261,373 research outputs found
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Pseudo-spin-valve with L 10 (111)-oriented FePt fixed layer
No full textRecently we proposed a spin torque oscillator where the fixed layer has its magnetization easy-axis tilted with respect to the film plane to simultaneously achieve zero-field operation and high output power [Y. Zhou, C. L. Zha, S. Bonetti, J. Persson, and J. Åkerman, Appl. Phys. Lett. 92, 262508 (2008)]. Here we take the first step toward the realization of this device and fabricate successfully a pseudo-spin-valve using an L 10 (111)-oriented FePt fixed layer with tilted magnetocrystalline anisotropy. A total magnetoresistance (MR) of 0.86% is experimentally observed for the standard pseudo-spin-valve of the L 10 FePt/Cu/NiFe structure in applied fields up to 1.5 T. While part of the MR may originate from the FePt film alone, the dominating part of MR correlates with switching of the NiFe free layer. © 2009 American Institute of Physics.link_to_subscribed_fulltex
LEI, J.Q., CAI, J., ZHOU, S.D. & HE, X.J. (2023) Ligusticopsis miyiensis (Apioideae, Apiaceae), a new combination from China revealed by morphological and molecular evidence. Phytotaxa 591 (4): 273-282.
No full textLei, J.Q., Cai, J., Zhou, S.D., He, X.J. (2023): LEI, J.Q., CAI, J., ZHOU, S.D. & HE, X.J. (2023) Ligusticopsis miyiensis (Apioideae, Apiaceae), a new combination from China revealed by morphological and molecular evidence. Phytotaxa 591 (4): 273-282. Phytotaxa 592 (2): 178-178, DOI: 10.11646/phytotaxa.592.2.12, URL: http://dx.doi.org/10.1094/PDIS-04-22-0755-PD
Unveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora [Erratum]
No full textLi B, Liu J, He C, Deng Z, Zhou X, Peng R. J Inflamm Res. 2024;17:10849—10869.
The authors have advised the second listed corresponding author, Zhou Deng, is incorrect. The correct corresponding author is Xiaohong Zhou. The remaining details are correct.
This error was introduced by the Editorial staff during the publication process
DMM Prize 2018 winner: Wenqing Zhou
No full textDisease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Prize 2018 is Wenqing Zhou, for her paper entitled ‘Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish’ (Zhou et al., 2018a). The prize of $1000 is awarded to the first author of the paper that is judged by the journal's editors to be the most outstanding contribution to the journal that year. To be considered for the prize, the first author must be a student or a postdoc of no more than 5 years standing
A Corrected Proof of the Stochastic Verification Theorem within the Framework of Viscosity Solutions
No full textWe present a full and corrected proof of the stochastic verification theorem that was first obtained by Zhou, Yong, and Li [SIAM J. Control Optim., 35 (1997), pp. 243--253]
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