272 research outputs found
Effects of bisphenol A, diethylhexyl phthalate and pentabrominated diphenyl ether 99 on steroid synthesis in cultured bovine luteal cells
No full textKABAKCI, Ruhi/0000-0001-9131-0933; YIgit, Ayse Arzu/0000-0001-5837-6877Bisphenol A (BPA), diethylhexyl phthalate (DEHP) and pentabrominated diphenyl ether 99 (PBDE 99) are environmental toxicants belonging to the endocrine disrupting compounds (EDCs). They exert adverse effects on the various physiological systems, especially the reproductive system of humans and animals. The aim of this study was to investigate the effects of BPA, DEHP and PBDE 99 on progesterone (P4) synthesis in cultured bovine luteal cells. The bovine luteal cells isolated from the mid-luteal corpora lutea were exposed to different concentrations of BPA (1, 3, 10 and 30 mu M), DEHP (1, 3, 10 and 30 mu M) and PBDE 99 (0.1, 0.3, 1 and 3 mu M) in a serum-free culture media for 48 and 96 hr. At 48 hr, the P4 level in the luteal cells decreased after treatment with all concentrations of BPA; 3, 10 and 30 mu M of DEHP; and 3 mu M of PBDE 99 compared to the control (p < .05). Treatment of cells with 3-30 mu M of BPA, 1-30 mu M of DEHP and 1-3 mu M of PBDE 99 for 96 hr resulted in reduction in P4 synthesis (p < .05). However, lower concentrations of PBDE 99 (0.1 and 0.3 mu M) increased P4 levels at 48 and 96 hr. Synthesis of P4 was lower at 96 hr compared to the 48 hr in the groups treated with BPA (30 mu M), DEHP (1-30 mu M), PBDE 99 (0.3-3 mu M) and control group. Our results showed that BPA, DEHP and PBDE 99 are able to alter luteal steroidogenesis in bovine cells and can disrupt hormonal balance in the ovary. However, it is necessary to evaluate the exact mechanism underlying these effects in future studies.Kirikkale University, Scientific Research Projects Coordination UnitKirikkale University [2015/129]Kirikkale University, Scientific Research Projects Coordination Unit, Grant/Award Number: 2015/12
Co-culture of rat luteal cells with islet cells enhances islet viability and revascularization
No full text/0000-0002-3453-2967; YIgit, Ayse Arzu/0000-0001-5837-6877Islet cell transplantation is a major treatment strategy for type I diabetes, and has proven to be effective for maintaining glucose homeostasis. However, this treatment requires an extended period of immunosuppression to prevent rejection and recurrent transplantation to maintain function. Thus, to enhance the properties of transplanted islet cells, we examined the effect of the co-culture of luteal cells, which secrete progesterone, on islet cell viability, functionality, and revascularization. It was found that islet viability and functionality were higher in the co-cultured group than in single cultures of islets at 48 and 96 h, in parallel with increased progesterone and vascular endothelial growth factor (VEGF) secretion from luteal cells. In the co-culture groups, VEGF levels at 48 and 96 h and CD31 levels at 48 h were significantly higher than those in the islet groups (p < 0.001 and p < 0.05, respectively), and basic fibroblast growth factor (bFGF) levels were increased at 96 h (p < 0.001). Thus, co-culture with luteal cells may increase islet vascularity by enhancing VEGF and bFGF levels for up to 96 h, which could help to markedly increase the pre-transplantation time to allow for effective immunosuppression therapy. This method may also promote islet cell viability and functionality. Progesterone and angiogenic factors secreted from luteal cells may be responsible for these positive effects.KU SRPCU [2015/128]; Turkish National Science Foundation (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2214A]This study was supported by the KU SRPCU (2015/128). Additionally, we would like to thank the Turkish National Science Foundation (TUBITAK) for providing support for the study (scholarship 2214A)
The dichotomy between dreams and reality in Hüseyin Rahmi Gürpınar's novels İffet and Son Arzu
No full textİffet (1896) ve Son Arzu (1918), Hüseyin Rahmi Gürpınar’ın sonları facia ile biten iki romanıdır.Romanlar; ana karakterleri devirlerine göre eğitimli ve erdemli iki genç kızın, İffet veNuruyezdan’ın ölümüyle sona erer. Her iki eser de gerçek hayat hikâyelerine dayanmaktadır.Hüseyin Rahmi Gürpınar, İffet romanında olayın kahramanlarından biri olduğunu eserinönsözünde açıklar. Son Arzu’nun hikâyesi ise Nuruyezdan’ın eşi tarafından kendisine aktarılmıştır.Yazarın bu romanlarla öncelikle dönemin toplumsal yapısını gözler önüne sermek istediğianlaşılmaktadır. Toplumun ahlak anlayışı ise sorgulanan diğer bir kavram olarak ortaya çıkar. İffetromanı özelinde romantizm ile realizmin irdelendiği görülür. Son Arzu özelinde ise eski