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Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease
No full textAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive and non-cognitive decline associated with neuropathological hallmarks, including neuroinflammation. Palmitoylethanolamide (PEA), an endogenous lipid with anti-inflammatory and neuroprotective properties, has emerged as a promising therapeutic agent in managing AD. This study investigated the therapeutic effects of chronic (6-months) PEA administration via subcutaneous pellet in Tg2576 mice, a validated model of AD. The impact of PEA on amyloid precursor protein (APP) processing, astrocytic activation, microglial reactivity and neuroinflammation, nitrosative stress, dendritic spine density in hippocampal CA1 pyramidal neurons, and cognitive performance was assessed. Chronic PEA treatment of Tg2576 mice increased the expression of the α-secretase ADAM9 and reduced astrogliosis. Furthermore, PEA attenuated microglia reactivity, downregulated pro-inflammatory (CXCL13, MCP-1, GCSF) and upregulated anti-inflammatory (CXC3CL1 and IL-9) cytokine expression. Chronic PEA administration also decreased protein nitrosylation, downregulated calcineurin expression, restored dendritic spine density, and improved cognitive functions. Chronic PEA administration offers a promising therapeutic approach for AD by mitigating neuroinflammation, oxidative stress, and synaptic dysfunction, ultimately leading to cognitive function restoration
Digital History
No full textI diversi contributi del volume rappresentano un'originale riflessione sulla diffusione delle pratiche e delle tecniche della digital history vista da tre particolari angoli di osservazione: la didattica, la ricerca, il patrimonio cultural
Foster the use of Hackathons in Collaborative Research Projects: Methodology, Experience Report and Lesson Learned
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Comunicare l’agire amministrativo: trasparenza e performance nelle pubbliche ammini- strazioni
No full textEpizootiological update on the occurrence of Angiostrongylus vasorum and respiratory Capillaria spp. in dogs from Italy
No full textRecent advances in sustainable strategies for the integration of nanostructured sensing surfaces in electroanalytical devices
No full textNanomaterials (NMs) integration in electrochemical devices as conductive nanostructured freestanding transducers and sensing surfaces has emerged in the analytical scenario, toward on-demand device manufacturing and fully exploiting NMs' features. This review reports the advances in developing electroanalytical devices based on nanostructured sensing films/surfaces obtained via accessible/sustainable strategies. Various manufacturing approaches are discussed including emerging nanostructured film-transfer technologies and nanofilms' direct generation onto low-cost substrates. Additive manufacturing and printed electronics are also treated, focusing on straightforward strategies for printed device nano-structuring. Post-production nano-modifications of preexisting transducers/electrodes are not considered. This review outlines a critical overview concerning technological novelties to obtain nanofilm-based sensors, biosensors, and electroanalytical devices, and related analytical advancements. In particular, attention is paid to nanofilms 'manufacturing strategies' based on user-friendly technologies, focusing on approaches devoted to improving sustainability. The topics will be covered describing noteworthy advancements, giving technical/practical advice, pointing out limitations, and outlining future perspectives
