238 research outputs found
The multiple myeloma treatment landscape: international guideline recommendations and clinical practice in Europe
No full textGuidelines provide recommendations on the management of multiple myeloma (MM), but there are no standard algorithms for the choice and sequencing of treatments. As a result, there is widespread variation in the interpretation and implementation of these guidelines. Areas covered: This review will cover: the real-world data on MM treatment patterns; the approved agents available for the treatment of MM; a comparative summary of the national and international clinical guidelines; a discussion on the impact reimbursement decisions have on treatment availability. Expert commentary: In the future, treatment choices may become even more complex as clonal heterogeneity is better understood in the context of response to treatment, and next-generation agents become available. Although information on real-world practice patterns can provide further guidance, to date, few studies have generated data on patients treated with the newer agents in real-world settings. Furthermore, the translation of guideline recommendations into clinical practice across Europe is inconsistent. Additional real-world data are therefore vital to understanding current clinical practice patterns, so that new agents can be effectively incorporated into existing treatment strategies. Such information may aid the development of better guidance, which will ultimately help to ensure that patients receive the best possible care
Translation of dialect and cultural transfer : an analysis of Eduardo De Filippo’s theatre
No full textThe thesis sets out to examine cultural transfer from Neapolitan dialect into English, in the
translations of plays by the contemporary Neapolitan playwright Eduardo De Filippo
(1900-1984). It involves a comparative textual analysis of English translations of a
selection of De Filippo’s plays in order to identify the translation strategies employed by
each translator to represent Neapolitan cultural identity. Eduardo De Filippo can be defined
as one of the most prominent contemporary Italian playwrights who employed dialect to
portray characters who trespassed the boundaries of both Neapolitan and Italian society and
to address social issues which were comprehensible to a vast public. In fact, his innovative
contribution resided in the ability to bring vernacular theatre to national and international
level. Thus the objective of the study is to bring to light the universality of De Filippo’s
message albeit the limited linguistic medium and to show how his theatre is represented in
the Anglo-Saxon milieu. The aim of previous critical studies on the matter has been to
focus on the stage representations of De Filippo’s oeuvres, without particular emphasis on
the analysis of the dialect. Drawing on a variety of theatre as well as translational
frameworks (critical work on translation and in particular on theatre translation, the
polysystem theory, the descriptive approach, anthropology, and sociolinguistics) I argue
that dialect theatre represents an autonomous genre, separate from standard Italian theatre,
which needs to be accounted for in translation, and in particular that the domestication of
the language reduces the cultural impact of the original plays. The thesis is the first study to
suggest that lexicological issues reflect the interpretation of the Neapolitan society in the
translated texts and to provide evidence of the appropriation of Neapolitan culture by the
receiving theatrical system through the linguistic choices made in translation
"Reason's feminist disciples" : Cartesianismus und englische Frauen des 17. Jahrhunderts
No full textTwentieth-century scholars have thought little about the attractions of Descartes’ thinking. Especially in feminist theory, he has a bad press as the ‘instigator’ of the body-mind-split – seen as one of the theoretical bases for the subordination of women in Western culture. Seen from within seventeenth-century discourse it is the dictum that can be inferred from his writings that ‘the mind has no sex’ and which can be seen as an appeal to think about rational capacities in the utopian perspective of a gender neutral discourse. My work analyses this “face” of Cartesianism as it was adapted in favour of English seventeenth-century women. How were the specific tenets of Descartes’ philosophy employed on behalf of English women in the second half of the seventeenth century in England? My focus