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Lo sviluppo urbano di Tolfa
No full textIn questo volume sono pubblicati i risultati di una ricerca dal titolo “Valorizzazione del patrimonio del borgo storico di Tolfa con particolare attenzione ai palazzi storici” svolta tra gennaio 2023 e maggio 2025 in base a un accordo di collaborazione tra il Comune Tolfa e il Dipartimenti di Architettura dell’Università Roma Tre nell’ambito del Progetto PRNN "Il Borgo di Tolfa tra artigianato e turismo" finanziato con decreto di assegnazione n. 453 del 7.06.2022.
La ricerca è stata sviluppata da un gruppo di lavoro interdisciplinare in cui sono coinvolti docenti del Dipartimento afferenti ai Settori Disciplinari del Restauro, della Progettazione architettonica e urbana e del Rilievo e rappresentazione.
Obiettivo della ricerca è stato quello di sviluppare uno studio del patrimonio architettonico e ambientale del centro storico di Tolfa, finalizzato a mettere la comunità nelle condizioni di riconoscere e comprendere i valori insiti nel proprio ambiente di vita. Il progetto si propone un duplice scopo: da un lato, fornire alle autorità locali, ai professionisti e alle imprese uno strumento operativo utile per accrescere la qualità dei progetti sul costruito e sugli spazi pubblici, in grado di migliorare la vita degli abitanti senza compromettere la conservazione dei caratteri identitari della struttura urbana consolidata; dall’altro, valorizzare e diffondere le qualità di un patrimonio considerato “minore”, promuovendo un turismo sostenibile e consapevole del valore artistico e culturale espresso da questi luoghi.In this book are published the results of a research entitled "Valorization of the heritage of the historic village of Tolfa with particular attention to historical buildings" held between January 2023 and May 2025 on the basis of a collaboration agreement between the Municipality of Tolfa and the Departments of Architecture of the University Roma Tre as part of the PRNN Project "Il Borgo di Tolfa tra artigianato e turismo" financed by decree of allocation n. 453 of 7.06.2022.
The research has been developed by an interdisciplinary working group in which teachers from the Department are involved in the Disciplinary Areas of Restoration, Architectural and Urban Design and Relief and Representation.
The aim of the research was to develop a study of the architectural and environmental heritage of the historic center of Tolfa, aimed at putting the community in a position to recognize and understand the values inherent in their living environment. The project has a twofold objective: on the one hand, to provide local authorities, professionals and businesses with an operational tool useful for improving the quality of projects on built and public spaces; able to improve the life of the inhabitants without compromising the preservation of the identity characteristics of the consolidated urban structure; on the other hand, to enhance and disseminate the qualities of a heritage considered "minor", promoting sustainable tourism that is aware of the artistic and cultural value expressed by these places
Simon Magus in Middle English Prose Sermons. A ‘bad guy’ Among Magic, Heresy and Simony
No full textThe character of Simon Magus in the Middle English prose sermons is particularly
interesting. As far as in his original characterisation produced by late Christian society,
magic serves as a central element of several strongly stigmatised traits in the ethicalreligious
thought of the time, later, in other historical-cultural contexts of medieval
Europe, these traits, variously adapted, will still be valid for the construction of an antisocial
enemy, a dangerous Other to be fought and destroyed. The aim of this paper is to
provide a preliminary analysis of how English preachers of late Middle Ages transposed
and reworked the plurality of negative aspects traditionally attributed to Simon Magus
1,2,4-Oxadiazoles in medicinal chemistry: trends of the last years
No full text1,2,4-Oxadiazoles have emerged as a significant class of heterocyclic compounds in medicinal chemistry due to their diverse biological activities and versatile applications in drug discovery. Herein is reported an in-depth analysis of the structural properties, synthetic methodologies, and pharmacological significance of 1,2,4-oxadiazoles. The compound's unique five-membered ring containing three heteroatoms offers remarkable stability and tunable physicochemical properties, making it an attractive scaffold for the development of novel therapeutic agents, as confirmed by already approved drugs. The review highlights the broad spectrum of biological activities associated with 1,2,4-oxadiazoles, including