1,358,485 research outputs found
Cell scientist to Watch - Tobias Zech
No full textABSTRACT
Tobias Zech studied biochemistry and received his Master's degree at the Freie Universität (FU) Berlin, Germany, before moving to the University of Oxford, UK, for a PhD in the laboratory of Thomas Harder on T cell receptor signalling and activation. In 2008, Tobias joined Laura Machesky at the Beatson Institute in Glasgow for post-doctoral work on cell migration and motility and the role of the actin cytoskeleton. Tobias established his research group in the Department of Cellular and Molecular Physiology at the University of Liverpool, in 2014. There, his group studies processes of cell migration and cancer cell invasion, with an emphasis on actin dynamics and receptor trafficking.</jats:p
A 16-ka delta O-18 record of lacustrine sugar biomarkers from the High Himalaya reflects Indian Summer Monsoon variability
No full textWe investigated a late glacial-Holocene lacustrine sediment archive located at 4,050 m a.s.l. in the small carbonate-free catchment of Lake Panch Pokhari, Helambu Himal, Nepal. A delta O-18 sugar biomarker record was established by applying novel compound-specific delta O-18 analysis of plant sugar biomarkers (Zech and Glaser in Rapid Commun Mass Spectrom 23:3522-3532, 2009). This method overcomes analytical challenges such as extraction and purification faced by previous methods aimed at using delta O-18 of aquatic cellulose as a paleoclimate proxy. The delta O-18 results for sugar biomarkers arabinose, xylose and fucose agree well and reveal a pronounced trend towards lower delta O-18 values during the deglaciation and the onset of the Bolling/Allerod interstadial. By contrast, the period of the Younger Dryas is characterized by higher delta O-18 values. The early Holocene again reveals lower delta O-18 values. We suggest that our lacustrine delta O-18 record reflects coupled hydrological and thermal control. It is strongly related to changes in the oxygen isotopic composition of paleo-precipitation and resembles the delta O-18 records of Asian speleothems. With respect to the 'amount effect,' the record is interpreted as reflecting the Indian Summer Monsoon intensity. The precipitation signal is, however, amplified in our record by evaporative O-18 enrichment that is controlled by the ratio of precipitation to evaporation. We suggest that our delta O-18 record reflects the variability of the Indian Summer Monsoon, which was strong during the Bolling/Allerod interstadial and early Holocene, but weak during the Younger Dryas stadial. This interpretation is corroborated by a pollen-based index for Lake Panch Pokhari that estimated the strength of the Indian Summer Monsoon versus the strength of the Westerlies. Millennial-scale synchronicity with the Greenland delta O-18 temperature records highlights the previously suggested strong teleconnections between the Asian Monsoon system and North Atlantic climate variability
Appendix ad tractatum Honorati Leotardi ... seu r.p. Francisci Zech e Societate Jesu, dissertationes tres
No full textMarca tipográfica en portadaSign.: [ ]4, A-Z8, Aa-Mm8 ; [A]2, B-Z2, Aa-Mm2Portada a dos tintasTexto a dos columnasAnteportadaSegunda parte con portada, paginación y signaturización propiasTítulo de la segunda parte: "Appendix ad tractatum Honorati Leotardi ... seu R.P. Francisci Zech e Societate Jesu, dissertationes tres ...
Zech-Selector vs. density-gradient centrifugation vs. swim-up method - : do different selection methods select for functioning receptors for hyaluronic acid?
