60 research outputs found
"Moujik Marei": Contextual analysis and close reading
No full text“Mujique Marei” é um texto único de F. M. Dostoiévski, em que ao longo de quatro páginas o escritor apresenta de modo evidente ao leitor a sua estrutura da imagem (a estrutura que reproduz cada coisa do mundo da forma como ela se revela ao olhar profundo do artista), seu método criativo e sua maneira de discutir temas teológicos. O método de close readinge contextual permitem analisar e descrever a estrutura da imagem, o método criativo e as formas de discussões teológicas, assim como enxergar o sentido e o objetivo da presença de textos artísticos no Diário de um escritor e analisar os profundos significados do conto propriamente dito, que descrevem o processo de transformação do olhar, o surgimento do “olhar do artista”, que é carregado de “lembranças trazidas da infância”, tão caras a Dostoiévski."Moujik Marei" is a unique text of F.M. Dostoevsky, who in the space of four pages clearly presents the reader with his structure of image (a structure that reproduces every object of the world the way it reveals itself to the eye of the artist), his creative method and his theology. The method of contextual and close reading allows us to analyze and describe this structure of image, the creative method and forms of theological discussions, as well as to see the meaning and the purpose of the appearance of artistic texts in the midst of the "Diary of a Writer" and to analyze the deeper meaning of the story itself, which describes the process of change of view, of the appearance in the author of the "artist\u27s eye", that is provided by "memory, carried from childhood", which is so important to Dostoevsky.«Мужик Марей» - уникальный текст Ф.М. Достоевского, в котором на пространстве четырех страниц писатель наглядно представляет читателю свою структуру образа (воспроизводящую структуру всякой вещи в мире в том виде, в каком она открывается глубокому взгляду художника), свой творческий метод и свой способ богословствования. Метод пристального и контекстуального чтения позволяет нам проанализировать и описать эти структуру образа, творческий метод и способ богословствования, а также увидеть смысл и цель появления художественных текстов в составе «Дневника писателя» и проанализировать глубинные смыслы самого рассказа, описывающего процесс изменения взгляда, появления у автора «глаза художника», обеспеченный столь важным для Достоевского «воспоминанием, вынесенным из детства»
Schreibförderung lernen: Lehramtsstudierende als Schreibcoach/innen - ein Lehrexperiment
No full textDie hohe Diversität (schrift-)sprachlicher Fähigkeiten von Lernenden erfordert, Lehrkräfte differenziert auf den adäquaten Umgang damit vorzubereiten. Dazu wurde ein Seminar entwickelt, das ein sprachdidaktisches Konzept der halbstandardisierten, individuellen Rückmeldung zur Textqualität förderbedürftiger Schüler/innen vermittelt. In einem Lehrexperiment mit Lehramtsstudierenden des Faches Deutsch (BA vs. MA) wurde das Seminar durchgeführt und in einem Prä?Post-Follow up-Design evaluiert. Erste Ergebnisse zeigen, dass sich die Studierenden unabhängig von ihrer Studienerfahrung verbessern und die Nachhaltigkeit der Leistungssteigerung je nach Aufgabenformat variiert.
