482 research outputs found

    Characterizing the targets of dysregulated microRNAs in colorectal cancer

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    Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01The student, Saba Ghaffari, accepted the attached license on 2021-12-07 at 15:39.The student, Saba Ghaffari, submitted this Thesis for approval on 2021-12-07 at 15:53.This Thesis was approved for publication on 2021-12-08 at 10:34.DSpace SAF Submission Ingestion Package generated from Vireo submission #17404 on 2022-04-29 at 16:10:40Made available in DSpace on 2022-04-29T21:58:40Z (GMT). No. of bitstreams: 2 GHAFFARI-THESIS-2021.pdf: 317203 bytes, checksum: 3686867d2dedd25088c02a7895508eaf (MD5) LICENSE.txt: 4210 bytes, checksum: 85494f53d42f44056c50d360725d5f39 (MD5) Previous issue date: 2021-12-08Embargo set by: Seth Robbins for item 123472 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemAuthor requested closed access (OA after 2yrs) in Vireo ETD systemLimitedDysregulated microRNAs have been largely associated with tumorigenesis and cancer invasion. Therefore, identifying their direct/indirect targets is crucial to study the cellular processes that are altered as a result of microRNA dysregulation. In this thesis, we aim to identify the targets of dysregulated microRNAs in colorectal cancer progression by adapting a network-guided gene set characterization technique in which prior biological knowledge can be utilized to find novel molecular associations. Further analysis of the targets found by our approach revealed a protein complex that has been proposed as a therapeutic target for inhibiting colorectal cancer in recent studies

    Photographic Images, Distanced Realism, and the State of Being Modern in the Works of Mohammad Ghaffari and Otto Dix

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    In this study, I investigate the works of two painters, Otto Dix (1891-1969, Germany) and Mohammad Ghaffari (known as Kamal-al-Molk, 1848-1940, Iran), whose turn to a distanced realism reflects ruptures and transformations in their respective socio-historical contexts mutually inflected by a rapid proliferation of photographic realism. I examine the distanced mode of realism in their works, mainly in the use of linear perspective and a mechanically descriptive mode of representation to point out the impact of photographic cameras on the formation of realism in the works of these artists. Juxtaposing two painters from two distinct cultures is an adaptation of a novel comparative methodology, collage, to construct a non-hierarchical and inclusive concept of modern art. Therefore, by scrutinizing the impact of photography on the advent of realism in the works of Ghaffari and Dix, I elucidate the relation between realism and modernism. While stereo-typically modern art refers to moving away from the illusionistic representation of the external reality, I argue that the emergence of realism in the cases under study embodies new levels of integration of the camera and its particular mode of depiction within modern aesthetics in a cross-cultural scope.Embargo status: Restricted to TTU community only. To view, login with your eRaider (top right). Others may request the author grant access exception by clicking on the PDF link to the left

    Evolution of galaxy overdensities around high-redshift 3C radio galaxies and quasars at 1 < z\it z < 2.5

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    Die Suche von Galaxienhaufen mit hoher Rotverschiebung (1 < z\it z < 2) und die Untersuchung ihrer Entwicklung, ist eine anspruchsvolle Herausforderung der extragalaktischen Forschung. In dieser Dissertation untersuche ich die Umgebung von 3C Radioquellen mit hoher Rotverschiebung, die als Hinweis auf Galaxienhaufen im frühen Universum angesehen werden. Zu diesem Zweck standen Bilddaten zur Verfügung, die mit dem Spitzer Weltraum Teleskop, PanSTARRS und dem Hubble Weltraumteleskop, gemacht wurden und die ich mit Beobachtungen am 6.5m Magellan Teleskop von Las Campanas ergänzt habe. Die Anordnung der Galaxienhaufen zeigt einen evolutionären Effekt für die leuchtkräftige (∼ L∗) rote Galaxienpopulation zwischen z\it z ∼ 2 und z\it z ∼ 1. Diese neuen Ergebnisse bereichern unser Wissen über Galaxienhaufen mit hoher Rotverschiebung, als das Universum erst 4Gyr alt war. Sie können in einem konsistenten Bild der Haufenevolution vom jungen Universum bis heute verstanden werden

