3,668 research outputs found
Lila (Rita) Seldin Kramer
No full textDr. Lila (Rita) Seldin Kramer, a Palo Alto resident since 1959, died Sept. 17, 2015, with loved ones at her side. She was 87. A psychiatrist and Jungian analyst, she was born May 17, 1928, in Brooklyn to oral surgeon Dr. Harry M. and Tena E. Seldin, and was raised there and in Putnam Valley, New York. She got her undergraduate degree from University of Wisconsin, Madison, her M.D. from New York University, and was certified as a Jungian analyst by the C. G. Jung Institute of San Francisco. Lila did her residency in psychiatry, and was on the clinical faculty, at Stanford and maintained a private practice in Palo Alto for many years. Lila is survived by her daughter, Linda Kramer (Steven), grandchildren, Sara and David her son, Ron Kramer (Kim), granddaughters, Hannah and Abby sisters, Evelyn Rakower (Bill) and Marlene Cohen (Mel) and many beloved nieces, cousins, other extended family and dear friends. Lila was predeceased by her son-in-law Alex Fried. Lila was the adventurist sort. She rode horseback around the pyramids, backpacked the High Sierras including climbing Mount Whitney, skied black diamond trails, rafted, traveled the world and generally lived life to the fullest. In many ways Lila was ahead of her times. For example, she got an M.D. in 1953, at a time when few women did. She was an early feminist and mentor to many younger women. She was the consummate listener. She worked a plot at Palo Alto main community garden for decades, was an awesome cook (grandma's famous chocolate cake scrumptious meatloaf, brisket, matzo balls, chopped liver and cabbage rolls), a prolific ceramicist and an avid reader. Lila loved spending time with her family and friends, Frank Sinatra, lobster, listening to opera at Davies Symphony Hall and seeing Shakespeare in the redwoods at UC Santa Cruz. She was the coolest mom and grandma ever. Hey, she wore tie die and got a tattoo at age 85! We miss you
Self-designing networks and structural influences on safety: Developing a theory on the relation between organizational design and safety in temporary organizations that operate in a dynamic environment
No full textContains fulltext :
178382.pdf (Publisher’s version ) (Open Access)Delft University of Technology, 01 juni 2017Promotores : Ale, B.J.M., Kramer, E.H.213 p
Data from range-wide study of migratory connectivity of Vermivora warblers
No full textSee ReadMe.txt for detailed description of files.This collection of files provide data from a range-wide study of the migratory ecology of Vermivora warblers. Data include raw light-level data from geolocators, R code, and associated output. These data can be used to recreate analyses including:
(1) Individual nonbreeding occurrence and population-level nonbreeding overlap
(2) Individual migration routes and spatial distribution of individuals and populations during migrationU.S. Fish and Wildlife ServiceU.S Geological SurveyMinnesota Cooperative Fish and Wildlife Research UnitNational Science FoundationVirginia Department of Game and Inland FisheriesGrace Jones Richardson TrustKramer, Gunnar R; Andersen, David E; Buehler, David A.; Wood, Petra B; Peterson, Sean M; Lehman, Justin A; Aldinger, Kyle R; Bulluck, Lesley P; Harding, Sergio; Jones, John A; Loegering, John P; Smalling, Curtis; Vallender, Rachel; Streby, Henry M. (2018). Data from range-wide study of migratory connectivity of Vermivora warblers. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/D6D97W
Birago Project - What has happened thirty years after the introduction of macrocyclic lactones in a historically endemic area for Dirofilaria immitis? Preliminary data
No full textIntroduction: The first observation of Dirofilaria immitis in dogs was made by Birago in 1626, a nobleman living in Northern Italy. Since the 1980s, scientific studies have identified Northern Italy, particularly the area around the Po River, as a highly endemic region for heartworm disease, with prevalences ranging from 31% to 98% (Martini et al., 1996). After the introduction of ivermectin in 1988 and other macrocyclic lactones in the following years, parasitic pressure gradually decreased, leading to a reduction in the prevalence and incidence of heartworm disease in this area. However, in recent years, this reduction has led to some practitioners to pay less attention to the disease, including in terms of diagnosis and prevention.
Objectives: The aim of the study was to assess, approximately 30 years after the introduction of macrocyclic lactones preventives, the prevalence and distribution of D. immitis in Northern Italy, a historically endemic region for heartworm disease.
Materials & methods: The study population consisted of 500 dogs. The inclusion criteria were stray dogs or those without microchips referred to shelters or veterinary facilities, older than 10 months of any breed, and untreated with macrocyclic lactones for heartworm prevention. Approximately 2 ml of blood was collected from each dog and stored at +4°C in tubes with anticoagulant. An identification form was completed for each animal, including the location of recovery, age, breed, sex, weight, and the presence of any clinical signs. Each blood sample was analyzed using Knott's test (Genchi et al., 2021) and a antigen test (Idexx 4DX).
