428 research outputs found
Central macular choriocapillaris impairment as a manifestation of microvascular disease in eyes with subretinal drusenoid deposits
Full text linkBackground/objectives: microvascular alterations and choroidal impairment are emerging as a pathologic pathway in age-related macular degeneration (AMD). This study aimed to evaluate the central macular choriocapillaris (CC) in eyes with subretinal drusenoid deposits (SDD) and the retinal microvasculature in patients with early AMD phenotypes.Subjects/methods: this was an institutional, multicentric observational cross-sectional study. Ninety-nine eyes of 99 subjects; 33 eyes with SDD only, 33 eyes with conventional drusen (CD) only, and 33 eyes of healthy age-matched subjects were included. Comprehensive ophthalmologic examination and optical coherence tomography angiography (OCTA) was performed. The central macular flow area of the CC was analysed in the SDD group and the vessel density of the retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) was analysed in the SDD and CD groups using automated OCTA output parameters.Results: the flow area of the CC in the SDD group was significantly reduced (p ≤ 0.001) with respect to the healthy control group. There was a trend of reduction of vessel density of the SCP and the DCP in the SDD and CD group with respect to controls, although this did not reach statistical significance.Conclusions: OCTA data in the present report corroborate the role of vascular damage in early AMD with CC impairment in the central macular area in eyes with SDD
FUTURE PERSPECTIVES IN NON-ADVANCED AGE-RELATED MACULAR DEGENERATION: FROM MULTIMODAL IMAGING APPROACH TO ESTABLISHING CORE OUTCOME MEASURES
No full textLa degenerazione maculare legata all'età (AMD) è la principale causa di perdita della vista nei paesi sviluppati e la sua prevalenza è destinata a crescere con l’aumento dell'aspettativa di vita. Questa tesi di dottorato si pone di studiare lo stadio precoce della malattia, durante la quale la capacità visiva è in gran parte preservata. Un eventuale trattamento precoce dell’AMD, con lo scopo di rallentarne la progressione, potrebbe evitare il declino visivo conseguente alla sua cronicizzazione.
Dopo un capitolo introduttivo dedicato ad una revisione della letteratura sull'AMD non avanzata, il primo studio clinico esplora il ruolo dell'imaging multimodale nella rilevazione precoce dell'invecchiamento retinico in soggetti sani, utilizzando una tecnica innovativa e non invasiva chiamata “retromode”. I risultati indicano che il retromode è in grado di identificare un numero significativamente maggiore di depositi sottoretinici (DLD) rispetto alla fotografia convenzionale del fondo oculare. Tuttavia, è importante evidenziare che questi DLD non si associano a biomarcatori di patologia, poiché la loro quantità aumenta fisiologicamente con l’età.
Il secondo studio valuta l'accuratezza e la riproducibilità di diverse modalità di imaging nel delineare l’area maculare interessata dalle pseudodrusen reticolari (RPD). I risultati indicano che la combinazione della tomografia a coerenza ottica (OCT) e riflettanza nel vicino infrarosso (NIR) rappresenta il metodo più affidabile per la rilevazione delle RPD.
Il terzo studio esamina la relazione tra il pigmento maculare (MPOV) e lo spessore dei singoli strati retinici, rilevando una correlazione con lo strato nucleare esterno (ONL). Si ipotizza che il ONL possa in un futuro fungere da biomarcatore per la valutazione dei livelli di pigmento maculare. Tuttavia, saranno necessari ulteriori dati per chiarire il legame tra AMD e MPOV.
Infine, è stato condotta un’analisi Delphi per stabilire un consenso tra un gruppo di esperti internazionali sugli outcome minimi da rilevare nella AMD non avanzata. Questo processo ha lo scopo finale di sviluppare un registro internazionale dedicato alla AMD non avanzata, che permetterà la raccolta di dati real life per migliorare la comprensione della progressione naturale della malattia e facilitare lo studio di potenziali interventi terapeutici.
Nel complesso, i risultati presentati in questa tesi offrono una solida base scientifica per un futuro approccio alla gestione dell’AMD non avanzata.Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in developed countries, and its prevalence is expected to rise due to increasing life expectancy. This doctoral dissertation focuses on the earlier stage of the disease, known as non-advanced AMD, during which vision is largely preserved. There is growing evidence that this stage should be targeted for early treatment to manage this chronic condition effectively.