is on Descartes as a thinker, who – whatever his real or imagined intention might have been – provided women in seventeenth-century England with tools with which to change their status, in other words: with instruments of empowerment. So why were Descartes’ arguments so attractive for women? Descartes had argued for equal rational abilities among individuals in a gender neutral way. He had further critiqued generally accepted truth with his universal doubt. I believe this specific combination of ideas, affirming their rational capabilities, was seen by a number of women as an invitation to become involved in spheres of activity from which they were previously excluded. Moreover, a specific set of Descartes’ arguments provided a number of English women with a strategy to extend female agency. Not only did Descartes’ views legitimate female rationality, they also allowed an acknowledgement that this female intellect was equally connected to “truth” as that of their male contemporaries. As a consequence, women developed an increased self-esteem and inspiration to pursue their own independent study (and in some cases publishing). These ideas eventually helped to bring forward a demand for female education, as girls and women were still excluded from formal education in seventeenth-century England. My general thesis is that Cartesianism, as one of the earliest universalist theories on the nature of human reason, introduced new possibilities into the English debate over the nature and, hence, social position of women. It brought a radical twist to the already existing discussion on women by offering new critical tools which were taken up to argue on behalf of English women. In my work I examine the specific historical conditions of the reception of Descartes’ thought in England, the philosophical appeal of his ideas for women and analyse the writings of two English ‘disciples’ of Descartes: Margaret Cavendish, Duchess of Newcastle and Mary Astell.Die Forschung des 20. Jahrhundert war kaum an der Attraktivität von Descartes’ Theorien interessiert. Vor allem in der ‚Feminist Theory’ hat René Descartes als Hervorbringer des Körper-Geist-Trennung eher eine „schlechte Presse“, da sie als eine der theoretischen Grundlagen der Unterdrückung der Frauen in der westlichen Kultur verstanden wird. Betrachtet man den Diskurs jedoch aus der Perspektive des 17. Jahrhunderts, tritt das Diktum „die Vernunft hat kein Geschlecht“ aus Descartes’ Schriften hervor, womit der Blick auf die Vernunft aus der utopischen Perspektive eines geschlechtsneutralen Diskurses möglich wird. Meine Arbeit analysiert genau dieses „Gesicht“ des Cartesianismus und dessen Form, wie es zugunsten englischer Frauen des 17. Jahrhunderts angewendet wurde. Aber wie genau sah diese Anwendung von Descartes’ Ideen in der zweiten Hälfte des 17. Jahrhunderts aus? Mein Fokus liegt hier auf Descartes’ Philosophie – völlig unabhängig von einer möglichen oder tatsächlichen Intentionen Descartes’ – die englischen Frauen des 17. Jahrhunderts mit einem Ermächtigungs-Instrumentarium ausstattete, durch das sie ihren Status verändern konnten. Was genau war an Descartes’ Argumenten so attraktiv für Frauen? Descartes hatte argumentiert, dass jeder Mensch Vernunft besitzt und zwar in einer geschlechterneutralen Sprache. Er hatte außerdem die allgemein anerkannte Vorstellung von Wahrheit kritisiert durch seinen universellen Zweifel. Diese spezifische Kombination von Ideen ließ die Interpretation zu, dass auch Frauen Vernunft besitzen, was von vielen Frauen als Einladung verstanden wurde, an Bereichen teilzuhaben, von denen sie bisher ausgeschlossen wurden. Descartes’ Philosophie ermöglichte außerdem seinen englischen Zeitgenossinnen, eine Strategie zu entwickeln, durch die sie ihre weibliche Handlungsfähigkeit deutlich erweitern konnten. Seine Philosophie erlaubte nicht nur die Interpretation, dass auch Frauen vernunftbegabt sind, sondern legte auch nahe, dass diese Vernunft eine ähnlich direkte Anbindung zur „Wahrheit“ hat, wie die der männlichen Zeitgenossen. Aus dieser Vorstellung resultierte, dass Frauen ein Selbstwertgefühl entwickelten und Inspiration erfuhren und sich neuen Feldern und unabhängigen Studien widmeten (die sie teilweise auch publizierten). Diese Vorstellungen halfen schließlich die Forderung nach einer institutionalisierten Bildung von Mädchen und Frauen, die bis dahin immer noch von formaler Bildung im England des 17. Jahrhunderts ausgeschlossen waren, auf den Weg zu bringen. Meine These ist, dass der Cartesianismus