1,721,374 research outputs found
Recommended from our members
New perspectives on two late Ming novels: "Hsi-yu Pu" and "Jou P'u T'uan"
No full textAs the Ming dynasty (1368-1644) collapsed, two outstanding novels were authored, Supplement to the Journey to the West (Hsi-yu Pu) and Prayer Mat of Flesh (Jou P'u T'uan). Although modern critics have studied these two works, important aspects of each novel have been overlooked. Therefore, this study explores three elements of Jou P'u T'uan: the novel as a picaresque novel, the hero's character consistency, and the book's morality. Also examined are the Ch'an Buddhist aspects present in Hsi-yu Pu. Information on the authors, editions, and controversies of these novels has also been presented. An initial chapter is provided discussing the historical and intellectual background. Finally, a comparative study of the two authors and their works has been undertaken to further understanding of both novels. Thus, it is hoped that this work has made a valuable contribution to the study of these two novels
[dataset] Bingchuan Li, Jian Yu, Pu Wang et al., Suppression of potential-induced degradation in monofacial PERC solar cells with gradient-designed capping layer
No full text[dataset] Bingchuan Li, Jian Yu, Pu Wang et al., Suppression of potential-induced degradation in monofacial PERC solar cells with gradient-designed capping laye
Synthesis of 2-iodoynamides and regioselective [2+2] cycloadditions with ketene
Get PDFThe first synthesis of 2-iodoynamides is described as well as the first [2+2] cycloadditions of ketene with iodo alkynes.National Institutes of Health (U.S.) (GM 28273)Boehringer Ingelheim PharmaceuticalsMerck Research Laboratorie
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Benzannulation via the Reaction of Ynamides and Vinylketenes. Application to the Synthesis of Highly Substituted Indoles
No full textA two-stage “tandem strategy” for the synthesis of indoles with a high level of substitution on the six-membered ring is described. Benzannulation based on the reaction of cyclobutenones with ynamides proceeds via a cascade of four pericyclic reactions to produce multiply substituted aniline derivatives in which the position ortho to the nitrogen can bear a wide range of functionalized substituents. In the second stage of the tandem strategy, highly substituted indoles are generated via acid-, base-, and palladium-catalyzed cyclization and annulation processes.National Institutes of Health (U.S.) (Grant GM28273)National Science Foundation (U.S.) (Grant CHE-1111567)Merck Research LaboratoriesBoehringer Ingelheim PharmaceuticalsEli Lilly and Company (Graduate Fellowship)Massachusetts Institute of Technology. Dept. of Chemistry (C.P. Chu and Y. Lai Fellowship Fund
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Detection and characterization of R-loops at the immunoglobulin switch alpha (Sα) region
No full textAfter stimulation with external antigens and coupling with activation of T cell , naïve B cells can differentiate into plasma cells that produce antibodies . External antigens are processed and bound to B cells. That activates the appropriate immune response in B cells and antibody production to protect the body. Antibody can be divided into five main isotypies according to constant regions, namely IgM, IgG, IgA, IgD and IgE; Different antigens stimulate B cells to undergo class switch recombination (CSR) for production of different types of antibodies. Different isotypies of antibodies trigger different immune response so as to enhance the ability of removing different kinds of antigens. class switch recombination is initiated by activation-induced cytidine deaminase (AID), which in two switch (S) regions of the antibody genes so that S region can further generate double-stranded breaks and then two S region are combined by non-homologous end joining (NHEJ) and other mechanisms.
When RNA polymerase transcribes DNA in the S region, RNA is produced and base paired with the template strand DNA, so that another strand of DNA exists in single-stranded form, which is called the R-loop. The target of AID is single-stranded DNA. Therefore, it’s assumed that R-loop structures may provide AID’s substrates, and which makes AID trigger CSR. However, this hypothesis needs to be confirmed with more experiments.
Previous research indicates that R-loop structures exist at the Sμ, Sγ2b and Sγ3 in primary B cells of mice, and which makes it more possible that R-loops structure provide substrates for AID. In order to better apprehend the function of R-loop structures, we test whether R-loop structures existat the Sα in CH12F3-2A cells (a murine B cell line). The CH12F3-2A cell would switch to IgA positive cells through CSR after stimulation. If R-loops exist at the Sα, where are initiation sites and the endpoints of R-loops? In addition, whether the frequency of R-loops is directly proportional to the frequency of CSR? If so, it can further determine that R-loops structure is important to CSR.
In the thesis, results show that R-loop structures also exist at the Sα, and it supports that R-loops are the common features of S regions. Surprisingly, the initiation sites of some R-loops are located in the region upstream of the Sα; this phenomenon is never observed in other acceptor switch regions, and this particular R-loop has a recurring phenomenon, which may be correlated with that fact that the G density of Sα is lower than the other S regions. However, it needs to be confirmed by more experiments. In addition, R-loop with initiation sites in the Sα region are detected in stimulated cells but not in unstimulated cells. With increasing of stimulation time, there is no significant difference of the pattern of R-loops. Moreover, since CSR breakpoints often appear in the core region of Sα, we also detect and analyze R-loops in the core region of the Sα
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
