148 research outputs found
Impact of polymer formulations on neointimal proliferation after Zotarolimus-eluting stent with different polymers: Insights from the RESOLUTE Trial
No full textBackground—Polymer formulation may affect the efficacy of drug-eluting stents. Resolute, Endeavor, and ZoMaxx are zotarolimus-eluting stents with different stent platforms and different polymer coatings and have been tested in clinical trials. The aim of this analysis was to compare the efficacy of zotarolimus-eluting stents with different polymers. Methods and Results—Data were obtained from the first-in man trial or first randomized trials of each stent, The Clinical RESpOnse EvaLUation of the MedTronic Endeavor CR ABT-578 Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions (RESOLUTE), Randomized Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE ABT-578 Eluting Driver Coronary Stent in De Novo Native Coronary Artery Lesions (ENDEAVOR II), and ZoMaxx I trials. Follow-up intravascular ultrasound analyses (8 to 9 months of follow-up) were possible in 353 patients (Resolute: 88, Endeavor: 98, ZoMaxx: 82, Driver: 85). Volume index (volume/stent length) was obtained for vessel, stent, lumen, peristent plaque, and neointima. Cross-sectional narrowing was defined as neointimal area divided by stent area (%). Neointima-free frame ratio was calculated as the number of frames without intravascular ultrasound–detectable neointima divided by the total number of frames within the stent. At baseline, vessel, lumen, and peristent plaque volume index were not significantly different among the 4 stent groups. At follow-up, percent neointimal obstruction was significantly lower in Resolute compared with Endeavor, ZoMaxx, and Driver (Resolute: 3.7±4.0, Endeavor: 17.5±10.1, ZoMaxx: 14.6±8.1, Driver: 29.4±17.2%; P<0.001). Greater maximum cross-sectional narrowing and higher neointima-free frame ratio, suggesting less neointimal coverage, were observed in Resolute compared with other stent groups. Multiple regression analysis confirmed that the biodurable polymer used in Resolute independently correlated with neointimal suppression among 3 zotarolimus-eluting stents. Conclusions—The different polymer formulations significantly affect the relative amount of neointima for zotarolimus-eluting stents.Katsuhisa Waseda, Junya Ako, Masao Yamasaki, Tomomi Koizumi, Ryota Sakurai, Yoichiro Hongo, Bon-Kwon Koo, John Ormiston, Stephen G. Worthley, Robert J. Whitbourn, Darren L. Walters, Ian T. Meredith, Peter J. Fitzgerald and Yasuhiro Hond
On Tanka Poems by HONGO Sumie — The Significance of Depicting the Glory and Decline of Nishijin, Kyoto —
No full textThis article aims to demonstrate three significances of tanka poems by HONGO Sumie (1934～), who has lived for sixty years in Nishijin, Kyoto: the significance of her poems in depicting the glory and decline of Nishijin fabric industry and the ever-inspiring historic places of and figures in Kyoto; the beauty and artistry of her poems in exploiting a variety of rhetorical expressions; the possibility of making ordinary Japanese people realize the beauty and richness of the Japanese language. Among her conspicuous rhetorical expressions is the use of onomatopoeia like saya-saya, light and rhythmic sounds of a bamboo or a small waterfall, describing a Nishijin fabric machine and a small waterfall in a well-known garden in Kyoto. Another is the frequent use of hikari or light, referring to encouraging aspects of the world around her. In a tanka poem her late husband is associated with light (hikari) and a shield (tate). Not well-known to the tanka-related people, the poet deserves, the author believes, to be accepted as a distinguished Nishijin- and Kyoto- related poet. (Kyoto and Nishijin need a poet who gives literary description of its glorious culture and history.) Her use of uta-kotoba or words frequently used in tanka poems like modasu or ‘to remain silent’ might enable ordinary Japanese people to be impressed with not-daily-used beautiful Japanese expressions, thereby being more interested in their native language.departmental bulletin pape
Spread of Ca<sup>2+</sup>in the sarcomere during fast and slow activation of mammalian cardiac myocytes