    Photocatalytic, corrosion protection and adhesion properties of acrylic nanocomposite coating containing silane treated nano zinc oxide: A combined experimental and simulation study

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    The influence of silane treated nano zinc oxide (nZnO) on the protection, photocatalytic properties and interfacial interactions in acrylic/carbon steel systems was investigated. For this purpose, nZnO particles have been synthesized using microwave irradiation method. The morphology of synthesized zinc oxide nanoparticles was studied by scanning electron microscopy (SEM). The nZnO were treated by 3(2-amino ethyl amino) propyl trimethoxysilane. Fourier transforms infrared spectroscopy (FTIR) and thermogravimetry (TGA) techniques have been used to prove success of nZnO surface modification. In the next step, nanocomposites were prepared and coated on carbon steel by dip-coating method. Corrosion resistances of coatings were evaluated by electrochemical impedance spectroscopy (EIS). Field emission scanning electron microscopy (FE-SEM) has been carried out to study morphology of cross section of films. Moreover, to study the hydrophillicity and photocatalytic properties of coating surface, contact angle of the nanocomposites coating surface have been measured. Finally interfacial adhesion and their mechanisms have been studied by molecular dynamics (MD) and first principle quantum mechanics (QM) simulation method.Accepted Author Manuscript(OLD) MSE-

    Older adults&rsquo; attitudes and barriers toward the use of mobile phones

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    Nasrin Navabi, Fatemeh Ghaffari, Zahra Jannat-Alipoor Nursing and Midwifery Department, Babol University of Medical Sciences, Mazandaran, Iran Background and objectives: The limitations caused by the process of aging and the prevalence of chronic diseases contribute to reduced performance in physical, psychological, and social areas of life in older people. The use of mobile phones as easily accessible portable tools with a high performance is associated with an increased health literacy, self-care, and independence in older people. The present study was conducted to determine older people&rsquo;s attitudes toward the use of mobile phones and the barriers to their use. Materials and methods: The present descriptive study was conducted on a sample population of 328 individuals older than 60 years presenting to health centers across cities in west Mazandaran, Iran. The data collection tools used included a mobile phone use checklist, a questionnaire on older people&rsquo;s attitude toward the use of mobile phones, and a questionnaire on the barriers to the use of mobile phones. The reliability and validity of these questionnaires were confirmed by the researchers. The data obtained were recorded and then analyzed using SPSS. The level of statistical significance was set at P&le;0.05. Results: According to the results, 80% of the older people had regular mobile phones and 20% had smartphones. In 95% of the male and 80% of the female participants, the greatest use of mobile phones pertained to making phone calls. A total of 5% of the male and 2% of the female participants used the Internet in their mobile phones. A total of 44% of the female and 42.80% of the male participants had poor attitudes (score from 0 to 40) toward mobile phone use. As for the different dimensions of the attitude toward mobile phone use, the highest score obtained by the female participants (71.66%) pertained to the psychoemotional dimension and the highest score in the male participants (72.85%) to the instrumental dimension. The results also revealed the lack of knowledge of English as the greatest barrier to mobile phone use in both sexes. There was a significant relationship between sex and the attitude toward mobile phone use in all the three dimensions examined, the sociocultural, psychoemotional, and instrumental. Discussion and conclusion: The results of the study revealed that the majority of older people have negative attitudes toward the use of mobile phones as a teaching aid, although they used them for performing daily tasks. Promoting this age group&rsquo;s knowledge about the different mobile phone applications available to help them and increasing their ability to learn the use of these applications through the mass media, family members, and peer groups can help improve older people&rsquo;s attitudes toward the use of mobile phones and thus increase their use of these devices. Keywords: attitude, mobile phone, barriers to use, older peopl

