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The impact of Techonology Transfer in Italy: Some Preliminary Remarks
No full textMany scholars have examined the evolution of economic growth theories,
focusing on the shift from neoclassical to endogenous models, which highlight
knowledge, ideas, and human capital as productivity drivers. Many among them
agree that innovation has a key role in economic development, with R&D
investments crucial for national competitiveness; in this contest, university R&D
generally provides long-term benefits, while corporate R&D yields quicker returns.
This study explores the impact of patents and R&D expenditures by universities and
firms on national and regional economic growth in Italy. Panel data analysis shows a
positive correlation between value added per worker and R&D expenditures, with
university R&D having a greater impact than firm R&D. Patents affect growth with a five-year lag, while gross fixed investments show an immediate, lower impact
Dal mondo del pressappoco all'universo del certo: la 'rivoluzione' irneriana
No full textil saggio analizza il passaggio dall'alto medioevo (durante il quale la certezza del diritto non era un valore ricercato dai governanti che amministravano la giustizia) al basso medioevo quando - a causa dei mutamenti sociali, politici ed economici - l'esigenza della certezza del diritto si manifestò con impellenza. La riscoperta dei testi nomativi di Giustiniano si rivelò certamente utile, ma fu necessario un puntuale lavoro filologico, per il quale grosso merito va attribuito al giurista Irneri
Leveraging synthetic trace generation of modeling operations for intelligent modeling assistants using large language models
No full textContext: Due to the proliferation of generative AI models in different software engineering tasks, the research community has started to exploit those models, spanning from requirement specification to code development. Model-Driven Engineering (MDE) is a paradigm that leverages software models as primary artifacts to automate tasks. In this respect, modelers have started to investigate the interplay between traditional MDE practices and Large Language Models (LLMs) to push automation. Although powerful, LLMs exhibit limitations that undermine the quality of generated modeling artifacts, e.g., hallucination or incorrect formatting. Recording modeling operations relies on human-based activities to train modeling assistants, helping modelers in their daily tasks. Nevertheless, those techniques require a huge amount of training data that cannot be available due to several factors, e.g., security or privacy issues. Objective: In this paper, we propose an extension of a conceptual MDE framework, called MASTER-LLM, that combines different MDE tools and paradigms to support industrial and academic practitioners. Method: MASTER-LLM comprises a modeling environment that acts as the active context in which a dedicated component records modeling operations. Then, model completion is enabled by the modeling assistant trained on past operations. Different LLMs are used to generate a new dataset of modeling events to speed up recording and data collection. Results: To evaluate the feasibility of MASTER-LLM in practice, we experiment with two modeling environments, i.e., CAEX and HEPSYCODE, employed in industrial use cases within European projects. We investigate how the examined LLMs can generate realistic modeling operations in different domains. Conclusion: We show that synthetic traces can be effectively used when the application domain is less complex, while complex scenarios require human-based operations or a mixed approach according to data availability. However, generative AI models must be assessed using proper methodologies to avoid security issues in industrial domains
Note sul matrimonio romano tra Oriente e Occidente
No full textThis essay concerns the relationship between factuality and legality of the affective relationship and the problem of contamination of the iustum matrimonium model in relation to the obligation of fidelity, and therefore on the extension of protection and the punitive nature of the violation, as well as the reversal of perspective between antiquity and modernity in relation to subjective rights and public interest
Unraveling the Role of Foods on Chronic Anti- and Pro-Inflammatory Cytokines: A Systematic Review of Chronic Dietary Intervention Trials in Humans
No full textViaggiar per chiese: l’itinerario di Rubens fuori dall’Italia
No full textIl saggio ricostruisce l'esperienza visiva e culturale di Peter Paul Rubens durante i suoi viaggi al di fuori dell'Italia, concentrandosi in particolare sul soggiorno nella penisola iberica, intrapreso per incarico del duca di Mantova Vincenzo I Gonzaga. Grazie a una ricca documentazione d'archivio e all'analisi iconografica delle opere successive, si evidenzia come la permanenza spagnola – specialmente la visita all'Escorial, a Valladolid e ad altri centri della monarchia asburgica – abbia influenzato profondamente la produzione rubensiana. L'artista assimilò modelli compositivi e iconografie derivate da capolavori di Tiziano, Rogier van der Weyden e dalla scultura ispanica, rielaborandoli nella propria pittura in funzione delle esigenze politiche e religiose delle corti cattoliche europee. Lo studio mette inoltre in relazione l'attività rubensiana con i paradigmi visivi asburgici, ponendo le basi per comprendere l'evoluzione del linguaggio artistico dell'artista fiammingo nel contesto della Controriforma.This essay reconstructs Peter Paul Rubens’s visual and cultural experience during his travels outside of Italy, focusing in particular on his Iberian sojourn commissioned by Vincenzo I Gonzaga, Duke of Mantua. Drawing on extensive archival sources and iconographic analysis of his subsequent works, the study demonstrates how Rubens’s stay in Spain—especially his visits to the Escorial, Valladolid, and other key sites of the Habsburg monarchy—profoundly influenced his artistic production. The Flemish master absorbed compositional models and iconographic motifs from masterpieces by Titian, Rogier van der Weyden, and Spanish sculpture, reworking them to suit the political and religious needs of Catholic courts across Europe. The research also connects Rubens’s activity with established Habsburg visual paradigms, shedding light on the development of his distinctive artistic language within the framework of the Counter-Reformation
Epigenetic alterations and microbiota changes in the saliva of individuals with binge-eating spectrum disorders compared with normal weight healthy controls
No full textAims: Binge-eating spectrum disorders, including bulimia nervosa (BN) and binge-eating disorder (BED), have psychological, behavioral, and physical effects, which present significant challenges for accurate diagnosis and treatment. Identifying biomarkers is thus of relevance to improve diagnostic and treatment strategies. Main methods: Saliva collected from female individuals with BED (n = 20), BN (n = 17), and normal weight healthy controls (NW-HC) (n = 20) was analyzed to assess salivary microbiome, exosomal miRNA expression, and DNA methylation of dopaminergic system gene components. Key findings: Microbial diversity was significantly reduced in BED and BN groups compared to NW-HC. Differential abundance analysis revealed that Bacilli (class-level) were enriched in BN and BED, while Lachnospirales (order-level) were significantly depleted in BN compared to NW-HC. In total, 79 miRNAs were differentially expressed in patients compared with controls. Alteration in four of these miRNAs (let-7b-5p, mir-15b-5p, mir-429, and mir-221-3p) identified via network analysis as potentially relevant to psychiatric disorders, were confirmed to be significantly upregulated in both BED and BN compared with controls. Significant hypomethylation at specific CpG sites of the DAT1 gene was also observed in BED and BN groups relative to controls. Correlation analysis highlighted significant associations between specific microbiota genera, miRNA expression, and DNA methylation of DAT1 in both the BED and BN groups. Significance: Our findings provide new evidence on the role of epigenetic modifications linked to alterations in salivary microbial composition and diversity in BED and BN, opening new avenues for future research and therapeutic interventions in eating disorders targeting miRNAs and microbiota
