1,115 research outputs found
sj-docx-1-jet-10.1177_15266028231161242 – Supplemental material for Institutional Volume and Initial Results for Endovascular Treatment for Chronic Occlusive Lower-Extremity Artery Disease: A Report From the Japanese Nationwide Registry
No full textSupplemental material, sj-docx-1-jet-10.1177_15266028231161242 for Institutional Volume and Initial Results for Endovascular Treatment for Chronic Occlusive Lower-Extremity Artery Disease: A Report From the Japanese Nationwide Registry by Takahiro Tokuda, Mitsuyoshi Takahara, Osamu Iida, Shun Kohsaka, Yoshimitsu Soga, Yasuhiro Oba, Keisuke Hirano, Toshiro Shinke, Tetsuya Amano and Yuji Ikari in Journal of Endovascular Therapy</p
sj-docx-2-jet-10.1177_15266028231161242 – Supplemental material for Institutional Volume and Initial Results for Endovascular Treatment for Chronic Occlusive Lower-Extremity Artery Disease: A Report From the Japanese Nationwide Registry
No full textSupplemental material, sj-docx-2-jet-10.1177_15266028231161242 for Institutional Volume and Initial Results for Endovascular Treatment for Chronic Occlusive Lower-Extremity Artery Disease: A Report From the Japanese Nationwide Registry by Takahiro Tokuda, Mitsuyoshi Takahara, Osamu Iida, Shun Kohsaka, Yoshimitsu Soga, Yasuhiro Oba, Keisuke Hirano, Toshiro Shinke, Tetsuya Amano and Yuji Ikari in Journal of Endovascular Therapy</p
sj-docx-3-jet-10.1177_15266028231161242 – Supplemental material for Institutional Volume and Initial Results for Endovascular Treatment for Chronic Occlusive Lower-Extremity Artery Disease: A Report From the Japanese Nationwide Registry
No full textSupplemental material, sj-docx-3-jet-10.1177_15266028231161242 for Institutional Volume and Initial Results for Endovascular Treatment for Chronic Occlusive Lower-Extremity Artery Disease: A Report From the Japanese Nationwide Registry by Takahiro Tokuda, Mitsuyoshi Takahara, Osamu Iida, Shun Kohsaka, Yoshimitsu Soga, Yasuhiro Oba, Keisuke Hirano, Toshiro Shinke, Tetsuya Amano and Yuji Ikari in Journal of Endovascular Therapy</p
Gestão do trabalho e participação: Chega de oba-oba?
No full textThis article aims at investigating the work management in the advertising agencies in the city of
Belo Horizonte. The scope for the analysis was the work developed by Meir (2005) in the book “End
of the fun”. The repercussion aroused by the considerations in the book was the reason to choose
this author, because she proposes a return to the old fashion way of managing the work. The
authors discusses that the forms of managing work are not suitable for the advertisement agencies
and the professional that work for them. She believes that the office cannot be an extension of the
home and the leisure. The qualitative research developed for this investigation presents data
related to the ways of working of these organizations and corroborates with the author’s
statements. It was observed that the employees of the agencies fall into two categories of workers:
a rigid group, that works under strict and well definite rules, and the other group that performs the
tasks in accordance with the demands of the client’s advertising campaign. The results point out to
other issues such as “the lack of creativity toward the administrative procedures” and the clear
division of the work relations in only one organization.Esse artigo tem por finalidade investigar a gestão do trabalho nas agências de publicidade do município de Belo Horizonte. O escopo para a análise da pesquisa foi o trabalho desenvolvido por Meir (2005), no livro “Chega de oba-oba”. A escolha pela autora foi proveniente da repercussão causada por suas considerações, visto que ela propõe um retorno às estruturas antigas nas formas de gerir o trabalho. A autora argumenta que as novas formas de gerir o trabalho não são adequadas para as agências e nem para os profissionais que nelas trabalham. Isto porque acredita que o local de trabalho não pode ser uma extensão do lar e do lazer. A pesquisa de cunho qualitativo, desenvolvida para essa investigação, apresenta dados sobre as formas de se trabalhar e corrobora com as teses da autora. Observou-se que os empregados das agências se enquadram em dois grupos de trabalhadores: um rígido, que trabalha sob regras muito definidas, e um outro que desempenha suas funções em acordo com as exigências demandadas pelas campanhas publicitárias dos clientes da organização. Os resultados apontam para outras questões tais como a “falta de criatividade dos procedimentos administrativos” e da nítida divisão das relações de trabalho nas empresas