    شناسایی و رتبه بندی عوامل مؤثر بر اصلاح رفتارهای بهداشت، ایمنی و محیط زیست (مطالعه موردی: شهرداری تهران)

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    Background and Objectives: Numerous theories and frameworks have been used to understand and intervene in behavioral determinants, but these variables have not been validated in the safety behavior of individuals in all industrial societies and diverse industries with different cultural characteristics. The purpose of this study is to identify and prioritize the factors affecting the improvement of safety behaviors of the executive staff of Tehran Municipality. Materials and Methods: The statistical population of this study is HSE experts of Tehran Municipality. The data collection tool in this study is the use of library studies and the Delphi technique to identify individual and organizational factors affecting the correction of employee behaviors. Data analysis was performed using AHP hierarchical analysis and EXPERT CHOICE software. Results: According to the results of the identification of the organizational factors, it can be stated that among the organizational factors affecting the improvement of safety behaviors of municipal executive staff, safety culture with a relative weight of 0.109 is recognized as the most important organizational factor. In general, it can be said that between individual and organizational components; Individual components had a higher rank than organizational components. On the other hand, the findings of ranking individual factors also expressed that the risk perception component with an average rank of 0.179 has the highest rank. Discussion: For earlier conclusions in advancing the system and correcting the behavior of Tehran Municipality employees in the fields of safety, it is suggested that goal setting and planning be prioritized on 1- risk perception 2- attitude 3- awareness and knowledge 4- culture) Safety 5- Management commitment 6- Organizational safety atmosphere 7- Effective communication. &nbsp; How to cite this article: Ghorbali Z, Nikoomram H, Mohammadfam I, Ghaffari F. Identification and Prioritization of the Factors Affecting the Improvement of Health، Safety Environment Behaviors (Case study: Tehran Municipality). Irtiqa Imini Pishgiri Masdumiyat. 2022;10(2):131-41.سابقه و هدف: تئوری‌ها و چارچوب‌های بی‌شماری برای درک و مداخله در تعیین‌کننده‌های رفتاری مورداستفاده قرارگرفته است اما اين متغيرها در رفتار ايمني افراد در همه جوامع صنعتي و صنايع متنوع با ویژگی‌های مختلف فرهنگي تأييد نشده است. هدف از این پژوهش شناسایی و رتبه‌بندی عوامل مؤثر بر اصلاح رفتارهای ایمنی کارکنان اجرایی شهرداری تهران بود. مواد و روش‌ها: مطالعه این پژوهش از نوع موردی و جامعه آماري، متخصصان، خبرگان و کارشناسان بهداشت، ایمنی و محیط زیست شهرداری تهران بودند. ابزار گرداوری اطلاعات در این پژوهش استفاده از مطالعات کتابخانه‌ای و تکنیک دلفی برای شناسایی عوامل فردی و سازمانی مؤثر بر اصلاح رفتارهای کارکنان بود. تجزیه‌وتحلیل داده‌ها با استفاده از روش تحلیل سلسله مراتبی و نرم‌افزارEXPERT CHOICE صورت گرفت. یافته‌ها: با توجه به نتایج حاصل در رابطه با شناسایی عوامل سازمانی می‌توان ابراز داشت که از میان عوامل سازمانی مؤثر بر اصلاح رفتارهای ایمنی کارکنان اجرایی شهرداری، فرهنگ ایمنی با وزن نسبی 109/ 0 به‌عنوان مهم‌ترین عامل سازمانی شناخته‌شد. به‌طورکلی می‌توان گفت از بین مؤلفه‌های فردی و سازمانی؛ مؤلفه‌های فردی رتبه بالاتری را نسبت به مؤلفه‌های سازمانی به خود اختصاص دادند از طرفی یافته‌های حاصل از رتبه‌بندی عوامل فردی نیز ابراز داشت مؤلفه درک ریسک با ميانگين رتبه 0.179 داراي بالاترين رتبه بود. نتیجه گیری: در شهرداری تهران برای حصول نتیجه‌ زودتر در پیشبرد سیستم و اصلاح رفتار کارکنان در حوزه ایمنی می توان به ترتیب بر روی 1- درک ریسک 2- نگرش 3- آگاهی و دانش 4- فرهنگ ایمنی 5- تعهد مدیریت 6- جو ایمنی سازمانی 7- ارتباطات مؤثر هدف‌گذاری و برنامه‌ریزی کرد. How to cite this article: Ghorbali Z, Nikoomram H, Mohammadfam I, Ghaffari F. Identification and Prioritization of the Factors Affecting the Improvement of Health، Safety Environment Behaviors (Case study: Tehran Municipality). Irtiqa Imini Pishgiri Masdumiyat. 2022;10(2):131-41

