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La responsabilità civile e amministrativa di fronte alle sfide dell’intelligenza artificiale
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Opere e spazi, logiche di acquisizione e modelli museali del Contemporary Sculpture Garden dell’Università di Teramo
No full textThe essay analyses the genesis, structure, and functions of the Contemporary Sculpture Garden – Unite Museum of the University of Teramo, inaugurated in 2018 and now among the most significant experiences within the Italian landscape of university museums devoted to contemporary art. Following an introductory reflection on the role of university museums as spaces for preservation, education, and third mission engagement, the text investigates the logics of acquisition and the relationship between the museum and its territory. Works by Venanzo Crocetti, Diego Esposito, and the collective project Il Cielo d’Italia express a strong sense of local identity rooted in the Abruzzo region, while the donations by Immacolata Datti and Alejandro Marmo broaden its international scope. Particular attention is devoted to the architectural context of the Colleparco campus, designed by Marco Tamino, and to the museum’s distinctive display model, which transforms the entire university complex into a living, daily museum. The case of Teramo is compared with other Italian experiences—particularly the Aratro Contemporary Art Centre of the University of Molise, the CAMUSAC of Cassino, the MLAC of Sapienza University of Rome, and the newly founded Museum of Contemporary Art of the University of Verona—highlighting the centrality of education and public engagement. Through projects such as toMetarte, VRSciT, SMICUPA, and A tutto DAMS!, the museum asserts itself as a laboratory of interdisciplinary research and civic participation, combining digital innovation, heritage enhancement, and territorial identity.Il saggio analizza la genesi, la struttura e la funzione del Contemporary Sculpture Garden – Unite Museum dell’Università di Teramo, inaugurato nel 2018 e oggi tra le esperienze più significative nel panorama dei musei universitari italiani dedicati all’arte contemporanea. Dopo una riflessione introduttiva sul ruolo dei musei universitari come luoghi di tutela, didattica e terza missione, il testo indaga le logiche di acquisizione e la relazione tra museo e territorio. Le opere di Venanzo Crocetti, Diego Esposito e la collettiva Il Cielo d’Italia testimoniano un forte legame identitario con la regione abruzzese, mentre le donazioni di Immacolata Datti e Alejandro Marmo allargano l’orizzonte internazionale. Ampio spazio è riservato al contesto architettonico del campus di Colleparco, progettato da Marco Tamino, e alla distribuzione diffusa delle opere, che trasforma l’intero complesso universitario in un museo vivo e quotidiano. Il saggio colloca il caso di Teramo nel confronto con altre esperienze italiane – in particolare l’Aratro dell’Università del Molise, il CAMUSAC di Cassino, il MLAC della Sapienza e il nuovo Centro Museale per l’Arte Contemporanea di Verona – sottolineando la centralità della dimensione formativa e di public engagement. Attraverso progetti come toMetarte, VRSciT, SMICUPA e A tutto DAMS!, il museo si afferma come laboratorio di ricerca interdisciplinare e di partecipazione civica, capace di coniugare innovazione digitale, valorizzazione del patrimonio e identità territoriale
Oxysterol fingerprinting via UPLC-APCI-MS/MS for monitoring developmental stages in the zebrafish model
No full textOxysterols, oxidized derivatives of cholesterol, play multifaceted roles in cholesterol homeostasis and cellular signalling. Despite their recognized biological relevance, the temporal dynamics of oxysterol profiles during vertebrate development remain poorly understood. In this study, we developed and validated a robust UHPLC-MS/MS method for the quantification of ten oxysterols in zebrafish (Danio rerio) embryos across five developmental stages (3-, 24-, 48-, 72-, and 96-hours post-fertilization). The method exhibited excellent performance in terms of sensitivity, recovery, and reproducibility, following EMA guidelines. A combination of hierarchical clustering analysis (HCA) and Random Forest classification revealed distinct stage-specific oxysterol profiles. Notably, 6α-hydroxycholesterol emerged as the most discriminative marker, followed by 24- and 27-hydroxycholesterol, indicating their potential involvement in neurodevelopmental and metabolic regulation processes. These findings provide new insights into the role of oxysterols during embryogenesis and establish a reliable platform for evaluating oxysterol dynamics in developmental, toxicological, and pharmacological studies using the zebrafish model
Regional Ecosystem Quality and University Spin-Off Growth in Internal Areas: Evidence on Territorial Resilience from Italian Academic Entrepreneurship
