1,720,957 research outputs found
The spray drying of acetazolamide as a method to modify crystal properties and to improve compression behaviour
Full text linkAcetazolamide shows a very poor compression ability and tablets must usually be produced through a wet
granulation process. However, the possibility to obtain pure acetazolamide for direct compression could be interesting
for industrial application. With the scope to obtain a material for direct compression, three different crystallisation
methods were chosen, with respect to acetazolamide solvent solubility. (a) Acetazolamide was dissolved in an
ammonia solution and then spray dried. It was possible to characterise the spherical particles as a mixture of two
polymorphic forms, I and II by Powder X-ray diffraction study. (b) Pure form I was obtained by slowly cooling to
room temperature a boiling water solution. (c) Pure form II, the marketed form, was obtained by neutralisation of
an ammonia solution. Their compression behaviour was investigated firstly by a rotary press. Whilst pure polymorphic
forms I and II could not be compressed, the spray dried particles showed very good compression properties. In
fact, tablets were obtained only by spray dried particles, which show very good properties under compression and the
absence of capping tendency. On the other hand, it was impossible to obtain tablets from polymorphic forms I and
II, whatever compression pressures were used. In order to explain their densification mechanism, a single-punch tablet
machine, equipped for the measurement of the upper punch displacement in the die, was used. From calculated
Heckel’s parameters, it was demonstrated that the spray dried material shows a greater particle rearrangement in the
initial stage of compression due to its spherical habit and minor wrinkledness of particle surface. The crystalline
structure due to the presence of polymorphic forms I and II concur to lowering the intrinsic elasticity of the material.
This fact avoids the risk of the rupturing the interpaticulate bonds, which are formed during the compression,
concurring to the consolidation of the tablet
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Aspects chimiques et physico-chimiques des relations structure-activité : synthèse peptidique de mimes de sites protéiques et études de la morphologie et de la réactivité d'interfaces solide-liquide
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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