No full textSpermien mit funktionierenden Hyaluronsäure-Rezeptoren sind für die Befruchtung der Eizelle in vivo und bei der herkömmlichen IVF-Methode essentiell, da diese Rezeptoren bei der Bindung des Spermiums an der Zona Pellucida und im Weiteren für die Akrosomreaktion wichtig sind. Drei verschiedene Spermien-Selektionsmethoden wurden auf ihre Fähigkeit, Spermien mit funktionierenden Hyaluronsäure-Rezeptoren zu selektieren getestet. Dabei wurden zwei gängige und routinemäßig eingesetzte Methoden, die Dichtegradienten-Zentrifugation und die Swim-up Methode, mit dem neuerem und seltener routinemäßig eigesetzten Zech Selector verglichen. Die Nativ-Ejakulat Probe wurden dazu in drei gleiche Teile geteilt und je ein Teil mit einer der drei Methoden aufbereitet. Von der nativen Probe und von den drei aufbereiteten Samenproben wurde mittels Hyaluronic-Binding-Assay die Anzahl der Spermien mit funktionierenden Hyaluronsäure-Rezeptoren bestimmt.Der Zech Selector schneidet mit einer Effektivstärke von 0,6 am besten ab. Darauf folgt die Swim-up Methode mit einer schwachen Effektivstärke von 0,28. Am schlechtesten schließt die Dichtegradienten-Zentrifugation ab, da hier kein signifikantes Ergebnis, hinsichtlich der Selektion auf Hyaluronsäure-Rezeptoren, erzielt wurde.Im Vergleich selektierte der Zech Selector 98,6% Spermien mit funktionierende Hyaluronsäure-Rezeptoren, mit einer Effektivstärke von 0,32 besser als die Swim-up Methode, die 89,75% der Spermien selektierte und mit einer Effektivstärke von 0,36 besser als die Dichtegradienten-Zentrifugation, die 87,27% selektierte. 79,66% der Spermien des nativen Ejakulats hatten funktionierende Hyaluronsäure-Rezeptoren. Diese Studie zeigt, dass sich der Zech-Selector am besten zum Selektieren von Spermien mit funktionierenden Hyaluronsäure-Rezeptoren, eignet.Sperm with functioning receptors for hyaluronic acid are essential for fertilization of oocytes in vivo and for conventional IVF method as they have an important role during the binding of the sperm to the zona pellucida and during acrosome reaction.Three different methods for sperm selection have been compared for their ability to select for sperm with functioning receptor for hyaluronic acid. Two well-known and routinely used methods, the density-gradient centrifugation and the swim-up method, have been compared to a newer and fewer used method, the Zech-Selector. Therefore the native ejaculate has been split into three parts and each part has been processed with one of the mentioned selection methods. The number of sperm with functioning receptors for hyaluronic acid have been evaluated by the means of Hyaluronic-Binding-Assay.The Zech-Selector selects 98.6% of Sperm with functioning receptor for hyaluronic acid and an effective power of 0.6. The swim-up method selects89.75% Sperm with functioning receptors for hyaluronic acid and an effective power of 0.28. A non-significant result for the density-gradient-centrifugation has been obtained, regarding the selection of 87.27% sperm with functioning receptors for hyaluronic acid. 79.66% of the sperm in the native ejaculate had functioning receptors for hyaluronic acid.In comparison, the Zech-Selector selects sperm with functioning receptors for hyaluronic acid more efficiently with an effective power of 0.32 compared to the swim-up method, and an effective power of 0.36 compared to the density gradient centrifugation.This study shows that the Zech-Selector works best for the selection of Sperm with functioning receptors for hyaluronic acid.Michael ZechZusammenfassungen auf Deutsch und EnglischAbweichender Titel laut Übersetzung des Verfassers/der VerfasserinMasterarbeit Karl-Franzens-Universität Graz 202
Zech-Selector vs. density-gradient centrifugation vs. swim-up method - : do different selection methods select for functioning receptors for hyaluronic acid?
