343 research outputs found
On the Influence of Rabbi ‘Haim Joseph David Azulai (‘Hida)’s Shem Ha-Guedolim on the Hebraic Bio-bibliography
No full textBefore entering into the subject of the history of this book and its offspring, the author, the ‘Hida, must be presented briefly. Moritz Steinschneider says of him: “’Haim Joseph David Azulai of Jerusalem (1724-1806) wrote a book about the biographies of the sages of Israel and their works. The content of the book was collected by him throughout his travels.” The ‘Hida, like his father Isaac Zera’hia before him, had been appointed as a rabbinic envoy (shalia’h) to collect the funds necessary ..
Higher Hida theory and p-adic L-functions for GSp(4)
No full textWe use the "higher Hida theory" recently introduced by the second author to p-adically interpolate periods of non-holomorphic automorphic forms for GSp(4), contributing to coherent cohomology of Siegel threefolds in positive degrees. We apply this new method to construct p-adic L-functions associated to the degree 4 (spin) L-function of automorphic representations of GSp(4), and the degree 8 L-function of GSp(4) x GL(2)
A model of Steady-state Faulting at Depths for GPS Surface Displacements and the Stress Field in the Hida Mountains in the Chubu District, Central Honshu, Japan
No full textTwo significant tectonic features in the Chubu district, central Honshu, Japan, are the abrupt change of the GPS displacement pattern along the Niigata-Kobe tectonic line and the anomalous direction NW-SE of compressional stresses derived from earthquake mechanisms and crater alignments of Quaternary volcanos in the Hida mountains, being deviated from the average direction of WNW-ESE of the island arc scale. We attempt to model the GPS displacements consisting of two elements, the right-lateral relative movement at a rate of ～2cm/yr between the northeast and the southwest Japan blocks and a locking fault in the upper crust along the Niigata-Kobe tectonic line. Subtracting the block movements from the GPS displacements yields a new data set of surface displacements, for which we make a geodetic inversion to obtain a backslip model of a left-lateral normal fault with the strike direction N43°E, the dip direction of -43°, the rake angle of 124°, the depth of the lower edge of 20 km, and the slip rate of ～2.9 cm/yr. Superposing the right-lateral block movements on the displacements produced by the backslip fault model recovers the original GPS displacements and a dislocation on the backslip fault becomes zero. The backslip fault turns to be the locking fault in this final situation. This model produces a compressional stress field with the direction NW-SE and a magnitude of ～10kPa/yr at a depth range of 0～10 km, which is qualitatively consistent with the anomalous compressional stress direction in the Hida mountains obtained by focal mechanisms. Based on the modeling, we propose the working hypothesis that the Niigata-Kobe tectonic line currently plays the role of the plate boundary between the Okhotsk (the northeast Japan) and the Amurian plates (southwest Japan blocks), instead of the Itoigawa-Shizuoka tectonic line
Synergistic Enhancement of Cellular Uptake With CD44-Expressing Malignant Pleural Mesothelioma by Combining Cationic Liposome and Hyaluronic Acid-Lipid Conjugate
No full textMalignant pleural mesothelioma (MPM) is a highly aggressive form of cancer, with a median survival of less than 1 year. It is well known that the hyaluronan (HA) receptor CD44 is highly expressed by MPM cells and is reported to be correlated with a poor prognosis. We herein report on the development of a new type if drug delivery system against CD44 that involves the use of lipid nanoparticles (LNPs) equipped with a new type of HA derivative. In this study, we evaluated HA-lipid conjugation (HAL) via the end of the HA molecule through reductive amination, a process that allowed the carboxylate group to remain intact. As a result, the HAL-modified LNP appears to be a potent nanoparticle for dealing with MPM. Surprisingly, the use of a combination of a cationic lipid and HAL had a synergistic effect on cellular uptake in MPM and consequently permitted an anti-cancer drug such as cis-diamminedichloro-platinum(II) (CDDP). Intrapleural injection of CDDP-loaded HAL-LNP (1.5 mg/kg as CDDP) per week significantly suppressed the progression of this type of cancer in an MPM orthotopic model. These results suggest that HAL-modified LNP represents a potent delivery system for MPM cells that express high levels of CD44. (c) 2019 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved
大山元谷の河床礫中に見られる片麻岩状捕獲岩
No full textPresent author recently found gneissic xenoliths in dacite gravels of Motodani, westward valley of Mt.Daisen.
From the results of petrological studies, these gneissic rocks are judged to be the rocks of Hida-Oki metamorphic belt.
It is important problem to know not only the basement rocks of Mt.Daisen but also south extremity of Hida-Oki metamorphic belt.
