University of Udine
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The Impact of Concordance between Liquid and Tissue Biopsy for Actionable Mutations: Insights from the ROME Trial
No full textPURPOSE: This analysis evaluated the influence of tissue and liquid biopsy concordance on outcomes in patients enrolled in the ROME trial. PATIENTS AND METHODS: The ROME trial, a phase II multicenter study, enrolled 1,794 patients with advanced solid tumors. Next-generation sequencing was performed on tissue and liquid biopsies using FoundationOne CDx and FoundationOne Liquid CDx. A centralized molecular tumor board reviewed results to identify actionable alterations, with 400 patients randomly assigned to tailored therapy (TT) or standard-of-care groups. TT improved objective response rate and progression-free survival (PFS) in the intention-to-treat population. Concordance was defined as the detection of the same druggable alteration in both biopsy types; discordance indicated detection in only one. RESULTS: Concordance was present in 49% of cases, with alterations detected exclusively in tissue (35%) or liquid (16%) biopsies. Patients in the concordant group receiving TT experienced improved survival outcomes. The median overall survival was 11.05 versus 7.70 months in the standard-of-care group [HR = 0.74; 95% confidence interval, 0.51-1.07], and the median PFS was 4.93 versus 2.80 months (HR = 0.55; 95% confidence interval, 0.40-0.76), respectively. In contrast, the survival benefit of TT was less pronounced or absent in patients with discordant results. Overall survival was higher in the T + L group (11.05 months), followed by tissue-only (9.93 months) and liquid-only (4.05 months) groups. PFS followed a similar pattern, with the longest PFS in the T + L group (4.93 months) versus 3.06 months in tissue-only and 2.07 months in liquid-only groups. CONCLUSIONS: The study highlights the potential value of integrating both biopsy modalities in selected clinical contexts. See related commentary by Saldanha and Siu, p. 7
Gerusalemme
No full textPossono le pietre raccontare delle storie? A Gerusalemme sì. Il volume ripercorre l’evoluzione urbana e architettonica della città dal periodo ellenistico alla conquista araba, attraverso nove secoli di trasformazioni politiche, culturali e religiose. Integrando archeologia, fonti storiche ed epigrafiche, delinea un ritratto chiaro e aggiornato della Gerusalemme ellenistica, romana e tardoantica e mostra come templi, strade, mura e quartieri abbiano plasmato non solo lo spazio urbano, ma anche l’immaginario delle comunità che lo abitarono. Le stratificazioni del passato diventano così chiavi per leggere la città contemporanea, tra continuità e fratture ancora riconoscibili. Il libro offre dunque un’introduzione accessibile e al tempo stesso rigorosa, pensata per studiosi, studenti e lettori interessati alla storia del Medio Oriente
Il ruolo semiotico della psicanalisi in Deleuze
No full textThis article examines the role that psychoanalysis plays in shaping Gilles Deleuze’s semiotic
thought, highlighting how the French thinker transforms psychoanalytic concepts into tools for a non-representational theory of signs. Through an analysis of Deleuze’s works on Freud, Masoch, structuralism, and the semiotics of images, the article shows how he employs psychoanalysis not as an explanatory model but as a conceptual device capable of generating new ways of readingdesire, enunciation, and processes of subjectivation. The article also underscores the relationship between psychoanalysis and language, and the way Deleuze’s critique of the signifier contributes to defining a semiotics of forces and intensities
Rapid, efficient and green solid-state mechanosynthesis of palladium complexes
No full textMechanochemistry has emerged as a powerful and environmentally benign alternative to conventional solution synthesis. In this study, we present a comprehensive investigation into the solid-state mechanochemical synthesis of a diverse library of palladium(II) complexes. This investigation utilized five commercially available Pd(II) precursors and twelve diene, N- and P-donor ligands. Systematic investigations have revealed that high-yielding and clean reactions can be achieved by tuning the milling frequency, reaction time, and metal-to-ligand stoichiometry, affording more than forty Pd(II) complexes. A comparison with conventional solution-based protocols is therefore indicated to underscore the operational simplicity and ecological advantage of the mechanochemical approach, as demonstrated by favorable green chemistry metrics such as low E-factors and high effective mass yields (EMY). The validity of the methodology was established through gram-scale syntheses, which demonstrated high yields and reproducibility. These findings contribute a robust and generalizable synthetic strategy for accessing widely used palladium precursors, thus supporting the integration of mechanochemistry into green organometallic synthesis
Dimensional analysis: reasoning with units of measurement as a tool for improved problem-solving competency
No full textGeraert van der Leye e le Constitutioni de la patria de friuoli del 1484
No full textDescrive la carriera del tipografo Geraert van der Leye, che introdusse la stampa a Treviso (1471), Cividale (1480), e Udine (1484), con un capitolo sul primo libro stampato ad Udine
Trends in GVHD Epidemiology, Prophylaxis and Management: The Gruppo Italiano per il Trapianto di Midollo Osseo, Cellule Staminali Emopoietiche e Terapia Cellulare (GITMO) GVHD24 Study
No full textHospitalization burden in children on dialysis: insights from the Italian Registry of Pediatric Chronic Dialysis (IRPCD)
No full textBackground: Children receiving kidney replacement therapy frequently face complications resulting in recurrent hospitalizations. This nationwide retrospective observational study, conducted using data from the Italian Registry of Pediatric Chronic Dialysis (IRPCD), aimed to compare hospitalization rates and causes between children treated with chronic peritoneal dialysis (PD) and hemodialysis (HD). Methods: The study included children (< 18 years) on chronic PD or HD recorded between January 2000 and December 2019. Hospitalizations were defined as admissions involving at least one overnight stay, excluding those for dialysis initiation or kidney transplantation. Hospitalization causes were categorized as infectious and non-infectious dialysis-related complications, other infections, non-infectious conditions, diagnostic procedures, and complications related to kidney failure. Results: A total of 847 dialysis patients (493 on PD, 354 on HD) were included. Among 813 patients, 420 (51.7%) were hospitalized, with PD accounting for 72.9% at the first hospitalization. Dialysis-related infections were the most common cause (24.3%), particularly in PD patients, followed by non-infectious medical conditions (17.3%) and kidney failure-related complications (14.9%). Cox modeling indicated a lower risk of hospitalization for HD compared to PD (aHR 0.75 [95%CI 0.65–0.87]), with HD showing a protective effect over time. HD patients also had a lower likelihood of treatment changes after one year compared to PD (aHR 0.29 [95%CI 0.10–0.81]). Conclusions: This study highlights the significant burden of hospitalization among children on chronic dialysis, with PD patients experiencing higher risks over time compared to HD. These findings underscore the need for targeted strategies to mitigate hospitalization risks in pediatric dialysis populations
Survey of Neural Network Approaches to Target Tracking with an Emphasis on Interpretability
No full textThis survey examines recent advances in target tracking methods that incorporate neural networks, with a particular emphasis on their application to complex and dynamic tracking scenarios. While classical model-based approaches have traditionally dominated the field, they often struggle with nonlinear dynamics and unpredictable maneuvers. Conversely, learning-based methods, particularly those employing neural architectures, present compelling alternatives by leveraging data-driven representations and adaptive capabilities. This work provides a concise overview of conventional tracking frameworks to contextualize the evolution of neural approaches. A central contribution of the survey is a novel classification of neural tracking methods based on their level of interpretability, offering a unique perspective on how transparency and explainability are addressed in the design of modern tracking systems. The review synthesizes trends across a broad range of applications, compares methodological trade-offs, and identifies key challenges and open research directions, particularly in balancing performance with trustworthiness in real-world deployment