1,720,958 research outputs found
Granulomi piogenici in corso di terapia con acitretina.
No full textIl granuloma piogenico viene descritto come un raro effetto collaterale in corso di terapia con retinoidi.
L’atteggiamento terapeutico comprende la riduzione del dosaggio del farmaco o, preferibilmente, la rimozione chirurgica delle lesioni e l’applicazione di steroidi topici.
Viene discusso un caso caratterizzato dalla comparsa di granulomi piogenici in una donna con severa psoriasi in placche trattata con acitretina alla dose di 25 mg/die
Primary cutaneous plasmocytoma: a role for a triggering stimulus?
No full textPrimary cutaneous plasmacytoma is a rare type of cutaneous B-cell lymphoma,
characterized by clonal proliferation of plasma cells, that primarily develops in
the skin. Five cases have been described to date in which a local triggering
stimulus may be involved in development of this skin tumour. We describe the case
of a primary cutaneous plasmacytoma localized to the lower lip. This site had
been affected for 15 years with recurrent herpes simplex virus-1 infection.
Neoplastic plasma cells were found to be bcl-2-positive. We hypothesize that
chronic stimulation of keratinocytes by herpes simplex virus-1, possibly through
toll-like receptors, may have favoured the release of cytokines (e.g.
interleukin-6) able to induce plasma cell proliferation, transformation and
survival
Pili canaliculi: a familial study
No full textThe pili canaliculi is a rare defect, first described in 1973 by Dupre’ et al. as “le syndrome des cheveux incoiffables. The condition, characterized by dry, frizzy, unruly, rough and blond hair probably is due to a keratinization defect. The disorder may be autosomal dominant, recessive with variable levels of penetrance or sporadic . Sometimes
it is associated with ectodermal dysplasia , retinal dysplasia , dental anomalies, ichthyosis vulgaris, atopic eczema, progressive alopecia areata, hamartomas, lichen sclerosus, woolly hair nevus, brachydactyly, pili tort, digit and nail abnormalities. We report a three years old child with thin, blond, uncombable hairs, atopic dermatitis and onychoschizia. The maternal grandmother were said to have the same hairs in infancy. The mother had normal hairs. A study with scanning electron microscopy revealed the presence of typical triangular cross-sectional shapes with indentation, longitudinal grooving and flattening of the hair surfaces. These morphologic features were discontinuous and found on different surfaces along the length of the hair. The overlying cuticle of the hair was instead normal. These findings were present in many hairs of child and grandmother, but in few hairs of the mother. The repeating of this peculiar aspect in the hairs within this family suggests that inheritance pattern is autosomal dominant. Moreover, the characteristic hair morphology can be observed in relatives, without hair abnormality. Since, the disorder could be associated to other extracutaneous abnormalities, it is indispensable a follow-up of the affected patient
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Morphologic grading and treatment of facial actinic keratosis
No full textActinic keratoses (AKs) represent the earliest stage in the development of squamous cell carcinoma (SCC) and represent important biomarkers for individuals at risk for development of invasive SCC. Based on clinical morphology, AK can be subdivided into three different grades, which correspond to specific dermatoscopic, reflectance confocal microscopic, and histopathologic substrates. Given the risk for potential progression toward invasive SCC, AK should be treated at the earliest stage. A wide range of minimal destructive or topical therapies is available for the treatment of AK. The choice of treatment depends on the number, size, clinical grading, duration, and location of lesions, patient's compliance, general health conditions, and cosmetic outcome. Treatment can be divided into lesion-directed and field-directed therapies. Lesion-directed treatment focuses on the treatment of single lesions, whereas field-directed treatment aims to eliminate both clinically visible and subclinical lesions within the field of actinic damage (concept of field cancerization). Noninvasive techniques such as dermoscopy and reflectance confocal microscopy can be helpful in identifying AK potentially progressing toward SCC, as well as in the selection of the adequate treatment and monitoring of the treatment outcome
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