13.10.2017 | Marei Kotzerke, Moti Mathiebe & Joachim Grabowsk
Design procedures and guidelines for a novel self-centring concentrically braced steel frame based on displacement-based design approach
No full textThe introduction of the self-centring steel concentrically braced frame (SC-CBF) provides an innovative structural solution to seismic regions. Developed at the University of Galway, this innovative system possesses the unique ability to independently return to its original position after experiencing lateral deformation during an earthquake. Despite its significant benefits, it is noted that the lack of established guidelines in design codes, indicates that the development of the SC-CBF system is still in its preliminary phases.This article presents a Direct Displacement-Based Design (DDBD) methodology to design SCCBFs. Flowcharts for conducting DDBD of the SC-CBF system are produced. The flowcharts offer a detailed set of steps to create user-friendly guidelines for constructing earthquake-resistant structures equipped with self-centring capabilities. This paper also encompasses a thorough analysis of a specific case study that revolves around a four-storey structure. This case study provides an in-depth evaluation of the design procedures, effectively demonstrating the tangible implementation of the methodology. The target displacement of the SC-CBF system at a 2.5% drift ratio resulted in a total base shear of 1382.6 KN after five analysis iterations. The SC-CBF system exhibits an effective period of 2.37 seconds and an equivalent viscous damping of 8.6 %. This comprehensive analysis will provide a deeper understanding of the design process for the SC-CBF system.This research was funded by the Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA-H2020-INFRAIA-2016-2017/H2020 INFRAIA-2016- 1) under grant agreement No. 730900 for the project "Investigation of Seismic Deformation Demand, Capacity and Control in a Novel Self-Centring Steel Braced Frame (SCCBF)." The first author acknowledges the support of Science Foundation Ireland through the Career Development Award programme (Grant No. 13/CDA/2200) and the MaREI Centre (Grant No. 12/RC/2302_2). This research was also supported by the Marine Institute, funded under the Marine Research Programme by the Government of Ireland (PDOC/21/03/01)
Nonlinear time-history analysis of a novel self-centring concentrically braced steel structure
No full textThe recent development of self-centring steel concentrically braced frames (SC-CBF) represents a significant advancement in seismic engineering for regions with high earthquake risk. This innovative structural system exhibits the advantageous characteristic of self-centring following a seismic event. This behaviour minimises residual displacements and prevents permanent damage to the non-energy-dissipation components (beams and columns), enhancing its overall resilience. However, it is noteworthy that due to the early stage of SC-CBF technology, established design guidelines for their implementation have not yet been incorporated into current seismic codes. This paper presents research where a force-based design (FBD) procedure was developed and used to design a 4-storey SC-CBF structure. In this procedure, design strengths considered are decided upon the code and drift and residual drift limits. The performance of the designed structure is checked using twelve ground motions with a displacement spectrum matching the design displacement spectra using the non-linear time history analysis (NLTHA). The results indicate a favourable alignment between the design displacements, storey drifts, and residual drifts obtained from the FBD procedure for the case study and those recorded through NLTHA analyses. Furthermore, the residual drift is found to be relatively small in comparison to the design residual drifts. This indicates a successful performance of the self-centring system in achieving its intended goals.This research was funded by the Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA-H2020-INFRAIA-2016-2017/H2020 INFRAIA-2016- 1) under grant agreement No. 730900 for the project "Investigation of Seismic Deformation Demand, Capacity and Control in a Novel Self-Centring Steel Braced Frame (SCCBF)." The first author acknowledges the support of Science Foundation Ireland through the Career Development Award programme (Grant No. 13/CDA/2200) and the MaREI Centre (Grant No. 12/RC/2302_2). This research was also supported by the Marine Institute, funded under the Marine Research Programme by the Government of Ireland (PDOC/21/03/01)
Operational fatigue loading on tidal turbine blades using computational fluid dynamics
No full textAs the world moves to a greater reliance on renewable energy, a vital component will be the predictability and dependability of the energy source; tidal energy provides such a solution. Horizontal axis tidal turbines are the most mature technology of all the marine renewable energy devices currently under development, as full-scale porotypes are already being tested and operated. As the industry develops and strives for commercial viability, it is becoming increasingly vital to develop a robust understanding of the complex interaction between the tidal flow, turbine blades and the support structure. This study uses an advanced computational fluid dynamics model to explore the operational fatigue loadings induced on tidal turbine blades. Two factors are considered, the presence of a support structure and varying vertical velocity profile of the tidal current. In order to perform the investigation, a model of a concept 16 m diameter horizontal axis tidal turbine with a monopile support structure is created. An investigation of the operational fatigue loadings due to variations in the positioning and the diameter of the support structure, the tidal turbine blade loads were found to varying by up to 43% of the maximum total thrust force.This research was funded in part by Science Foundation Ireland (SFI) through the Marine and
Renewable Energy Ireland (MaREI) research centre (Grant no. 12/RC/2302), Science Foundation
Ireland (SFI) under Grant Number 16/IFB/4512, the Sustainable Energy Authority of Ireland (SEAI)
through the Ocean ERA‐NET Ocean Energy Prototype Research and Development Programme 2018 as
part of the SEABLADE project (Award no.: 18/OCN/102) and the European Commission under the
FloTEC project (Floating Tidal Energy Conversion, Funded under: Horizon 2020, Low Carbon Energy
(LCE), Grant Number: 691916). The last author would also like to acknowledge the support of Science
Foundation Ireland through the Career Development Award programme (Grant No. 13/CDA/2200).