No full textThis study examines how territorial peripherality and regional entrepreneurial ecosystem quality shape the growth trajectories of Italian university spin-offs, with a specific focus on internal areas. Combining firm-level data from NETVAL and AIDA with territorial indicators from the Italian Strategy for Inner Areas (SNAI) and ISTAT, we construct a panel of 655 university spin-offs observed between 2018 and 2022. Two composite indicators capture provincial peripherality and regional ecosystem quality. Using mixed-effects models, we analyse their effects on revenue and employment growth. Results show that stronger regional ecosystems support employment growth overall and significantly amplify revenue growth for spin-offs located in internal areas, partially compensating for structural territorial disadvantages. The findings highlight the importance of place-based ecosystem policies and the strategic role of universities in fostering knowledge-based development and proxy indicators of territorial resilience in peripheral regions
Mitochondria-Associated MicroRNAs: Emerging Roles in the Pathogenesis of Parkinson’s Disease
No full textIntegrated 3D-Printed Microfluidic Device for Immunocapture and Electrochemical Assessment of Transferrin Saturation in Point-of-Care Stroke Diagnostics
No full text: A 3D-printed electrochemical microfluidic device (3D-EMD) was developed to assess the transferrin saturation (TSAT) biomarker in ischemic stroke patients. The all-in-one 3D-EMD integrates a strategically engineered immunoassay module for the direct and selective isolation of transferrin (Tf) from unpretreated clinical samples, unaffected by sample coloration, with an interchangeable electrochemical sensor for the simultaneous detection of Tf and Tf-bound iron. Both modules are interconnected through microfluidic channels whose flow is regulated by a cylindrical rotary valve. The analytical workflow enables magnetic bead-based direct Tf immunocapture and simultaneous electrochemical detection of Tf and Tf-bound iron via square wave voltammetry, allowing TSAT assessment within 60 min using only 50 μL of sample. Validation with certified reference materials demonstrated excellent accuracy (Er ≤ 5%) and precision (RSD ≤ 4%). Application to human serum from ischemic stroke patients showed strong correlation (r = 0.87) and agreement (slope 0.9 ± 0.3; intercept 6 ± 10; p < 0.05) with the urea-PAGE reference method, which typically requires up to 18 h. Overall, the 3D-EMD constitutes an elegant, fully integrated dual-functionality platform that seamlessly combines customizable sample preparation with online electrochemical detection in a single device. This configuration enables direct serum analysis and supports clinical decision-making in time-critical conditions. The device shows strong potential as a rapid point-of-care testing candidate for ischemic stroke and as a next-generation platform for broader clinical diagnostics
Ultrasound-based technologies for managing and promoting dog reproductive health
No full textUltrasonography has become an essential component of reproductive diagnostics in the dog, yet its full potential remains only partially explored compared with human reproductive medicine. This PhD project aimed to advance the understanding and application of multiparametric ultrasonographic techniques in canine reproduction, with a particular focus on the testis and the uterus, two organs central to fertility assessment but for which imaging-based functional biomarkers are still limited.
The dissertation is structured to integrate a technological overview, a comprehensive synthesis of existing knowledge, and original experimental studies. First, the work provides an updated appraisal of the principles, capabilities, and technical considerations of B-mode imaging, Doppler ultrasonography, contrast-enhanced ultrasonography (CEUS), ultrasound elastography (UEl), and 3D/4D modalities, contextualising their historical development and differential adoption in human and veterinary medicine. These technologies are then examined in depth through two organ-specific reviews, which consolidate current understanding of anatomy, physiology, vascularisation, normal and abnormal ultrasonographic findings, and diagnostic applications for the canine testis and uterus.
The original research component comprises two experimental studies. The first investigates testicular strain elastography in dogs undergoing elective orchiectomy, demonstrating that testicular stiffness correlates with spermatogenic activity and histological parameters. The findings indicate that elastography may serve as a non-invasive adjunct for functional andrological assessment. The second study applies strain elastography to the canine cervix across reproductive phases, showing phase-dependent changes in cervical stiffness and identifying correlations with B-mode features and endocrine patterns, highlighting the technique’s potential for refining cycle staging and improving clinical decision-making.
Taken together, the thesis advances reproductive ultrasonography in the dog by integrating structural, functional, and biomechanical imaging approaches. It also identifies recurring diagnostic challenges and outlines future research directions aimed at enhancing clinical translation