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Hubungan Rasio Monosit-High Density Lipoprotein (HDL) Terhadap Derajat Keparahan Lesi Arteri Koroner dan Kejadian Kardiovaskular Mayor Selama Rawatan pada Pasien Sindroma Koroner Akut
No full textBackground: Circulating monocyte count is predictive of new atherosclerotic plaque development. HDL cholesterol has an anti-inflammatory effects and can inhibite monocyte activation. The ratio of monocyte count/HDL cholesterol (MHR) is a parameter that has recently been studied and can widely used and also has a value of prognosis. The RMH predictive value for assessing the severity of coronary artery lesions as well as major cardiovascular events (MACE) has not been widely studied. This study aims to evaluate whether the MHR value can be a predictor of the severity of coronary artery lesions and MACE during hospitalization in patients with acute coronary syndromes (ACS).
Methods : This is an ambispective study of 97 patients with ACS undergoing coronary angiography and treatment at Adam Malik Hospital from January 2015 – April 2018. Patients were divided into two groups based on Gensini score, severe coronary lesions (Gensini ≥ 30) and mild coronary lesions (Gensini < 30), as well as group based on MACE. Bivariate and multivariate analysis were performed to find the relationship between MHR and Gensini score and MACE during hospitalization. The p value < 0.05 was considered statistically significant.
Results : Of the 97 patients with ACS, 48 subjects (49.5%) were scored with a high Gensini score and 49 subjects (50.5%) with low Gensini score. The ROC curve analysis obtained MHR cutoff value in predicting the severity of coronary artery leion was 0.021 (AUC 0.725, 95% CI 0.623-0.827, p<0.046) with a sensitivity of 70.3% and specificity of 45%. This study found a significant relationship but with a weak correlation between MHR value and Gensini score (p=0.006)(r=0.252) and also with MACE during hospitalization (p=0.003)(r=0.277). Logistic regression analysis showed MHR value ≥ 0.021 (OR 2.68, 95%CI 1.069-6.716, p=0.035) along with medium to high TIMI score (OR 4.682, 95%CI 1.445-15.168, p<0.01) became an independent factor for predicting the severity of coronary artery lesions.
Conclusion : There is a positive but weak correlation between the MHR value and the severity of coronary artery lesions and MACE during hospitalization in ACS patients. MHR value ≥ 0.021 is an independent factor in predicting the severity of coronary artery lesions in patients with ACS.Latar Belakang : Monosit yang bersirkulasi dalam darah dapat memprediksi perkembangan plak aterosklerosis baru. Kolesterol HDL memiliki efek anti inflamasi dan dapat menghambat aktivasi monosit. Rasio hitungan monosit/HDL (RMH) merupakan suatu parameter yang baru-baru ini diteliti dan dapat digunakan secara luas serta memiliki nilai prognosis. Nilai prediktif RMH untuk menilai derajat keparahan lesi arteri koroner dan juga kejadian kardiovaskular mayor (KKvM) belum banyak diteliti. Penelitian ini bertujuan untuk mengevaluasi apakah nilai RMH dapat menjadi prediktor derajat keparahan lesi arteri koroner dan KKvM selama rawatan di rumah sakit pada pasien sindroma koroner akut (SKA).
Metode : Penelitian ini merupakan penelitian ambispektif terhadap 97 penderita SKA yang menjalani angiografi koroner dan perawatan di RSUP HAM dari Januari 2015 – April 2018. Pasien dibagi menjadi dua kelompok berdasarkan skor Gensini, lesi koroner berat (Gensini ≥30) dan lesi koroner ringan (Gensini < 30), dan juga kelompok berdasarkan KKvM. Analisis bivariat dan multivariat dilakukan untuk mencari hubungan antara RMH dengan skor Gensini dan KKvM selama rawatan di rumah sakit. Nilai p<0.05 dianggap bermakna secara statistik.
Hasil : Dari 97 penderita SKA, didapatkan 48 orang (49.5%) dengan skor Gensini tinggi dan 49 orang (50.5%) dengan skor Gensini rendah. Penelitian ini mendapatkan hubungan yang bermakna namun dengan korelasi yang tidak kuat antara nilai RMH dengan skor Gensini (p=0.006)(r=0.252) dan juga dengan KKvM selama rawatan di rumah sakit (p=0.003)(r=0.277). Analisa kurva ROC mendapatkan nilai titik potong RMH dalam memprediksi derajat keparahan lesi arteri koroner adalah 0,021 (AUC 0.725, 95% CI 0.623-0.827, p<0.046) dengan sensitivitas 70.3% dan spesifisitas 45%. Analisa regresi logistik menunjukkan nilai RMH ≥ 0.021 (OR 2.68, 95%CI 1.069-6.716, p=0.035) bersama dengan skor TIMI menengah sampai tinggi (OR 4.682, 95%CI 1.445-15.168, p<0.01) menjadi faktor independen untuk memprediksi derajat keparahan lesi arteri koroner.
Kesimpulan : Terdapat hubungan positif namun tidak kuat antara nilai RMH dengan derajat keparahan lesi arteri koroner dan KKvM selama rawatan di rumah sakit pada pasien SKA. Nilai RMH ≥ 0.021 merupakan salah satu faktor independen dalam memprediksi derajat keparahan lesi arteri koroner pada pasien SKA.Tesis Magiste
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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