Hydrogenation of acetaldehyde on interstellar ice analogs reveals limited destruction
No full text15 pages, 17 figures, 3 tablesWe sought to determine which are the main hydrogenation paths of acetaldehyde
(CH3CHO). As a partially unsaturated molecule, CH3CHO can have links with more
hydrogenated species, like ethanol (C2H5OH) or with more unsaturated ones, like
ketene (H2CCO). We used highly accurate quantum chemical calculations to
determine the reaction rate constants for the CH3CHO + H/D reaction. Our
theoretical results are confronted against our experiments on the hydrogenation
and deuteration of CH3CHO ice. We find that acetaldehyde resists hydrogenation,
with only a 10\% of conversion to products different than CH3CHO. This is due
to a predominance of H-abstraction at the HCO moiety, with reaction rate
constants up to four orders of magnitude higher than the next possible reaction
channel, that is hydrogenation at the aldehydic carbon. The formed CH3CO
radical experiences barrierless or nearly barrierless reactions in all possible
reaction positions, reforming CH3CHO and creating a closed loop that protects
the molecule against hydrogenation. We constrain the branching ratios for the
second reaction from experiments. Our experiments agree with the calculations
and from the combination of both we can explain the presence of H2CCO, CO, CH4,
C2H5OH, H2CO or CH3OH as minor products at the end of the reaction. We provide
recommendations for future modeling efforts. Our results show limited
destruction of acetaldehyde, reinforcing the vision of this molecule as an
abundant and resilient COM. From the experiments, we are not able to observe
the reactive desorption of this molecule. Our results align with other modeling
works, showing that the link between CH3CHO and C2H5OH is not direct. Finally,
our results can explain the excess of CH3CDO found in prestellar cores.G.M acknowledges the support of the grant RYC2022-035442-I funded by MICIU/AEI/10.13039/501100011033 and ESF+. G.M. also received support from project 20245AT016 (Proyectos Intramurales CSIC). We acknowledge the computational resources provided by bwHPC and the German Research Foundation (DFG) through grant no INST 40/575-1 FUGG (JUSTUS 2 cluster), the DRAGO computer cluster managed by SGAI-CSIC, and the Galician Supercomputing Center (CESGA). The supercomputer FinisTerrae III and its permanent data storage system have been funded by the Spanish Ministry of Science and Innovation, the Galician Government and the European Regional Development Fund (ERDF). Y.O and N.W. acknowledge the funding support from JSPS KAKENHI grant nos. JP23H03980, JP21H04501, and JP22H00159.Peer reviewe
Role of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis
No full textRole of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis.
GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group1, Oba K, Paoletti X, Bang YJ, Bleiberg H, Burzykowski T, Fuse N, Michiels S, Morita S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Shitara K, Tsuburaya A, Van Cutsem E, Buyse M.
Collaborators (54)
Buyse M, Michiels S, Oba K, Paoletti X, Rougier P, Yamamoto S, Nakamura K, Bang YJ, Bleiberg H, Burzykowski T, Buyse M, Delbaldo C, Michiels S, Morita S, Oba K, Ohashi Y, Paoletti X, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Van Cutsem E, Ajani J, Boku N, Barone C, Borner M, Bouche O, Bugat R, Coombes C, Cullinan S, Dank M, Douglass H, Fuse N, Glimelius B, Hawkins R, Kanzler S, Koizumi W, Kim TW, Lordick F, Moehler M, Nio Y, Ohtsu A, Pozzo C, Reichardt P, Roth A, Schumacher C, Shitara K, Thuss-Patience P, Tsuburaya A, Van Cutsem E, Vanhoefer U, Wils J, Yamamura Y.
