1,720,992 research outputs found
Kad Hari Raya
No full textKad ucapan hari raya yang diutuskan kepada Profesor Diraja Ungku Abdul Aziz daripada Tengku Mohamed Taib, Zuraihan Idris, Farina, Ariff Azhar dan Reza Affend
Identification and characterization of copy number variations (CNVs) in dengue patients and its impact with vascular leakage / Zuraihan Zakaria
Full text linkDengue fever is a mosquito-borne tropical disease caused by dengue virus. When infected by any of the four serotypes of dengue viruses, individuals may be asymptomatic or develop a dengue fever. The latter group can progress into severe form of dengue and the etiology of this is still uncertain. This study aims to elucidate copy number variations (CNVs) of the host genes as the factor causing dengue pathogenesis. Blood samples were collected from hospitalized dengue patients and proceeded to DNA extraction. DNA samples (136) were used for genotyping with Human Genome GeneChip 6.0. CNVs were called using Genotyping Console (GTC) 4.1 and Nexus Copy Number 7.0. Results from both algorithms were merged and stringent CNVs were filtered with three public databases; DGV, HapMap3 and SGVP in search for rare case- specific CNVs. Casespecific underlying genes were used in functional analysis with DAVID and IPA to explicate the dengue related biological processes. Significant genes of interest from both softwares were validated using qPCR. Hundred and thirty-six DNA samples from hospitalized dengue patients in four different hospitals were genotyped. A total number of 50,864 (24,806 gains and 26,059 loss) and 34,257 (31,725 gains and 2,534 loss) CNV events were discovered by GTC and Nexus, respectively. After merging, only 3,052 (2,132 gain and 920 loss) stringent CNVs were left
Identification and characterization of copy number variations (CNVs) in dengue patients and its impact with vascular leakage / Zuraihan Zakaria
Full text linkDengue fever is a mosquito-borne tropical disease caused by dengue virus. When infected by any of the four serotypes of dengue viruses, individuals may be asymptomatic or develop a dengue fever. The latter group can progress into severe form of dengue and the etiology of this is still uncertain. This study aims to elucidate copy number variations (CNVs) of the host genes as the factor causing dengue pathogenesis. Blood samples were collected from hospitalized dengue patients and proceeded to DNA extraction. DNA samples (136) were used for genotyping with Human Genome GeneChip 6.0. CNVs were called using Genotyping Console (GTC) 4.1 and Nexus Copy Number 7.0. Results from both algorithms were merged and stringent CNVs were filtered with three public databases; DGV, HapMap3 and SGVP in search for rare casespecific CNVs. Case-specific underlying genes were used in functional analysis with DAVID and IPA to explicate the dengue related biological processes. Significant genes of interest from both softwares were validated using qPCR. Hundred and thirty-six DNA samples from hospitalized dengue patients in four different hospitals were genotyped. A total number of 50,864 (24,806 gains and 26,059 loss) and 34,257 (31,725 gains and 2,534 loss) CNV events were discovered by GTC and Nexus, respectively. After merging, only 3,052 (2,132 gain and 920 loss) stringent CNVs were left. After filtering with public known databases, of the 385 novel rare CNVs, 257 were specific for cases, and 128 were specific for controls, respectively (p = 0.388). Six hundred and eighty genes were found underlying the CNVs specific for cases and were eventually loaded into functional analysis softwares. GO terms from unbiased DAVID analysis such as defense response (p<0.001; Benjamini corrected p = 0.034), inflammatory response (p<0.001; Benjamini corrected p = 0.04) and response to cytokine stimulus (p<0.001; Benjamini corrected p = 0.038). From the biased IPA analysis, the candidate genes were clustered into enrichment with antigen presentation pathway as the most significant (p <0.001), followed by IL-12 signaling and production in macrophages (p <0.001), and interferon signaling (p <0.001). Genes from both significant GO terms and pathways; namely BCKDHB, CTSB, MR1, TAP2, TNFRS1B and CXCR4 were considered for validation using qPCR. The 9 out of 10 similarities between SNP 6.0 genotyping and qPCR supported the reliability of this assay. In conclusion, the rare CNVs may be involved in dengue pathogenesis. The rare CNV, which has been reported in other diseases (neuropsychiatric diseases, congenital heart disease and dilated cardiomyopathy), is reported for the first time in infectious diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The relationship between rewords and employee's motivation among employees at Tenaga Nasional Berhad, Jitra, Kedah Darul Naim / Nur Zuraihan Mohd Zahir
No full textThe aim of this study is to identify the relationship between rewards and employee's motivation among permanent worker at Tenaga Nasional Berhad (TNB) Jitra, Kedah Darul Aman. The selection of respondents will be based on stratified sampling where the respondents had been choosing randomly among the worker in TNB Jitra. The list of departments including staffs working under their department has been given by the administrative assistant of record department. In this study, questionnaire is used as data instruments for data collection. There are three sections in the questionnaire. In section A, the respondents are needed to provide information regarding their demographic profile such as gender, age, educational level and length of services in the organization. For section 8, respondents required to answer the questions relate to rewards which are focused on bonus and promotion
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