No full textSpermien mit funktionierenden Hyaluronsäure-Rezeptoren sind für die Befruchtung der Eizelle in vivo und bei der herkömmlichen IVF-Methode essentiell, da diese Rezeptoren bei der Bindung des Spermiums an der Zona Pellucida und im Weiteren für die Akrosomreaktion wichtig sind. Drei verschiedene Spermien-Selektionsmethoden wurden auf ihre Fähigkeit, Spermien mit funktionierenden Hyaluronsäure-Rezeptoren zu selektieren getestet. Dabei wurden zwei gängige und routinemäßig eingesetzte Methoden, die Dichtegradienten-Zentrifugation und die Swim-up Methode, mit dem neuerem und seltener routinemäßig eigesetzten Zech Selector verglichen. Die Nativ-Ejakulat Probe wurden dazu in drei gleiche Teile geteilt und je ein Teil mit einer der drei Methoden aufbereitet. Von der nativen Probe und von den drei aufbereiteten Samenproben wurde mittels Hyaluronic-Binding-Assay die Anzahl der Spermien mit funktionierenden Hyaluronsäure-Rezeptoren bestimmt.Der Zech Selector schneidet mit einer Effektivstärke von 0,6 am besten ab. Darauf folgt die Swim-up Methode mit einer schwachen Effektivstärke von 0,28. Am schlechtesten schließt die Dichtegradienten-Zentrifugation ab, da hier kein signifikantes Ergebnis, hinsichtlich der Selektion auf Hyaluronsäure-Rezeptoren, erzielt wurde.Im Vergleich selektierte der Zech Selector 98,6% Spermien mit funktionierende Hyaluronsäure-Rezeptoren, mit einer Effektivstärke von 0,32 besser als die Swim-up Methode, die 89,75% der Spermien selektierte und mit einer Effektivstärke von 0,36 besser als die Dichtegradienten-Zentrifugation, die 87,27% selektierte. 79,66% der Spermien des nativen Ejakulats hatten funktionierende Hyaluronsäure-Rezeptoren. Diese Studie zeigt, dass sich der Zech-Selector am besten zum Selektieren von Spermien mit funktionierenden Hyaluronsäure-Rezeptoren, eignet.Sperm with functioning receptors for hyaluronic acid are essential for fertilization of oocytes in vivo and for conventional IVF method as they have an important role during the binding of the sperm to the zona pellucida and during acrosome reaction.Three different methods for sperm selection have been compared for their ability to select for sperm with functioning receptor for hyaluronic acid. Two well-known and routinely used methods, the density-gradient centrifugation and the swim-up method, have been compared to a newer and fewer used method, the Zech-Selector. Therefore the native ejaculate has been split into three parts and each part has been processed with one of the mentioned selection methods. The number of sperm with functioning receptors for hyaluronic acid have been evaluated by the means of Hyaluronic-Binding-Assay.The Zech-Selector selects 98.6% of Sperm with functioning receptor for hyaluronic acid and an effective power of 0.6. The swim-up method selects89.75% Sperm with functioning receptors for hyaluronic acid and an effective power of 0.28. A non-significant result for the density-gradient-centrifugation has been obtained, regarding the selection of 87.27% sperm with functioning receptors for hyaluronic acid. 79.66% of the sperm in the native ejaculate had functioning receptors for hyaluronic acid.In comparison, the Zech-Selector selects sperm with functioning receptors for hyaluronic acid more efficiently with an effective power of 0.32 compared to the swim-up method, and an effective power of 0.36 compared to the density gradient centrifugation.This study shows that the Zech-Selector works best for the selection of Sperm with functioning receptors for hyaluronic acid.Michael ZechZusammenfassungen auf Deutsch und EnglischAbweichender Titel laut Übersetzung des Verfassers/der VerfasserinMasterarbeit Karl-Franzens-Universität Graz 202
Plausus Votivus Serenissimo Principi in Furstenberg, Comiti in Heiligenberg & Werdenberg ... Sacrae Regiae Poloniarum Maiestatis Et Electoris Saxoniae In Electoratu Et Unitis Provinciis Gubernatori Eminentissimo, Domino Suo Clementissimo, Testandi Devotissmi Officii Causa d. Prid. Non. Ianuarii A.O.R. M.DC.XCVIII. Nuncupatus a Serenitatis Suae Humillime Subiectissimo Servo Bernhardo Zech, Lib. Art. Cult.
