1,720,956 research outputs found
ENHANCEMENT OF HYDROGEN TITANATE NANOTUBES (HTNT) ADSORPTION OF METHELYNE BLUE (MB) BY USING MULTI WALLED CARBON NANOTUBES (MWCNT): A KINETIC STUDY
No full textWater is an essential resource for both the survival of life on Earth and the growth of civilization. The textile industry is one of the man-made ones that uses water and contaminates water sources
Elucidation of apoptotic pathway on human breast adenocarcinoma cell lines mediated by labisia pumila var. alata extract / Muhammad Faiz Zulkifli
Get PDFLabisia pumila, or locally known as Kacip Fatimah were widely used by women in Malaysia to treat post-partum illnesses. Due to the increase uses of complementary medicine in breast cancer patient, this herbaceous shrub has been exploited as a replacement to the conventional therapies. Many studies indicated that Labisia pumila exerts a wide range of biological activities, including the anti-proliferation effect. However, details of the mechanism were still poorly understood. Therefore, this study was conducted to elucidate the mechanism of Labisia pumila var. alata (Lpva) inducing anti-proliferative effect towards breast adenocarcinoma (MCF-7) cell lines and the underlying mechanism. The treated cells were subjected to viability assay (MTT assay), apoptosis assay (Flow cytometry), and protein expression (Western blot). Moreover, Lpva was also tested for its estrogenic activity (Molecular docking and estrogen binding assay). Aqueous extracts from Lpva showed anti-proliferative activities in a dose- and time-dependent manner (p>0.005). Flow cytometry analysis showed that the anti-proliferative effect of Lpva induced through the apoptosis pathway where the early apoptotic cell population increase from 20 % in 24 hours to 50% in 72 hours. Molecular docking simulation showed that Lpva phytochemical able to bind to estrogen receptors with diadzein gives the lowest affinity at -9.1 for both estrogen receptors alpha and beta, while estrogen binding assay proved that aqueous extract of Lpva able to bind to estrogen receptor alpha and estrogen receptor beta. Furthermore, estrogen antagonist, fulvestrant (ICI 182,780), proved that Lpva aqueous extract exerts their anti-proliferative effect through the estrogen receptors of MCF-7 cells. Western blot analysis showed that Lpva extracts induced apoptosis through both intrinsic and extrinsic pathways. Lpva significantly increase the expression of caspase 8 and 9 at IC50 and IC75 concentration with caspase 9 showed the highest expression (1.47 protein ratio at IC50 and 1.57 protein ratio at IC75) (p>0.01). Western blot analysis also suggested that Lpva down-regulated the expression of Bcl-2 at IC75 (0.38 protein ratio) and up-regulated the expression of pro-apoptotic protein Bax at IC50 and IC75 (0.64 and 1.14 protein ratio) (p>0.01). These results elucidate the mechanism of Lpva anti-proliferative effect on MCF-7 cells
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
