1,244 research outputs found
Interaction between ribosomes and SecYEG/YidC in bacteria
Elke levende cel wordt omgegeven door een membraan dat het binnenste van de cel scheidt van de omgeving. In het membraan bevinden zich eiwitten die functies uitvoeren die essentieel zijn voor het overleven van de cel.
Een centrale vraag is hoe deze membraaneiwitten in het membraan terechtkomen zonder dat de integriteit van de cel verloren gaat. Belangrijk inzicht hierin is met name verkregen door dit proces te bestuderen in bacteriën, waarin het op een vergelijkbare manier verloopt als in menselijke cellen. Membraaneiwitten worden in de cel gesynthetiseerd door ribosomen en vervolgens naar het in het membraan gelegen Sec-translocon gebracht. Naast het Sec-translocon kan ook het zogenaamde YidC insertase membraaneiwitten inserteren. Uit het proefschrift van Zht Cheng Wu blijkt dat de binding van ribosomen aan het Sec-translocon of het YidC insertase een kritische stap is gedurende de vroege stadia van membraaninsertie. Ribosomen binden alleen specifiek aan het Sec-translocon of YidC wanneer ze geladen zijn met nieuw aangemaakte membraaneiwitten. Sommige bacteriën beschikken over meerdere YidC insertases met verschillende functies. Anders dan voorheen werd gesuggereerd blijken deze YidC insertases op een gelijke manier ribosomen te binden. De functionele verschillen moeten daarom gelegen zijn in substraatspecificiteit en niet in het werkingsmechanisme. Deze nieuwe inzichten zijn van belang voor, bijvoorbeeld, de verdere ontwikkeling van antibiotica gericht tegen het membraaneiwit insertie proces, een activiteit die essentieel is voor de levensvatbaarheid van de cel.
Every living cell is surrounded by a membrane that separates the inside of the cell from the environment. Embedded in this membrane are proteins that fulfill functions that are essential for the survival of the cell. A central question is how these membrane proteins are incorporated in the membrane without compromising the integrity of the cell. Insight in this membrane insertion process is largely obtained by studies in bacteria, where it occurs in a similar way as in human cells. Membrane proteins are synthesized at ribosomes inside the cell and subsequently transferred to the membrane embedded Sec-translocon. In addition to the Sec-translocon also the so-called YidC insertase can insert membrane proteins. The thesis of Zht Cheng Wu shows that binding of ribosomes to the Sec-translocon or YidC insertase is a critical step during the early stages of membrane protein insertion. Ribosomes only bind specifically to the Sec-translocon or YidC insertase when they are charged with newly synthesized membrane proteins. Some bacteria have multiple YidC insertases with different functions. In contrast to previous suggestions, these YidC insertases appear to bind ribosomes in a similar fashion. Therefore the functional difference between these YidC insertases must be due to their substrate specificity rather than their mechanism of membrane insertion. These new insights are important for further development of antibiotics against the membrane insertion process, an activity that is essential for the survival of the cell.
Shuai bian an wu zhi mo xing xia de yu zhou jie gou yan hua
Cheng, Dalong = 衰變暗物質模型下的宇宙結構演化 / 程大龍.Thesis Ph.D. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 105-115).Abstracts also in Chinese.Title from PDF title page (viewed on 26, October, 2016).Cheng, Dalong = Shuai bian an wu zhi mo xing xia de yu zhou jie gou yan hua / Cheng Dalong
Ju he wu tai yang neng dian chi de jie mian gong cheng yan jiu
Zheng, Shizhao = 聚合物太阳能电池的界面工程研究 / 鄭世昭.Thesis Ph.D. Chinese University of Hong Kong 2014.Includes bibliographical references.Abstracts also in Chinese.Title from PDF title page (viewed on 10, November, 2016).Zheng, Shizhao = Ju he wu tai yang neng dian chi de jie mian gong cheng yan jiu / Zheng Shizhao
[[alternative]]The Effect of Wai Tan Kung Exercise on Energy Expenditure And Heart Rate Variability
[[abstract]]The Effect of Wai Tan Kung Exercise on
Energy Expenditure And Heart Rate Variability
Graduate student: Cheng-Kun Wu
Advisor: Cheng-Chung Lin ,Ph.D.