No full textPLAUSUS VOTIVUS SERENISSIMO PRINCIPI IN FURSTENBERG, COMITI IN HEILIGENBERG & WERDENBERG ... SACRAE REGIAE POLONIARUM MAIESTATIS ET ELECTORIS SAXONIAE IN ELECTORATU ET UNITIS PROVINCIIS GUBERNATORI EMINENTISSIMO, DOMINO SUO CLEMENTISSIMO, TESTANDI DEVOTISSMI OFFICII CAUSA D. PRID. NON. IANUARII A.O.R. M.DC.XCVIII. NUNCUPATUS A SERENITATIS SUAE HUMILLIME SUBIECTISSIMO SERVO BERNHARDO ZECH, LIB. ART. CULT.
Plausus Votivus Serenissimo Principi in Furstenberg, Comiti in Heiligenberg & Werdenberg ... Sacrae Regiae Poloniarum Maiestatis Et Electoris Saxoniae In Electoratu Et Unitis Provinciis Gubernatori Eminentissimo, Domino Suo Clementissimo, Testandi Devotissmi Officii Causa d. Prid. Non. Ianuarii A.O.R. M.DC.XCVIII. Nuncupatus a Serenitatis Suae Humillime Subiectissimo Servo Bernhardo Zech, Lib. Art. Cult. ([1]r)
Titelseite ([1]r)
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Bertha Zech
No full textPhoto shows Bertha Zech, a witness in the Hans B. Schmidt murder trial. (Source: Flickr Commons project, 2010 and New York Times, Sept. 16, 1913)Title and date from data provided by the Bain News Service on the negative.Forms part of: George Grantham Bain Collection (Library of Congress).General information about the Bain Collection is available at http://hdl.loc.gov/loc.pnp/pp.ggbai
The Dinggedicht in the Crisis of Representation: An Example by the Poet Paul Zech
No full textEl Dinggedicht (poema-objeto) es un tipo de composición poética de cierta tradición en la lírica alemana que, en el marco de la crisis de la representación artística que comienza a mediados del siglo XIX y en el del período de las vanguardias históricas, adquiere una importancia particular como forma de elaboración del objeto artístico. Dentro de su tradición, han sido Rainer Maria Rilke –tanto por sus producciones como por sus reflexiones al respecto– y Paul Zech grandes exponentes de este tipo de forma poética.The Dinggedicht (object-poem) is a kind of poetic composition. It has a certain tradition in German poetry. It develops in the context of art representation crisis –which begins in the mid-19th century– and of the historical avant-gardes. During this period, the Dinggedicht acquires a peculiar significance as a way of elaborating the artistic object. Within its tradition Rainer Maria Rilke –not only because of his productions, but also because of his reflections on the subject– and Paul Zech were among the most important exponents of this kind of poetic form.Fil: Sufotinsky Reynoso, Eric Tomás. Universidad Nacional de Rosario. Facultad de Humanidades y Artes. Instituto de Estudios Críticos en Humanidades. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Estudios Críticos en Humanidades; Argentin
Anästhesie und perioperative Betreuung bei Patienten mit Morbus Parkinson
No full textIdiopathic Parkinson's syndrome is associated with the loss of dopaminergic cells. It is defined by the presence of akinesia together with one of the cardinal symptoms: rigor, tremor, or postural instability. As the perioperative management of these patients can be challenging and they have an increased perioperative risk, every anaesthesiologist should know some special features. If a patient with Parkinson's disease does not receive the required amount of dopa, akinetic crisis may occur. Moreover, the administration of dopamine-antagonistic drugs can trigger a malignant neuroleptic syndrome. These are life-threatening clinical pictures that require intensive medical treatment. Therefore, patients with Parkinson's disease should be enabled to keep the period without the intake of the specific medication as short as possible. General anaesthesia should be performed with short acting anaesthetics and a regional anaesthesia might be beneficial. Besides, all dopamine antagonists sometimes used for prophylaxis or therapy of delirium or PONV (haloperidol, metoclopramide) are contraindicated. Alternatives are short-acting benzodiazepines, atypical neuroleptics and domperidone
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