2,493 research outputs found
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
No full text14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid duplex. Comparison between the solution structure of 2′F-ANA•RNA and ANA•RNA hybrids indicates that the increased binding affinity of 2′F-ANA is related to several subtle differences, most importantly a favorable pseudohydrogen bond (2′F-purine H8) which contrasts with unfavorable 2′-OH-nucleobase steric interactions in the case of ANA. While both 2′F-ANA and ANA strands maintained conformations in the southern/eastern sugar pucker range, the 2′F-ANA strand's structure was more compatible with the A-like structure of a hybrid duplex. No dramatic differences are found in terms of relative hydration for the two hybrids, but the ANA•RNA duplex showed lower uptake of counterions than its 2′F-ANA•RNA counterpart. Finally, while the two hybrid duplexes are of similar rigidities, 2′F-ANA single strands may be more suitably preorganized for duplex formation. Thus the dramatically increased stability of 2′F-ANA•RNA and ANA•RNA duplexes is caused by differencesin at least four areas, of which structure and pseudohydrogen bonding are the most important. © The Author(s) 2010. Published by Oxford University Press.Spanish Ministerio de Ciencia e Innovacion (grants
CTQ2007-68014-C02-02 to CG and BIO2009-10964 to
MO); Fundacion Marcelino Botin (grant to MO);
Canadian Institutes for Health Research (grant to
M.J.D.); Natural Sciences and Engineering Research
Council of Canada (postgraduate scholarship to
J.K.W.). Funding for open access charge: Canadian
Institutes for Health Research
Perioperative Goal-Setting Consultations by Surgical Colleagues: A New Model for Supporting Patients, Families, and Surgeons in Shared Decision Making
No full textPatients with postoperative complications are often subjected to prolonged life-sustaining treatment based on erroneous assumptions about their goals of care. Shared decision making is an evidence-based approach that helps ensure patients’ wishes and values are honored in their course of treatment. Perioperative palliative care can help create goal-concordant trajectories of care for high risk, seriously ill, or complicated patients, through sophisticated prognostication, higher-level communication, and recommendations based on the best available evidence and patients’ stated goals and priorities. Here, we present a surgeon-to-surgeon consultative model that surmounts many barriers to perioperative palliative care consultation and, as illustrated in the cases presented herein, offers profound and unique benefits for patients, families, and surgeons alike. While the support of a surgical colleague with palliative care skills can be helpful postoperatively in the setting of unanticipated outcomes or prolonged recovery, it is particularly beneficial when accessed preoperatively for the purposes of goal-concordant decision making and advance care planning. We encourage both individuals and professional societies to develop and expand the niche for surgeons interested in assisting with goal setting and shared decision making for patients on a consultative basis, particularly in the preoperative period
Determining the need for an expanded fitness component in the Fire Science Program at Milwaukee Area Technical College
No full textIncludes bibliographical references
Efeito Ana C. : presença de Ana Cristina Cesar na poesia contemporânea brasileira
No full textOrientadora: Sandra M. StroparoDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Humanas, Programa de Pós-Graduação em Letras. Defesa : Curitiba, 31/05/2021Inclui referências: p. 141-151Área de concentração: Estudos LiteráriosResumo: A poeta carioca Ana Cristina Cesar é entendida como uma referência para diversos escritores contemporâneos em atuação. Sabendo disso, o presente trabalho procura investigar como o efeito da obra da poeta marginal opera na produção de seus herdeiros, partindo de três aspectos marcantes identificados na poética de Ana C.: linguagem, corpo e feminilidade. Para isso, foram analisadas as obras de dez escritores: Alice Sant'Anna, Ana Martins Marques, Angélica Freitas, Armando Freitas Filho, Ismar Tirelli Neto, Júlia de Carvalho Hansen, Laura Liuzzi, Marcos Siscar, Marília Garcia e Nina Rizzi. Escolheu-se, então, a metodologia de entrevistas, bem como a análise dos textos poéticos dos autores, de modo a compreender os dispositivos explorados pela poeta marginal na escrita contemporânea. Comparando os textos de Ana Cristina Cesar com a obra de seus herdeiros, é possível notar que essa presença produz uma forma de enunciação mais livre e permeada pela intimidade. Para a contextualização da