The discovery of gneissic xenoliths from Mt.Daisen sugests the existence of similar materials to those gneissic xenolithsin considerable amounts under Mt.Daisen
Derivation and validation of a nomogram model for pulmonary thromboembolism in patients undergoing lung cancer surgery
No full textBackground: A specific risk-stratification tool is needed to facilitate safe and cost-effective approaches to the prophylaxis of acute pulmonary thromboembolism (PTE) in lung cancer surgery patients. This study aimed to develop and validate a simple nomogram model for the prediction of PTE after lung cancer surgery using readily obtainable clinical characteristics.Methods: A total of 14,427 consecutive adult patients who underwent lung cancer surgery between January 2015 and July 2018 in our institution were retrospectively reviewed. Included in the cohort were 136 patients who developed PTE and 544 non-PTE patients. The patients were randomly divided into the derivation group (70%, 95 PTE patients and 380 non-PTE patients) and the validation group (30%, 41 PTE patients and 164 non-PTE patients). A nomogram model was developed based on the results of multivariate logistic analysis in the derivation group. The cut-off values were defined using Youden's index. The prognostic accuracy was measured by area under the curve (AUC) values.Results: In the derivation group, multivariate logistic analysis was carried out to evaluate the risk score. The risk assessment model contained five variables: age [95% confidence interval (CI): 1.008-1.083, P=0.016], body mass index (95% CI: 1.077-1.319, P=0.001), operation time (95% CI: 1.002-1.014, P=0.008), the serum level of cancer antigen 15-3 (CA15-3) before surgery (95% CI: 1.019-1.111, P=0.005), and the abnormal results of compression venous ultrasonography before surgery (95% CI: 2.819-18.838, P<0.001). All of them were independent risk factors of PTE. To simplify the risk assessment model, a nomogram model was established, which showed a good predictive performance in the derivation group (AUC 0.792, 95% CI: 0.734-0.853) and in the validation group (AUC 0.813, 95% CI: 0.737-0.890).Conclusions: A high-performance nomogram was established on the risk factors for PTE in patients undergoing lung cancer surgery. The nomogram could be used to provide an individual risk assessment and guide prophylaxis decisions for patients. Further external validation of the model is needed in lung cancer surgery patients in other clinical centers.</p
Significance of anti-angiogenic therapy in head and neck cancer—Heterogeneity of tumor endothelium
No full textSummaryTumor angiogenesis is necessary for solid tumor progression and metastasis. Thus, targeting tumor blood vessels is an important strategy for cancer therapy. Especially, it would give large benefit to head and neck cancer patients if ideal anti-angiogenic drug is developed. Tumor blood vessels have been shown to differ from their normal counterparts, for example, by changes in morphology. An important concept in tumor angiogenesis is that tumor endothelial cells are assumed to be genetically normal, even though these endothelial cells are structurally and functionally abnormal. To date, many anti-angiogenic drugs have been developed, but it has been also reported to cause toxic side effects. To develop ideal anti-angiogenic therapies, understanding tumor endothelial cell abnormalities is important. We have isolated tumor endothelial cells from mouse tumor xenografts and have shown that tumor endothelial cells are abnormal. Tumor endothelial cells upregulate many genes, such as epidermal growth factor receptor. Tumor endothelial cells are also more sensitive to EGF. Unexpectedly, tumor endothelial cells were cytogenetically abnormal. In marked contrast, freshly isolated normal endothelial cells were diploid. We conclude that tumor endothelial cells can acquire cytogenetic abnormalities while in the tumor microenvironment.Here, we provide an overview of the current studies on tumor endothelial cell abnormalities
Clinical evaluation of cholescintigram in hepatobiliary disease with Tc-99m-HIDA
No full text의학과/석사[한글]
종래의 방사선학적검사 뿐아니라, 초음파검사, 전산화 단층촬영과 감마 카메라를 이용한 동위원소 간담도조영술등의 발달로 간·담도계 질환의 진단은 점차 용이해지고 있다. 그러나 특수한 간·담도계 질환은 동위원소를 이용한 방법이 더욱 많이 이용되고 있다.
과거에는 방사성 동위원소를 이용한 간담도 조영술은 주로 I-l3l-Rose Bengal과 I-131- B.S.P 등을 사용하였으나, 1-131 (364 Kev )이 감마-카메라 ( low energy collimater, 100-200 Kev )에 필요한 에너지보다 너무 많은 광자에너지를 내기 때문에 제한되어 사용되
어 왔으며, 근래에는 Tc -99m ( 140 Kev )과 I-l23 ( 159 Kev )등이 적합한 동위원소로 알려져 왔다. 또한 Harvey등에 의해 간담도계로 배설이 잘되는 Tc - 99m - HIDA( N (2.6-dimethyl phenyl carbamoyl methyl) iminodiacetic acid )라는 물질이 개발되어 간·담도조영술에 이용하게 되었다.