Following a comprehensive literature review of non-advanced AMD, the first study explores the role of multimodal imaging in the early detection of retinal aging, using a novel, non-invasive technique called retromode imaging. The findings indicate that retromode imaging detects significantly more drusen-like deposits (DLDs) than conventional fundus photography in the maculae of healthy individuals. Importantly, these DLDs were not associated with pathological changes, as their frequency increased with normal aging.
The second study assesses the accuracy and reproducibility of imaging modalities in delineating reticular pseudodrusen (RPD) areas. The results identify the combined use of structural optical coherence tomography (OCT) and near-infrared reflectance (NIR) as the most reliable method for RPD detection.
The third study investigates the relationship between macular pigment optical volume (MPOV) and retinal layer thickness, suggesting that outer nuclear layer (ONL) thickness could serve as a biomarker for macular pigment levels. However, the need for further research into the effects of AMD on MPOV is emphasized.
Finally, a Delphi consensus process was employed to establish a minimum set of outcome measures for non-advanced AMD, paving the way for the development of an international, web-based registry. This registry will enable the collection of real-world data to enhance understanding of the disease’s natural progression and facilitate the evaluation of potential therapeutic interventions.
Overall, the findings presented in this dissertation provide a foundation for future research and clinical innovations aimed at earlier intervention and improved patient outcomes
Ophthalmic complications of Lemierre syndrome
Full text linkPurpose: Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome. Methods: We analysed data of 27 patients with ophthalmic complications from a large cohort of 712 cases with Lemierre syndrome reported globally between 2000 and 2017. We focused on initial manifestations, early (in-hospital) course and long-term ophthalmic deficits at the time of hospital discharge or during postdischarge follow-up. The study protocol was registered in the International Prospective Register of Systematic Reviews PROSPERO (CRD42016052572). Results: Nine (33%) patients were women; the median age was 20 (Q1–Q3: 15–33) years. Fusobacterium spp. was involved in 56% of cases. The most prevalent initial manifestations were decreased vision (35%) and periocular oedema (38%), followed by impaired eye movements/nerve palsy (28%) and proptosis (28%). Venous involvement, notably cerebral vein thrombosis (70%) and ophthalmic vein thrombosis (55%), explained the symptomatology in most cases. Septic embolism (7%), orbital abscesses (2%) and carotid stenosis (14%) were also present. Ophthalmic sequelae were reported in 9 (33%) patients, often consisting of blindness or reduced visual acuity, and nerve paralysis/paresis. Conclusion: Ophthalmic complications represent a severe manifestation of Lemierre syndrome, often reflecting an underlying cerebral vein thrombosis. Visual acuity loss and long-term severe complications are frequent. We call for an interdisciplinary approach to the management of patients with Lemierre syndrome and the routine involvement of ophthalmologists
Hundert Jahre Basler Friedenskongress (1912-2012) : die erhoffte "Verbrüderung der Völker"
Full text linkBilateral Implantation of Multifocal Intraocular Lenses: 10-Year Follow-Up
No full textPurpose To evaluate and compare the long-term results after bilateral implantation of different multifocal intraocular lenses (MIOLs).Methods This retrospective comparative study included 42 patients who underwent cataract surgery with bilateral MIOL implantation. Patients were divided into 5 groups: Group 1 received a refractive ReZoom NGX1 IOL (AMO), Group 2 a diffractive Acrysof ReSTOR SA60D3 IOL (Alcon), and Group 3 a diffractive Tecnis ZM900 IOL (AMO). Group 4 and Group 5 were implanted using the mix and match approach with refractive ReZoom-diffractive ReSTOR IOL and refractive ReZoom-diffractive Tecnis ZM900 IOL, respectively. Primary outcome measures were distance, near, and intermediate distance visual acuity measured 6 months (T0) and 10 years (T1) after surgery. Secondary outcomes were defocus curves, contrast sensitivity, patients' satisfaction, and spectacle independence.Results All patients achieved best-corrected distance visual acuity (BCDVA) greater than 0.11 logMAR and uncorrected distance visual acuity (UCDVA) greater than 0.14 logMAR at both time points. A decrease in contrast sensitivity was evident, particularly at high spatial frequencies; at T1, Group 4 reported statistically higher values than Group 2 at 12 cycles/degree and 18 cycles/degree and statistically higher values than Group 3 at 18 cycles/degree. Great overall satisfaction was reported even in the presence of dysphotopsia. Tecnis ZM900 IOL showed the lowest incidence of posterior capsular opacification.Conclusion MIOLs could provide adequate functional vision and patient satisfaction, despite the incidence of side effects, in carefully selected patients desiring spectacle independence
