1,991 research outputs found
Strategy Convergence
No full textIn fast-changing industries like communications, having the right strategy is critical to success. Didier Bonnet and George Yip explain why business models and strategic planning must converge into strategic formulation
Born Global
No full textSome companies rapidly become players on the global stage, often much faster than larger competitors. Alina Kudina, George Yip and Harry Barkema studied a dozen such firms all located in Silicon Fen. Such companies, the authors believe, have lessons to teach in an increasingly international marketplace
EBUS-GS and VBN for GGO lesions
No full textBackground: Endobronchial ultrasonography with guide sheath (EBUS-GS) could be useful for diagnosing ground-glass opacity (GGO) predominant-type lesions in the peripheral lung. Furthermore, several studies have reported that transbronchial biopsy using EBUS-GS and virtual bronchoscopic navigation (VBN) was safe and effective for diagnosing small peripheral lung lesions. Our objectives were to diagnose solitary peripheral GGO predominant-type lesions by transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance, and to evaluate the clinical factors associated with diagnostic yield. Methods: The medical records of 169 patients with GGO predominant-type lesions who underwent transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance were retrospectively reviewed. Results: Endobronchial ultrasonography images could be obtained for 156 (92%) of 169 GGO predominant-type lesions, and 116 (69%) were successfully diagnosed by this method (20 of 31 pure GGO lesions [65%]; 96 of 138 mixed GGO predominant-type lesions [70%]). The mean size of diagnosed lesions was significantly larger than that of nondiagnosed lesions (22 mm versus 18 mm, p < 0.01). Regarding diagnostic yield based on computed tomography sign, cases with presence of a bronchus leading directly to a lesion had significantly higher diagnostic yield than the other lesions (p < 0.01). Conclusions: The addition of VBN to EBUS-GS could be useful in clinical practice for diagnosing GGO predominant-type lesions in the peripheral lung
The comparison between Mini-Mental State Examination and Clinical Dementia Rating in evaluating patients with dementia of the Alzheimer type
No full textMolecular characterization of HMW-GS 1Dx3t and 1Dx4t genes from Aegilops tauschii and their potential value for wheat quality improvement
No full textTwo x-type high molecular weight glutenin subunits (HMW-GS) in Aegilops tauschii, 1Dx3 t and 1Dx4 t were identified by SDS-PAGE and MALDI-TOF-MS. Their complete coding sequences were isolated by AS-PCR. 1Dx3 t and 1Dx4 t genes consist of 2535 bp and 2508 bp and encode 845 and 836 amino acid residues, respectively. The deduced molecular masses of 1Dx3 t and 1Dx4 t gene products are 87655.26 Da and 86664.24 Da, respectively, well corresponding to the molecular masses measured by MALDI-TOF-MS. A total of 18 SNPs were identified between 1Dx3 t and 1Dx4 t. Comparing with 1Dx5 subunit, 1Dx3 t had a six amino acid insertion at 146-151 while the 1Dx4 t had a nine amino acid deletion when compared with 1Dx3 t subunit. The authenticity of the cloned 1Dx3 t and 1Dx4 t genes were confirmed by successful expression of their ORFs in E. coli. Comparison and phylogenetic tree based on the amino acid and nucleotide sequences confirmed that 1Dx3 t was most closely related to 1Dx5 subunit that is widely accepted as a superior subunit for bread-making property. The secondary structure prediction demonstrated that 1Dx3 t subunit has significantly high α-helix and β-strand contents, suggesting it might have positive effects on dough quality
Spinal cord trauma and the molecular point of no return
No full textAbstract A mechanical trauma to the spinal cord can be followed by the development of irreversible and progressive neurodegeneration, as opposed to a temporary or partially reversible neurological damage. An increasing body of experimental and clinical evidence from humans and animal models indicates that spinal cord injury may set in motion the development of disabling and at times fatal neuromuscular disorders, whose occurrence is not normally associated with any major environmental event. This outcome appears to be dependent on the co-occurrence of a particular form of mechanical stress and of a genetically-determined vulnerability. This increased vulnerability to spinal cord injury may depend on a change of the nature and of the timing of activation of a number of neuroprotective and neurodestructive molecular signals in the injured cord. Among the main determinants, we could mention an altered homeostasis of lipids and neurofilaments, an earlier inflammatory response and the failure of the damaged tissue to rein in oxidative damage and apoptotic cell death. These changes could force injured tissue beyond a point of no return and precipitate an irreversible neurodegenerative process. A better knowledge of the molecular signals activated in a state of increased vulnerability to trauma can inform future treatment strategies and the prediction of the neurological outcome after spinal cord injury.</p
Investigating the Interactions Between G Proteins and Estrogen Loss in the Mouse Skeletal System
No full textPostmenopausal osteoporosis is the most common bone disease, as estrogen deficiency is directly related to reductions in trabecular and cortical bone. In addition to sex steroids, G proteins play important roles in bone development and maintenance. We have previously developed two transgenic mouse models that have high levels of Gαs (Gs-Tg) or Gα11 (G11-Tg) in osteoblasts. Gs-Tg mice had increased bone, whereas G11-Tg mice had osteopenia. To investigate how variations in G protein signaling in osteoblasts impact postmenopausal bone health, we ovariectomized (ovx) Gs-Tg and G11-Tg mice at 4 months of age and examined their skeletal phenotypes 5 weeks post-surgery. The high bone turnover in Gs-Tg mice made them more susceptible to bone loss with ovx. Conversely, G11-Tg mice were protected from ovx-induced bone loss. This offers new insight into predicting postmenopausal bone health in individuals with high G protein levels, in addition to potentially elucidating therapeutic targets.M.Sc
Rigorous results on the strongly correlated electron systems by the spin-reflection-positivity method
No full textIn this talk, we shall briefly review some results on the strongly correlated electron systems, derived recently by applying Lieb's spin-reflection-positivity method. To explain the basic ideas of this method to a wide audience, we emphasize the important role played by Marshall's rule in studying the many-body systems.Physics, AppliedPhysics, Condensed MatterPhysics, MathematicalSCI(E)CPCI-S(ISTP)
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