338 research outputs found

    Applications of muon absorption radiography to the fields of archaeology and civil engineering

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    Muon radiography, also known as muography, is an imaging technique that provides information on the mass density distribution inside large objects. Muons are naturally produced in the interactions of cosmic rays in the Earth's atmosphere. The physical process exploited by muography is the attenuation of the muon flux, that depends on the thickness and density of matter that muons cross in the course of their trajectory. A particle detector with tracking capability allows the measurement of the muons flux as a function of the muon direction. The comparison of the measured muon flux with the expected one gives information on the distribution of the density of matter, in particular, on the presence of cavities. In this article, the measurement performed at Mt. Echia in Naples (Saracino 2017 Sci. Rep.7, 1181. (doi:10.1038/s41598-017-01277-3)), will be discussed as a practical example of the possible application of muography in archaeology and civil engineering.This article is part of the Theo Murphy meeting issue 'Cosmic-ray muography'

    Efficacy and mucosal toxicity of concomitant chemo-radiotherapy in patients with locally-advanced squamous cell carcinoma of the head-and-neck in the light of a novel mathematical model

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    Background: In the last several decades, combined radiotherapy (RT) and chemotherapy (CT) have beenrecognized as feasible in locally-advanced-squamous-cell-carcinoma of the head-and-neck (LA-HNSCC).Several meta-analyses identified concurrent RT + CT (CRT) most likely effective approach respect toRT-alone. However, radiobiological models comparing different chemotherapeutic schedules againstdelivered RT fractionation schedule for overall survival and toxicity are still needed.Methods and materials: Based on 9 randomized trials (2785 patients), radiobiological models andmultivariate logistic regression model were used to derive dose-response curves and estimate the 5-year-overall survival (OS) and ≥G3 acute mucositis rate of CRT or RT-alone.Results: Equivalent dose at 2 Gy/fraction (EQD2) was calculated using the linear quadratic model. Theeffect of CRT schedules, considering the CT type and its administration schedule and the HPV status oftumors were estimated using the univariate/multivariate logistic regression. The multivariate logisticregression model for 5y-OS indicated EQD2 and the type of CT, the chemo-sensitization fraction and theHPV status significant prognostic factors, while for toxicity both EQD2 and the concomitant adminis-tration of 5-fluorouracil (5Fu) resulted as significant prognostic factors. Combined schedules cisplatin(DDP)+/−5Fu + RT produced the higher OS compared with combined carboplatin+/−5Fu + RT or RT-alone

    Stand-alone Low Power Consumption FEE and DAQ for the Readout of Silicon Photomultipliers

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    We developed a front end electronics (FEE) and data acquisition (DAQ) system with a low power consumption, especially intended for stand-alone applications in unattended environments without standard electricity supply. The system works autonomously thanks to dedicated algorithms that are embedded. The FEE is based on the EASIROC chip, designed for the readout of Silicon photomultipliers (SiPMs). It digitizes the amplitude of the signals and provides time information with time of flight capability. The trigger logic is programmable and physical and accidental coincidences rates can be measured. The SiPMs temperature is controlled by thermoelectric cells. Thanks to a network of temperature and humidity sensors, a real-time software sets the optimal operating point of the SiPMs depending on external conditions and if necessary halts the system to avoid damage to the electronics. The system has been used in several muon radiography experiments
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