167 research outputs found
R from Zero to Hero (Arabic)
No full textThis is a course designed by Batool Almarzouq and delivered in JeelAIDM. All Materials are licensed under CC-BY license. CC-BY license means you can re-use, modify and build upon the materials with attribution to the source. The course is delivered over six weeks, with two sessions each week, each lasting two hours.
Week
Session
1
Introduction to R and Open Science
1
Project Management
2
R Markdown
2
GitHub in RStudio
3
Tidydata
3
Tidyverse
4
ggplot2 Part 1
4
ggplot2 Part 2
5
YAML in R Markdown
5
Blogging in R
6
Reproducibility with renv
6
Create your first R package!
The Slides are accompanied by live coding in this GitHub repository associated.The author acknowledges JeelAIDM for making the materials ope
Erratum: Cloaking using anisotropic multilayer circular cylinder (AIP Advances (2020) 10 (095312) DOI: 10.1063/5.0012769)
No full textCo-author Mehwish Nisar should have had an additional affiliation noted in the byline of our original manuscript.1 The correct affiliations for this manuscript are as listed above
Knowledge, Attitude and Awareness of Hepatitis B Vaccination in Patients Visiting Jinnah Postgraduate Medical Center, Karachi
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Importance of Raised Serum Homocysteine Levels in Ischemic Stroke Patients
No full textBackground: Around 5.5 million people die from stroke each year, making it the second leading cause of mortality worldwide.
Increased homocysteine levels lead to early neurological deteriorations in ischemic stroke and may have an association with other
risk factors of stroke.
Objective: To determine how closely homocysteine levels are associated with other risk factors for ischemic stroke.
Methods: This is a cross-sectional study, which was performed in the Department of Neurology, Liaquat National Hospital, Karachi
from January to December 2021. All ischemic stroke patients of either gender above the age of 16 were included. Ischemic stroke
was identified by neuroimaging MRI in patients presenting with focal neurological deficits lasting more than 24 hours. For statistical
analysis, data was entered into SPSS version 21.
Results: A total of 100 patients were included in the study with a mean age of 56.8 ± 15.6 years. Most of the patients were males
(65%). Hypertension and diabetes were present in 76% and 42% of patients respectively. 45% of patients had homocysteine levels
<15 μmol/l while 55 % had raised homocysteine levels. Amongst them, 42% had levels of homocysteine in the range of 15-30 μmol/l
(mild) whereas 13% had >30 μmol/l homocysteine levels (intermediate). None of them had a level >100 μmol (severe). On univariate
analysis, the odds of increasing homocysteine levels were higher in males than females. Increasing B12 levels were associated with
decreased odds of intermediate homocysteine levels. On the multivariable model after adjusting the model with other covariates,
increasing B12 levels remained associated with homocysteine levels with a lower likelihood of intermediate homocysteine levels.
Conclusion: According to the results of our study, there is a strong correlation between high homocysteine levels and low B12 levels,
making homocysteine a substantial risk factor for ischemic stroke. Vitamin B12 has a major role in homocysteine pathomechanisms
and its deficiency predisposes to hyperhomocysteinemia and hence stroke. Larger multicenter studies may be done to evaluate the
role of B12 as a homocysteine-lowering agent both for the treatment and prevention of ischemic strok
Exploring Pragmatic Strategies in Energy Drink Advertisements: A Comparative Gricean Analysis of Pakistani and Indian Sting Ads
No full textThe marketing of energy drinks in the global markets is often based on dramatic and hyperbolic messages targeting the youthful consumers in the fast-growing markets in regions like Pakistan and India. This paper has used comparative pragmatic and multimodal study of ten advertisements of Sting energy drinks; five advertisements of Sting energy drinks in Pakistan and five advertisements of Sting energy drinks in India. Based on an interpretivist paradigm and a qualitative approach, the study explores the relationship between verbal and visual elements and the way in which these elements of communicative messages strategically comply or do not align with the Cooperative Principle introduced by Grice (1975), including the Maxims of Quality, Quantity, Relevance and Manner. The results reveal that both Pakistani and Indian adverts are overly dramatizing, and violate the Maxim of Quality, building on their use of fantastical and hyperbolic imagery to form aspirational meaning. However, Indian adverts are more traditional and more willing to include declarations regarding the health of their products, and are overt in regard to product details, which serves to curb the possibility of misunderstanding and indicates a stronger level of regulatory and corporate accountability. In Pakistani advertisements, however, emphasis is placed more on foregrounded real-life situations and