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La queerness che perturba. «Vanessa» di Samuel Barber
No full textThe paper proposes a queer interpretation of Samuel Barber’s «Vanessa» (Metropolitan Opera House, 15 January 1958), whose plot focuses on the characters’ burning need to satisfy their urges and on how they each go about doing so. The possibility to interpret the three main characters as allegorical representations of different facets of queerness will be discussed. By focusing on the figures of Anatol (tenor), Vanessa (soprano) and Erika (mezzosoprano), whose actions are driven by desires that are perverse (Anatol), unusual (Vanessa) or deemed immoral (Erika), some aspects of the dramaturgy that contribute to the expression of queerness incarnated by each character will be examined. The paper aims to show that Anatol’s figure can be interpreted as an allegory of the disruptive and disorienting impact of queerness on someone who chose to live in an ivory tower, shielded from any contact with the diversity of the outside world. The two female characters can instead be read as allegories of two possible ways in which a queer individual can react to the disruption caused by the encounter with difference
Innovative formulation and technological approaches for the development of new hop-based ingredients with enhanced techno-functionalities
No full textPerspectives on cultured and traditional meat: An analysis of Italian consumers
No full textThis study investigates Italian consumers’ perceptions and preferences regarding cultured versus traditional meat. Two distinct consumer groups emerged: conservative consumers, who resist novel foods and are largely unwilling to buy cultured meat, and younger, more open-minded consumers, who prioritize environmental and animal welfare concerns and are more inclined to purchase cultured meat. Logistic regression analysis indicates that food neophobia, technophobia, and concerns about cultured meat’s impact on rural economies negatively influence the likelihood of purchasing cultured meat. Conversely, awareness of the meat industry’s environmental issues positively correlates with the likelihood of opting for cultured meat products
The application of the "ICU Veterinary Coma Scale" in the assessment of critically ill patients
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Gli operatori commerciali e finanziari stranieri a Genova (1450-1720)
No full textThis chapter focuses on foreign traders—such as Lombard, Catalan, Jewish, German, Flemish, French, and English people—in Genoa from 1450 to 1720s. While for the late fifteenth and the early sixteenth centuries notarial deeds are the only available sources, for later centuries consular letters provide a broader perspective on the groups as a community (natio). Sources from the early eighteenth century show that foreign merchants often integrated Genoese businessmen into their activities. This may be the key to understanding the success of foreign businesses in Genoa also in earlier periods. Usually, scholarship has focused only on European merchants. A shift in focus could
bring more information on enslaved people from North Africa who dealt in small business activities, as some research suggests. The chapter also shows the importance of finance and financial knowledge along with trade in traditional commodities
Novel therapeutic targets, biomarkers, and resistance mechanisms in canine melanoma: potential implications for human mucosal melanoma treatment
No full textThe dual nature of KLHL proteins: From cellular regulators to disease drivers
No full textThe Kelch-like (KLHL) protein family, characterized by its conserved BTB, BACK, and Kelch domains, serves as substrate adaptors for Cullin 3-RING ligases (CRL3), facilitating the ubiquitination and degradation of specific target proteins. Through this mechanism, KLHL proteins regulate numerous physiological processes, including cytoskeletal organization, oxidative stress response, and cell cycle progression. Dysregulation of KLHL proteins—via mutations or abnormal expression—has been implicated in various pathological conditions, including neurodegenerative disorders, cancer, cardiovascular diseases, and hereditary syndromes. This review provides a comprehensive overview of the physiological and pathological roles of KLHL proteins, emphasizing their specific substrates and mechanisms of action. By integrating structural and mechanistic insights with translational research, this review underscores the potential of KLHL proteins as promising therapeutic targets, offering new opportunities to combat a wide spectrum of complex diseases