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Contemporary Sculpture Garden Unite Museum: un luogo di identità e di relazione per l’arte contemporanea
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Enhancing Tourism demand forecasting in Italy: Integrating OTA data and CPI trends with statistical and Deep Learning models
No full textDigital Dynamics: Ceramics Route of Castelli (CerCAST)
No full textThe tradition of ceramic craftsmanship serves as a defining characteristic of the cultural and economic landscape in a substantial portion of European history. This tradition has facilitated the reproduction and evolution of highly efficient production systems, which have subsequently manifested as cultural and social capital of considerable importance to local communities, such as Castelli. Castelli is acknowledged as a pivotal center in the history of Italian maiolica production, celebrated for its exceptional cultural contributions and ornamental varieties that possess distinctive aesthetic value, particularly from the 16th to the 18th centuries. This research explores the development of digital practices to address the promotion and preservation requirements of Castelli ceramics, which is a significant yet vulnerable element of cultural heritage. The project analyzes the challenges and opportunities associated with employing digital strategies to advance and support the preservation of Castelli ceramics' cultural heritage in the digital age
Bad faith in EU trade mark law: the impact of SkyKick post-Brexit
No full textThis article explores the evolving concept of bad faith in EU trade mark law, particularly in light of the Court of Justice of the European Union (CJEU’s) judgment in SkyKick.
The concept, rooted in ethical and commercial fairness, has been clarified through pivotal cases, including Lindt, Koton, and—as mentioned—SkyKick. These judgments highlight how overly broad trade mark registrations can serve as anti-competitive tools, undermining fair market practices.
The UK Supreme Court’s alignment with CJEU jurisprudence post-Brexit underscores a commitment to a nuanced analysis balancing trade mark protection, honest commercial practices and market integrity. The findings provide a robust framework for addressing trade mark abuses while fostering fair competition
Fertility Preservation of Vacuum-Dried Ram Spermatozoa Stored for Four Years at Room Temperature
No full textL’azione dei cardinali di Santa Romana Chiesa nel ‘sistema’ e nel mercato delle arti fra Seicento e Settecento: il contributo di Alessandro Albani
No full textI cardinali del XVII e del XVIII secolo giocarono un ruolo attivo nel 'sistema' e ancor più nel mercato dell'arte. L'articolo affronta il caso del cardinale Alessandro Albani
Varietà diasistemiche nell’onomastica della novella quattro-cinquecentesca
No full textStudio trasversale sulle strategie di nominazione nella novella postdecameroniana (quattro-cinquecento) sulla base di un criterio di varietà linguistic
Targeting Neuronal Senescence: A High-Throughput In Vitro Strategy to Identify Anti-Aging Compounds
No full textFOOD-ASSOCIATED LACTIPLANTIBACILLUS PLANTARUM AS A PROMISING DIETARY INTERVENTION IN THE MICROBIOTA-GUT-BRAIN-AXIS OF A MOUSE MODEL OF AUTISM SPECTRUM DISORDER
No full textObjective: Recently, the use of probiotic is emerging as a promising alternative nutritional approach to address Autism Spectrum Disorder (ASD)-associated neurobehavioral and gastrointestinal dysfunctions, such as gut dysbiosis and impaired intestinal permeability. This study aimed to evaluate whether the administration of probiotic candidates of food-associated Lactiplantibacillus plantarum (LP), with anti-inflammatory activity, could positively modulate the composition of the intestinal microbiota, potentially alleviating ASD-associated intestinal and social symptoms in a genetic ASD mouse model.
Methods: The Neuroligin3 (NLGN3) R451C knock-in (KI) mouse model, was employed as monogenic ASD model. Wildtype (WT) and KI mice were fed with selected LP strains for 5-weeks. Following behavioral testing, mice were sacrificed, and gut and fecal samples were collected. Intestinal permeability was assessed by determining the mRNA levels of zonulin-1, claudin 1 and claudin-3. DNA from all fecal samples were subjected to library preparation followed by next-generation sequencing (NGS) of the V3-V4 variable regions of 16S rRNA gene.
Results: Results showed a clear impact of LP on improving impaired social behaviors, restoring intestinal permeability and shaping gut microbiota in LP-groups, leading to a normalized taxa distribution. The Firmicutes/Bacteroidetes (F/B) ratio decreased in the LP-treated KI mice thanks to a relative major increase of some gut-beneficial taxa. LP administration also played a key role in KI mice fostering Akkermansia muciniphila.
Conclusions: This study confirmed the central role of host- microbe interaction and dietary therapies in mitigating ASD- neurobehavioral and gastrointestinal symptoms, opening new frontiers for the development of targeted and personalized dietary intervention, providing an alternative biotherapeutic strategy in ASD