devrindüşünce biçiminin, durağanlığının eleştirisi yapılır. Kadın hakları ve kadın erkek ilişkileri diğereleştiri konularıdır. Tüm bu tartışmaların odak noktasını oluşturan asıl temaysa hayal ile hakikatarasındaki karşıtlıkla şekillenir. Her iki romanda da iyi örnek olarak gösterilebilecek çok az kişivarken, erdem sahibi iki kadın toplumun gözünde ahlaksız konumuna düşmüşlerdir. HüseyinRahmi Gürpınar’ın İffet ve Son Arzu romanları gerçekçilikle ilgili zayıf noktalarına rağmen evin içiile sokak arasında kurduğu simgesel zıtlıklarla dikkat çeker. Buna göre evin içi, gerçek hayattankopukluğu ile “hayal”in, sokak ise “hakikat”in temsilidir. Evdeki diyaloglarda, mektuplarda görülendil ne kadar erdemli ise, sokağın dili o kadar gayriahlakidir. Ev, eski düzeni ifade ederken ne kadaryıpranmış ya da yüzeyselse, sokakta akan hayat o kadar gerçektir. Kahramanların evlerindekurguladıkları aşk ne kadar yüce ise, dışarıda karşılaşılan duygu sadece cinsellik üzerinedir. Yazarınbüyük başarısı, hayal ve hakikat temi çevresinde oluşturduğu bu zıtlığı ustalıkla eserlerine aktarmışolmasıdır.İffet (1896) and Son Arzu (1918) are two novels of Hüseyin Rahmi Gürpınar, whose ends withtragedy. The novels end with the death of two young girls, İffet and Nuruyezdan, whose maincharacters are educated and virtuous according to their times. Both works are based on real lifestories. Hüseyin Rahmi Gürpınar explains in the preface of the work that he is one of the heroes ofthe event in his novel İffet. The story of the Son Arzu was conveyed to him by Nuruyezdan's wife. Itis understood that the author wanted to reveal the social structure of the era with these novels. Theethics of the society emerges as another questioned concept. It is seen that romance and realism areexamined in the novel of İffet. In the case of the Son Arzu, the way of thinking and the stagnation ofthe old age is criticized. Women's rights and women-men relations are other criticisms. The maintheme, which is the focus of all these discussions, is shaped by the opposition between imaginationand truth. While there are very few who can be set as good examples in both novels, two virtuouswomen have become immoral in the eyes of society. Despite their weaknesses in realism, HüseyinRahmi Gürpınar's novels Son Arzu and İffet attract attention with the symbolic contrasts theyestablish between the interior of the house and the street. According to this, the interior of thehouse is the representation of “dream” with its disconnection from real life, and the street is therepresentation of “truth”. The more virtuous the language seen in the dialogues and letters at home,the more immoral the language of the street. Home; the worn or superficial it is in expressing theold order, the more real is the life flowing on the street. No matter how sublime the love the heroesset up in their homes, the emotion encountered outside is only about sexuality. The great success ofthe author is that he skillfully transferred this contrast he created around the theme of dreams andreality to his works.</p
CAF across proficiency levels and profiles: an investigation of ESL student writings in an English placement test
No full textThis study was an examination of the predictive value of complexity, accuracy and fluency (CAF) across proficiency levels and profiles in second language writing. 150 ESL essays of international students registered at a North American university were analyzed using various CAF measures. Descriptive statistics and one-way ANOVA results indicate that fluency is the strongest indicator of proficiency. Accuracy is also found to distinguish across proficiency levels. Length-based complexity measures are found to better predict proficiency while subordination is found to be a comparatively weak indicator. For lexical complexity, number of different words could better distinguish writers across proficiency levels. When results are analyzed for language profiles, it is found that syntactic complexity and accuracy better distinguish across profiles.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-08-01The student, Arzu Avci, accepted the attached license on 2020-07-15 at 12:08.The student, Arzu Avci, submitted this Thesis for approval on 2020-07-15 at 12:24.This Thesis was approved for publication on 2020-07-16 at 18:47.DSpace SAF Submission Ingestion Package generated from Vireo submission #15637 on 2020-10-02 at 15:33:38Made available in DSpace on 2020-10-07T22:44:39Z (GMT). No. of bitstreams: 2
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Are There Any Effects of Respiratory Muscle Strength on Dyspnea, Core Muscle Strength and Functional Capacity in Adolescents with Substance Use Disorder?
