1,721,101 research outputs found
The effects of different cognitive and motor tasks on the dual task cost of walking in multiple sclerosis: a case-control study
No full textPalliative care in progressive multiple sclerosis
No full textIntroduction: Multiple sclerosis (MS) is a progressive disease of the central nervous system with unknown etiology. It could be associated with severe disability and losses of physical, psychological and social role functioning over time. People with MS share experiences in common with people affected by diseases with a shorter and clearer terminal phase. Therefore, it is appropriate to offer a palliative care approach to people with severe MS and their caregivers.Areas covered: Benefits for severe MS patients and their caregivers were shown when palliative care was included in their care. However, many neurologists show no interest toward palliative care services for people with severe MS. Misunderstandings about the services of palliative care are still prevalent.Expert commentary: When all results are considered, they show that palliative care for severe MS patients may be beneficial. The five-year view will discuss the barriers of palliative care inclusion for people with severe MS
A Personalized Approach in Progressive Multiple Sclerosis: The Current Status of Disease Modifying Therapies (DMTs) and Future Perspectives
No full textUsing the term of progressive multiple sclerosis (PMS), we considered a combined population of persons with secondary progressive MS (SPMS) and primary progressive MS (PPMS)
Misdiagnosis of lumbar-sacral radiculopathy: usefulness of combination of EMG and ultrasound
No full textIn the presence of sensitive symptoms along the lumbar-sacral dermatomeric region, it is easy to suspect a lumbar-sacral radiculopathy, it being a very common disease. Clinical evaluation, neurophysiology and magnetic resonance imaging are common tools in diagnosing lumbosacral radiculopathy. Nevertheless, sometimes tumour may mimic radiculopathy. With the improvement of ultrasound, most peripheral nerves may be virtually identified. We describe two patients where tumour of sural nerve and tibial nerve mimicked S1 radiculopathy. We diagnosed the tumours only through a comprehensive nerve assessment combining clinical evaluation, US and neurophysiology. The association of neurophysiological and imaging US assessments, possibly in the same session, may avoid misdiagnosis
Visualizzare e mappare le informazioni dei luoghi per la conoscenza dei territori. Annotazioni critiche e modelli progettuali
No full textNella nostra contemporaneità un rilievo cruciale riveste il tema della visualizzazione delle informazioni in qualità di strumenti
“democrazia dei saperi” nella cornice di una democrazia dei saperi. Questa condizione mette in evidenza il ruolo della mappatura dei dati come sistema per guidarne e orientarne significati e, di conseguenza, quello del progetto del linguaggio grafico (grammatica e sintassi visiva) come dispositivo per mettere in scena la molteplicità dei valori che combinano l’inalienabilità delle relazioni di un luogo, reale o metaforico che sia. In questa direzione il saggio esercita un percorso critico che attraversa la complessità plurisenso dell’ “idea di mappatura” (la mappa rappresenta l’astrazione di uno spazio fisico e metafisico)annotandone le sue diverse declinazioni nel quadro di pratiche di pratiche infografico-narrative che rendono possibile la “conoscenza dei territor
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pharmacokinetic drug evaluation of daclizumab for the treatment of relapsing-remitting multiple sclerosis
No full textIntroduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Despite the availability of several disease-modifying therapies for relapsing MS, there is a need for highly efficacious targeted therapy with a favorable benefitârisk profile and a high level of treatment adherence. Daclizumab is a humanized monoclonal antibody directed against CD25, the α subunit of the high-affinity interleukin 2 (IL-2) receptor, that reversibly modulates IL-2 signaling. Areas covered: Daclizumab blocks the activation and expansion of autoreactive T cells that plays a role in the immune pathogenesis of MS. As its modulatory effects on the immune system, daclizumabâs potential for use in MS was tested extensively showing a high efficacy in reducing relapse rate, disability progression and the number and volume of gadolinium-enhancing lesions on brain magnetic resonance imaging. Moreover, phase II and III trials showed a favorable pharmacokinetic (PK) profile with slow clearance, linear pharmacokinetics at doses above 100 mg and high subcutaneous bioavailability, not influenced by age, sex or other clinical parameters. Expert opinion: Among the new emerging drugs for MS, daclizumab also, thanks to a favorable PK profile, may represent an interesting and promising therapeutic option in the wide MS therapies armamentarium
Cognitive-motor dual-task interference:A systematic review of neural correlates
No full textCognitive-motor interference refers to dual-tasking (DT) interference (DTi) occurring when the simultaneous performance of a cognitive and a motor task leads to a percentage change in one or both tasks. Several theories exist to explain DTi in humans: the capacity-sharing, the bottleneck and the cross-talk theories. Numerous studies investigating whether a specific brain locus is associated with cognitive motor DTi have been conducted, but not systematically reviewed. We aimed to review the evidences on brain activity associated with the cognitive-motor DT, in order to better understand the neurological basis of the CMi. Results were reported according to the technique used to assess brain activity. Twenty-three articles met the inclusion criteria. Out of them, nine studies used functional magnetic resonance imaging to show an additive, under-additive, over- additive, or a mixed activation pattern of the brain. Seven studies used near-infrared spectroscopy, and seven neurophysiological instruments. Yet a specific DT locus in the brain cannot be concluded from the overall current literature. Future studies are warranted to overcome the shortcomings identifie
Negative prognostic impact of MRI spinal lesion in the early stages of relapsing-remitting multiple sclerosis
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