Results: Preliminary data from 328 dogs examined with Knott"s test, from 10 provinces of Lombardy and Emilia-Romagna, showed a D. immitis prevalence of 25% (fig.1). In particular, 14% were positive for D. immitis, 8% for D. repens and 11% mixed infection. The antigen prevalence was 29%, 9 dogs were antigen- positive but microfilariae negative, while 2 dogs were antigen-negative but microfilaremic.
Conclusion: The data show that even 40 years after the introduction of chemoprophylaxis, in a historically endemic area such as Northern Italy, parasitic pressure has remained high. These data underline the importance of continuing to make a correct diagnosis and prevention not only for D. immitis but also for D. repens and how practitioners must not lower their attention towards these parasites.
Birago F. Trattato cinegetico, overo della caccia. Milano: GB Bidelli, 1626:59
Genchi M, Ciuca L, Vismarra A, Ciccone E, Cringoli G, Kramer L, Rinaldi L. Evaluation of alternative reagents on the performance of the modified Knott's test. Vet Parasitol. 2021 Oct;298:109555.
Martini M, Capelli G, Poglayen G, Bertotti F, Turilli C. The validity of some haematological and ELISA methods for the diagnosis of canine heartworm disease. Vet Res Commun. 1996;20(4):331-
Including oxygen enhancement ratio in ion beam treatment planning: Model implementation and experimental verification
No full textWe present a method for adapting a biologically optimized treatment planning for particle beams to a spatially inhomogeneous tumor sensitivity due to hypoxia, and detected e.g., by PET functional imaging. The TRiP98 code, established treatment planning system for particles, has been extended for including explicitly the oxygen enhancement ratio (OER) in the biological effect calculation, providing the first set up of a dedicated ion beam treatment planning approach directed to hypoxic tumors, TRiP-OER, here reported together with experimental tests. A simple semi-empirical model for calculating the OER as a function of oxygen concentration and dose averaged linear energy transfer, generating input tables for the program is introduced. The code is then extended in order to import such tables coming from the present or alternative models, accordingly and to perform forward and inverse planning, i.e., predicting the survival response of differently oxygenated areas as well as optimizing the required dose for restoring a uniform survival effect in the whole irradiated target. The multiple field optimization results show how the program selects the best beam components for treating the hypoxic regions. The calculations performed for different ions, provide indications for the possible clinical advantages of a multi-ion treatment. Finally the predictivity of the code is tested through dedicated cell culture experiments on extended targets irradiation using specially designed hypoxic chambers, providing a qualitative agreement, despite some limits in full survival calculations arising from the RBE assessment. The comparison of the predictions resulting by using different model tables are also reported. © 2013 Institute of Physics and Engineering in Medicine
Federal Legislative and Administrative regulation of Hydraulic Fracturing Operations
No full textBruce M. Kramer examines the evolving federal role in regulating hydraulic fracturing within the broader context of U.S. energy and environmental law. Kramer traces the historical predominance of state control over oil and gas production and explores how federal statutes such as the Safe Drinking Water Act and the Clean Air Act intersect with hydraulic fracturing activities. The article analyzes key legislative and administrative developments, including the so-called “Halliburton Loophole,” which exempts most hydraulic fracturing operations from federal underground injection control requirements. Kramer evaluates the policy debates surrounding federal oversight, weighing arguments for increased uniform regulation against concerns for state autonomy and industry innovation. Ultimately, the article concludes that the fragmented regulatory framework reflects enduring tensions between environmental protection, energy independence, and federalism
Three-dimensional printing of an X-ray phantom of the heart
No full textUvod: Bolezni koronarnih arterij predstavljajo tretji najpogostejši vzrok smrti v svetu. Za diagnostiko in zdravljenje zožitev koronarnih arterij se primarno uporabljata znotrajžilna koronarografija in koronaroplastika. Rentgenski fantomi imajo pri učenju anatomije koronarnih arterij in projekcij, ki se uporabljajo pri koronarografiji, pomembno vlogo. Tehnologija tridimenzionalnega tiskanja ponuja možnost izdelave specifičnih, cenovno ugodnih in anatomsko ustreznih fantomov, ki lahko pripomorejo k izboljšanju učnega procesa v interventni radiologiji. Namen: Namen našega diplomskega dela je bil izdelati anatomsko ustrezen rentgenski fantom srca s koronarnimi arterijami, ki bi bil uporaben kot učni pripomoček za učenje anatomije in projekcij pri invazivni koronarni angiografiji. Metode dela: Uporabili smo deskriptivno in eksperimentalno metodo dela. Za pripravo teoretičnih izhodišč smo izvedli pregled strokovne literature. V eksperimentalnem delu smo izdelali fantom srca. Izdelava je obsegala štiri faze: načrtovanje, oblikovanje koncepta, oblikovanje modela in preverjanje). S programom 3D Slicer smo izvedli segmentacijo računalniških tomografskih slik in tako ustvarili tridimenzionalen model srca. Model smo natisnili s tehniko ciljanega nalaganja, pri čemer smo uporabili plastičen filament iz polilaktične kisline, ki je omogočil optimalen prikaz struktur na rentgenskih slikah. Naris koronarnih arterij smo izvedli z nanašanjem mešanice ultravijoličnega gela in kovinskega prahu. Izvedli smo tudi rentgensko