1,721,036 research outputs found
El origen del ADN : un recorrido por las hipótesis sobre su evolución química
Get PDFDada la importancia que tiene la genética hoy día en muchos campos de la ciencia, se hace la presente revisión con el fin de sintetizar las principales hipótesis que hay alrededor del surgimiento del ADN antes del inicio de la vida.Given the importance that genetics has nowadays in many fields of science, this revision is made with the purpose of synthetize the main hypothesis around the emergence of DNA before the beginning of life.https://orcid.org/0000-0003-1060-3422https://orcid.org/0000-0002-0729-6866Revista Internacional - No indexadaN
Congenital Malformations of Pediatric Surgical Interest: Prevalence, Risk Factors, and Prenatal Diagnosis Between 2005 and 2012 in the Capital City of a Developing Country. Bogotá, Colombia.
No full textLas malformaciones congénitas (MC) causan un tercio de las muertes infantiles, con una variabilidad importante según la región del mundo evaluada y el impacto relativo de otras causas de mortalidad como la desnutrición o enfermedades infecciosas, así como el acceso y calidad del cuidado neonatal. En el año 2007, por primera vez en la historia del país, las MC ascendieron a la primera posición dentro de las causas de mortalidad en los niños menores de un año de edad. Se han establecido sistemas de vigilancia en MC a nivel local y regional en diversos países del mundo, entre ellos el Programa de Vigilancia de Malformaciones Congénitas de la ciudad de Bogotá (BCMSP). Algunas malformaciones son de especial interés para los cirujanos pediatras: onfalocele, gastrosquisis, atresias intestinales y esofágicas, malformación ano rectal, anomalías vasculares, hernia diafragmática, hipospadias y criptorquidia. El objetivo de este estudio es establecer posibles factores de asociados al embarazo, variables de la madre y del recién nacido, que puedan estar relacionados con la presentación de malformaciones congénitas de manejo por el cirujano pediatra.
Métodos: El estudio a realizar es de tipo retrospectivo, y corresponde a un estudio de casos y controles que se llevará a cabo mediante el análisis de la información consignada en la base de datos del BCMSP entre 2005 y 2012. La selección de la muestra se realiza por conveniencia, tomando los recién nacidos registrados en dicha base de datos durante el periodo evaluado.
Resultados: 282.523 nacimientos fueron vigilados por el sistema BCMSP. Del total de nacimientos vigilados, 4.682 (1.66%) presentaron MC. La frecuencia de malformaciones de manejo por el cirujano pediatra fie de 0.1%. Las MC más frecuente fueron las anomalías vasculares, hipospadias, criptorquidia, y malformación ano rectal. La exposición a factores físicos tuvo una asociación significativa con las malformaciones seleccionadas. El 51% de las malformaciones no tuvieron diagnóstico prenatal por ecografía.
Conclusiones: El presente estudio recalca la importancia de conocer la prevalencia local de MC y posibles factores de riesgo asociado, con el fin de comparar nuestros datos con otros programas, detectar situaciones que son de interés para la salud pública e identificar posibles áreas de intervención. El principal problema detectado in esta población fue el bajo porcentaje de diagnóstico prenatal por ecografía.Congenital anomalies (CA) cause nearly one third of infant deaths worldwide. Various surveillance systems have been established, such as the Bogota Congenital Malformations Surveillance Program (BCMSP). Some CA are of special interest to pediatric surgeons: omphalocele, gastroschisis, intestinal and esophageal atresia, anorectal malformations, vascular anomalies, diaphragmatic hernias, hypospadias and cryptorchidism. The aim of this study is to determine the prevalence of such CA, and identify possible risk factors.
Methods: Data from the BCMSP were collected between January 2005 and April 2012. CA were classified in accordance with the ICD-10 and grouped for analysis purposes. Data on CA frequencies were obtained from the BCMSP. Association analyses were performed using the case-control methodology.
Results: 282,523 births were registered. 4,682 (1.66%) had one or more CA at birth. The prevalence of CA requiring pediatric surgery was 1 in 1,000. The most frequent CA were vascular anomalies, hypospadias, and anorectal malformations. Exposure to external factors was significantly associated with selected CA. 51% of selected birth defects were not diagnosed in prenatal ultrasound.
Conclusions: This study highlights the importance of evaluating the local prevalence of congenital malformations. We propose the creation of specialized centers in Bogota to manage patients with CA
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Análisis de los loci ministr´s D10S1248, D14S1434 y D22S1045 en la población de Bogotá D.C. de Colombia, con fines genético poblacionales y forenses
Get PDFLos sistemas MiniSTR´s han demostrado ser de gran utilidad en la actividad forense ya que por una parte permiten aumentar el poder de discriminación y por otra aumentan la sensibilidad de las pruebas utilizando menos cantidad de DNA, mejorando así los resultados de casos en los que no se obtiene éxito con los STR disponibles ya sea por la cantidad o la degradación del DNA
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Evaluation of the surveillance program for gestational and congenital syphilis, and the impact of prenatal infection with cytomegalovirus and toxoplasma gondii, and the use of antiretrovirals, in children with congenital anomalies in Bogotá D.C.
Get PDFObjetivo: es Evaluar el Programa de Vigilancia de Sífilis Gestacional y Congénita, y el impacto del antecedente prenatal de Citomegalovirus (CMV), Toxoplasma gondii y uso de Antirretrovirales (ARV), en niños con anomalías congénitas de Bogotá D.C., entre los años 2008 y 2012.Objective: To evaluate the monitoring program Gestational and Congenital Syphilis , and the impact of prenatal diagnosis of cytomegalovirus (CMV ) , Toxoplasma gondii and Use of Antiretroviral (ARV ) in children with congenital anomalies of Bogotá DC , between 2008 and 2012.Bacteriólogo (a)Pregrad
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
CNVs in the 22q11.2 chromosomal region should be an early suspect in infants with congenital cardiac disease
Get PDFQ3Q2Infantes con Cardiopatía congénitaBackground: Congenital heart disease (CHD) is the most common congenital malformation, it is frequently found as an isolated defect,
and the etiology is not completely understood. Although most of the cases have multifactorial causes, they can also be secondary to chromosomal abnormalities, monogenic diseases, microduplications or microdeletions, among others. Copy number variations (CNVs) at
22q11.2 are associated with a variety of symptoms including CHD, thymic aplasia, and developmental and behavioral manifestations. We
tested CNVs in the 22q11.2 chromosomal region by MLPA in a cohort of Colombian patients with isolated CHD to establish the frequency of
these CNVs in the cohort.
Methods: CNVs analysis of 22q11.2 by MLPA were performed in 32 patients with apparently isolate CHD during the neonatal period. Participants were enrolled from different hospitals in Bogotá, and they underwent a clinical assessment by a cardiologist and a clinical
geneticist.
Results: CNVs in the 22q11.2 chromosomal region were found in 7 patients (21.9%). The typical deletion was found in 6 patients (18.75%)
and atypical 1.5 Mb duplication was found in 1 patient (3.1%).
Conclusions: CNVs in 22q11.2 is a common finding in patients presenting with isolated congenital cardiac disease, therefore these
patients should be tested early despite the absence of other clinical manifestations. MLPA is a very useful molecular method and provides
an accurate diagnosis.https://orcid.org/0000-0003-0882-2917https://orcid.org/0000-0002-0729-6866https://orcid.org/0000-0001-5439-5560https://orcid.org/0000-0002-0826-6191Revista Internacional - IndexadaA
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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