1,721,373 research outputs found
Progetto esecutivo per il riassetto ambientale del versante Nord del versante estrattivo
No full textSynaptic Activation of a Detailed Purkinje Cell Model Predicts Voltage-Dependent Control of Burst-Pause Responses in Active Dendrites
No full textThe dendritic processing in cerebellar Purkinje cells (PCs), which integrate synaptic inputs coming from hundreds of thousands granule cells and molecular layer interneurons, is still unclear. Here we have tested a leading hypothesis maintaining that the significant PC output code is represented by burst-pause responses (BPRs), by simulating PC responses in a biophysically detailed model that allowed to systematically explore a broad range of input patterns. BPRs were generated by input bursts and were more prominent in Zebrin positive than Zebrin negative (Z+ and Z-) PCs. Different combinations of parallel fiber and molecular layer interneuron synapses explained type I, II and III responses observed in vivo. BPRs were generated intrinsically by Ca-dependent K channel activation in the somato-dendritic compartment and the pause was reinforced by molecular layer interneuron inhibition. BPRs faithfully reported the duration and intensity of synaptic inputs, such that synaptic conductance tuned the number of spikes and release probability tuned their regularity in the millisecond range. Interestingly, the burst and pause of BPRs depended on the stimulated dendritic zone reflecting the different input conductance and local engagement of voltage-dependent channels. Multiple local inputs combined their actions generating complex spatio-temporal patterns of dendritic activity and BPRs. Thus, local control of intrinsic dendritic mechanisms by synaptic inputs emerges as a fundamental PC property in activity regimens characterized by bursting inputs from granular and molecular layer neuron
Loxoconchidea Bonaduce, Ciampo & Masoli 1976
No full textGenus <i>LOXOCONCHIDEA</i> Bonaduce, Ciampo & Masoli, 1976 <p> 137. <i>L. dolgoiensis</i> Brouwers, 1993 <b>­</b> Schornikov & Sokolenko, 1999a: 182; 1999b: 216; Schornikov & Zenina, 2004b: 217.</p>Published as part of <i>Schornikov, Evgeny I., 2006, Checklist of the ostracod (Crustacea) fauna of Peter the Great Bay, Sea of Japan, pp. 29-59 in Zootaxa 1294</i> on page 44, DOI: <a href="http://zenodo.org/record/173519">10.5281/zenodo.173519</a>
Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers
Get PDFThis is the final version. Freely available on open access from Springer Verlag via the DOI in this recordLetter to the EditorThis report is independent research supported by the National Institute for Health Research (NIHR Doctoral Research Fellowship, Dr. Jane Masoli, DRF-2014-07-177)
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.
No full textThe Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex input patterns remained unknown. Here we have used 8 detailed morphological reconstructions to develop multicompartmental models of Golgi cells, in which Na, Ca, and K channels were distributed along dendrites, soma, axonal initial segment and axon. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons. Basal dendrites turned out to be more tightly electrically coupled to the axon initial segment than apical dendrites. During synaptic transmission, parallel fibers caused slow Ca-dependent depolarizations in apical dendrites that boosted the axon initial segment encoder and Na-spike backpropagation into basal dendrites, while inhibitory synapses effectively shunted backpropagating currents. This oriented dendritic processing set up a coincidence detector controlling voltage-dependent NMDA receptor unblock in basal dendrites, which, by regulating local calcium influx, may provide the basis for spike-timing dependent plasticity anticipated by theory
High-Voltage-Activated Calcium Channels
No full textThe annual Computational Neuroscience Meeting (CNS) began in 1990 as a small workshop called Analysis and Modeling of Neural Systems. The goal of the workshop was to explore the boundary between neuroscience and computation. Riding on the success of several seminal papers, physicists had made "Neural Networks" fashionable, and soon the quantitative methods used in these abstract model networks started permeating the methods and ideas of experimental neuroscientists. Although experimental neurophysiological approaches provided many advances, it became increasingly evident that mathematical and computational techniques would be required to achieve a comprehensive and quantitative understanding of neural system function. “Computational Neuroscience” emerged to complement experimental neurophysiology. In 2002, the non-profit organization, Organization for Computational Neuroscience (OCNS) was formed. OCNS has now become the first professional society serving the global computational neuroscience community. OCNS as a society lives at the interface where experimental neuroscience meets theoretical, statistical and computer-simulation analyses, with the hope of turning large collections of experimental results into a principled understanding of nervous systems. It also supports the development of new engineering, computational and informatics techniques for data collection, analyses and management
Analysis of the magnetization switching using the rotational hysteresis integral
No full textThe relation of the rotational hysteresis integral with the magnetization switching mode is experimentally analysed in materials which are subjected to different treatments which can modify the magnetization switching mode. As expected, the value of the integral depends on the basic processes of magnetization. They evolve with the evolution of the switching in the expected way, both when the switching changes from wall motion to rotation of the magnetization, and when, in single-domain particles, the rotation occurs with different reversal modes. © 1999 Elsevier Science B.V. All rights reserved
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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