als eine der ersten universalistischen Theorien zur Vernunft, neue Impulse in die englische Debatte über die Natur und gesellschaftlichen Stellung der Frau einbrachte. Hieraus ergab sich eine radikale Veränderung der bereits existierenden Debatte über die Frau, vor allem durch die Aufnahme der neu zu Verfügung stehenden kritischen Instrumentarien, die zugunsten englischer Frauen aufgenommen wurden. Ich untersuche in meiner Arbeit die spezifischen historischen Rezeptions-Bedingungen von Descartes’ Ideen in England, die philosophische Attraktion seiner Ideen für Frauen und analysiere die Werke von zwei englischen ‚Anhängerinnen’ von Descartes: Margaret Cavendish, Duchess of Newcastle und Mary Astell
O racista ignóbil e o perspectivista compassivo: refletindo sobre a tradução de poemas de A Kasïdah de Richard Burton
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2014.O tema desta tese é a tradução da ira. Este sentimento, que está presente na literatura ocidental já como primeira palavra daquele que é o primeiro dos seus livros, A Ilíada, e que varia, como pretendo demonstrar, de grupo humano para grupo humano. Escolhi tratar da ira de um escritor em especi-al, sir Richard Francis Burton (1821-1890), propondo uma releitura do escritor britânico, famoso pela tradução das Mil e uma noites e por seus livros de viagem, como um autor revoltado, uma espécie de guerrilheiro das letras. Pretendo demonstrá-lo a partir da tradução de algumas estrofes de seu longo poema, A Kasidah, escrito e publicado em 1880, quando o autor tinha sessenta anos. Trata-se de um conjunto de duzentos e sessenta e quatro estrofes e quinhentos e vinte e oito versos, em que o escritor britânico ataca ingleses, franceses, árabes e hindus. Assim, primeiro, faço uma revisão das representações do escritor britânico na literatura especializada, mostrando que grande parte de sua ira se origina do temperamento revoltado e da expe-rimentação do ponto de vista do nativo. Depois, faço um estudo da história da representação dos gurus e poetas na literatura ocidental, mostrando de que forma deu origem à gurumania, isto é, a invocação em textos de poesia e prosa de teorias orientais com o propósito de explicar a razão da vida. A Kasidah, como quero mostrar, faz parte desta rede de textos. Em seguida, escrevo sobre as personalidades nas quais Burton, ao escrever A Kasidah, desdobrou-se. Mostro de que forma se originam nas experiências de troca de perspectivas que o escritor britânico fez. Mais tarde, demonstro que Richard Burton escreveu A Kasidah em resposta à tradução que Edward FitzGerald fez das Rubáiyát de Omar Khayyam. Por fim, em meu último capítulo, descrevo de que forma a ira varia de grupo humano para grupo humano. Assim, sigo por indicar a maneira em que, acredito, se deva tradu-zir a ira nos trabalhos de Richard Burton.Abstract : The theme of this thesis is the translation of anger. This feeling, which is already present in Western literature as the first word of that which is the first of his books, The Iliad, and it varies, as I will argue, from human group to human group. I chose to talk about the wrath of a particular writer, Sir Richard Francis Burton (1821-1890), proposing a reinterpretation of the British writer, famous for the translation of The Arabian Nights and his travel books, as an angry author, a kind of writer guerrilheiro. I intend to prove it from the translation of some verses of his long poem, The Kasidah, written and published in 1880, when the author was sixty years old. It is a set of two hundred sixty-four stanzas and five hundred twenty-eight verses, in which the British writer attacks English, French, Arabic and Hindu people. So first, I review the representations of the British writer in the specialized literature, showing that much of his anger stems from angry temperament and experimentation from the point of view of the native. Then I do a study of the history of the representation of gurus and poets in Western literature, showing how it gave rise to gurumania, ie the invocation of poetry and prose texts of oriental theories purporting to explain the rea-son of life. The Kasidah, as I want to show, is part of this network of texts. Then I write about the personalities in which Burton, writing The Kasidah, unfolded. I show how they come from the experiences of exchange of pers-pectives that the British writer did. Later, I show that Richard Burton wrote The Kasidah in response to Edward FitzGerald translation of the Rubaiyat of Omar Khayyam. Finally, in my last chapter, I describe how the anger will vary from human group to human group. Then, I indicate the way in which, I believe, the anger should be translated Richard Burton's work