    تأثیر عوامل فردی و عوامل سازمانی بر اصلاح رفتارهای بهداشت، ایمنی و محیط زیست کارکنان در مدیریت شهری

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    Background and Aim: Apart from the economic costs associated with high accident rates, the occurrence of major work-related injuries may also have a serious impact on the internal and external credibility of the organization and its activities and services/products. It seems that the cause of an accident cannot be simply related to a specific action performed by an individual, but rather due to the interaction of different individual and organizational conditions. The purpose of this study was to investigate the effect of individual and organizational factors on the improvement of health, safety, and environmental (HSE) behaviors of the executive staff of Tehran Municipality. The statistical population of this study was executive staff, including 137 staff and municipal services in Tehran Municipality with a number of about 1000 people. Methods: The data collection tool in this study was a researcher-made questionnaire based on the research literature. To investigate the effect of individual and organizational factors on improving employee behavior, the structural equation technique was used using Smart-Pls software. Results: The results showed that individual factors (attitude towards behavior, awareness, knowledge, and perceived risk) and organizational factors (management commitment, HSE atmosphere, HSE culture, and effective communication) are effective in improving the behavior of the Tehran Municipality executive staff. As a result. Conclusion: It is necessary for employees to learn the steps of the behavioral safety process and its strategy, and on the other hand, the organization should provide a platform for the whole system to participate in the safety process. Please cite this article as: Ghorbali Z, Nikoomram H, Mohammadfam I, Ghaffari F. The Effect of Individual and Organizational Factors on Improving the Health, Safety and Environmental Behaviors of Employees in Urban Management. Irtiqa Imini Pishgiri Masdumiyat. 2022;10(4):336-48. Doi: 10.22037/iipm.v10i4.38428سابقه و هدف: هدف از این پژوهش بررسی تأثیر عوامل فردی و سازمانی بر اصلاح رفتارهای سلامت، ایمنی و محیط‌زیست (HSE) کارکنان اجرایی شهرداری تهران بود. جامعه آماري این پژوهش کارکنان اجرایی شامل کارکنان 137 و خدمات شهری در شهرداری تهران به تعداد حدود 1000 نفر بود. روش کار: ابزار گرداوری اطلاعات در این پژوهش پرسشنامه محقق ساخته بر اساس ادبیات پژوهش بود. تجریه و تحلیل داده­ها با روش­هاي آمار توصيفي از جمله نمودارها، جداول و شاخصهاي عددي (ميانگين و انحراف معيار) و آمار استنباطی از جمله آزمون‌های کولموگروف اسمیرونوف و روش های معادلات ساختاری و شاخص های برازش مدل از طریق نرم افزارهای آماری SPSS، Smart- PLS استفاده شد. یافته‌ها: نتایج نشان داد از عوامل فردی قدرت رابطه بین نگرش نسبت به رفتار و اصلاح رفتار برابر 793/ 0، آگاهی و دانش برابر776 /0&nbsp; و درک ریسک برابر 779/ 0 محاسبه ‌شده است و از عوامل سازمانی قدرت رابطه بین تعهد مدیریت و اصلاح رفتار برابر&nbsp; 682/ 0، جو HSE سازمانی375 /0، فرهنگ HSE 0/710 و ارتباطات مؤثر 330/ 0، محاسبه ‌شده است كه مقدار قابل ‌قبولی محسوب می‌شود و نشان می­دهد بر اصلاح رفتار کارکنان اجرایی شهرداری تهران مؤثرند. نتیجه‌گیری: از یک‌سو نیاز است که کارکنان مراحل فرایند ایمنی رفتاری و راهبرد آن را فراگرفته و از طرفی در سازمان بسترسازی برای مشارکت کل سیستم در فرایند ایمنی فراهم گردد که شناسایی عوامل تأثیرگذار بر اصلاح رفتار برای ارتقاء رفتار ایمن در سازمان­ها، مقدمه­ای برای انجام این مهم می­باشد. به این مقاله، به صورت زیر استناد کنید: Ghorbali Z, Nikoomram H, Mohammadfam I, Ghaffari F. The Effect of Individual and Organizational Factors on Improving the Health, Safety and Environmental Behaviors of Employees in Urban Management. Irtiqa Imini Pishgiri Masdumiyat. 2022;10(4):336-48. Doi: 10.22037/iipm.v10i4.3842