antimicrobial, anti-inflammatory, anticancer, antiviral, and central nervous system related activities. These diverse effects underscore the scaffold's potential for targeting multiple disease pathways. Several studies demonstrate that structural modifications on the oxadiazole ring can significantly influence its pharmacokinetic and pharmacodynamic profiles, enabling the design of selective and potent drug candidates. Additionally, it has explored recent advances in synthetic strategies for constructing the 1,2,4-oxadiazole core, such as cyclization reactions involving amidoximes, nitrile oxides, and other precursors. Modern approaches using transition-metal catalysis, microwave-assisted synthesis, and green chemistry techniques are also discussed, emphasizing their importance in improving efficiency and scalability for pharmaceutical applications. Furthermore, the role of 1,2,4-oxadiazole as bioisostere replacement for esters and amides is highlighted, particularly in enhancing metabolic stability and modulating target selectivity. Application of computational methods, including molecular docking and QSAR modeling, have been also covered in understanding ligand-receptor interactions and guiding lead optimization. This review underscores the growing prominence of 1,2,4-oxadiazoles in modern drug design and their potential to address unmet medical needs. With continued research and innovation, these scaffolds are poised to play a pivotal role in the next generation of therapeutic agents across multiple disease areas
L’origine e le norme. Dalla riservatezza alla protezione dei dati personali. Profili introduttivi
No full textGossip-Based Estimation of Centroid and Common Reference Frame in Open Multi-Agent Systems
No full textDecentralized estimation of centroid and common reference frame in multi-agent systems is a challenging problem, particularly when agents do not have access to global positioning data. This challenge intensifies in Open Multi-Agent Systems (OMAS), where the network composition dynamically changes due to agents joining or leaving, causing fluctuations in the number of participants. This paper presents a novel, decentralized gossip-based algorithm that enables agents in OMAS to collaboratively estimate both the centroid and a common reference frame in a 2-D environment where the number of agents may fluctuate over time. Notably, our approach remains robust despite noisy distance measurements and intermittent participation, as it relies on asynchronous, local pairwise interactions. Designed to accommodate the dynamic nature of network topologies, our algorithm can be employed for real-world applications where agents can join or leave the system due to failures, resource limitations or external environmental factors
Role of Cosolvent in peptide hydration: The effect of ionic liquid in aqueous glutathione solution.
No full textA major challenge in molecular biophysics lies in understanding biophysical processes such as peptide hydration. Techniques like Neutron Diffraction with Isotopic Substitution (NDIS) and UV-resonance Raman (UVRR) spectroscopy have proven to be powerful tools for probing the peptide hydration at atomic and vibrational levels, respectively. Water plays a crucial role as a basic solvent in many biological processes. The existence of biological water in the vicinity of the peptides has profound implications and is particularly important for the structural and biological functions of the peptides. The functional properties of peptides are governed by a sensitive interplay between their interactions with the surrounding aqueous environment. This balance can be modulated by the addition of various organic and inorganic small molecules known as cosolvents. Molecular-level understanding of how these cosolvents affect the hydration shell near the biomolecules is important for understanding the factors that affect the stability of peptides. In recent years, room-temperature ionic liquids have emerged as an excellent greener cosolvent for biomolecules such as proteins and peptides compared to conventional organic/inorganic solvents because of their biocompatibility, high tunability, low volatality, and high thermal stability. The presence of both cationic and anionic constituents of IL in the solution, the hydration property of peptide is modulated. In this context, the present research work focuses on investigating the effect of BMIM iodide IL on the hydration structure of the GSH peptide and any plausible interaction of BMIM iodide with GSH at the atomic and vibrational levels. These results will offer new insights on the hydration of peptides and the role of cosolvents in modulating biomolecular functionality