obra da poeta, utiliza-se como base os trabalhos de Ítalo Moriconi (1996), Maria Lucia de Barros Camargo (2003) e Annita Costa Malufe (2010 e 2011). Como fundamentação teórica do efeito, recorreu-se a obra de Wolfgang Iser, em O ato da leitura (1996), que analisa a experiência da recepção do texto a partir dos efeitos de leitura que ele produz. Além disso, de modo a entender as relações que a poesia contemporânea estabelece com a tradição literária, recorreu-se às fundamentações de Marjorie Perloff, em O gênio não original: poesia por outros meios no novo século (2013). Identificando uma linhagem estética da poesia de Ana Cristina Cesar, é possível compreender os modos como sua escrita autorizou a experimentação de certas práticas poéticas, utilizando-se da escrita missiva, da intimidade e da alteridade.Abstract: Ana Cristina Cesar is understood as a reference for several contemporary writers. The present work seeks to investigate the effect of the poet's work in the works of her heirs, starting from three striking aspects identified in Ana C.'s poetry: language, body and femininity. With that in mind, we analyzed the works of ten poets: Alice Sant'Anna, Ana Martins Marques, Angélica Freitas, Armando Freitas Filho, Ismar Tirelli Neto, Júlia de Carvalho Hansen, Laura Liuzzi, Marcos Siscar, Marília Garcia and Nina Rizzi. We chose the methodology of interviews, as well as the analysis of the each author's poetry, in order to understand the devices explored by the marginal poet in contemporary writing. Comparing the texts of the marginal author with the work of her heirs, it is possible to notice that this presence produces a freer and more intimate form of enunciation. For the contextualization of her poetry, the works of Ítalo Moriconi (1996), Maria Lucia de Barros Camargo (2003) and Annita Costa Malufe (2010 and 2011) are used as a basis. As a theoretical basis for the effect, we used the work of Wolfgang Iser in The act of reading (1996), which analyzes the experience of reception from the reading effects the text produces. In order to understand the relationships that contemporary poetry establishes with literary tradition, we took Marjorie Perloff's foundations in Unoriginal genius: poetry by other means in the new century (2013). By identifying an aesthetic lineage of Ana Cristina Cesar's poetry, it is possible to understand the ways in which her writing authorized the experimentation of poetic practices, using missive writing, intimacy and otherness
Stages for the More Sustainable Farm
No full textCurrently, agricultural farm units are faced with a double and most times contradictory challenge, in order to be successful: on the one hand the invested capital has to be profitable and the economic performance has to be maximised. On the other hand, given the socio-environmental situation, it is necessary to preserve and to protect the environment and natural resources. Given the potential conflict of the two aims, since the satisfaction of one implies the underperformance of the other (and vice versa), the question then is: which is the solution to choose? We intend, in this work, to formulate a farm plan with the purpose of reconciling the criteria of environmental sustainability with that of economic competitiveness. For this achievement we proceed to the comparative study of sustainability of different groups of farms identified in the study area (first evaluation cycle) through MESMIS (“Marco para la Evaluación de Sistemas de Manejo de Recursos Naturales Mediante Indicadores de Sustentabilidad” - Framework for Evaluation of Natural-Resource Systems Handling through Sustainability Indicators) methodology, that allowed to select the more sustainable group of farms. Based on the found potentialities and weakness on these production systems, we stepped to the planning of a production unit of bovine meat, which obeys simultaneously to economic and environmental objectives, using Multicriteria Decision. We finished the work with the sustainability evaluation between groups of farms identified previously and the planned farms (second evaluation cycle), based, again, in the MESMIS methodology, to confirm (or not) the greatest sustainability of the last ones. Analyses of the results allow us to confirm the greatest relative sustainability of the planned farm, for the diverse traced scenarios.Decision taking, planning, sustainability, Environmental Economics and Policy, Farm Management,
The cinematographic cut in Ana Cristina Cesar