Abstract
The purpose of the present study was to investigate the effect of long-term Wai Tan Kung exercise on heart rate (HR), energy expenditure, oxygen uptake (VO2), ventilation (VE), heart rate variability and blood pressure. Two different groups of older adults were recruited. One group subjects (n =16; 65.0 ± 4.2 yrs, 163.3 ± 7.3 cm, 63.3 ± 7.3 kg) had been participated at least 10 years of regular Wai Tan Kung exercise (long-term group, LTG), and the other (n = 16; 59.0 ± 3.7 yrs, 162.0 ± 3.9 cm, 65.7 ± 3.6 kg) had been participated as same exercise as LTG but less than one year (short-term group, STG). The results of this study showed that there were significant differences (p < .05) in rest systolic pressure, and HR, energy expenditure, VO2, VE, high frequency power (HFP) and low frequency power (LFP) during exercise between LTG and STG (p < .05). LTG subjects had a significant lower in rest heart rate and blood pressure (p < .05) than STG subjects, and the former also reached higher (p < .05) exercise intensities during exercise testing than the latter. Moreover, there were significant higher heart rate, VO2 and VE during exercise testing for LTG than STG, suggesting that LTG subjects had higher metabolic rate. Additionally, LTG had a higher HFP than STG, suggesting that there was a significant increase in parasympathetic division of autonomic nervous activity during exercise testing for LTG than STG, indicating LTG subjects may prevent from coronary artery disease and improve functions of the heart. It is concluded that older adults participate in regular long-term of Wai Tan Kung exercise have a positive effect on their cardiovascular fitness. Therefore, such kind of exercise may especially fit for older adults.
Key words: oxygen uptake (VO2), ventilation (VE), heart rate, heart rate variability, Wai Tan Kung exercise.
A quantitative model in dialect subgrouping: The case of modern Wu dialects
This thesis is intended to present a new model for the comparative study of dialects with the quantitative measurements, and under this new model, the subgrouping of the Modern Wu dialects, one of the major groups of Chinese dialects, is carried out, based on the syllable initials.An overview is given on the previous approaches in the literature of the dialectology--namely, the traditional approach, structural approach and generative approach. Each approach has been applied to the case of the Wu dialects to accomplish the task of subgrouping. But none of them can overcome the difficulty of synthesizing the isoglosses, since they ignore the concrete processes of sound changes, and thus fails to determine the degree of associations among a number of related dialects. To study the sound change in process, based on the theory of lexical diffusion, initials a new route for quantitative study into dialect comparison.Following the methodology in Hsieh (1977), Cheng (1982), Lu and Cheng (1985), Cheng (1986, 1988), Lu (1986a, 1987a, 1987b, 1987c, 1988, 1989, 1990), the thesis proposes a new model, namely, the systematic quantitative comparative model. Since sound change is carried out by means of lexical items, the comparison of quantity of the influenced lexical items in the course of sound change will reveal the degree and scope of sound change in process. Under this new model, the syllable initials of more than 2,700 characters pronounced in 33 localities of the Wu dialects are collected and grouped with the reference of the Ancient Chinese to provide a large database for the systematic comparison. Then, the procedure designed for dialect comparison, which includes correlational analysis, cluster analysis and principal components analysis, is followed to carry out the subgrouping of these 33 localities. The results are presented and discussed.Made available in DSpace on 2011-05-07T12:28:31Z (GMT). No. of bitstreams: 2
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Effect of music therapy on the pressure pain threshold, cognitive function, and emotion: a randomized controlled trial
Corresponding author: *Yu Fang, Shanghai University of Engineering Science, Shanghai, China *Xueqiang Wang, School of Kinesiology, Shanghai University of Sport, Shanghai, China† Kailimi Li and Cheng-Cheng Wu made equal contributions to this manuscriptThe original data of characteristics of Participants, pressure pain threshold, Color-Word Stroop test, the Self-Assessment Maniki ScoreTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Phoebus 6, number 2: Chinese Painting under the Qianlong Emperor