Reference Curve for Indian Role Model Scientist
No full textAnalysis of the publication productivity of well-known Indian scientists has been documented and linear regression analysis curve is plotted which can be used to forecast promising young scientists who may become role model scientists, based on their present publication productivity considering history of their fifteen years of number of publications
Evaluación del efecto de la suplementación con (Moringa oleífera) y Caña de azúcar (Saccharum officinarum) sobre la producción y calidad composicional de la leche de vacas Costeño con Cuernos en primer tercio de lactancia en un Sistema Silvopastoril en época de sequía en la microrregión del valle del Cesar
No full textCon el objetivo de evaluar el efecto de la suplementación con Caña de azúcar (Saccharum officinarum) y Moringa oleífera sobre la producción y la calidad nutricional de la leche, el experimento se realizó en el municipio de Agustín Codazzi (Cesar) en el Sistema Silvopatoril del Centro de Investigación Motilonia de AGROSAVIA en época de sequía. Se utilizaron 6 vacas Costeño con Cuernos con un peso vivo (PV) de 430 kg en el primer tercio de lactancia distribuidos completamente al azar en 3 tratamientos, a uno de los cuales solo recibió pastoreo (T0) y los otros se alimentaron con pastoreo más un suplemento del 1% del PV en materia seca con dos niveles de inclusión: 70 – 30 % (T1) y 50 – 50 % (T2) de Caña de Azúcar (Saccharum officinarum) y Moringa oleífera, respectivamente. La toma de datos se realizó junto las muestras de leche por 3 días luego del periodo de adaptación. Todos los datos fueron analizados en Microsoft Excel. El consumo del suplemento en T1 y T2 estuvo en promedio del 73% y 70%, respectivamente. Los resultados obtenidos no mostraron un efecto significativo (P < 0,05) en la producción de leche, Proteína y Solidos no Grasos (SNG), mientras que, si existieron efectos significativos (P < 0,05) en la concentración de Grasa, observándose que en el T1 y T2 tuvieron un mayor % de Grasa (4,53 y 4,69 %, respectivamente). Se puede concluir de este estudio que al suministrar un suplemento energético – proteico, se encontró que tiene efectos positivos sobre la concentración de la grasa láctea.In order to evaluate the effect of sugarcane (Saccharum officinarum) and Moringa oleífera supplementation on milk production and nutritional quality, the experiment was carried out in the municipality of Agustin Codazzi (Cesar) in the Silvopastoral System AGROSAVIA Motilonia Research Center during the dry season. 6 cows -Costeño con Cuernos- with 430 kg of body weight (BW) in the firth lactation stage were used distributed in a completely randomized 3 treatments, one of which received only grazing (T0) and the others fed with grazing plus a 1% supply of BW in Dry Matter with two inclusion levels: 70 – 30 % (T1) y 50 – 50 % (T2) of Sugarcane and Moringa oleifera, respectively. Data collection was performed together with milk samples for 3 days after the adaptation period. All data were run in Microsoft Excel. The results obtained didn't show a significant effect (P < 0,05) on milk production, protein and solids-not-fat, whereas, existed significant effects (P < 0,05) on fat concentration, observing that in the T1 and T2 had a higher % fat (4,53 y 4,69 %, respectively). One can conclude from this study that by providing supplementation energy – protein was found to have positive effects on the milk Fat concentration.Pregrad
Evaluation of phytoremediation potential of Peltophorum pterocarpum (DC.) Heyne Leucaena leucocephala (Lam.) De Wit. and Crotolaria retusa Linn for waste oil contaminated soils
No full textAn ecological study was carried out to evaluate remediation potential of three hydrocarbon tolerant species (Peltophorum pterocarpum (DC.) Heyne, Leucaena leucocephala (Lam.) De Wit., and Crotolaria retusa Linn) of Fabaceae plant family in relation to enzyme activity for cleaning up soils contaminated with waste oil hydrocarbon. Biochemical analyses were carried out using classical standard procedures to assess the level of enzyme expression in relation to hydrocarbon index assessment in remediation performance through a holistic test of significance using the PROC ANOVA and Duncan’s New Multiple Range Test (DNMRT) procedures. Enzyme expression, oil removal and organic carbon sequestration