The authors would like to express their gratitude to the Irish centre for high‐end computing (ICHEC)
for the computation processing power provided. The authors would like to acknowledge Dr Philippe
Gleizon and the Environmental Research Institute at the Centre for Energy and the Environment of
the University of the Highlands and Islands, UK for their kind contribution of the ADCP data for the
Inner Sound, Pentland Firth.2022-01-2
Current neoadjuvant treatment options for HER2 positive breast cancer
No full textHikmat Abdel-Razeq, Lina MareiSection of Hematology and Medical Oncology, Department of Internal Medicine, King Hussein Cancer Center, Amman, JordanAbstract: Approximately one quarter of patients with breast cancer demonstrate amplification of the human epidermal receptor type 2 (HER2) gene, the expression of which is associated with a relatively poor prognosis independent of other clinical and pathologic variables. Trastuzumab, a humanized recombinant monoclonal antibody specifically directed against the HER2 receptor, has been shown to be biologically active and of considerable clinical utility in HER2-positive breast cancer patients. Neoadjuvant chemotherapy has been used in breast cancer to downstage the tumor and increase the opportunity for breast-conserving surgery. Preoperative chemotherapy can also serve as an in vivo testing of chemotherapy sensitivity. Additionally, a pathologic complete response is usually a surrogate marker of disease-free survival. Following the successful use of trastuzumab in the metastatic and adjuvant settings, many clinical trials have recently reported the successful use of anti-HER2 therapy in combination with different chemotherapy regimens in the neoadjuvant setting with a significantly higher pathologic complete response. With the recent introduction of new anti-HER2 drugs, interest has shifted toward dual HER2 blockade. Two such studies were recently reported, both showing a significant advantage of dual anti-HER2 therapy using lapatinib or pertuzumab in addition to trastuzumab and chemotherapy. However, several key questions need to be investigated further, such as the preferred combination chemotherapy and the optimal duration of trastuzumab in patients who achieve a pathologic complete response following preoperative chemotherapy with trastuzumab. These issues and others are discussed in this review.Keywords: neoadjuvant, breast cancer, trastuzumab, pertuzumab, lapatini
Spectral and correlation analyses of the verapamil-induced conversion of ventricular fibrillation to tachycardia in isolated rat hearts
No full textVentricular tachycardia (VT) is considered to be the most common precursor of ventricular fibrillation (VF). However, the mechanisms underlying the transition from VT to VF remain unclear. Here, we investigated whether and how perfusion of the heart with verapamil, a blocker of L-type calcium channels, changed the macro-dynamics of the heart between VT and VF. The experiments were performed with Langendorff perfused isolated rat hearts, in which left ventricular pressure and left ventricular cardiomyogram were measured. Sustained VT or VF was induced by burst pacing of the left ventricular muscles. During sustained VF, verapamil perfusion resulted in the conversion of VF to VT. A cross-correlation analysis between left ventricular cardiomyogram and left ventricular pressure revealed that the correlation coefficient was small during VF, but became larger during VT. This study showed that inactivation of L-type Ca2+ channels occurred during verapamil-induced conversion of pacing-induced sustained VF to VT, and characterized the changes in macro-dynamics of the heart associated with the transition
Design and testing of a full-scale 2 MW tidal turbine blade
No full textThe Large Structures Research Group of MaREI, Orbital Marine Power Ltd and ÉireComposites Teo. have designed a full-scale blade for a next-generation 2 MW tidal turbine as part of the H2020 FloTEC project. The 8.5 m long blade will be tested under static load conditions through the H2020 MaRINET2 transnational access programme and fatigue conditions through the OCEAN ERA-NET SEABLADE project. This paper provides an overview of the initial design study which analysed the impact of using a single shear web or two shear webs in the design. The result of this design study led to optimisation of the laminates throughout the blade to reduce the cost of manufacture and, hence, the levelized cost of energy of the device. The finite element analyses were performed using the MaREI@NUI Galway composite blade design software BladeComp. From the results of the analyses a single web design was chosen for the blade. The present work also describes the set-up for the structural tests and an overview of the data acquisition and instrumentation requirements for full-scale static and fatigue blade testing.This material is in part based upon works supported by the Science Foundation Ireland Marine and Renewable Energy Ireland (MaREI) research centre under Grant No. 12/RC/2302. It was also funded by the H2020 FloTEC project and by the Ocean Energy ERA-NET Cofund grant no. 731200. The last author would like to acknowledge the support of Science Foundation Ireland through the Career Development Award programme (Grant No. 13/CDA/2200). Additional thanks are given to the technical staff at NUI Galway and engineering staff at Orbital Marine Power Ltd and ÉireComposites Teo
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