Author information
Abstract
We conducted an individual-patient-data meta-analysis of the efficacy of chemotherapy on overall survival (OS) and progression-free survival (PFS) in advanced/recurrent gastric cancer (AGC). Our primary research question was whether the experimental arms of the trials included in the meta-analysis showed a benefit as compared with their corresponding control arms. MEDLINE (up to 2010), Cochrane Central Register of Controlled Trials, National Institutes of Health (NIH) trial registry and proceedings of major oncologic and gastrointestinal cancer meetings were searched. Randomised controlled trials for AGC closed to patient accrual before the end of 2006 were eligible. As of December 2010, individual patient data were available from 22 trials (4245 patients, representing 47% of the targeted data) of 55 eligible trials. The overall comparison of experimental arms with the corresponding control arms showed statistically significant differences in terms of both OS and PFS. Hazard ratio was 0.88 (95% confidence interval 0.82-0.94, P<0.0001) for OS and 0.81 (0.76-0.88, P<0.0001) for PFS. The results of the sub-analysis of adding a given chemotherapeutic agent to any chemotherapy confirm the results of the overall analysis, with a hazard reduction of 11% for OS (P<0.01) and 26% for PFS (P<0.0001). This meta-analysis of individual patient data shows that the additions of experimental chemotherapeutic agents to pre-existing control or standard regimens have produced a modest improvement in OS and PFS. Median survival remained below 1 year for all investigated chemotherapy regimens and none emerged as a clear standard
Negative catalytic effect of water on the reactivity of hydrogen abstraction from the C-H bond of dimethyl ether by deuterium atoms through tunneling at low temperatures
No full textWe report an experimental study on the catalytic effect of solid water on the reactivity of hydrogen abstraction (H-abstraction) from dimethyl ether (DME) in the low-temperature solid DME-H2O complex. When DME reacted with deuterium atoms on a surface at 15-25 K, it was efficiently deuterated via successive tunneling H-abstraction and deuterium (D)-addition reactions. The 'effective rate constant for DME-H2O + D was found to be about 20 times smaller than that of pure DME + D. This provides the first evidence that the presence of solid water has a negative catalytic effect on tunneling H-abstraction reactions. (C) 2016 Elsevier B.V. All rights reserved
Proposed Importance of HOCO Chemistry: Inefficient Formation of CO2 from CO and OH Reactions on Ice Dust
No full textWith the advent of JWST ice observations, dedicated studies on the formation reactions of detected molecules are becoming increasingly important. One of the most interesting molecules in interstellar ice is CO _2 . Despite its simplicity, the main formation reaction considered, CO + OH → CO _2 + H through the energetic HOCO* intermediate on ice dust, is subject to uncertainty because it directly competes with the stabilization of HOCO as a final product, which is formed through energy dissipation of HOCO* to the water ice. When energy dissipation to the surface is effective during the reaction, HOCO can be a dominant product. In this study, we experimentally demonstrate that the major product of the reaction is indeed not CO _2 , but rather the highly reactive radical HOCO. The HOCO radical can later evolve into CO _2 through H-abstraction reactions, but these reactions compete with additional reactions, leading to the formation of carboxylic acids (R-COOH). Our results highlight the importance of HOCO chemistry and encourage further exploration of the chemistry of this radical
Experimental studies of surface reactions among OH radicals that yield H2O and CO2 at 40-60 K
No full textWe investigated the OH-related formation routes of two astrophysically important molecules, H2O and CO2, under relatively warm astrophysical conditions. OH radicals, together with other neutral species such as H, O, H2, and O2, were produced in H2O microwave-discharge plasma and cooled to 100 K before being deposited on an Al substrate at 40-60 K. H2O formed at 40 and 50 K, but not at 60 K. Taking the experimental conditions into account, a possible route of H2O formation is via reactions involving OH + OH, which yield H2O2 as the main reaction product. The present study is the first to show experimentally that surface reactions of two OH radicals can yield H2O at low temperatures. The products' branching ratio was 0.2 and 0.8 for H2O and H2O2, respectively. When CO was co-deposited with neutral species that formed in the H2O plasma, CO2 was formed at 40-60 K. H2CO3 formed at 40 and 50 K. The present results may suggest that chemical reactions related to OH radicals are effective at yielding various molecules in relatively warm astrophysical environments, such as protostars
Physico-chemical Behavior of Hydrogen Sulfide Induced by Reactions with H and D Atoms on Different Types of Ice Surfaces at Low Temperature
No full textTo elucidate the physico-chemical behavior of hydrogen sulfide (H2S) on icy grains in dense molecular clouds, we investigated the surface reactions of solid H2S with H and D atoms in low-temperature laboratory experiments. We confirmed that H2S was lost from the surface by reaction with H atoms via chemical desorption. We found no strong association between the effective desorption cross section and the ice structure (porous amorphous, nonporous amorphous, or crystalline) or temperature (10-30 K). At 10 K, the reaction rate constant for the H-D substitution of solid H2S with D atoms almost matched that for the D-H substitution of solid D2S with H atoms. The present experimental results clearly suggest that the observed abundances of H2S and its deuterated isotopologues (HDS and D2S) in the interstellar medium are controlled, at least partly, by surface reactions on interstellar icy grains
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