culturally identifiable metaphors, like witches, exam success, and transformation in the workplace, but there is often a lack of disclosure in terms of health, so Pakistani youth viewers are more likely to be ethically troubled. Combining semiotic analysis (Barthes, 1977; Kress and van Leeuwen, 2006), with Relevance Theory (Sperber and Wilson, 1995), the paper contends that seemingly irrelevant or exaggerated visual features serve to create cognitive salience and produce implicatures that help advertisements to get remembered and persuade audiences. Such comparative analysis would develop a global discourse as it provides a Gricean pragmatics approach to the multimodal advertisement in the South Asian region and, in the process, would explain how the regulatory cultures and repertoires influence pragmatic choices, applied when creating marketing practices of health-sensitive products, that reach younger customers. Policy implications and future work related to the experimental work are outlined
CDK 4/6 Inhibitors in Metastatic Hormone Receptor Positive Breast Cancer: An Outcome-Based Study from a Tertiary Care Center in Pakistan
No full textNot Availabl
A Crisis within a Crisis Human Trafficking and Illegal Immigration: An Emerging Threat to Pakistan
No full textHuman trafficking is the offence in contrast to individual since the violation of victim's freedoms of movement concluded coercion or since for their profitable exploitation Interpretation to Article (3) of the UN, Conventions, trafficking in individuals aim to sold, transportation, handover, concealing and delivery of individuals, resources of threat and practice of power and additional methods of extortion, like kidnapping, deception, and bogus, exploitation of authority and position of susceptibility, assistances to accomplish the approval of an individual must regulator above one more individual, for the sake of manipulation is prohibited crime. This paper expressively focused on reasons of human trafficking, reflecting the similarities or changes among studies, trafficking is the mean of progression, somewhat that an individual rights have been violated. This paper highlights that human trafficking has been appreciated as one of the major encounters faced by nations in this present-day. Trafficking of human beings unlawfully into a country or internationally has increased in recent years which is progressively related with severe human rights defilements and deaths, in specific when it transpires by sea. The paper also focused on that how this crime damage of immigrant’s lives by the hands of smugglers particularly in the Mediterranean Sea. Although trafficking or smuggling are the same process for illegal immigration and become curse for the society, the point that migrant Transition linkages are closely related to other practices of serious and systematized crimes including violence, human transferring, and money legalizing specifies that there is a dreadful need to regulator this unlawful action to avoid any disastrous condition that may occur in the forthcoming. Unfortunately Pakistan become a victim of irregular immigrants and become the world’s foremost nation state from where irregular immigrants move overseas through diverse linkages and with irregular methods
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Identification of ancestral gnathostome Gli3 enhancers with activity in mammals.
No full textAbnormal expression of the transcriptional regulator and hedgehog (Hh) signaling pathway effector Gli3 is known to trigger congenital disease, most frequently affecting the central nervous system (CNS) and the limbs. Accurate delineation of the genomic cis-regulatory landscape controlling Gli3 transcription during embryonic development is critical for the interpretation of non-coding variants associated with congenital defects. Here we employed a comparative genomic analysis on fish species with a slow rate of molecular evolution to identify seven previously unknown conserved noncoding elements (CNEs) in Gli3 intronic intervals (CNE15-21). Transgenic assays in zebrafish revealed that most of these elements drive activities in Gli3 expressing tissues, predominantly the fins, CNS, and the heart. Intersection of these CNEs with human disease associated SNPs identified CNE15 as a putative mammalian craniofacial enhancer with conserved activity in vertebrates and potentially affected by mutation associated with human craniofacial morphology. Finally, comparative functional dissection of an appendage-specific CNE conserved in slowly evolving fish (elephant shark), but not in teleost (CNE14/hs1586) indicates co-option of limb specificity from other tissues prior to the divergence of amniotes and lobe-finned fish. These results uncover a novel subset of intronic Gli3 enhancers which arose in the common ancestor of gnathostomes and whose sequence components were likely gradually modified in other species during the process of evolutionary diversification. This article is protected by copyright. All rights reserved
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