Changes in Anterior Segment Morphology and Intraocular Pressure after Cataract Surgery in Non-glaucomatous Eyes
No full textBackground It is known that cataract extraction is associated with a significant reduction in intraocular pressure, especially in narrow angled eyes; however, the modifications of anterior segment parameters associated with this phenomenon have still not been completely defined. The purpose of this study was to evaluate changes in anterior segment anatomy and intraocular pressure after cataract surgery in non-glaucomatous eyes.Methods and Material This retrospective case series study included 64 eyes of 64 consecutive patients who underwent phacoemulsification with intraocular lens implantation. Anterior segment parameters and intraocular pressure were assessed and compared before and 6 months after surgery. Anterior segment imaging was performed using Casia SS-1000 anterior segment optical coherence tomography (Tomey, Nagoya, Japan). Anterior segment measurements included anterior chamber depth, anterior chamber width, anterior chamber volume, angle opening distance at 500 mu m anterior to the scleral spur, angle recess area 750 mu m from the scleral spur, lens vault, trabecular iris space area at 500 mu m from the scleral spur, and trabecular iris angle at 500 mu m from the scleral spur. Intraocular pressure was measured using the Goldmann applanation tonometer (Model AT 900 C/M, Haag-Streit, Bern, Switzerland). Anterior segment parameters and the relationship of changes in intraocular pressure were also evaluated.Results All anterior segment parameters increased significantly after surgery (p < 0.05). Both angle opening distance at 500 mu m anterior to the scleral spur and anterior chamber depth changes were positively correlated with the preoperative lens vault. The mean intraocular pressure significantly decreased from 14.91mmHg (+/- 2.8 SD) to 12.91mmHg (+/- 3.13 SD) (p < 0.001). Changes in intraocular pressure correlated negatively with values for the width of the preoperative anterior chamber (r = - 0.533; p = 0.001).Conclusion Cataract surgery led to significant widening of the anterior chamber angle and lowering of intraocular pressure. Further investigations are needed to better understand whether anterior chamber width may be a new independent predictive factor for reduction in postoperative intraocular pressure
Dataset in support of the thesis 'The Effect of High-Fat Diet During Mouse Preimplantation and Pregnancy-Lactation on Uterine Fluid Protein Composition, Maternal Metabolism and Offspring Health''
No full textDataset and omic data from Thesis entitled: The Effect of High-Fat Diet During Mouse Preimplantation and Pregnancy-Lactation on Uterine Fluid Protein Composition, Maternal Metabolism and Offspring Health. Author: Irene Peral-Sanchez
The added dataset included raw data generated from the period from Oct 2019 to December 2023.
As explained in the thesis, the data were analyzed using SPSS syntax (hierarchical model) and Prism. The omics data (RNA seq and Proteomics) were additionally studied by String and Gene Ontology, apart from R (collaborators).
If any other questions or clarification is needed, contact the author or main supervisor. </span
Dynamics of Treatment Response to Faricimab for Diabetic Macular Edema
Full text linkThis study analyzes the dynamics of short-term treatment response to the first intravitreal faricimab injection in eyes with diabetic macular edema (DME). This retrospective, single-center, clinical trial was conducted at the Department of Ophthalmology, University Hospital Zurich. Patients with treatment-naïve and pretreated DME were included. Patient chart data and imaging were analyzed. Safety and efficacy (corrected visual acuity (CVA), central subfield thickness (CST), and signs of intraocular inflammation (IOI)) of the first faricimab intravitreal therapy (IVT) were evaluated weekly until 4 weeks after injection. Forty-three eyes (81% pretreated) of 31 patients were included. Four weeks after the first faricimab IVT, CVA remained stable and median CST (µm) decreased significantly (p p p = 0.002) between baseline and week 4 CST. Weekly safety assessments did not show any sign of clinically significant IOI. This study suggests faricimab is an effective treatment for (pretreated) DME, showing structural benefit 1 month following the first injection without short-term safety signals
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