이에 저자는 연세대학교 의과대학 연세암센타에서 1980년 5월부터 1981년 9월까지 황달성 간, 담도 질환중 그 원인이 확인된 37예에 대한 Tc-99m-HIDA 간, 담도 조영술의 결과를 분석하여 다음과 같은 결론을 얻었기에 보고하는 바이다.
1. 정상에서는 5분 영상에서 간실질이 균일한 방사능을 보였으며 담도, 담낭과 소장은 30분이내에 나타났으며 간 실질은 40분이내에 급격한 방사능의 저하를 보였다.
2. 간세포성황달과 페쇄성황달의 감별은 혈청 담즙소치가 5.0 mg% 이하에서는 담도와 소장으로의 방사능 배출을 확인함으로써 감별이 가능하였고 5.0 mg%부터 10.0mg%까지는 감별에 어려움이 있었고 10.0mg%이상에서는 감별이 거의 불가능 하였다.
3. 담낭의 악성종양은 담낭이 조영되지 않았으며 담도의 부분적인 협착이 있었고 또한 이행시간의 증가도 있었다.
4. 담낭염 환자에서는 급성 담낭염 5예 모두 담낭에 방사능출현이 없었고 만성 담낭염 4예는 1시간 이상의 지연 영상에서 담낭을 볼 수 있었으며 1예는 전혀 담낭이 보이지 않았다.
5. 총담관 낭종과 외상성 담즙 누출은 방사능의 출현이 해부학적 구조를 명확히 관찰할 수 있었다.
이상의 결과에서 간, 담도, 담낭와 병변이 있는 환자에서, 특히 간세포성 황달과 폐쇄성 황달의 감별과 급성 및 만성 담낭염, 담도의 구조적 이상의 진단에 Tc-99m-HlDA 간, 담도 조영술은 경구적 및 혈관 담도 담낭 조영술등의 검사법보다 간단하고 신속하게 판명해 줄 수 있는 검사법임을 알 수 있었다.
[영문]
Recently, Ultrasonogram, C-T scan and imaging technique using gamma camera as well as conventional contrast study have developed for the detection of hepatobiliary diseases.
Of the radioisotope imaging materials, I-131 Rose Bengal and I-131-BSP have been used as hepatobiliary radiopharmaceutical. But because the I-131 labelled has the limitation which is the undersorable physical characteristic of too high photon (364 Kev) for efficient gamma camera imaging with 100-200 low energy collimater, Tc-99m (140 Kev) and I-123 (159 Kev) have been promising agents for their desirable properties. Harvey et al have recently synthesized a technetium labelled N-substituted iminodiacetic acid derivative (Tc-99m-HIDA) as a hepatobiliary
scintigraphic agent.
The author studied the utility of Tc-99m-HIDA imaging in 37 patients suspected of the hepatobiliary disease from May `80 to Sept. `81 at the YUMC Hospital.
The results were as follows :
1. In normal subjects, the even radioactivity of the liver parenchyme appear at 5-min. image and the gallbladder, bile duct and the small bowel are clearly visualized within 30 min. after injection. The radioactivity of the liver parenchyme rapidly disappeared within 40 minutes.
2. The differential diagnosis of hepatocellular disease and complete obst��ion was possible in jaundiced patients with hyper-bilirubinemia up to 5.0 mg% and equivocal in patients with serum bilirubin level ranging from 5.0 to 10.0 mg%. Beyond that level, it was difficult to persuade.
3. In case of gallbladder carcinoma, there was nonvisualization of gallbladder and segmental dilatation and narrowing of bile duct. The transit time was delayed from bile duct to small bowel.
4. The gallbladder was net visualized in 5 cases of acute cholecystitis and faintly delayed visualized in 4 cases .of chronic cholecystitis.
5. The anatomical abnormalities of the bile duct were disclosed in two cases of choledochal cyst and one case of traumatic bile leakage.
With the above results, Tc-99m-HIDA cholescintigram was found more easily available and accurate method than oral cholecystogram or intravenous cholangiogram in the differential diagnosis between the hepatocellular jaundice and the obstructive jaundice and the diagnosis of the acute cholecystitis, the chronic cholecvstitis and the anatomical abnormality of the bile duct.restrictio
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