No full textThe effect of information technological investments on labor productivity with the view of new economical connections
No full textAzer, Özlem Arzu (Arel Author)Towards the end of the 20th century, it is often encountered with "New Economy" concept. This concept has come into being with the main development of information technology. With this development, fast globalization process has made time and place differences useless. At the same time it has caused national economies to turn into industrial ones. Because the arrangement in "New Economy" has been changing both in structure and in content, similar situations mentioned above forced governments to invest on information technology on the basis of "New Economy". In this study, analyzing investment data on information technology in the USA, which some researchers think is a leading country, it will be tried to lay out their effects on labor productivity. With the results derived from the study, the future of the world countries is going to be evaluated. © EuroJournals, Inc. 2011
A participatory approach to the sustainable development of an historic landscape; management plan proposal for Hisar district, Bursa/Turkey
No full textHisar District is located within the borders of Osmangazi County. Hisar has a rich historical and cultural heritage and is a valuable historic landscape which carries not only the physical and spatial traces of this heritage but also preserves social and cultural features. With these features, Hisar District should be conserved for a sustainable future. Bursa Metropolitan Municipality considered the Hisar (Citadel) District as an Ottoman and World Heritage site and a research team from Bursa Uludag University has been given the task of preparing a management plan as a project in order to achieve conservation of the site with a sustainable approach. Led by the author of this paper, Dr cahantimur, Bursa Uludag University Project Team prepared the plan with a place-specific and participatory approach. This study presents both the significance of Hisar heritage site and the participatory process of the site management plan. It also presents a critical review of the actions undertaken by the municipality since then
Reviewers as Readers with Power : What a Case of Retranslation Says about Author, Translator and Reader Dynamics
No full textThe Black Book, Orhan Pamuk’s second novel in English translation, was published in Güneli Gün’s translation in 1994 and in a retranslation by Maureen Freely in 2006. The decision for retranslation was mainly taken by the author on the basis of the criticism the first translation received from the reviewers, the most significant readers of translations with their power to consecrate foreign authors and their work in their new cultural settings. This study will present an analysis of the two translations of The Black Book, taking as its point of departure the criticism expressed in the reviews. The analysis will reveal the ways in which the first translation served as a criterion for the retranslation and how the two translators represented the author and his work differently, which was mainly enabled because of the changing status of Orhan Pamuk as an author in the English-speaking world between 1994 and 2006.Le livre noir, deuxième roman d’Orhan Pamuk en traduction anglaise, a été publié en 1994 dans la traduction de Güneli Gün, puis dans la retraduction de Maureen Freely en 2006. La décision de retraduire a relevé surtout de l’auteur, sous l’influence de l'accueil réservé à la première traduction par les critiques, ces derniers étant les lecteurs les plus importants des traductions, puisqu'ils détiennent le pouvoir de consacrer les auteurs étrangers et leurs oeuvres dans de nouveaux lieux culturels. Le présent article propose une analyse des deux traductions anglaises du Livre noir, à la lumière de la recension critique. Il permettra de voir la manière dont les choix faits dans la première traduction ont, en quelque sorte, servi de critères pour la seconde, et de constater que les deux traductrices ont représenté l’auteur et son oeuvre différemment, surtout en raison de l'évolution du statut de Pamuk en tant qu'auteur dans le monde anglophone entre 1994 et 2006
Nitric Oxide Synthase Inhibition by L-NAME in Streptozotocin Induced Diabetic Rats: Impacts on Oxidative Stress
No full textSEVEN, A., GUZEL, S., SEYMEN, O., CIVELEK, S., BOLAYIRLI, M., YIGIT, G. and BURCAK, G. Nitric Oxide Synthase Inhibition by L-NAME in Streptozotocin Induced Diabetic Rats: Impacts on Oxidative Stress. Tohoku J. Exp. Med., 2003, 199 (4), 205-210 - The effects of nitric oxide synthase (NOS) inhibition by Nw-nitro-L-arginine methyl ester (L-NAME) administration on oxidative stress parameters were investigated in streptozotocin (STZ) induced diabetic rats. Lipid peroxidation as reflected by thiobarbituric acid reactive substances (TBARS) was insignificantly higher in diabetic rats. Plasma NO2+ NO3 values (p < 0.05) and erythrocyte CuZn superoxide dismutase (CuZn SOD) and glutathione peroxidase (GSH Px) activities were significantly higher (p < 0.01, p < 0.001, respectively) in diabetic rats. L-NAME administration to diabetic rats caused significantly lower CuZn SOD and GSH Px activities (p < 0.01) and NO2+NO3 values (p < 0.001), whereas a significantly higher GSH level (p < 0.01). TBARS/ GSH ratio was significantly higher in diabetic rats than controls (p < 0.05) and significantly lower in L-NAME administered diabetic rats than diabetic rats (p < 0.05). This experimental study highlightens the importance of NOS inhibition by L-NAME in the attenuation of oxidative stress in STZ diabetic rats nitric oxide; L-NAME; diabetes; oxidative stress (C) 2003 Tohoku University Medical Press
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