    Investigating the Effect of Virtual Training of Communication Skills to Mothers Based on Interaction Analysis Approach on Girls' Life Satisfaction and Parent-Adolescent Relationship

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    Background: The critical changes and emotional fluctuations associated with puberty often lead to conflicts and communication challenges between adolescents and their parents. Adolescent girls, in particular, tend to experience more conflicts with their parents, especially their mothers, due to the sensitive nature of puberty and the involvement of heightened emotional dimensions. This underscores the importance of educational interventions aimed at improving communication skills to resolve conflicts and enhance parent-adolescent relationships. Objectives: The present study was conducted to evaluate the effect of virtual communication skills training for mothers, utilizing the interaction analysis approach, on the life satisfaction of girls and the quality of parent-adolescent relationships. Methods: This randomized controlled quasi-experimental study employed a parallel design, incorporating pre-test, post-test, and follow-up assessments. The study which was conducted in 2022, involved 66 mothers who were randomly assigned to either the intervention or control group. Participants completed the Life Satisfaction Questionnaire and the Parent-Adolescent Relationship Questionnaire at three time points: Before the intervention, immediately after the intervention, and one month post-intervention. The intervention consisted of eight consecutive weeks of virtual communication skills training using an interaction analysis approach, delivered to the mothers in the intervention group. Data were analyzed using SPSS version 16. Results: At the study's outset, the two groups were homogeneous regarding demographic variables. The results indicated a significant difference in the mean score of the parent-adolescent relationship in the intervention group, with scores of 67.94 ± 31.04 before the intervention, 126.19 ± 27.25 immediately after, and 93.06 ± 15.02 one month post-intervention (P < 0.001). Additionally, there was a significant difference in the mean score of life satisfaction in the intervention group, with scores of 15.06 ± 5.35 before the intervention, 26.63 ± 4.63 immediately after, and 22.44 ± 5.06 one month post-intervention (P < 0.001). Conclusions: The results of this study demonstrated that virtual training in communication skills for mothers, based on the interaction analysis approach, can enhance girls' life satisfaction and parent-adolescent relationships. Given that "girls' life satisfaction" and "parent-adolescent relationship" are critical psychological components, this approach may be utilized to improve adolescents' mental health and strengthen the relationship between adolescents and their parents. © 2025, Ghaffari et al

    In regard to Cuccia et al.: impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5�T MR-guided stereotactic body radiotherapy

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    We read the article entitled "Impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy" with great interest. In that study, the author reported that there is a statistically significant difference in the rotational antero-posterior shifts between the spacer and the non-spacer groups. Also, there was no statistically significant difference between the groups in terms of translational shifts. However, there are some points about the study. In this letter, we aimed to clarify these points
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