No full textA multi-compartment model was used to estimate Ca2+gradients in a sarcomere of a cardiac myocyte. The mathematical model assumed Ca2+release from the sarcoplasmic reticulum as a driving function, and calculated Ca2+binding to myoplasmic buffers, Ca2+uptake by the sarcoplasmic reticulum, and diffusion of Ca2+(and the buffers). During the fast Ca2+transient similar to those observed during a twitch, the model predicted a large Ca2+gradient in the sarcomere. A trajectory of the instantaneous relation between spatially averaged concentrations of Ca2+and the Ca2+-troponin complex showed a counterclockwise loop, indicating non-equilibrium Ca2+binding to troponin. During slow changes in [Ca2+] with time to peaks of ~500 ms or longer, the gradient of [Ca2+] was largely dissipated and the apparent equilibrium of the Ca2+-troponin binding reaction was suggested with little hysteresis of the trajectory. We conclude that a steady-state relation between [Ca2+] and mechanical activity can be achieved uniformly in the sarcomere by slowing the rate of Ca2+release from the sarcoplasmic reticulum.Key words: calcium, troponin, cardiac myocytes, mathematical model.</jats:p
Morphological and physiological responses of Siebold's beech (Fagus crenata) seedlings grown under CO2 concentrations ranging from pre-industrial to expected future levels
No full textSiebold's beech (Fagus crenata) is a common species in the cool temperate forests of Japan. As the natural regeneration of beech forests is expected to contribute to forest conservation in future, we investigated the effects of different CO2 concentration ([CO2]) on the growth of beech seedlings in relation to morphology and physiological changes. Acorns collected from beech forest in Minakami, central Japan were germinated and grown during a first growing season of six months under four [CO2] levels (200, 350, 550, and 750 μL L^[-1]). Stem mass increased with increasing [CO2]; however, root mass did not change significantly among the treatments. With increasing [CO2], net photosynthetic rate (Pn) and leaf area increased, whereas transpiration (Tr), stomatal conductance, leaf chlorophyll content, and leaf longevity decreased. Although water use efficiency (WUE; i.e., Pn/Tr) improved with increasing [CO2], the density of stomata did not significantly change. Increases in the number of bud and the terminal bud length with increasing [CO2] indicated accelerated formation of additional branches and leaves in the next season. At high [CO2] environment in future, improved WUE may be nevertheless advantageous for the survival of beech seedlings preferring mesic conditions
Estudio de diferentes sustratos usados en la obtención de una bebida probiótica empleando el hongo kombucha (Medusomyces gisevi).
No full textEl objetivo de la investigación fue estudiar las características de diferentes sustratos usados en la obtención de una bebida probiótica y de identificar cual es el mejor sustrato que puede ser usado como medio de cultivo del hongo Kombucha (Medusomyces gisevi). La metodología que se aplicó fue la revisión bibliográfica basado en revistas científicas, journals y repositorios de instituciones de educación superior donde se recopiló información para comparar los datos de diferentes autores. Así mismo, a través de fuentes bibliográficas y con el método de sistematización de información se establece un resumen en tablas con los resultados cuantitativos de cada autor. Con respecto a los resultados, se establece que se obtuvo las siguientes características fisicoquímicas de los sustratos estudiados siendo estos: café (pH de 2.32, acidez de 0.24, ºBrix de 10.05 y % alcohol de 0%), canela (pH de 4,36, acidez de 0.32 y ºBrix de 11.46 y % alcohol de 0%), té negro (pH de 4.16, acidez de 0.28, ºBrix de 11.03 y % alcohol de 0.11%), hierba luisa (pH de 3.80, acidez de 0.18, ºBrix de 7.07 y % alcohol de 0%) y en el té verde (pH de 4.12, acidez de 0.32, ºBrix de 11.48 y % alcohol de 0.11%). Concluimos que, el mejor sustrato usado para la elaboración de una bebida probiótica empleando el hongo kombucha (Medusomyces gisevi), es el té negro debido a las características finales que presentó la bebida realizada con dicho sustrato pH de 4.10; acidez de 0.34; ºBrix de 11.03; °Alcohólico de 0.11; Análisis microbiológico: ausencia de microorganismos patógenos y en la Evaluación sensorial general obtuvo un Me gusta de aceptación por parte de los catadores. Por lo que se recomienda consumir la bebida de Kombucha elaborada con té negro, debido a sus beneficios medicinales y nutricionales que presenta esta bebida funcional.The objective of the research was to study the characteristics of different substrates used in the production of a probiotic beverage