of the species and the species treated soils showed that in pre-polluted soil foliar enzyme expression in the order Cr>Ll>Pp was high but reduction in post-polluted and post-phytoremediation soils in the order Cr>Ll>Pp. Generally, among species Peroxidase (POD) was higher in activity and expression than Polyphenoloxidase (PPO). The oil and grease recorded a lower content in the pre-pollution soil which increased in content in post-pollution with increase in pollution. However, the impact of phytoapplication has shown some significant (p<0.05) reduction in L. leucocephala soil in the order Ll<Pp<Cr but higher foliar content among the species in the order Ll>Pp>Cr at low enzyme expression in which P. pterocarpum had higher carbon content in the order Pp>Cr> Ll. The pre-pollution soil had a significantly lower carbon than post-polluted soils. The impact of phytoremediation has shown reduction in carbon content with P. pterocarpum treated soil significantly lower in content in the order Pp<Cr< Ll and higher foliar content in the order Pp>Cr> Ll. Thus by the forgoing trajectories and trend of indigenous enzymes, P. pterocarpum and L. leucocephala can thus be recommended as an integral component in any bioremediation technology package for waste oil polluted terrestrial environment.Keywords: Peroxidase, Polyphenoloxidase, Organic carbon, Oil & grease, Phytoapplicatio
Recent progress in relapsed multiple myeloma therapy: implications for treatment decisions
No full textHabilitación del instrumento AVE, en la realidad de los estudiantes del centro sur de la ciudad de Sangolquí
No full textEl trabajo de investigación se realizó en la Unidad Educativa Geovanny Farina, en estudiantes comprendido entre las edades de 12 a 15 años. La misma que conlleva a la HABILITACIÓN DEL INSTRUMENTO AVE, EN LA REALIDAD DE LOS ESTUDIANTES DEL CENTRO SUR DE LA CIUDAD DE SANGOLQUÍ. Este trabajo se efectuó a estudiantes comprendido entre las edades de 12 a 15 años. Este documento se encuentra organizado en forma capitular. En el Capítulo I, se plantea y se formula el Problema de la investigación, con las variables de estudio, también se plantea los objetivos tanto generales como específicos y la respectiva justificación del trabajo realizado. En el Capítulo II, se desarrolla el Marco Teórico, en los antecedentes de investigaciones anteriores y los contenidos de la información literaria científica que existe sobre las variables, dimensiones e indicadores de estudio, que permitieron fundamentar la presente investigación. En el Capítulo III, se plantea la metodología utilizando en la ejecución de la investigación el diseño y las clases de investigación realizada, la muestra utilizada, y la Operacionalización de las variables de estudio y las técnicas e instrumentos para la recolección de los datos. En el Capítulo IV, se desarrolla el procedimiento de cada uno de los datos y análisis de resultados, a nivel de tablas y graficas estadísticas con sus respectivos análisis e interpretaciones, lo que dio lugar a la elaboración de cada una de las
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conclusiones y recomendaciones del trabajo efectuado. Este informe finaliza con la exposición de las referencias utilizadas en la investigación y los anexos correspondientes.The reseaarch work will be carriedout in the Geovanny Farina high school. In the same high school will be taken the “AVE”, instrment in the reality of the studentd.
This Research was taken for studen of ages betcugen 12 and 15 years.
This document is organized in chapters. In capter I, the problem of the Research is raised and formulated with its study variables, also, it is raise the general objetive as well as the specific objectives wit its justification.
In chapter II, the theoretical frameware is develaped, with the backgrond of previous researchs cientific information about the variables, dimentions and indicadols that allow is bose the present Research. In chapter III the methodology use is raised and the ejecution of the desigh of the Research. Also, the type of Research, the simple use and the operationalitation or the variables as well as the tecnics and the tolos use is colect data. In chapter IV, is develop the process of each data and analysis of results in tables and statistical graphs with its own analysis and interpretation, with this information the conclusions and recomendations work done.
The rinal chapter have the references use in this Research with aim attachmens
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