1,721,015 research outputs found
L'esperienza di valutazione del Piano di Sviluppo Rurale. Il caso della misura di sostegno agli investimenti delle aziende agricole.
No full textLa valutazione degli investimenti delle aziende agricole sovvenzionati dal Piano di Sviluppo Rurale della Regione Lombardia ha messo in luce come lo strumento quantitativo (osservazione di un campione di beneficiari confrontato con un gruppo di controllo) abbia permesso di capire cosa è successo ma solo grazie ad uno strumento qualitativo (i casi studio) si è avuta maggiore chiarezza del perché è successo. Il caso analizzato mette in luce una delle criticità con cui frequentemente si deve confrontare l’attività valutativa: spesso mediante un unico strumento non è possibile dare risposta a tutte le esigenze informative connesse alla valutazione, anche se rivolta ad uno specifico intervento. Di conseguenza, compatibilmente con la disponibilità di risorse e di tempo, può essere utile abbinare strumenti ed approcci diversi, al fine di combinare le diverse potenzialità e bilanciare i punti deboli
Il valore di una SWOT partecipata nei programmi di sviluppo locale: il caso del programma "Competitività" 2007-2013 della PA di Bolzano
No full textDescrizione e individuazione dei punti di forza di un processo di coinvolgimento del partenariato socioeconomico nel fase di analisi SWOT relativa alla programmazione del Fondo Europeo di Sviluppo Regionale nella Provincia Autonoma di Bolzano per il periodo 2007-201
L'esperienza Lombarda dei distretti regionali per l'innovazione
No full textIl capitolo illustra la valutazione di una esperienza di sostegno a progetti innovativi di rete tra imprese e centri di ricerca promossa da Regione Lombardia (Programma DRIADE
Il restauro novecentesco della Casa di Tiziano a Pieve di Cadore: analisi documentale e letture dirette
No full textRapid recovery of postnivolumab vemurafenib-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome after tocilizumab and infliximab administration
No full textBackground Immune checkpoint inhibitors such as nivolumab and targeted BRAF inhibitors have dramatically altered the treatment outcomes of metastatic melanoma over the past few years. Skin toxicity is the most common adverse event (AE) related to the commonly used BRAF inhibitor vemurafenib, affecting more than 90% of patients. Vemurafenib-related severe AEs with early onset are reported in patients who were previously treated with anti-programmed cell death-1 (anti PD-1) antibodies. A prolonged administration of systemic steroids is the first-line treatment of severe or life-threatening AEs. We report the case of a woman suffering from vemurafenib-related severe, rapidly worsening Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome, resolved in a few hours after single-dose administration of a combination of TNF-α antagonist infliximab with interleukin (IL)-6 receptor antagonist tocilizumab.Case presentation A 41-year-old woman treated with single-agent nivolumab presented with a melanoma progression. Biopsy samples were revised, revealing a BRAF V600E mutation. The patient was started on vemurafenib and cobimetinib treatment only 10 days after the last administration of nivolumab. On the third day of anti-BRAF therapy, profound lymphopenia was detected, and maculopapular eruption appeared afterward. Subsequently, the clinical conditions deteriorated further, and the woman was admitted on an emergency basis with high fever, respiratory and cardiocirculatory failure, diffuse rash, generalized edema, and lymphadenopathy. Diagnosis of DRESS syndrome with overexpressed capillary leakage was made. A single dose of tocilizumab was administered with an improvement of cardiocirculatory and renal function in a few hours. Because of worsening of liver function, skin lesions and mucositis, a single dose of infliximab was prescribed, and dramatic improvement was noted over the next 24 hours. Dabrafenib and trametinib were initiated, and coinciding with washout of infliximab from the patient’s blood, the drug toxicity recurred.Conclusion Anti-IL-6 and anti-TNF-α target treatment of very severe AEs may afford an immediate resolution of potentially life-threatening symptoms and reduce the duration and the costs of hospitalization. Maintenance of therapeutic infliximab blood concentrations permits an early switch to dabrafenib after vemurafenib-related AEs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Fabula rasa: Gamifying a storytelling platform to enhance proactive science communication from TU Delft researchers
No full textThis research project proposes a theoretical gamified design of a storytelling platform to engage TU Delft researchers into proactive submission of story ideas to co-create online storytelling for wide audiences. While universities have focused on improving communication with the general public in the past decades, researchers may still find barriers to engage in public communication of science. One of these barriers is proactive media contact, as the scientific community may perceive it as outside of the researchers’ role and subject the “transgressor” to informal peer-based sanctions. By assessing a sample of TU Delft researchers’ attitude towards an online TU Delft non-profit storytelling platform for internal and external communication similar to the target one, response efficacy proved to be the primary variable to motivate TU Delft researchers to engage in co-creation of online storytelling. The findings further confirm existing theories that younger and more intrinsically motivated researchers seem more willing to engage in online storytelling compared to older and more extrinsically motivated peers. The study translated these guidelines into a gamified design based on graph force models that challenge researchers to create tags related to their story, and form connections with peers within the TU Delft. To access these functionalities, TU Delft researchers must register to the platform by submitting a story idea, e.g. related to their researcher or field of study, and be willing to co-create online storytelling if their story is chosen. The design targets different groups of users by balancing the experience through the Octalysis framework, and implementing social points, competitions among faculties and badges. According to an evaluation with the case owner and a gamification expert of the first iteration of the design, rewarding the submission of stories with a network, seem effective in engaging TU Delft researchers to submit story ideas proactively and enhance collaboration and innovation with the TU Delft.Applied Sciences | Science Communicatio
- …