identifying the best substrate that can be used as a culture medium for the Kombucha fungus (Medusomyces gisevi). The methodology applied was the bibliographic review based on scientific magazines, journals and repositories of higher education institutions where information was collected to compare data from different authors. Likewise, through bibliographic sources and with the method of systematization of information, a summary was presented in tables with the quantitative results of each author. With respect to the results, the following physicochemical characteristics were obtained for the substrates studied: coffee (pH of 2.32, acidity of 0.24, ºBrix of 10.05 and % alcohol of 0%), cinnamon (pH of 4.36, acidity of 0.32, ºBrix of 11.46 and % alcohol of 0%), coffee (pH of 4.36, acidity of 0.32 and ºBrix of 11. 46 and % alcohol of 0%), black tea (pH of 4.16, acidity of 0.28, ºBrix of 11.03 and % alcohol of 0.11%), lemon verbena (pH of 3.80, acidity of 0.18, ºBrix of 7.07 and % alcohol of 0%) and green tea (pH of 4.12, acidity of 0.32, ºBrix of 11.48 and % alcohol of 0.11%). It is concluded that the best substrate used for the elaboration of a probiotic beverage using the kombucha fungus (Medusomyces gisevi) is black tea due to the final characteristics of the beverage made with this substrate: pH of 4.10; acidity of 0.34; ºBrix of 11.03; °Alcoholic of 0.11; microbiological analysis: absence of pathogenic microorganisms and in the general sensory evaluation the testers showed their acceptance. Therefore, it is recommended to consume the Kombucha beverage elaborated with black tea, due to its medicinal and nutritional benefits that this functional beverage presents
. 42 Tomo XIII (1960) Sexta Época (1939-1966). Anales del Instituto Nacional de Antropología e Historia
No full textPublicación que recopila y difunde cien años de trabajo de la antropología en México (1877-1977), integrada por documentos y manuscritos arqueológicos, antropológicos, históricos, geológicos, botánicos y lingüísticos.- Información general de las actividades del Instituto Nacional de Antropología e Historia durante 1960 por Eusebio Dávalos Hurtado. - La doceava temporada de exploraciones en Tula, Hgo. por Jorge R. Acosta. – Zoyatzingo por Manuel Romero de Terreros. - La mixteca en el estudio comparativo del hongo alucinante por Robert Raviez. - La organización social de Jiliapan por Leonardo Manrique Castañeda. - Relaciones entre la región tzotzil contemporánea y la maya antigua por William R. Holland. - Aspecto social de la región del Bajío por Arturo Monzón y Enriqueta Ramos Chao. - Intento de apreciación del mestizaje en algunos grupos mexicanos por Felipe Montemayor. - El rendimiento escolar en la Escuela Nacional de Antropología e Historia. Estudio preliminar por Cecilia Batres, Luz María Galvis, Gabriel Galvis y Lilia Portilla. - Datos sobre el desarrollo de la conducta en niños de la Ciudad de México por Guadalupe Carrasco. - Algunas observaciones sobre la dialectología tzeltal por Moisés Romero Castillo. - El idioma de los señores de Tepozcolula por Evangelina Arana Osnaya. - Interrelaciones de las lenguas mayences por Mauricio Swadesh. - Reconstrucciones matlatzincas-ocuiltecas por Juan A. Hasler
Morphological variety of capillary ends invading the epiphyseal plate in rat femora using scanning electron microscopy with osmium maceration
No full textObjectives: The function of capillary ends at the epiphyseal plate has been actively investigated. However, their morphology is still poorly understood. This study was designed to examine the capillary ends invading the epiphyseal plate three-dimensionally by scanning electron microscopy and discuss the relationship between their morphology and function. Methods: Distal halves of the femora of eight-week-old male Wistar rats were used. The specimens were divided into two groups for transmission and scanning electron microscopy. For transmission electron microscopy, sagittal ultrathin sections were routinely prepared after the demineralization of the specimens, and the chondro-osseous junction was examined at the epiphyseal plate. For scanning electron microscopy, the specimens were sagittally freeze-cracked, osmium-macerated, and routinely processed. Results: Endothelial cells of capillary ends had fine fenestrations, and hence they were distinguishable from perivascular cells (also known as septoclasts). Based on the outline and the presence or absence of pores, the capillary ends were