University of Udine
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Which individual and organizational factors shape nurses' attitudes toward family involvement in nursing care? A multicenter cross-sectional study
No full text«Fortunato, ma non fortuito». L’IGI e gli incunaboli udinesi
No full textSintesi del rapporto fra le raccolte incunabolistiche udinesi e la redazione dell'Indice generale degli incunaboli (1943-81)
Chest computed tomography of trastuzumab-deruxtecan (T-DXd)-related interstitial lung disease: Key points for radiologists
No full textArcipelaghi produttivi per una urbanità alpina
No full textCome viene modificato il paesaggio montano dalla produzione industriale diffusa? Come possono essere ripensate le aree produttive nei contesti orografici complessi? L’articolo affronta il tema progettuale delle aree industriali sparse nelle urbanità alpine attraverso un caso studio in Trentino. Il fenomeno della diffusione degli insediamenti produttivi nelle Alpi è interpretato come parte di una condizione più ampia, che ricorre anche nelle forme urbane diffuse di pianura, dove il moltiplicarsi di frammenti produttivi – spazi sottoutilizzati, edifici abbandonati, capannoni invenduti, lotti liberi – contribuisce alla costruzione di una “campagna urbana” segnata da processi di urbanizzazione periferica e di consumo incrementale di suolo. La questione progettuale attiene alla necessità di razionalizzare gli insediamenti e di riparare il paesaggio, avviando processi di riqualificazione ambientale e funzionale. Le caratteristiche del contesto orografico, la sua “anisotropia territoriale” e la ricchezza delle diversità consentono di riconoscere nell’eterogeneità e nella discontinuità un valore: una risorsa per il progetto di coesistenza tra elementi disuguali in forma di “arcipelaghi” produttivi. Le zone di bassa e media montagna rappresentano un banco di prova sensibile per restituire le aree industriali come parti di un’architettura territoriale in transizione. Ciò implica intervenire su parti trascurate, marginali o scartate, che sfuggono alla percezione comune e sono spesso considerate insignificanti. La comprensione degli spazi e la reinterpretazione delle loro relazioni con i contesti prefigurano elementi e logiche di progetto utili a riconsiderare gli insediamenti produttivi come costruzioni capaci di produrre ecologie e paesaggi, contribuendo a una riflessione sulle nuove urbanità e sui futuri assetti della “città-paesaggio”
Lp(a) in the Horizon of Diagnostics and Therapy
No full textLow-density lipoprotein cholesterol (LDL-C) has traditionally been the primary biomarker used to assess cardiovascular risk. However, a substantial proportion of cardiovascular events occur in individuals with LDL-C levels within the normal range, highlighting the need for additional risk markers. Lipoprotein(a) [Lp(a)] has emerged as an independent and genetically determined cardiovascular risk factor that is not adequately captured by conventional lipid profiling. Elevated Lp(a) levels are associated with an increased risk of atherosclerotic cardiovascular disease, including coronary artery disease, ischemic stroke, and calcific aortic valve stenosis, and appear to be particularly relevant in the context of premature cardiovascular events. The pathogenicity of Lp(a) is driven by distinct mechanisms that extend beyond cholesterol transport. These include pro-atherogenic, pro-inflammatory, and pro-thrombotic effects mediated largely by oxidized phospholipids carried by the particle and by the structural properties of apolipoprotein(a), which interfere with fibrinolysis. Despite its strong and stable genetic determination, Lp(a) remains underrecognized and inconsistently measured in clinical practice, partly due to historical limitations in assay standardization and reporting. This minireview summarizes current knowledge on the pathophysiological mechanisms underlying elevated Lp(a), discusses its clinical implications for cardiovascular risk assessment, and highlights the importance of standardized Lp(a) measurement in routine practice, particularly in light of emerging Lp(a)-targeted therapies
Flowchart for endometrial cancer classification integrating FIGO 2023 staging and ESGO/ESTRO/ESP 2025 risk categories
No full textPerché i ricorsi non fermeranno il voto sul referendum
No full textArticolo sulla legittimità dell'azione di Governo quanto alla scelta della data di svolgimento del 'referendum' confermativo 2026 sulla c.d. 'riforma della giustizia
Adherence to oral immunosuppressors using therapeutic drug monitoring: A retrospective study
No full text: BackgroundAfter hospital discharge, recipients of allogeneic hematopoietic stem cell transplantation (HSCT) must adhere to immunosuppressants to reduce the risk of complications such as graft-versus-host disease (GvHD). The use of therapeutic drug monitoring (TDM), a measure of medication adherence (MA), in the transplantation field has received limited research attention.ObjectivesWe used TDM to measure MA to the oral calcineurin inhibitors (CNIs) cyclosporine A (CSA) and tacrolimus (FK), from the patient's first follow-up visit after discharging up to 100 days after HSCT. The secondary aim was to identify risk factors for medication non-adherence (MNA) and the relationship between MNA and HSCT-related complications.Materials and MethodsA retrospective observational study was conducted at an academic hospital in northeast Italy. We included 269 adults undergoing allogeneic HSCT and a total of 1493 CNI serum assays.ResultsUsing an MA threshold of ≥ 80%, 37.2% of patients were adherent (57.9% to CSA and 17.9% to FK). There were no differences at the analyzed time points; however, MNA with TDM below the target range increased over time. There were no risk factors for MNA, nor differences in GvHD or hospital readmissions between adherent and non-adherent patients.ConclusionTDM can be used to assess MA to CNIs up to 100 days after HSCT, but due to the limitations of this measure, it would be useful to corroborate the results with other MA measurement systems. Prospective studies are required to identify risk factors, outcomes of MNA, and to validate which MA threshold could establish clinical relevance
La Parabola del Figliol Prodigo nella varietà di Timau
No full textThis study provides a comprehensive analysis of the translation of the Parable of the Prodigal Son into the Timau variety (Tischlbongarisch), a Germanic linguistic island located in Friuli, Italy. The research focuses on a version collected in 1929 by Ugo Pellis, which serves as a pivotal historical document for the diachrony of this variety. The contribution presents the evangelical text and proposes hypotheses regarding the fieldwork methodology and the specific linguistic competence of the informant. Subsequently, the study highlights key differences between the recorded variety and contemporary Timau speech. A central objective is to determine whether these divergent features represent the authentic ‘langue’ of the early twentieth century or if they should be attributed to the influence of Standard German within the informant’s personal idiolect
Reducing real-time complexity via sub-control Lyapunov functions: From theory to experiments
No full textThe techniques to design control Lyapunov functions (CLF), along with a proper stabilizing feedback, possibly in the presence of constraints, often provide control laws that are too complex for proper implementation online, especially when an optimization problem is involved. In this work, we show how to acquire an alternative, computationally attractive feedback. Given a nominal CLF and a nominal state feedback, we say that a different positive definite function is a Sub-control Lyapunov function (SCLF) if its Lyapunov derivative is negative-definite and bounded above by the Lyapunov derivative of the nominal function with the nominal control. It turns out that if we consider a family of basis functions, then an SCLF can be computed by linear programming, with an infinite number of constraints. The idea is that although the offline computational burden to achieve the new controller and solve the linear program is considerable, the online computational burden is drastically reduced. Comprehensive simulations and experiments on drone control are conducted to demonstrate the effectiveness of the study