30 research outputs found
Smart service value: Conceptualization, scale development, and validation in the retailing context
No full textIn-store smart technology is rapidly transforming service delivery and value creation in the retail sector. However, despite these advances, academic acumen of customers' perceived value of their smart service interactions remains tenuous, exposing an important omission in extant literature. Addressing this gap, we conceptualize, operationalize, and validate smart service value (SSV) in the retailing context. We first define SSV as the costs and benefits as perceived by customers of using in-store smart service applications. We then operationalize SSV and validate a third-order, reflective-formative construct by means of a scale development survey through Amazon MTurk (study 1; n = 326). To further validate the proposed SSV scale, we subsequently tested our conceptual model using a survey querying a hypothetical retail setting through an Australian panel provider (study 2; n = 298), which was analyzed by using PLS path modeling. Specifically, we explore SSV's effect on customer engagement and trust, which are in turn envisaged to impact customers' quality of life. The results reveal a significant mediating effect of affective customer engagement/trust in the association of SSV and customer-perceived quality of life, highlighting the pertinence of customers' emotional (vs. cognitive) SSV assessments. Our findings are aimed at helping retailers to strategically position smart service technologies in their stores based on customer-perceived SSV.</p
The role of customer engagement behavior in value co-creation : a service system perspective
No full textRecent developments in marketing highlight the blurring of boundaries between firms and customers. The concept of customer engagement aggregates the multiple ways customer behaviors beyond transactions may influence the firm. However, the term is embryonic and academics and practitioners alike lack understanding on how customer engagement contributes to value co-creation. This paper marks the first attempt to conceptualize the role of customer engagement behavior (CEB) in value co-creation within a multi-stakeholder service system. We combine the theoretical perspectives of customer engagement and value co-creation research to the analysis of a rich case study of a public transport service system involving consumers, communities, businesses, and governmental organizations. Our findings describe drivers for CEB, identify four types of CEB, and explore the value outcomes experienced by various stakeholders. This paper proposes that CEB affects value co-creation by virtue of customers’ diverse resource contributions towards the focal firm and/other stakeholders that modify and/or augment the offering, and/or affect other stakeholders’ perceptions, preferences, expectations or actions towards the firm or its offering. Through inducing broader resource integration, CEB makes value co-creation a system level process. We offer nine research propositions explicating the connections CEB has to value co-creation by focal customers, the focal firm and other stakeholders. Our research suggests that firms focus greater attention on the resources that customers can contribute, explore the potential to engage diverse stakeholders around a common cause and employ organically emerging systems which provide opportunities for more extensive value co-creation
Prosocial consequences of third-party anger
No full textAnger has traditionally been associated with aggression and antagonistic behavior. A series of studies revealed that experiences of third-party anger (anger experienced when observing that harm is done to someone) can also lead to prosocial behavior. More specifically, three studies, hypothetical scenarios as well as a behavioral study, revealed that third-party anger can promote compensation of the victim. The results also showed a preference for such prosocial behaviors over antagonistic behaviors. We conclude that behaviors stemming from anger, whether antagonistic or prosocial, are reactions to inequity, albeit determined by the constraints of the situation
Molecular Characterization of ‘p53 Family Network’ in Human Head and Neck Cancer and Anti-EGFR Therapy
No full textUnderstanding of p53 family protein (p53, p63 and p73) networks in head and neck squamous cell carcinoma (HNSCC), can positively influence in cancer screening, diagnosis, treatment and prevention. P53 family proteins are regulating diverse cell signalling pathways at diverse conditions to determine cell fate. At each condition of cells state, how these proteins are controlling cell fate is more complexed due to the presense of several isoforms for each p53 family proteins and their multifaceted interactions. Like other solid tumours, the p53 pathway is disabled by several mechanisms in HNSCC. Despite of the convincing evidence of a high frequency of p53 mutations in HNSCC, a subset of cancers arise in the absence of mutations. The molecular mechaninsms through which p53 lacking mutations subvert its tumor supressor functions in HNSCC still remain uncertain. In fact, some cancers and established cancer cell lines are over-expressing wild type p53 protein makes questionable of p53 role as only a tumor suppressor or it has some other additional functions, even in cancer cells. For an answer of this hypothesis, we have performed detailed molecular characterization, in an invitro model of head and neck cancer, in a broad panel of 12 newly established HNSCC cell lines. In our studies, we found that some head and neck cancer cell lines are accumulating wild p53 protein hyperphosphorylated at serine15 and 392 and it leads to the over expression of DNp73, the mechanism already reported from our laboratory in HPV38 immortalized keratinocytes. To better understand the functions of accumulated wild p53 role in HPV positive and negative cancer cell lines, we have performed p53 knock down by