46,406 research outputs found
Histoire de la Deuxième Guerre Mondiale (1992-1997) (12) - face A
No full textSéminaire organisé et enregistré par l'IHTP (Paris), entre 1992 et 1997 ; sous la direction de Jean-Pierre Azéma et Dominique Veillon. Raymond Aubrac, "Jours du siècle"/France Inter
Histoire de la Deuxième Guerre Mondiale (1992-1997) (12) - face B
No full textSéminaire organisé et enregistré par l'IHTP (Paris), entre 1992 et 1997 ; sous la direction de Jean-Pierre Azéma et Dominique Veillon. Raymond Aubrac, "Jours du siècle"/France Inter
Authorship in the Interstices of History, Biography, Reality and Memory: Histoire(s) du cinéma and Cabra Marcado para Morrer
No full textEste artigo contrasta Histoire(s) du cinéma de Jean-Luc Godard e Cabra Marcado Para Morrer de Eduardo Coutinho, estão engajadas com a questão da autoria no cinema. Enquanto a imagem de Godard enfatiza a capacidade que tem um filme de transmitir a visão de mundo pessoal de um artista, a presença de Coutinho na tela funciona menos como um meio de subjetivar a obra do que como um catalizador instigando cetas reações nos "atores" filmados
Yifeng du shu ji /
No full textShaotao lu ; Jianquan ri ji ; Shu Taowu ; Shao shi wen jian lu ; Song Taizhou Benxunzi yu xi ning ben tong yi ji ; Song jiao kan Wu jing zheng yi zou qing diao ban biao ; Hua yang guo zhi Ba Jun shi nü yi wen ; Jianyan yi lai chao ye za ji yi wen ; Jiu guo zhi ; Jiu guo zhi yi wen ; Yanyuan ji ; Yanyuan ji yi wen.Mode of access: Internet
Norma Coverdale, B.A.: the treatment of women in selected works of Henry de Montherlant
No full textThe aim of this thesis is to determine how women are treated in selectedworks of Henry de Montherlant. This is explored by examining their relationshipswith other women as well as with men. Inevitably, this leads to an analysis ofthe multifaceted area of love. Part I researches Montherlant's prose work and included in this section is the investigation of the importance of 'l'ordre male' to the author and the influence this exerts over his early prose work in the areas of tauromachy, war and sport, and where the male adherence to this concept leaves women. The 'syncretisme et alternance' which is central to Montherlant's thinking is explored in this section.Part 2 is concerned with Montherlant's theatre in which the psychological development of the main characters is of great importance. It is in this section that a comparative study is made of the influence of Mme. Elisabeth Zehrfuss' written contribution to La Reine morte. Her unpublished notes are set out in full in the Appendix. The thesis also draws on the unpublished correspondence between Henry de Montherlant and Elisabeth Zehrfuss between the years 1934 and 1945. An investigation is made as to whether or not there are any differences between the way women are treated in Montherlant's prose and in his theatre and the conclusion is drawn that there are
Notable plant species recently observed in the Luberon Regional Natural Park
No full textL’auteur présente des découvertes récentes de 3 espèces végétales nouvelles pour le territoire du Luberon, voire des Alpes-de-Haute-Provence et du Vaucluse.The author presents recent discoveries of 3 plant species new in the Luberon area, even in the Alpes-de-Haute-Provence and Vaucluse
Abstract 3114: The role of prostaglandin signaling in human glioblastoma cell activities and growth in vitro and in vivo
No full textAbstract
Glioblastoma multiforme (GBM) constitutes the most frequent and aggressive form of malignant brain primary tumors. Despite current combined treatment involving surgery, chemotherapy and radiation therapy, the median survival of GBM patients is only about one year, with less than 3-5% of patients surviving over 5 years. Cyclooxygenase-2 (COX-2) is overexpressed in glioblastoma, and its expression level is highly positively correlated with the tumor grade. As a major enzymatic product of COX-2, prostaglandin E2 (PGE2) mediates inflammatory processes within the brain and facilitates progression of many chronic inflammation-associated neurological diseases via its four downstream receptors - EP1-EP4. We hypothesize that selectively targeting these receptors might provide an alternative therapeutic strategy for GBM with more specificity than generic blockade of the entire COX-2 cascade. In this study, two engineered human GBM cells with or without activated COX-2 were used to explore the PGE2 signaling involved in the development and progression of GBM. COX-2 activation by LPS or its overexpression facilitated migration, invasion, and transformation of these GBM cells in vitro. Moreover, the COX-2-mediated GBM cell activities were substantially suppressed by selective antagonists of PGE2 receptors that are highly expressed in these cells. Furthermore, the tested PGE2 receptor selective antagonists also suppressed the growth of GBM cells in vivo. In sum, our results suggested the inflammatory PGE2 signaling is involved in human GBM cell inflammation, migration, invasion and transformation through its downstream receptors, and should be explored as alternative molecular targets for novel GBM therapies.
Citation Format: Jiange Qiu, Yifeng Du, Qianqian Li, Zhi Shi, Jianxiong Jiang. The role of prostaglandin signaling in human glioblastoma cell activities and growth in vitro and in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3114. doi:10.1158/1538-7445.AM2017-3114</jats:p
Justice et politique (18) - face A
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Henry Rousso et Francine Soubiran-Paillet. Enregistré à l'IHTP (Paris), entre 1995 et1998
Justice et politique (19) - face A
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Henry Rousso et Francine Soubiran-Paillet. Enregistré à l'IHTP (Paris), entre 1995 et1998
Justice et politique (19) - face B
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Henry Rousso et Francine Soubiran-Paillet. Enregistré à l'IHTP (Paris), entre 1995 et1998
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