tableOfContents: Preface p. 207
Figure, Fiction and Figment in Eighteenth century Chinese Painting by Richard Vinograd p. 209
Yuan Jiang: Image Maker by Alfreda Murck p. 228
Zheng Xie's Price List: Painting as a Source of Income in Yangzhou by Ginger Cheng-chi Hsu p.261
Jin Nong: The Eccentric Painter with a Wintry Heart by Marshall P. S. Wu p. 272
An Overview of Li Jian's Painting by Christina Chu p. 295
Eighteenth-century Foundations in Modern Chinese Painting by Chu-tsing Li p. 316
Epilog: Rubric and Art History - The Case of the Eight Eccentrics of Yangzhou
by Ju-hsi Chou p.329
Notes p. 351
Glossary p. 381
Index p. 39
Flood prevention on the lower reaches of the Rellow River
Proceedings of a congerence in Zhenzhou, China, 1990: Gong Shiyan, Wu Zhiyao: Introduction. Bao Zicheng, Zhang Mingde, Wang Rudiu: Strenghtening of dykes by Warping. Cheng Zidao, Liu Yuli: To remedy hidden defects in dykes by probing with pointed steed rods and subsequent grouting. Hu Yisan: River training works on the lower reaches of the Yellow River. Shen Hongxin, Xu Fuling: Engineering structures for river correction on the lower reaches of the Yellow River. Bao Xicheng, Zho Guangming, Wang Hongxiang: Ice dam on the lower reaches of the Yellow River. Liu7 Ruyun, Tong Linlang: Organizing for flood protection on the lower reaches fo the Yellow river. A brief account of Dongpinghu detention reservoir
Tao Xingzhi ge qu. I
Side A. 1. 捧著一顆心來不帶半根草去(一)(二) ; 2. 在我的世界里小孩青年最大 ; 3. 一群小好漢(一)(二) ; 4. 追悼慈母歌 ; 5. 梅香苦 ; 6. 三代 ; 7. 朝陽歌 ; 8. 小庄晓 ; 9. 问江 ; 10. 诗的学校 ; 11. 紀念牛頓与伽利略 ; 12. 拉車 ; 13. 马克思颂 ; 14. 跟青年學 ; 15. 歌唱现代 ; 16. 寂寞 ; 17. 爱国歌 ; 18. 科学的春天 ; 19. 小小徽机真灵巧 ; 20. 玩科学把戏真有趣 ; 21. 水姑娘午曲 -- Side B. 1. 大哉陶子 ; 2. 哭陶先生 ; 3. 我是中国人 ; 4. 國民與我 ; 5. 人民教师我爱你 ; 6. 我们的青春常在 ; 7. 千教万教教人求真, 千学万学学做真人 ; 8. 我要看看世界 ; 9. 今天 ; 10. 少年 ; 11. 我的小怀抱 ; 12. 看荷花舞 ; 13. 人的体操 ; 14. 问到底 ; 15. 立大志, 求大智, 做大事 ; 16. 团结御侮文体 ; 17. 民之所好三首 ; 18. 诗人节祝词 ; 19. 只道早还乡 ; 20. 好了歌 ; 21. 中国小孩子过新年 ; 22. 教师歌 ; 23. 忠心之歌 ; 24. 我爱有趣的谈天会 (未录完).陶城曲 ; 陶城演唱 ; 杜鳴心, 陳貽鑫, 巫漪丽鋼琴演奏.Possibly reproduced from other commercial recording or radio broadcast (Pending for review)"如蘭, 學鐄教授惠存: 陶城, 陳樹新贈, 1988.8.26"--Side A.Electronic reproduction from Rulan Chao Pian Audio Cassette Collection.Composer : 陶城.Singer : 陶城 ; Piano : 杜鳴心, 陳貽鑫, 巫漪丽.Sung in Chinese.Tao Cheng qu ; Tao Cheng yan chang ; Du Mingxin, Chen Yixin, Wu Yili gang qin yan zou."Rulan, Xuehuang jiao shou hui cun: Tao Cheng, Chen Shuxin zeng, 1988.8.26"--Side A.Composer, Tao Cheng.Singer: Tao Cheng ; Piano: Du Mingxin, Chen Yixin, Wu Yili.Detailed contents in vernacular field only
Bei Song li xue de guan wu gong fu.
漢字的「觀」指的不僅是一種身體的知覺能力,其為視覺活動背後包涵了豐富的心靈活動,讓事物呈現更深邃的面向。「觀物」在北宋以前一直潛伏於儒家的語脈當中,尚未成為一個突出的概念,直到邵康節始點化出來作顯題處理, 直指一種窮理體道的活動。與邵康節並世的周濂溪、張橫渠和二程兄弟都分別有觀窗前草、觀驢鳴、觀雞雛、觀魚游等的雅事為人所樂道。觀物不僅是理學家的休閒活動,更和他們的道德修養息息相關,悠然帶著成德工夫的意味。有見及此,一、我們可以探討北宋理學中的觀物在什麼意義下是一種修道的工夫;二、以觀物工夫切入北宋五子,可以提供一個新的角度審視理學的發展 。The Chinese character Gun (Cantonese) or Guan (Mandarin) entails not only our physical sensibility, the visual activity itself also unfolds a rich exercising of the mind, revealing a dimension lying in the depth of objects. Before Northern Song, the concept of Guan Wu (Deep Viewing of Things) has been latent in the Confucius linguistic context. It has not been a significant concept until highlighted by Master Shao Yong, who argued that this is an activity of articulating and embodying the truth. Other four contemporaries of Master Shao Yong, namely Zhou Dunyi, Zhang Zai, Cheng Hao and Cheng Yi, were acclaimed for the engagements in the deep viewing of different entities: the deep viewing of the grass before window, the deep viewing of a donkey braying, the deep viewing of the chicks and the deep viewing of the swimming fish. Guan Wu is not only a pastime to the Neo-Confucianists, it is also closely related to their own self-cultivation with a hint of manifesting Dao aplomb. In view of this, this thesis aims to, firstly, examine to what understanding is Guan Wu (Deep Viewing of Things) a way of self-cultivation in Northern Song Neo-Confucianism. Secondly, it shall argue that understanding the five masters of Northern Song through the self-cultivation of Guan Wu can provide a new perspective in examining the development of Neo-Confucianism.Detailed summary in vernacular field only.鄧康宏.Thesis (M.Phil.) Chinese University of Hong Kong, 2014.Includes bibliographical references (leaves 162-163).Abstracts in Chinese and English.Deng Kanghong
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