siRNA and the results have showed that p53 knock down inhibited cell proliferation in both HPV positive and negative cancer cells. Moreover, p53 knock down induced significant morphological changes and senescence associated beta galactosidase activity in these cells. Our results pinpoint, wild-type p53 protein accumulated in transformed cell lines has an additional role in cell proliferation other than its well known tumor supressor activity. Moreover, the key role of p53 family network in modulating epidermal growth factor receptor (EGFR) expression and in controlling cell proliferation and apoptosis arises the question of whether p53 family proteins status influences the efficacy of EGFR inhibitors, investigating its ability to reduce cell growth, to induce apoptosis and to modulate cell cycle and various EGFR pathwayrelated targets in head and neck cancer. Because, recently improved understanding of the pathogenesis of human head and neck squamous cell carcinoma has led to the development of new, molecular based therapeutic strategies, one of the most promising is the utilization of tyrosine kinase (TK) inhibitors, targeting EGFR. The comparison between the targets analysed and gefitinib effectiveness evidenced the absence of a clear relationship, exluding them as predictive factors for gefitinib efficacy. Our results confirmed the in vitro efficacy of an anti-EGFR approach, but other targets than those analysed here should be characterized in order to identify valid predictive factors for gefitinib utilization in head and neck cancer. We have also performed chemoresistance analysis in our invitro model of HNSCC cell lilnes and found that p53 family network has less predictive role in HNSCC chemoresistance but ABCG2, a multidrug resistance protein, has over-expressed in HNSCC
Clin Infect Dis
No full textHuman noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are sparse.|We followed a birth cohort of children to estimate norovirus infection and diarrhea incidence in a Peruvian community. Stool samples from diarrheal episodes and randomly selected nondiarrheal samples were tested by polymerase chain reaction for norovirus genogroup and genotype. Excretion duration and rotavirus coinfection were evaluated in a subset of episodes.|Two hundred twenty and 189 children were followed to 1 and 2 years of age, respectively. By 1 year, 80% (95% confidence interval [CI], 75%-85%) experienced at least 1 norovirus infection and by 2 years, 71% (95% CI, 65%-77%) had at least 1 episode of norovirus-associated diarrhea. Genogroup II (GII) infections were 3 times more frequent than genogroup 1 (GI) infections. Eighteen genotypes were found; GII genotype 4 accounted for 41%. Median excretion duration was 34.5 days for GII vs 8.5 days for GI infection (P = .0006). Repeat infections by the same genogroup were common, but repeat infections by the same genotype were rare. Mean length-for-age z score at 12 months was lower among children with prior norovirus infection compared to uninfected children (coefficient: -0.33 [95% CI, -.65 to -.01]; P = .04); the effect persisted at 24 months.|Norovirus infection occurs early in life and children experience serial infections with multiple genotypes, suggesting genotype-specific immunity. An effective vaccine would have a substantial impact on morbidity, but may need to target multiple genotypes
Remote monitoring in chronic immune-mediated inflammatory diseases: A systematic review of active and passive approaches
No full textGenetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam
No full textA second cluster of COVID-19 cases imported from Europe occured in Vietnam from early March 2020. We describe 44 SARS-CoV-2 RT-PCR positive patients (cycle threshold value <30) admitted to the National Hospital for Tropical Diseases in Hanoi between March 6 and April 15 2020. Whole SARS-CoV-2 genomes from these patients were sequenced using Illumina Miseq and analysed for common genetic variants and relationships to local and globally circulating strains. Results showed that 32 cases were Vietnamese with a median age of 37 years (range 15-74 years), and 23 were male. Most cases were acquired outside Vietnam, mainly from the UK (n = 15), other European countries (n = 14), Russia (n = 6) and countries in Asia (n = 3). No cases had travelled from China. Forty-one cases had symptoms at admission, typically dry cough (n = 36), fever (n = 20), sore throat (n = 14) and diarrhoea (n = 12). Hospitalisation was long with a median of 25 days, most commonly from 20-29 days. All SARS-CoV-2 genomes were similar (92-100% sequence homology) to the reference sequence Wuhan_1 (NC_045512), and 32 strains belonged to the B.1.1 lineage. The three most common variants were linked, and included C3037T, C14408T (nsp12: P323L) and A23403G (S: D614G) mutations. This group of mutations often accompanied variant C241T (39/44 genomes) or GGG 28881..28883 AAC (33/44 genomes). The prevalence of the former reflected probable European origin of viruses, and the transition D614G was dominant in Vietnam. New variants were identified; however, none could be associated with disease severity
Evaluation of the effects of the electronic recommendation on the value co-creation in the Colombian online market
No full textilustraciones, diagramas, figurasEl presente estudio se enfoca en evaluar los efectos de la Recomendación Electrónica en el Valor de Co-creación dentro del mercado online colombiano. En la era digital, las recomendaciones electrónicas han adquirido un papel destacado en la influencia de las decisiones de compra de los consumidores. Estas recomendaciones pueden provenir de diversas fuentes, como reseñas de productos, testimonios de clientes, calificaciones y comentarios en plataformas de comercio electrónico y redes sociales. Sin embargo, a pesar de su creciente uso, aún existe una falta de conocimiento sobre cómo estas recomendaciones electrónicas impactan en la creación de valor compartida entre empresas y consumidores.
