1,728,490 research outputs found
Copper-mediated transformation of organosilanes to nitriles with DMF and ammonium iodide
No full textCyanation of aryl-, diaryldimethyl-, and styrylsilanes was developed for the first time under copper-mediated oxidative conditions using ammonium iodide and DMF as the combined source of nitrogen and carbon atom of the introduced cyano unit, respectively. The reaction was observed to proceed in a two-step process: initial conversion of organosilanes to their iodo intermediates and then cyanation. This method has a broad substrate scope with high functional group tolerance. © 2013 American Chemical Society.143451sciescopu
A study of "One-carbon metabolism supports S-Adenosylmethionine and histone methylation to drive inflammatory macrophages". Weiwei Yu, Zhen Wang, Kailian Zhang et al.
No full textActivated macrophages adapt their metabolic pathways to drive the pro-inflammatory phenotype, but less is known about the mechanistic basis for this process. Here we find that lipopolysaccharide (LPS) activates glycolysis offshoots pentose phosphate pathway (PPP), serine synthesis pathway (SSP), and one-carbon metabolism, whose synergism drives epigenetic reprogramming for the expression of interleukin-1β (IL-1β) but not tumor-necrosis factor-α in pro-inflammatory macrophages. In contrast to predominantly supporting nucleotide synthesis for rapidly dividing cells, one-carbon flux synergistically supported by glucose and serine metabolism integrate into methionine cycle through de novo ATP synthesis, and fuels the generation of S-adenosylmethionine (SAM) in pro-inflammatory macrophages. Impairments of these metabolic pathways or depletions of exogenous amino acids that feed SAM generation lead to anti-inflammatory outcomes, implicating SAM as a key immunometaboite during LPS-induced inflammation. Mechanistically, SAM generation and its controlled SAM/SAH ratio coordinately support histone H3 lysine 36 trimethylation (H3K36me3) to promote IL-1β production in response to LPS. We therefore identify a synergistic effect of glucose and amino acids metabolism on orchestrating SAM availability that is intimately link to the chromatin state for LPS-induced inflammation. The datasets mainly includes all the Western Blotting images used in the article. The ".jpg" files are named after figure identifier plus name of bloting protein, for example, "1A Actin.jpg" stands for the protein Actin of Figure 1A. The ".pptx" files consist of the labeled figure panel and some small descriptions. Every figure has a independent zip file, which involved all the ".jpg" and ".pptx" files associated with the corresponding figure in the article
Supplementary data - Supplemental material for Study in Pesticide Activities of <i>Polygonum cuspidatum</i> Extracts and its Active Ingredient Resveratrol
No full textSupplemental material, Supplementary data, for Study in Pesticide Activities of Polygonum cuspidatum Extracts and its Active Ingredient Resveratrol by Wenqiang Yang, Fenglu Li, Xiaoyi Xing, Zhen Wang, and Xiuling Yu in Natural Product Communications</p
sj-docx-1-pwq-10.1177_03616843241242711 - Supplemental material for Chinese Negative Reactions to Positive Gender Stereotypes: A Perspective of Psychological Reactance Theory
No full textSupplemental material, sj-docx-1-pwq-10.1177_03616843241242711 for Chinese Negative Reactions to Positive Gender Stereotypes: A Perspective of Psychological Reactance Theory by Zhen Wang, Li Zhao, Guoguo Zuo and Jian Guan in Psychology of Women Quarterly</p
Supplemental material for Influence of Line Pair Selection on Flame Tomography Using Infrared Absorption Spectroscopy
No full textSupplemental Material for Influence of Line Pair Selection on Flame Tomography Using Infrared Absorption Spectroscopy by Kin-Pang Cheong, Liuhao Ma, Zhen Wang and Wei Ren in Applied Spectroscopy</p
sj-docx-1-eeg-10.1177_15500594211058260 - Supplemental material for QEEG Biomarkers for ECT Treatment Response in Schizophrenia
No full textSupplemental material, sj-docx-1-eeg-10.1177_15500594211058260 for QEEG Biomarkers for ECT Treatment Response in Schizophrenia by Jiayue Cheng, Yanyan Ren, Qiumeng Gu, Yongguang He and Zhen Wang in Clinical EEG and Neuroscience</p
sj-pdf-1-pid-10.1177_09544070231205063 – Supplemental material for Study on dynamic prediction method for degradation state of electric drive system based on deep learning and uncertainty quantification
No full textSupplemental material, sj-pdf-1-pid-10.1177_09544070231205063 for Study on dynamic prediction method for degradation state of electric drive system based on deep learning and uncertainty quantification by Zhen Wang, Lihui Zhao, Dongdong Zhang and Chuliang Yan in Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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