divided into four types: closed dome, closed spire, porous dome, and porous spire. The two dome types generally occupied more than half of a lacuna, whereas the two spire types generally occupied only a small part of a lacuna. The porous types engulfed cellular remnants, indicative of degraded chondrocytes, via their pores. Some of the spire types penetrated the transverse septum. Conclusions: The morphological variety of capillary ends reflected their functional variety. Observations suggest that the capillary ends change their morphology dynamically in response to various functions, including the removal of degraded chondrocytes and perforation of transverse septa. (c) 2022 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved
Three-dimensional reconstruction of the Golgi apparatus in osteoclasts by a combination of NADPase cytochemistry and serial section scanning electron microscopy
No full textThe three-dimensional morphology of the Golgi apparatus in osteoclasts was investigated by computer-aided reconstruction. Rat femora were treated for nicotinamide adenine dinucleotide phosphatase (NADPase) cytochemistry, and light microscopy was used to select several osteoclasts in serial semi-thin sections to investigate the Golgi apparatus by backscattered electron-mode scanning electron microscopy. Lace-like structures with strong backscattered electron signals were observed around the nuclei. These structures, observed within the Golgi apparatus, were attributed to the reaction products (i.e., lead precipitates) of NADPase cytochemistry. Features on the images corresponding to the Golgi apparatus, nuclei, and ruffled border were manually traced and three-dimensionally reconstructed using ImageJ/Fiji (an open-source image processing package). In the reconstructed model, the Golgi apparatus formed an almost-continuous structure with a basket-like configuration, which surrounded all the nuclei and also partitioned them. This peculiar three-dimensional morphology of the Golgi apparatus was discovered for the first time in this study. On the basis of the location of the cis- and trans-sides of the Golgi apparatus and the reported results of previous studies, we postulated that the nuclear membrane synthesized specific proteins in the osteoclasts and, accordingly, the Golgi apparatus accumulated around the nuclei as a receptacle
Visual and olfactory input segregation in the mushroom body calyces in a basal neopteran, the American cockroach
No full textThe cockroach Periplaneta americana is an evolutionary basal neopteran insect, equipped with one of the largest and most elaborate mushroom bodies among insects. Using intracellular recording and staining in the protocerebrum, we discovered two new types of neurons that receive direct input from the optic lobe in addition to the neuron previously reported. These neurons have dendritic processes in the optic lobe, projection sites in the optic tracts, and send axonal terminals almost exclusively to the innermost layer of the MB calyces (input site of MB). Their responses were excitatory to visual but inhibitory to olfactory stimuli, and weak excitation occurred in response to mechanosensory stimuli to cerci. In contrast, interneurons with dendrites mainly in the antennal lobe projection sites send axon terminals to the middle to outer layers of the calyces. These were excited by various olfactory stimuli and mechanosensory stimuli to the antenna. These results suggest that there is general modality specific terminal segregation in the MB calyces and that this is an early event in insect evolution. Possible postsynaptic and presynaptic elements of these neurons are discussed
La mixteca en el estudio comparativo del hongo alucinante.. Anales del Instituto Nacional de Antropología e Historia. Num. 42 Tomo XIII (1960) Sexta Época (1939-1966)
No full textBorhegyi, S. F. Ms. Miniature Mushroom-Stones from Guatemala, 1960.Dahlgren, B. La Mixteca. México. 1954.Heim, R. y Wasson, R. G. Les Champignous Hallucinogènes du Mexique. Paris, 1958.La Barre, W. Twenty Years of Peyote Studies. Current Anthropology, Vol. I, No. I, 1960.Ravicz. R. Ms. A Comparative Study of Selected Aspects of Mixtec Social Organization, 1958.Schultes, R. E. Ms. Economic Aspects of the Flora of Northeastern Oaxaca, Mexico, 1941.Tamayo, J. L. Geografía General de México. México, 1949.Wasson, V. P. y Wasson, R. G. Mushrooms Russia and History. New York, 1957
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