1,721,016 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Computational Studies on Realkylation Reactions of Aged-Acetylcholinesterase with Quinone Methide Precursors for Regenerating Nerve Agent Aged Acetylcholinesterase
Get PDFOrganophosphorus compounds (OPs) such as sarin, soman, and tabun are toxic nerve agents used in chemical warfare and as pesticides. These OPs covalently bond with Ser203, a catalytic residue in the enzyme acetylcholinesterase (AChE), preventing hydrolysis of the neurotransmitter acetylcholine into acetate and choline. Once exposed to an OP compound, the inhibited AChE will undergo an irreversible process known as aging, where the OP-AChE complex will dealkylate and form a stable phosphonate anion on the Ser203 residue, inactivating the enzyme. Without functioning AChE, acetylcholine accumulates in the central nervous system causing seizures, vomiting, and often death. Currently, there are no known therapeutic methods to reverse this aging process to regain enzymatic activity. However, inhibited AChE can be restored to the active AChE before the onset of the aging process by treatment with pharmaceuticals containing an oxime functional group. The goal of this project is to discover a compound that will realkylate the phosphonate group on the Ser203 in aged-AChE, which can then be restored to the active AChE by oxime treatment. Literature shows that quinone methides (QMs) are capable of alkylating phosphodiesters, which are structurally similar to the phosphylated Ser203 residue in the aged-AChE active site. Through computational methods (molecular docking, molecular dynamics, and tomodock), potential poses in AChE of a variety of quinone methide precursors (QMPs) were analyzed in silico to determine their putative efficacy in vitro.No embargoAcademic Major: Biochemistr
Binding Affinity Profiles of G-protein Coupled Receptors and Mutated Protein Arginine N-methyltransferase 5
No full textProtein arginine methyltransferase 5 (PRMT5) is an enzyme involved in transcriptional regulation and DNA damage repair, making it an emerging target in cancer therapeutics. Patient-derived PRMT5 mutations identified in the Catalogue of Somatic Mutations in Cancer (COSMIC) were analyzed using molecular docking with known PRMT5 inhibitors. Comparative analysis of wild-type and mutant structures revealed alterations in predicted binding affinities, underscoring how point mutations may influence inhibitor efficacy and therapeutic outcome. In parallel, the glucagon-like peptide-1 receptor (GLP-1R) has gained attention as a therapeutic target due to the clinical success of GLP-1R agonists in weight management. Interest in cannabinoids such as Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) has simultaneously risen with the easing of cannabis restrictions in the United States. Both systems are mediated by G-protein-coupled receptors (GPCRs), suggesting possible molecular overlap. Using molecular docking, the binding of endogenous cannabinoids (2-AG, anandamide) and exogenous cannabinoids (THC, CBD) was compared with danuglipron, a small-molecule GLP-1R agonist, across these GPCRs. Danuglipron demonstrated higher predicted binding affinity to both CB1 and CB2 than any tested cannabinoid ligand, indicating potential cross-reactivity between GLP-1R and the endocannabinoid system. PRMT5 mutations overall had a more destabilizing effect on the PRMT5-inhibitor complex, although CMP5 in the SAM binding site did average a more stable relative energy compared to wild type in the presence of a mutation.NIH- Ruben PetreacaNo embargoAcademic Major: Biolog
Protein-Protein Surface Modeling of Double-Stranded Break Complexes
No full textThe purpose of this study is to computationally model proteins to view double-stranded break repair complexes. Double-strand breaks (DSBs) in DNA are extremely problematic and require intricate, complicated repair. DSBs also have an unknown mechanism. A lack of repair can result in a loss of a region of chromosome, while incorrect repairs result in cancer development. In order to prevent cancer development, the mechanism must be more well understood. Protein-protein docking, the modeling technique used in this study, is a snapshot of two proteins interacting with each other on their surfaces and was used to look at a combination of the yeast proteins RAD52, MST1, and HIP1. Comparing computational data with experimental results will give better insights as to what is happening among the protein complexes involved with DSB repair. Tertiary yeast structures (RAD52, MST1, and HIP1) were generated using homology modeling of the corresponding primary sequences in the yeast strain s. pombe. Each of the protein- protein docking calculations provided ten solutions with different intermolecular interactions to be analyzed. Interactions between side chains, such as hydrogen bonding, become extremely important in order to predict residues of interaction needed for experimentation. In the future, these computational methods could predict the outcomes of yeast experimentation with mutational analysis. Once the mechanism is well understood, further studies may find a way to ensure DSBs are repaired correctly.OSUM Dean's Undergraduate Research ScholarshipNo embargoAcademic Major: Biolog
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Computational Study of GPR55 Tertiary Model and Potential Mutation Hotspots
Get PDFThe purpose of the first part of this study is to computationally model theoretical the three-dimensional structures of proteins that interact with cannabinoids. The synthetic cannabinoids, THC and CBD, can interact with G-protein couple receptors (GPCRs). Their primary targets are cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). A potential cannabinoid receptor 3 (CB3), which is known as the cannabinoid orphan receptor GPR55, has also been shown to interact with THC and CBD. Because GPR55 does not have a known crystal structure, computational methods were used to create a theoretical structure using homology modeling and AlphaFold. Then using docking programs, CBD was docked into both molecules to provide a better understanding of the theoretical structures. The purpose of the second part of this study is to better understand the relationship between the endocannabinoid system and cancer, as links have been suggested in the literature. GPR55 had a total of six hotspots mutations at three different sites, based on analysis of the COSMIC database. Computational models of the R133L and R133W mutants showed potentially significant changes that may affect the overall tertiary structure.No embargoAcademic Major: Biolog
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