Para abordar este problema, se plantea un análisis de cómo las recomendaciones electrónicas afectan el valor de co-creación de los consumidores en el mercado online colombiano. Esto involucra explorar cómo estas recomendaciones influyen en la participación activa de los consumidores en la co-creación de productos, servicios o experiencias, así como su nivel de satisfacción y lealtad hacia las marcas y empresas.
Para lograrlo, se identificaron origen, definiciones, enfoques, evolución, antecedentes, modelos y métricas de cada variable, se generó el modelo teórico y la hipótesis, y se diseñó el instrumento de medida. Se recolectaron 1505 encuestas de usuarios de plataformas de comercio electrónico en Colombia, lo que permitió validar el modelo mediante el análisis factorial exploratorio y confirmatorio. Utilizando la técnica de modelado de ecuaciones estructurales, se contrasto la hipótesis planteada. Los resultados revelan una relación positiva entre las variables. (Texto tomado de la fuente)This study focuses on evaluating the effects of e-recommendation on co-creation value in the Colombian online market. In the digital era, e-recommendations have acquired a prominent role in influencing consumers' purchasing decisions. These recommendations can come from a variety of sources, such as product reviews, customer testimonials, ratings and comments on e-commerce platforms and social networks. However, despite their growing use, there is still a lack of knowledge on how these e-recommendations impact the creation of shared value between companies and consumers.
To address this problem, an analysis of how e-recommendations affect the co-creation value of consumers in the Colombian online market is proposed. This involves exploring how these recommendations influence consumers' active participation in the co-creation of products, services or experiences, as well as their level of satisfaction and loyalty towards brands and companies.
To achieve this, the origin, definitions, approaches, evolution, antecedents, models and metrics of each variable were identified, the theoretical model and hypothesis were generated, and the measurement instrument was designed. A total of 1505 surveys were collected from users of e-commerce platforms in Colombia, which allowed validating the model by means of exploratory and confirmatory factor analysis. Using the structural equation modeling technique, the hypothesis was tested. The results reveal a positive relationship between the variables.MaestríaMagíster en AdministraciónEl enfoque metodológico de la presente investigación es de tipo positivista, esto debido a que la aplicación de diferentes métodos estadísticos para el análisis de la información es su elemento central. Se utilizará la verificación de hipótesis establecida desde un enfoque del conocimiento según las variables trabajadas, la investigación se obtiene gracias a la información a partir de encuestas, aplicadas a usuarios de diferentes portales de comercio electrónico B2C ubicados en Colombia.
El diseño metodológico establecido para el desarrollo de la investigación se sitúa desde el proceso establecido por Duque (2020). La investigación se realizó en tres fases a saber:
● Acercamiento preliminar al tema
● Estructura del proyecto de investigación
● Ejecución
La fase de acercamiento preliminar al tema comprendió la exploración de literatura sobre eWOM, valor de co-creación y comercio electrónico. A partir de la información consultada se estableció la problemática las preguntas detonantes y el problema concreto en donde se relacionaba los efectos del eWOM sobre el valor de cocreación, lo anterior se delimitó a un contexto colombiano desde la aplicación online. Teniendo claridad en la relación que se quería estudiar, se procedió a formular la pregunta de investigación. En cuanto a la estructuración del proyecto de investigación incluyó la formulación y delimitación del objetivo general; la estructuración del diseño metodológico; y la definición de los materiales y métodos requeridos para realizar la investigación, estableciendo en esta etapa la muestra requerida y las escalas a valorar para el valor de co-creación y el eWoM. Finalmente, el desarrollo y ejecución de la investigación implicó la aplicación del instrumento previamente diseñado para recolectar la información correspondiente, la evaluación de la fiabilidad y validez del instrumento, la solución del modelo propuesto, para, pasar a elaborar la discusión y las conclusiones sobre el tema.Gestión funcional. Gestión de mercado
