14,503,040 research outputs found
Jane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia, 4 December 1808
No full textJane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia. Cannot imagine why Mr. Callaway wcould have led her, Jane C. Charlton, to believe that she, Sarah C. Watts, was to marry Mr. Irvine; there are almost 70 eligible men in town, "which is a large number considering the Embargo"; Mr. Anderson is pleased to be in Lynchburg; mention of Mrs. Camp and Maria Moody; the students have formed a military company, and parade every Saturday in beautiful scarlet coats and "black velvet gaters," including her, Sarah C. Watts, handsome beau, Mr. Irvine(?); also heard that he is superior to anyone in the Junior Class, and hopes that she will pass the information on to his sister; has heard that Eliza (Wright) Mayo and her husband are doing poor financially, neither of them being "economists"; more mention of various girls and their beaux. 3 pages. Autograph letter signed. Including typescript. 2 pages
Jane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia, 8 May 1808
No full textJane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia. Apologizes for not writing, but has been in Surry for the past month at Mr. Edwards', where there has been much company; Sally Bracken went with her, and they had a wonderful visit; but was not able to see Sally Browne; had a rough trip home on the James River, with pouring rain; Williamsburg will perk up a bit with some upcoming weddings, one of which is Eliza Wright's and Mr. Mayo's; encloses locks of hers and Mary's hair; doesn't feel well. 2 pages. Autograph letter signed. Including typescript. 1 page
A+C
No full textLa Revista A+C es una publicación editada por la Escuela de Arquitectura de la Universidad de Santiago de Chile. A+C nace en el año 2001 con el objetivo de dar cuenta de la creación de nuevas ideas, generando así un espacio pluridisciplinario para el intercambio de ideas y la difusión de conocimientos de alto nivel, en torno a la relación entre arquitectura y cultura.
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
Jane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia, 14 July 1808
No full textJane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia. Eliza (Wright) Mayo has gone to North Carolina to stay with her new in-laws, and seems very happy; tells of various speeches delivered in Williamsburg on July 4th, one on universal suffrage delivered by Mr. Greenhill, one on civil liberties delivered by Mr. Bushrod(?) Washington "(a Nephew of the immortal General's)," and another delivered by Mr. McCandellish, sic, McCandlish, which was a eulogy on George Washington; Mrs. Pardice, sic, gave a ball which was too crowded; Mrs. Camp's girls have gone, including Maria Moody; students at the College of William and Mary (?) are also leaving fast, and relates ill-feelings toward them; Mr. Anderson, a teacher, may be moving to Lynchburg; has heard she is to be married, and asks for the initials of his name and other details. 3 pages. Autograph letter signed, Including typescript. 2 pages
Jane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia, 10 January 1808
No full textJane C. Charlton, Williamsburg, Virginia, to Sarah C. Watts, New London, Virginia. Tells of Miss Moir's birthday party, and helping her sister and Sally Bracken "look very smart" for it; Mr. Callaway, "a very genteel Young Man," but "extremely homely," came to visit; gossip; mention of a literary society; "the Bishop", James Madison, stopped the gentlemen's weekly parties because it was interrupting their studies, which she is disappointed by, because before the dancing began, the men discussed various political subjects, some speaking quite eloquently; Mr. Anderson ill, suffering fom an ankle problem, and misses Sally Browne very much, as do they all; tells of a romance between Eliza Wright and Mr. Mayo; her mother is ill; freezing weather. 3 pages. Autograph letter signed. Including typescript. 2 pages
Jane C. Charlton, Williamsburgh, Virginia, to Sarah C. Watts, New London, Virginia, 13 September 1807
No full textJane C. Charlton, Williamsburgh, sic, Virginia, to Sarah C. Watts, New London, Virginia. Glad to hear about her return home; gives local news including details about the arrival of Eliza Wright and her subsequent illness, and the departure of the Savages and the Smiths; expresses her sadness at the "loss of your society" and how much she misses her and the other girls; Mrs. Faulcon left for Carolina; tells of Miss Donoville, sic, Deneufville and Mr. Pryor tying the "gordianknot," and states the "Wmsbg. will be quite gay at that time, as they are to have a great wedding"; influenza rampant; tells of a party given by Mr. and Mrs. Mason, describing the handsome men, the dancing, and the fact that even Mrs. Anderson, Mrs. Paradice, sic, and her mother were there; "War" is still the main topic of discussion, with revenge at the "epidemical" stage, even affecting the ladies; mentions E. Coleman and his politicing. 3 pages. Autograph letter signed. Including typescript. 2 pages
Molecular structure of highly excited resonant states in Mg-24 and the corresponding Be-8+O-16 and C-12+C-12 decays
No full textExotic Be-8 and C-12 decays from high-lying resonances in Mg-24 are analyzed in terms of a cluster model. The calculated quantities agree well with the corresponding experimental data. It is found that the calculated decay widths are very sensitive to the angular momentum carried by the outgoing cluster. It is shown that this property makes cluster decay a powerful tool to determine the spin as well as the molecular structures of the resonances.Physics, NuclearSCI(E)7ARTICLE5null8
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
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