimise its completion rate and meaningfulness. Exploration and confirmatory analysis techniques were applied to identify the questionnaire's underlying structures, and the models' reliability and validation secured the validity of our findings. Questionnaire factors appeared to be connected to different aspects of temperature and humidity, each accounting for a significant portion of response variability, indicating that the questionnaire items effectively capture multiple dimensions within these constructs. The proposed thermal comfort questionnaire was also found to be reliable, with room for improvement through additional testing of individual elements. Overall, the questionnaire serves its intended purpose and can be used in subsequent analysis to improve the indoor environments of building occupants. The validation logic presented here, an essential step in the process of monitoring and building improvements, can serve as a set of guidelines and be replicated by other studies employing subjective feedback collection in the indoor environmental quality realm
Rheology as a Tool to Investigate the Degradability of Hyaluronic Acid Dermal Fillers
Get PDFBackground: In the current landscape of aesthetic medicine, the use of hyaluronic acid (HA)-based dermal fillers is increasingly prevalent. Although HA is widely acknowledged for its safety and efficacy the study of its degradability represents a critical aspect in ensuring safety.
Methods: Rotational rheology was chosen to study the HA-based fillers interaction with hyaluronidase enzyme; this allows to establish a correlation between the viscoelastic parameters of the sample and its degradation.
Results: The obtained results indicate that the products exhibit sensitivity to the enzyme and that the rheological parameters vary depending on the contact time and dosage of administration.
Conclusion: Our findings propose a standardized rheological protocol for assessing the degradability of HA-based dermal fillers, offering an alternative to existing methods
European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Infertility
No full textBackground and objective: To present a summary of the updated 2025 European Association of Urology (EAU) Guidelines on Sexual and Reproductive Health (SRH) on male infertility, providing practical recommendations on the clinical work-up with a focus on diagnosis, treatment and follow-up. Methods: For the 2025 SRH guidelines, new and relevant evidence was identified, collated, and appraised via a structured assessment of the literature. Databases searched included Medline, EMBASE, and the Cochrane Libraries. Recommendations within the guidelines were developed by the panel to prioritise clinically important care decisions. The strength of each recommendation was determined according to a balance between desirable and undesirable consequences of alternative management strategies, the quality of the evidence (including the certainty of estimates), and the nature and variability of patient values and preferences. Key findings and limitations: Key recommendations emphasise the importance of a thorough urological assessment of all men seeking medical help for fertility problems to ensure appropriate treatment. The guidelines also stress the clinical relevance of a parallel investigation of the female partner during the diagnostic and management work-up of the infertile couple, to promote shared-decision making in terms of timing and therapeutic strategies. Furthermore, the guidelines recommend to counsel all infertile men and men with abnormal semen parameters on the associated health risks. Key changes in the male infertility guidelines for 2025 include: the addition of two new sections addressing exome sequencing and probiotic treatment; and significant update of the evidence base and recommendations for the diagnostic work-up of male infertility. Conclusions and clinical implications: This overview of the 2025 SHR guidelines offers valuable insights into the diagnosis, classification, treatment and follow-up of male factor infertility and are designed for effective integration into clinical practice