124,599 research outputs found
Occurence and development of folding related to normal faulting within a mechanically heterogeneous sedimentary sequence : a case study from Inner Moray Firth,Uk
No full textWe are grateful to Ithaca Energy and Dave Brett for releasing proprietary seismic data for publication. We are thankful to Badley Geoscience Ltd and Dave Quinn for providing a licence and training for TrapTester software. We also thank Schlumberger for providing an academic licence for Petrel, Midland Valley for providing a licence for Move software and Foster Findlay Associates Ltd for providing access to GeoTeric software. We thank Al Lacazette, Paul Whipp and Scott Young for the permission to use their figures in this paper. Jonathan Imber acknowledges a Royal Society Industry Fellowship with Badley Geoscience Ltd and Geospatial Research Ltd. Christopher Jackson, Douglas Paton and Tom Manzocchi provided constructive reviews that significantly improved the clarity of the manuscript.Peer reviewe
Prediction of Structure, Function, and Spectroscopic Properties of G-Protein-Coupled Receptors: Methods and Applications
No full textG-protein-coupled receptors are of great pharmaceutical interest, comprising the majority of targets for currently marketed drugs. The theme of my thesis is the development of the structure prediction method, MembStruk, for the superfamily of G-protein-coupled receptors. The first part of this thesis focuses on the methods and their validation. There are several steps involved in MembStruk that are detailed and tested for membrane proteins with known structures in the first few chapters (Chapters 2-6). Specifically, the first principles methods for predicting the transmembrane helical ranges and the helix hydrophobic centers are tested. The program for predicting the transmembrane helical ranges, TM2ndS, ranks in the top two when comparing performance with other top prediction methods. And because it is based on general principles, it can be applied robustly for membrane protein families for which little structural information is available. The simulation of the EC-II closing is also tested on bovine rhodopsin. The use of the MembStruk method on bovine rhodopsin as a validation case is presented in detail (Chapter 2). The large majority (71%) of the residues involved in binding in rhodopsin are predicted and the protein structure itself is 2.84 Å coordinate root mean square error in the transmembrane main chain atoms from the crystal structure.
The second part of the thesis discusses applications on various G-protein-coupled receptor systems. The application of the MembStruk method to other peptide chemokine G-protein-coupled receptors like CCR1 and CCR5 is discussed in Chapter 9. The fundamental scientific problems of G-protein-coupled receptor modulation of absorption and relaxation properties of a bound chromophore (retinal) are addressed and results are presented for the predictions of these properties.
The prediction of structure and function of G-protein-coupled receptors would allow for structure-based drug design and a rational approach to reducing drug cross-reactivity across receptor families.</p
Fault Seal Analysis in an Onshore Unconventional Gas Target, North Perth Basin
No full textDuring the 1980s, hydrocarbons were logged in aquifers during drilling of conventional gas wells in the Woodada gasfield. The gasfield is located in the North Perth Basin in Western Australia. Using Fault Seal Analysis Technology, our goal was to test the hypothesis that faults in the Kockatea Shale that are currently being reactivated may be leak prone. Wells proximal to faults with a fracture stability of greater than 5 MPa logged only methane. Wells proximal to faults with a fracture stability ≤5 MPa logged both methane and condensate in aquifers confirming that hydrocarbon leakage is correlated with critically stressed faults. This assessment assumes that fault rocks in the Kockatea Shale, which is a regional source rock and seal, comprise uncemented phyllosilicate rock. For the normal stress case, faults oriented west-north-west with moderate dip have the lowest integrity. For the strike slip stress case, faults oriented north-west and west-south-west, with moderate to steep dip have the lowest integrity. If the Kockatea Shale fault rock is assumed to be a cemented phyllosilicate, then the fracture stability increases to 14 MPa for both the normal and strike slip case. In this case, Jurassic-Permian fault intersections may be contributing to hydrocarbon leakage, however, this would require numerical modeling for confirmation. Based on leak off tests, the increase in pressure required to hydraulically fracture the formation varies between 10.7 and 13.8 MPa. The treatment pressures used during hydraulic fracturing may potentially exacerbate leakage in areas such as the Woodada gasfield.Full Tex
On the Equivalence of G-weak and -strong Cores in the Marriage Problem
No full textIn the marriage problem (two-sided one-to-one matching problem), it is well-known that the weak core, the strong core and the set of stable matchings are all equivalent. This paper generalizes the above observation considering the G-weak core and the G-strong core. These are core concepts in which blocking power is restricted to the coalitions belonging to the prescribed class of coalitions G. I give a necessary and sufficient condition that G should satisfy for the equivalence of the G-weak core and the G-strong core.
Analysis of temperature effects near mode I cracks in glassy polymers
No full textA previous isothermal study has shown that the toughness of glassy polymers is governed by the competition between shear yielding and crazing. The present work aims at investigating loading rates for which thermal effects need to be accounted for. The influence of the heat coming from the viscoplastic shear yielding and from crazing on their competition and on the toughness is examined. Crazing is shown to be the dominant heat source, and the dependence of the craze properties on temperature appears to be key in controlling the toughness of the material.
Fatigue crack shielding in plain bearings under large scale yielding
No full textMulti-layered bearing systems used in the automotive industry show shielding and antishielding effects that reduce or amplify the crack driving force under large-scale yielding conditions. Using finite element analysis, it is shown that shielding in such systems results in path deflection and bifurcation despite the absence of mixed-mode loading. As the crack approaches a stiff layer, the tangential strains measured around a blunted crack tip model show a maximum corresponding to the direction of crack propagation. The distribution of such strains indicates the effect of shielding and the likelihood of the tip to deflect or bifurcate.The suitability of bi-layer and tri-layer bearing architectures is assessed through crack path and respective crack driving force prediction
The role of friction in the yielding of adhesive non-Brownian suspensions
No full textYielding behavior is well known in attractive colloidal suspensions. Adhesive non-Brownian suspensions, in which the interparticle bonds are due to finite-size contacts, also show yielding behavior. We use a combination of steady-state, oscillatory and shear-reversal rheology to probe the physical origins of yielding in the latter class of materials, and find that yielding is not simply a matter of breaking adhesive bonds, but involves unjamming from a shear-jammed state in which the micro-structure has adapted to the direction of the applied load. Comparison with a recent constraint-based rheology model shows the importance of friction in determining the yield stress, suggesting novel ways to tune the flow of such suspensions.The dataset comprises six .zip files. Five files, Fig1.zip to Fig5.zip, that contain data and corresponding plotting for Figures 1 to 5 of the related paper "The role of friction in the yielding of adhesive non-Brownian suspensions" and an additional folder, Data.zip, containing data referenced in the paper, e.g. from which values have been extracted and used in other figures. All file formats and contents are described in the corresponding readme text files labelled e.g. README_fig1.txt for Figure 1
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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