No full textThis article analyzis the cut procedures that we find in some poems of the Brazilian Ana Cristina Cesar (1952-1983). Author of an extremely fragmentary poetry, Ana C. constructed her workmanship very close to the artistic vanguards of the XX century, including the most experimental cinema. Our objective is to observe how the poet constructs the fragmentation in her poetry, keeping, at the same time, a singular fluency between the fragments; fluency that would not be narrative, but that approaches her poems to a certain cinematographic way of composition and experience
Tagging of Biomedical Articles on CiteULike: A Comparison of User, Author and Professional Indexing
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and professional indexers. User tags, author keywords and descriptors were collected from academic journal articles, which were both indexed in Pubmed and tagged on CiteULike, and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the use of keywords between the three groups in addition to similarities which can be used to enhance support for search and browse. While tags and author keywords were found that matched descriptors exactly, other terms which did not match but provided important expansion to the indexing lexicon were found. These additional terms could be used to enhance support for searching and browsing in article databases as well as to provide invaluable data for entry vocabulary and emergent terminology for regular updates to indexing systems. Additionally, the study suggests that tags support organisation by association to task, projects and subject while making important connections to traditional systems which classify into subject categories
"Eres sol con muchos rayos": la subversión heliocéntrica en "Valor, agravio y mujer" de Ana Caro
No full textThis article examines the Sun metaphor in the Spanish drama Valor, agravio y mujer (c. 1630) by Ana Caro. The study proposes that this female author deviates from literary convention (based on the Ptolemaic model) in order to incorporate the Heliocentric paradigm, thus giving voice to a subversive discourse by which a female character becomes the symbolic center of the ficcional universe.
Keywords: sun, heliocentrism, feminism, comedia, Ana Caro.Este artículo examina la metáfora del Sol en la comedia Valor, agravio y mujer (c. 1630) de Ana Caro, proponiendo que la autora se desvía de la convención (basada en el modelo ptolemaico) para incorporar el paradigma heliocéntrico, dando así voz a un discurso subversivo por el que la mujer se constituye en centro simbólico del universo ficcional de los personajes.
Palabras clave: sol, heliocentrismo, feminismo, comedia, Ana Caro
El Tlacuache Núm. 305 (2008). 305 Año 9 (2008) marzo. El Tlacuache
No full textOfrenda del centro ceremonial de Tepoztlán por Ana Emma Peña Rodríguez y Giselle Canto Aguilar. - El estudio de la tecnología prehispánica a través de la arqueología experimental por Emiliano Ricardo Melgar Tísoc. - Patrimoio Cultural en Imágenes
Ana Cristina Cesar e Sophie Calle: pistas e despistas
No full textIn Ana Cristina Cesar and Sophie Calle: clues and clues, the focus is given to the detective aspect of the works of Sophie Calle and Ana Cristina Cesar. The works Detective (CALLE, 1980) and Suite Vétinienne (1984), both by the artist Sophie Calle, are associated with Poe's Man in the Crowd (2010) and Baudelaire's The Painter of Modern Life (2010). The author Hugo Friedrich in Structure of the modern lyric (1991) has the role of helping the reading of works by Ana C. and Calle from their reflection on the Baudelairean method of “fantasy guided by the intellect” and “enthusiastic excitement” designed by Edgar Allan Poe. Ana Cristina Cesar's poetics is placed in the detective aspect when the poet cites several references in the body of her text leaving clues for her readers to identify (or not) excerpts from poems, works of art, songs, among others that she points out in her poetics.Em Ana Cristina Cesar e Sophie Calle: pistas e despistas, o enfoque é dado ao aspecto detetivesco das obras de Sophie Calle e Ana Cristina Cesar. Os trabalhos Detective (CALLE, 1980) e Suite Vétinienne (1984), ambos da artista Sophie Calle, são associados ao Homem na Multidão (2010), de Poe e o Pintor da Vida Moderna (2010), de Baudelaire. O autor Hugo Friedrich em Estrutura da lírica moderna (1991) tem o papel de auxiliar a leitura de trabalhos de Ana C. e de Calle a partir da sua reflexão sobre o método baudelairiano da “fantasia guiada pelo intelecto” e a “excitação entusiástica” concebida por Edgar Allan Poe. A poética de Ana Cristina Cesar é colocada no aspecto detetivesco quando a poeta cita várias referências no corpo de seu texto deixando pistas para seus leitores identificarem (ou não) trechos de poemas, obras de arte, músicas, dentre outros que ela aponta em sua poética
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