slikanje in primerjavo pridobljenih slik z referenčnimi koronarogrami iz literature. Rezultati: Uspešno smo izdelali votel, anatomsko pravilen model srca z rentgensko jasno vidnim potekom koronarnih arterij. Rentgenske slike fantoma so, pri prikazu desne in leve koronarne arterije ter njunih vej, pokazale dobro primerljivost s slikami iz literature. Razprava in zaključek: Z raziskavo smo potrdili, da je s segmentacijo računalniško tomografskih slik in tridimenzionalnega tiskanja mogoče izdelati anatomsko ustrezen rentgenski fantom srca, primeren za poučevanje anatomije in učenje projekcij pri koronarografiji. Kljub uspešni izvedbi ostajajo določene omejitve, zlasti pri ponovljivosti in standardizaciji zarisovanja koronarnih arterij. V prihodnosti bi bilo zato smiselno raziskati avtomatizacijo tega koraka. Prav tako bi bilo smiselno preučiti različne materiale, ki bi predstavljali tkivni ekvivalent in s tem omogočili še bolj realističen prikaz organa na rentgenskih slikah.Introduction: Coronary artery disease is the third most common cause of death in the world. Invasive coronary angiography is the primary imaging modality used for both diagnosis and treatment of narrowed or occluded coronary arteries. X-ray phantoms play a crucial role in learning coronary artery anatomy and projections used in coronary angiography. Three-dimensional printing offers a novel approach to develop specific, inexpensive and anatomically accurate phantoms that can improve the learning process in various medical fields, including interventional radiology. Purpose: The purpose of the study was to create an anatomically accurate radiographic phantom showing the heart and coronary arteries that can be used as a teaching tool for learning anatomy and image projections in invasive coronary angiography. Methods: Descriptive and experimental methods were used in the study. The literature review was used to create the theoretical background. The process of model development included four phases: Planning, Concept development, model designing and validation. The computed tomography images were segmented using 3D Slicer software, resulting in a three-dimensional model of the heart. The model was printed using the polylactic acid filament and fused deposition modelling technique. Visualization of the coronary arteries was achieved by applying a mixture of ultraviolet gel and metal powder. Radiographs (on a C-arm) were also taken and the resulting images were compared with reference coronary angiograms from the literature. Results: A hollow, anatomically accurate heart model with clearly visible coronary artery pathways was successfully produced. The X-ray images of the phantom showed good comparability with reference images from the literature. Discussion and conclusion: The study confirms that an anatomically accurate model suitable for teaching anatomy and learning projection techniques in coronary angiography can be produced using computed tomography image segmentation and three-dimensional printing. Despite the successful implementation, certain limitations remain, particularly in the visualization of the coronary arteries. It would therefore make sense to automate this step. In the future, different materials simulating tissue-equivalent properties can also be investigated, which could allow a more realistic representation of the organ and other structures on X-ray images
Sensory Bench
No full textGreen Fund project with Rebecca Weller and Christy Prothero;
The idea is to re-green the rear podium of the Marylebone campus, with the modular pentagonal design, made out of scaffolding boards. Maria Kramer said "Students learned about the entire design and construction process, we had meetings with makers to discuss detailing and feasibility and students took the lead on the construction, learning so much from the complexity of managing the different aspects of building, including health and safety procedures.
Interpreting the Royalty Obligation by Looking at the Express Language: What a Novel Idea
No full textThis article focuses on the importance of adhering to the express language of contracts when interpreting royalty obligations in Texas. The article critiques the tendency of courts to rely on extrinsic evidence or canons of construction when the language of the agreement is clear and unambiguous. Kramer emphasizes that the intent of the parties should be derived from the four corners of the document, avoiding unnecessary judicial intervention. The author explores the challenges and inconsistencies that arise when courts deviate from this principle, particularly in the context of oil and gas leases. Ultimately, the article advocates for a disciplined approach to contract interpretation that prioritizes the express terms agreed upon by the parties
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction
No full textAbnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance. We hypothesized that Nrf2 regulates steroid sensitivity via HDAC2 in response to inflammation in mouse lung. Furthermore, HDAC2 deficiency leads to steroid resistance in attenuating lung inflammatory response, which may be due to oxidant/antioxidant imbalance. Loss of antioxidant transcription factor Nrf2 resulted in decreased HDAC2 level in lung, and increased inflammatory lung response which was not reversed by steroid. Thus, steroid resistance or inability of steroids to control lung inflammatory response is dependent on Nrf2-HDAC2 axis. These findings have implications in steroid resistance, particularly during the conditions of oxidative stress when the lungs are more susceptible to inflammatory response, which is seen in patients with chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and inflammatory bowel disease
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